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Protein Alignment AGO1 and Ago2

DIOPT Version :10

Sequence 1:	NP_725341.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_694818.3	Gene:	Ago2 / 239528	MGIID:	2446632	Length:	860	Species:	Mus musculus

Alignment Length:	871	Identity:	641/871 - (73%)
Similarity:	731/871 - (83%)	Gaps:	20/871 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PAIATATPATQPDMP--VFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRK 179
            |.:|:..|.|.| :|  .|..|.||:.|..||.|.|:||.|::.:|:..::||:::|:|:||||:
Mouse     7 PVLASPAPTTSP-IPGYAFKPPPRPDFGTTGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRR 70

  Fly   180 VNREIIETMV-HAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKW 243
            |||||:|.|| |..::|||..|||||||.||||..|||||.:::|||||||||||||||:|:|||
Mouse    71 VNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKW 135

  Fly   244 QAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVW 308
            .:.|||..|.:||.||...:|::.|.||||||||||||.|||||||||::.||..:|||||||||
Mouse   136 VSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVW 200

  Fly   309 FGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKG 373
            ||||||||||.|||||||||||||||||||||:|:|||||.:.|.||:|||||||||||||||||
Mouse   201 FGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKG 265

  Fly   374 LKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQ 438
            ||:||||||||:|||||||||||||..|:||||.|:|||||||||:||.|::::.||||||||||
Mouse   266 LKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQ 330

  Fly   439 VGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYV 503
            ||||.||||||||||||||||||||||||.||||||:|||||||||:.||:.|::.|.||.|.||
Mouse   331 VGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYV 395

  Fly   504 QEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFT 568
            :|||:.:.:.|.:|.||||.||.:.||||              || ::|:|.|||||||.|||.|
Mouse   396 REFGIMVKDEMTDVTGRVLQPPSILYGGR--------------NK-AIATPVQGVWDMRNKQFHT 445

  Fly   569 GVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLK 633
            |:||::||||||||||...|..|::||:||:|||.||||||.|||||||||.|.|.||||||:||
Mouse   446 GIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLK 510

  Fly   634 ITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGI 698
            .|:.|||||||:|||||||||||||||||||||||||||.|||.:|:|||||||||||||||||:
Mouse   511 NTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGV 575

  Fly   699 NSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEII 763
            |:||:|..||.||.:||||||||||||||||.||||||||||||||||:||.|||||||||||||
Mouse   576 NNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEII 640

  Fly   764 QELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGIT 828
            |:|::|||||||.||||| .:||.|||.||||||||||..||.|||.||||||||||.:|:||||
Mouse   641 QDLAAMVRELLIQFYKST-RFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGIT 704

  Fly   829 FIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVL 893
            ||||||||||||||.:|.|:.|||||||||||||..||||||||||||||.||||||||||||||
Mouse   705 FIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVL 769

  Fly   894 WDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGC 958
            ||||.|.|||||.|||||||||||||||||||||||||||||||||||||:|||||.||||.||.
Mouse   770 WDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQ 834

  Fly   959 SEDRTPGAMARAITVHADTKKVMYFA 984
            |..|...|:|:|:.||.||.:.||||
Mouse   835 SNGRDHQALAKAVQVHQDTLRTMYFA 860

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.