DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AGO1 and AGO3

DIOPT Version :9

Sequence 1:NP_001246314.1 Gene:AGO1 / 36544 FlyBaseID:FBgn0262739 Length:984 Species:Drosophila melanogaster
Sequence 2:NP_079128.2 Gene:AGO3 / 192669 HGNCID:18421 Length:860 Species:Homo sapiens


Alignment Length:882 Identity:628/882 - (71%)
Similarity:717/882 - (81%) Gaps:35/882 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 GSVTPAIATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCP 177
            ||..||.|         .|:...||||..|..|:||.|.||.|||.:|:..|:.|:::|:|||||
Human     4 GSAGPAGA---------QPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCP 59

  Fly   178 RKVNREIIETMV-HAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGE-GKDRIFRVT 240
            |:||||::::|| |....|||..:||:||:.:|||.:|||:....::|:|||||| ||||.|:|:
Human    60 RRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVS 124

  Fly   241 IKWQAQVSLFNLEEALEGRT--------RQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGY 297
            ||:.::||...|.|.|.|||        :.|..:.:.|:|||:||||||.||||||||||:||||
Human   125 IKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGY 189

  Fly   298 YHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDS 362
            .|||||||||||||||||||:.|||||||||||||||||||||.||||||||.:|:||.:|||||
Human   190 DHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDS 254

  Fly   363 QRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRM 427
            .||||||||||||:|:||||.|||||||||||||||..|:||||||||||||.|||:||.:||.:
Human   255 HRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTL 319

  Fly   428 KLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLV 492
            :|:||||||||||||.||||||||||||||||||||||||.||||||||||||||||:.||:.||
Human   320 QLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLV 384

  Fly   493 KRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQG 557
            :.|::..|.:||||...:.:.|..|.|||||.|.||||||..|               :|:|:.|
Human   385 RSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRT---------------VATPSHG 434

  Fly   558 VWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGP 622
            |||||||||.|||||::|||||||.||..||:.|:.||.||:|||.||||||.|||||||||.|.
Human   435 VWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGA 499

  Fly   623 DQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNL 687
            |.||||||:||.|:.||||::|:|||||||||||||||||:|||||||||.|||.||||||||||
Human   500 DSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNL 564

  Fly   688 CLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAAT 752
            ||||||||||||:||||..||.||.:||||||||||||||||.|||||||||||||||||||.||
Human   565 CLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCAT 629

  Fly   753 VRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACI 817
            ||||:.||||||:|:||||||||.||||| .:||.|||.||||||||||..||.:||.|||||||
Human   630 VRVQRPRQEIIQDLASMVRELLIQFYKST-RFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACI 693

  Fly   818 KLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQ 882
            .||.:|:||||:||||||||||||||::.|:.|:|||||||||||..||||.|||||||||.|||
Human   694 SLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQ 758

  Fly   883 GTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEH 947
            |||||||||||||||.|.:||||.|||||||||||||||||||||||||||||||||||||:|||
Human   759 GTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEH 823

  Fly   948 DSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA 984
            ||.||||.||.|..|.|.|:|:|:.:|.||.:.||||
Human   824 DSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA 860

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AGO1NP_001246314.1 ArgoN 146..275 CDD:406799 65/138 (47%)
ArgoL1 285..335 CDD:400854 45/49 (92%)
PAZ_argonaute_like 336..456 CDD:239212 97/119 (82%)
Piwi_ago-like 502..942 CDD:240015 336/439 (77%)
AGO3NP_079128.2 ArgoN 73..167 CDD:406799 41/93 (44%)
ArgoL1 177..227 CDD:400854 45/49 (92%)
PAZ_argonaute_like 228..348 CDD:239212 97/119 (82%)
Piwi_ago-like 393..818 CDD:240015 336/440 (76%)
Interaction with guide RNA. /evidence=ECO:0000305|PubMed:29040713 530..567 33/36 (92%)
Interaction with guide RNA. /evidence=ECO:0000305|PubMed:29040713 758..805 42/46 (91%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 530 1.000 Domainoid score I282
eggNOG 1 0.900 - - E1_KOG1041
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1308 1.000 Inparanoid score I153
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG58336
OrthoDB 1 1.010 - - D159407at2759
OrthoFinder 1 1.000 - - FOG0000468
OrthoInspector 1 1.000 - - otm41559
orthoMCL 1 0.900 - - OOG6_100361
Panther 1 1.100 - - O PTHR22891
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3246
SonicParanoid 1 1.000 - - X379
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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