Protein Alignment AGO1 and Ago3

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_001258122.1
• Gene: Ago3 / 313593
• RGDID: 1309163
• Length: 860
• Species: Rattus norvegicus
• Alignment Length: 864
• Identity: 622/864 - (71%)
• Similarity: 712/864 - (82%)
• Gaps: 26/864 - (3%)

  Fly   131 PVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMV-HAYSK 194
            |:...||||..|..|:||.|.||.|||.:|:..|:.|:::|:||||||:||||::::|| |....
  Rat    13 PLLIVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVT 77

  Fly   195 IFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGE-GKDRIFRVTIKWQAQVSLFNLEEALEG 258
            |||..:||:||:.:|||.:|||:....::|:|||||| ||||.|:|::|:.::||...|.|.|.|
  Rat    78 IFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSVKFVSRVSWHLLHEVLTG 142

  Fly   259 RT--------RQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSV 315
            ||        :.|..:.:.|:|||:||||||.||||||||||:||||.|||||||||||||||||
  Rat   143 RTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSV 207

  Fly   316 RPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITH 380
            ||:.|||||||||||||||||||||.||||||||.:|:||.:|||||.||||||||||||:|:||
  Rat   208 RPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTH 272

  Fly   381 CGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKH 445
            ||.|||||||||||||||..|:||||||||||||.|||:||.:||.::|:||||||||||||.||
  Rat   273 CGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKH 337

  Fly   446 TYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLTI 510
            ||||||||||||||||||||||.||||||||||||||||:.||:.||:.|::..|.:||||...:
  Rat   338 TYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKV 402

  Fly   511 SNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIW 575
            .:.|..|.|||||.|.||||||..|               :|:|:.||||||||||.|||||::|
  Rat   403 RDEMAHVTGRVLPAPMLQYGGRNRT---------------VATPSHGVWDMRGKQFHTGVEIKMW 452

  Fly   576 AIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQ 640
            ||||||.||..||:.|:.||.||:|||.||||||.|||||||||.|.|.||||||:||.|:.|||
  Rat   453 AIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQ 517

  Fly   641 LVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPS 705
            |::|:|||||||||||||||||:|||||||||.|||.||||||||||||||||||||||:||||.
  Rat   518 LIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPH 582

  Fly   706 IRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMV 770
            .||.||.:||||||||||||||||.|||||||||||||||||||.||||||:.||||||:|:|||
  Rat   583 QRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMV 647

  Fly   771 RELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKR 835
            |||||.||||| .:||.|||.||||||||||..||.:||.|||||||.||.:|:||||:||||||
  Rat   648 RELLIQFYKST-RFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKR 711

  Fly   836 HHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFD 900
            ||||||||::.|:.|:|||||||||||..||||.|||||||||.||||||||||||||||||.|.
  Rat   712 HHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFT 776

  Fly   901 SDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCSEDRTPG 965
            :||||.|||||||||||||||||||||||||||||||||||||:|||||.||||.||.|..|.|.
  Rat   777 ADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQ 841

  Fly   966 AMARAITVHADTKKVMYFA 984
            |:|:|:.:|.||.:.||||
  Rat   842 ALAKAVQIHQDTLRTMYFA 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	64/138 (46%)
		ArgoL1	285..335	CDD:462567	45/49 (92%)
		PAZ_argonaute_like	336..456	CDD:239212	97/119 (82%)
		Piwi_ago-like	502..942	CDD:240015	336/439 (77%)
Ago3	NP_001258122.1	ArgoN	73..167	CDD:465134	40/93 (43%)
		ArgoL1	177..227	CDD:462567	45/49 (92%)
		PAZ_argonaute_like	228..348	CDD:239212	97/119 (82%)
		Piwi_ago-like	393..818	CDD:240015	336/440 (76%)