DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and wago-5

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_495151.3	Gene:	wago-5 / 191545	WormBaseID:	WBGene00022877	Length:	912	Species:	Caenorhabditis elegans

Alignment Length:	938	Identity:	218/938 - (23%)
Similarity:	367/938 - (39%)	Gaps:	208/938 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 VFTCPRRPNLGREGRPIVLRANHFQVTMPR-GYVHHYDINIQPDKCP------RKVNRE---IIE 186
            ::|.|..|  |..|:.:.:..|.|.|.:.: ..||.:.::.:.|...      .|..:|   :::
Worm    39 IYTTPTEP--GTLGKQVDVGTNIFGVEVTKETTVHRFVVHAKADLTSTKEVTFTKKGKEDFVVLD 101

  Fly   187 TMVHAYSKIFGVLKP-------------VFDGRNNLYTRDPL-------------------PIGN 219
            ......:..|..::.             |:||::.|||...|                   ..||
Worm   102 RREKCCNLFFNAVEKNPDFFKMKDGNHIVYDGQSTLYTTINLFSELDCNQTKSKVFQINGADTGN 166

  Fly   220 ERLE------LEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHL 278
            :.|:      ||:..|   :|....::.|...:.:   .::.:|...|:......|||:   :|.
Worm   167 DELKTLPCISLEIHAP---RDNSITISAKILGERT---ADQNIEVNNREYTQFLELALN---QHC 222

  Fly   279 PSMTYT----PVGRSFF--SSPEGYYH----PLGGGREVWFGFHQSVR------------PSQWK 321
            ...|..    ..|:.:|  ::.||:..    .:|.|:.::.|..::::            ||
Worm   223 TRETKRFGCFEHGKVYFLNATEEGFDQRDCVDVGDGKALYPGLKKTIQFIEGPFGRGQNNPS--- 284

  Fly   322 MMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQM-- 384
              |.||....||:|.|.||..:.|:..    .:....|:...|.|.|..||||     .|..|
Worm   285 --LVIDGMKAAFHKEQTVIQKLFEITG----QDPSNGLSSMAREKATPVIKGL-----DCYSMYT 338

  Fly   385 --RRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTY 447
              :|..|:..:....|....|  :|.:|:|  |::|:||.|||.:.|:||....:.......:.|
Worm   339 SRKRHLRIVGIFHESATGTRF--ELPDGKT--CSIAEYFRDKYSINLQYPKANLVVCKDRGNNNY 399

  Fly   448 LPLEVCNIVAGQRC-IKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLTIS 511
            .|.|:..|...||. |.:.|..|.:|...|.   .||..:.|  ::|.....|        :|..
Worm   400 FPAELMTISKNQRATIPQQTQSQKTTKECAV---LPDVRQRI--IIKGKTAVN--------ITAE 451

  Fly   512 NSMMEVRG-RVLPPP------KLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDM-----RGK 564
            |.::...| :|...|      :|.|.........|:...||.:.|..|: .|.:|.:     :..
Worm   452 NELLNALGIKVYSEPLKVSLKELGYQRSTVKSELGKWRPPPGSFVKPAA-FQDLWALYAVGNQNS 515

  Fly   565 QF-------FTGVEIRIWAIACFAPQRTVR---EDALRNFTQQLQKISNDAGMPIIGQPCFCKYA 619
            :|       |||:.|.    ||......::   |.:|.:....:..:.|.|...       ||:|
Worm   516 RFSVSDLSQFTGMFID----ACKKRGMIIKPPSETSLCHMDNIISLLENAAASK-------CKFA 569

  Fly   620 --TGPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQ 682
              ...|.:..:.:..|           .|..|:.:..:..::.           :|.:|.|...:
Worm   570 FVITDDSITHLHKKYK-----------ALEQKSMMVIQDMKIS-----------KANSVVKDGKR 612

  Fly   683 -TLSNLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAG-----DNK---KPSIAAV 738
             ||.|:..|.|:||||:|..:  |...|...:..:.:|..|:.||||     |||   .|.|...
Worm   613 LTLENVINKTNMKLGGLNYTV--SDAKKSMTDEQLIIGVGVSAPPAGTKYMMDNKGHLNPQIIGF 675

  Fly   739 VGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPH 803
            ..:..|: ..:.....:....|:.:..:..:::..:.:| :......|.|||:||.|.|:|....
Worm   676 ASNAVAN-HEFVGDFVLAPSGQDTMASIEDVLKSSIDLF-EMNRNTLPKRIIIYRSGASDGSHAS 738

  Fly   804 VLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSG--NIPAGTTVDVGIT 866
            :|.:|:...|........:.  .:.:|:|.|.|..|.| .::....||:.  |||.|..:|..:|
Worm   739 ILAYEIPLARATIQGYSKDI--NLIYIIVTKEHSYRFF-RDQLRSGGKATEMNIPPGIVLDSAVT 800

  Fly   867 HPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYA 931
            :|....|:|..|..:|||::...|.:|.||.:...|.|:.|||.|||.:.....|.|||.|.|.|
Worm   801 NPACKQFFLNGHTTLQGTAKTPLYTILADDCNAPMDRLEELTYTLCHHHQIVALSTSIPTPLYVA 865

  Fly   932 HLVAFRAR------------YHLVEKEH 947
            :..|.|.|            ||   :||
Worm   866 NEYAKRGRDLWAHGPNEANEYH---EEH 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	29/176 (16%)
		ArgoL1	285..335	CDD:400854	14/67 (21%)
		PAZ_argonaute_like	336..456	CDD:239212	34/123 (28%)
		Piwi_ago-like	502..942	CDD:240015	117/486 (24%)
wago-5	NP_495151.3	ArgoN	47..>143	CDD:293095	17/95 (18%)
		PAZ_argonaute_like	297..407	CDD:239212	34/122 (28%)
		Piwi	568..876	CDD:280353	89/336 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910