DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and AGO4

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_060099.2	Gene:	AGO4 / 192670	HGNCID:	18424	Length:	861	Species:	Homo sapiens

Alignment Length:	870	Identity:	620/870 - (71%)
Similarity:	717/870 - (82%)	Gaps:	29/870 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 PDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMV-HA 191
            |...:|..||||.||..|:||.|.||||||.:|:..|:|||::|:|:|.||:||||:::||| |.
Human     8 PPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHF 72

  Fly   192 YSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEAL 256
            ..:|||..:|.:||:.|:||..|||||.:|:::||||||||||:.|:|:::|.:.|||..|.|||
Human    73 KMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEAL 137

  Fly   257 EGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWK 321
            .|...::|.|::.||||:.||||||.||||||||||.||||||||||||||||||||||||:.|.
Human   138 AGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWN 202

  Fly   322 MMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRR 386
            |||||||||||||:|||:|:||||||||::||||.|||||||||||||||:|||:|:||||||:|
Human   203 MMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKR 267

  Fly   387 KYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLE 451
            ||||||||||||..|:|||||||||.:|||||:||..||.::|:||||||||||||.||||||||
Human   268 KYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLE 332

  Fly   452 VCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADF--NNDSYVQEFGLTISNSM 514
            ||||||||||||||||.||||||||||||||||:.||:.|||....  ..|.|::|||:.:.|.|
Human   333 VCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEM 397

  Fly   515 MEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIAC 579
            .|:.|||||.|.||||||              || ::|:|||||||||||||:.|:||::||:||
Human   398 TELTGRVLPAPMLQYGGR--------------NK-TVATPNQGVWDMRGKQFYAGIEIKVWAVAC 447

  Fly   580 FAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVV 644
            ||||:..|||.|::||.||:|||.||||||.|||||||||.|.|.|||||::||:|:.||||:||
Human   448 FAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVV 512

  Fly   645 VLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPK 709
            :|||||||||||||||||:|||||||||.|||.|||||||||||||||.||||||::|||..||.
Human   513 ILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPS 577

  Fly   710 VFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEI----------IQ 764
            ||.:||||||||||||||||.|||||||||||||.|||||.||||||..||||          ||
Human   578 VFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQ 642

  Fly   765 ELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITF 829
            :|::|||||||.||||| .:||.|||.||.||||||...|...||.|||:|||.||.:||||||:
Human   643 DLTNMVRELLIQFYKST-RFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITY 706

  Fly   830 IVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLW 894
            ||||||||||||||:|.|:.|||||:|||||||..||||:|||||||||.|||||||||||.|||
Human   707 IVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLW 771

  Fly   895 DDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCS 959
            |||.|.:||||.|||||||||||||||||||||||||.|||||||||||:|:|||.||||.||.|
Human   772 DDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQS 836

  Fly   960 EDRTPGAMARAITVHADTKKVMYFA 984
            ..|.|.|:|:|:.:|.||:..||||
Human   837 NGRDPQALAKAVQIHHDTQHTMYFA 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	69/129 (53%)
		ArgoL1	285..335	CDD:400854	45/49 (92%)
		PAZ_argonaute_like	336..456	CDD:239212	97/119 (82%)
		Piwi_ago-like	502..942	CDD:240015	330/449 (73%)
AGO4	NP_060099.2	ArgoN	26..155	CDD:406799	68/128 (53%)
		ArgoL1	166..216	CDD:400854	45/49 (92%)
		PAZ_argonaute_like	217..337	CDD:239212	97/119 (82%)
		Piwi_ago-like	384..819	CDD:240015	330/450 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	825..846		12/20 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2490
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1308	1.000	Inparanoid score	I153
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	1	1.000	-	-		otm41559
orthoMCL	1	0.900	-	-		OOG6_100361
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840