DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and Ago4

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	XP_006238924.1	Gene:	Ago4 / 298533	RGDID:	1304583	Length:	861	Species:	Rattus norvegicus

Alignment Length:	870	Identity:	619/870 - (71%)
Similarity:	716/870 - (82%)	Gaps:	29/870 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 PDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMV-HA 191
            |...:|..||||.||..|:||.|.||||||.:|:..|:|||::|:|:|.||:||||:::||| |.
  Rat     8 PPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHF 72

  Fly   192 YSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEAL 256
            ..:|||..:|.:||:.|:||..|||||.:|:::||||||||||:.|:|:::|.:.|||..|.|||
  Rat    73 KMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEAL 137

  Fly   257 EGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWK 321
            .|...::|.|::.||||:.||||||.||||||||||.||||||||||||||||||||||||:.||
  Rat   138 AGHLSEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWK 202

  Fly   322 MMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRR 386
            |||||||||||||:|||:|:||||||||::||||.|||||||||||||||:|||:|:||||||:|
  Rat   203 MMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKR 267

  Fly   387 KYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLE 451
            ||||||||||||..|:|||||||||.:|||||:||..||.::|:|.||||||||||.||||||||
  Rat   268 KYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYNLQLKYSHLPCLQVGQEQKHTYLPLE 332

  Fly   452 VCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADF--NNDSYVQEFGLTISNSM 514
            ||||||||||||||||.||||||||||||||||:.||:.|||....  ..|.|::|||:.:.|.|
  Rat   333 VCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSVLGGPDPYLKEFGIVVHNEM 397

  Fly   515 MEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIAC 579
            .|:.|||||.|.||||||              || ::|:|||||||||||||:.|:||::||:||
  Rat   398 TELMGRVLPAPMLQYGGR--------------NK-TVATPNQGVWDMRGKQFYAGIEIKVWAVAC 447

  Fly   580 FAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVV 644
            ||||:..|||.|::||.||:|||.||||||.|||||||||.|.|.|||||::||:|:.||||:||
  Rat   448 FAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVV 512

  Fly   645 VLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPK 709
            :|||||||||||||||||:|||||||||.|||.|||||||||||||||.||||||::|||..||.
  Rat   513 ILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPS 577

  Fly   710 VFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEI----------IQ 764
            ||.:||||||||||||||||.|||||||||||||.|||||.||||||..||||          :|
  Rat   578 VFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEIAQELLFSQEVVQ 642

  Fly   765 ELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITF 829
            :|:||.|||||.||||| .:||.|||.||.||||||...|...||.|||:|||.||.:||||||:
  Rat   643 DLTSMARELLIQFYKST-RFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITY 706

  Fly   830 IVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLW 894
            ||||||||||||||:|.|:.|||||:|||||||..||||:|||||||||.|||||||||||.|||
  Rat   707 IVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLW 771

  Fly   895 DDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCS 959
            |||.|.:||||.|||||||||||||||||||||||||.|||||||||||:|:|||.||||.||.|
  Rat   772 DDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQS 836

  Fly   960 EDRTPGAMARAITVHADTKKVMYFA 984
            ..|.|.|:|:|:.:|.||:..||||
  Rat   837 NGRDPQALAKAVQIHHDTQHTMYFA 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	69/129 (53%)
		ArgoL1	285..335	CDD:400854	46/49 (94%)
		PAZ_argonaute_like	336..456	CDD:239212	96/119 (81%)
		Piwi_ago-like	502..942	CDD:240015	329/449 (73%)
Ago4	XP_006238924.1	PLN03202	15..860	CDD:215631	614/860 (71%)
		ArgoN	18..155	CDD:293095	73/136 (54%)
		ArgoL1	167..216	CDD:285861	45/48 (94%)
		PAZ_argonaute_like	217..337	CDD:239212	96/119 (81%)
		Piwi_ago-like	384..819	CDD:240015	329/450 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4563
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100361
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X379
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930