DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and AGO1

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_001304051.1	Gene:	AGO1 / 26523	HGNCID:	3262	Length:	891	Species:	Homo sapiens

Alignment Length:	881	Identity:	640/881 - (72%)
Similarity:	729/881 - (82%)	Gaps:	27/881 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 ASALGATTGSVTPAIATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDI 169
            |...||..|:..|          |...||..||||.:|..|:||.|.||:|:|.:|:..|:||::
Human     3 AGPSGAAAGAYLP----------PLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEV 57

  Fly   170 NIQPDKCPRKVNREIIETMV-HAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGK 233
            :|:||||||:||||::|.|| |...:|||..|||:||:.|:||...|||||||::.|||:|||||
Human    58 DIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGK 122

  Fly   234 DRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYY 298
            ||||:|:|||.|.||...|.|||......:|.:::.||||.||||.||.||||||||||.|||||
Human   123 DRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYY 187

  Fly   299 HPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQ 363
            |||||||||||||||||||:.|||||||||||||||||||||:|||||||||:|:||.|||||||
Human   188 HPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQ 252

  Fly   364 RVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMK 428
            ||:|||||||||:|:||||||:|||||||||||||..|:||||||:|||||||||:||..||.::
Human   253 RVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQ 317

  Fly   429 LRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVK 493
            |:||||||||||||.||||||||||||||||||||||||.||||||||||||||||:.||:.|:|
Human   318 LKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMK 382

  Fly   494 RADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGV 558
            .|.:|.|.|:||||:.:.:.|.||.|||||.|.||||||              |: ::|:|||||
Human   383 NASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGR--------------NR-AIATPNQGV 432

  Fly   559 WDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPD 623
            ||||||||:.|:||::|||||||||:..||:.|:|||.||:|||.||||||.|||||||||.|.|
Human   433 WDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGAD 497

  Fly   624 QVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLC 688
            .||||||:||.|:.||||::|:|||||||||||||||||:|||||||||.|||.|||||||||||
Human   498 SVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLC 562

  Fly   689 LKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATV 753
            |||||||||||:||||..|..||.:||||||||||||||||.|||||.|||||||||||||.|||
Human   563 LKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATV 627

  Fly   754 RVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIK 818
            |||:.|||||::||.|||||||.||||| .:||.|||.|||||.|||.|.:|.:||.|||:||||
Human   628 RVQRPRQEIIEDLSYMVRELLIQFYKST-RFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIK 691

  Fly   819 LEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQG 883
            ||.:|:||||:||||||||||||||:|.|:.|||||||||||||..||||.|||||||||.||||
Human   692 LEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQG 756

  Fly   884 TSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHD 948
            |||||||:||||||.|.:||||.|||||||||||||||||||||||||.|||||||||||:||||
Human   757 TSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHD 821

  Fly   949 SGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA 984
            ||||||.||.|..|.|.|:|:|:.||.||.:.||||
Human   822 SGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	72/129 (56%)
		ArgoL1	285..335	CDD:400854	46/49 (94%)
		PAZ_argonaute_like	336..456	CDD:239212	99/119 (83%)
		Piwi_ago-like	502..942	CDD:240015	334/439 (76%)
AGO1	NP_001304051.1	PLN03202	26..856	CDD:215631	620/830 (75%)
		ArgoN	26..164	CDD:293095	77/138 (56%)
		ArgoL1	175..224	CDD:285861	43/48 (90%)
		PAZ_argonaute_like	225..345	CDD:239212	99/119 (83%)
		Piwi_ago-like	390..815	CDD:240015	314/424 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	530	1.000	Domainoid score	I282
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1308	1.000	Inparanoid score	I153
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	1	1.000	-	-		otm41559
orthoMCL	1	0.900	-	-		OOG6_100361
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3246
SonicParanoid	1	1.000	-	-		X379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870