Protein Alignment AGO1 and alg-1

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_001367206.1
• Gene: alg-1 / 181504
• WormBaseID: WBGene00000105
• Length: 1023
• Species: Caenorhabditis elegans
• Alignment Length: 1015
• Identity: 647/1015 - (63%)
• Similarity: 770/1015 - (75%)
• Gaps: 81/1015 - (7%)

  Fly     2 STERELAPGGPAQLHPHTLPLTFPDLQMTSTVGIIGKVYESQWTPSPTRPQSPSQA-QTSFDTLT 65
            ||..::.|...|...|     .||..|..::..:...:.|...:| ||:||:.|.. |....:|
 Worm    58 STSSQVVPTSGATQQP-----PFPSAQAAASTALQNDLEEIFNSP-PTQPQTFSDVPQRQAGSL- 115

  Fly    66 SPPAPGSSVNPTAVTSPSAQNVAAGGATVAGAAATAAQVASALGATTGSVTPAIATATPATQPDM 130
               |||..:..|:|:.....|...||  :.|.|.         |...|.....|.
 Worm   116 ---APGVPIGNTSVSIGEPANTLGGG--LPGGAP---------GQLPGGNQSGIQ---------- 156

  Fly   131 PVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKI 195
              |.||||||.|.|||.|:||||||.|.:|.|.:.||.:::.||||||:||||||..::.|:||.
 Worm   157 --FQCPRRPNHGVEGRSILLRANHFAVRIPGGTIQHYQVDVTPDKCPRRVNREIISCLISAFSKY 219

  Fly   196 FGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGK-DRIFRVTIKWQAQVSLFNLEEALEGR 259
            |..::||:||:.|:|||:|||||.||::.:|||||:.. :|.|.|::||..||||..||:|:|||
 Worm   220 FTNIRPVYDGKRNMYTREPLPIGRERMDFDVTLPGDSAVERQFSVSLKWVGQVSLSTLEDAMEGR 284

  Fly   260 TRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSP--------------------------EGYY 298
            .||:|::|:.|:||::|||||:.||||||||||.|                          .|.|
 Worm   285 VRQVPFEAVQAMDVILRHLPSLKYTPVGRSFFSPPVPNASGVMAGSCPPQASGAVAGGAHSAGQY 349

  Fly   299 H---PLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIR-DINEQRKPL 359
            |   .||||||||||||||||||||||||||||||||||::.|||:|:.|||::. ....:|:.|
 Worm   350 HAESKLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYRSMPVIEFIAEVLELPVQALAERRAL 414

  Fly   360 TDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDK 424
            :|:|||||||||:|||||||||||||||||||||||||||.|:||||||.|||:||||||||.||
 Worm   415 SDAQRVKFTKEIRGLKIEITHCGQMRRKYRVCNVTRRPAQTQTFPLQLETGQTIECTVAKYFYDK 479

  Fly   425 YRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREIN 489
            ||::|:||||||||||||.||||||.||||||.||||||||||:||||||||||||||:|||||:
 Worm   480 YRIQLKYPHLPCLQVGQEQKHTYLPPEVCNIVPGQRCIKKLTDVQTSTMIKATARSAPEREREIS 544

  Fly   490 NLVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASP 554
            |||::|:|:.|.:..|||:||:.:|.||:||||..|||.||||..               :.|.|
 Worm   545 NLVRKAEFSADPFAHEFGITINPAMTEVKGRVLSAPKLLYGGRTR---------------ATALP 594

  Fly   555 NQGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYA 619
            ||||||||||||.||:::|:|||||||.|:.|:|:.||.||.|||:|||||||||:|.|||||||
 Worm   595 NQGVWDMRGKQFHTGIDVRVWAIACFAQQQHVKENDLRMFTNQLQRISNDAGMPIVGNPCFCKYA 659

  Fly   620 TGPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTL 684
            .|.:||||||:|||..:.|:||||||||||||||||||||||||||:|||||||||..:|:||||
 Worm   660 VGVEQVEPMFKYLKQNYSGIQLVVVVLPGKTPVYAEVKRVGDTVLGIATQCVQAKNAIRTTPQTL 724

  Fly   685 SNLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRY 749
            ||||||:||||||:||||:|::||::|||||||.|.|:|||||||::||||||||||||||||||
 Worm   725 SNLCLKMNVKLGGVNSILLPNVRPRIFNEPVIFFGCDITHPPAGDSRKPSIAAVVGSMDAHPSRY 789

  Fly   750 AATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIRE 814
            ||||||||||||||.:|:.||||||:.||::| .:||.||::||||||||||.:|||:||.||||
 Worm   790 AATVRVQQHRQEIISDLTYMVRELLVQFYRNT-RFKPARIVVYRDGVSEGQFFNVLQYELRAIRE 853

  Fly   815 ACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQ 879
            ||:.||..|:||||||.||||||||||..:||:|.||:.|||.|||||||||||||||||||||.
 Worm   854 ACMMLERGYQPGITFIAVQKRHHTRLFAVDKKDQVGKAYNIPPGTTVDVGITHPTEFDFYLCSHA 918

  Fly   880 GIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVE 944
            ||||||||||||||||||:..:||||.||||:||||||||||||||||||||||||||||||||:
 Worm   919 GIQGTSRPSHYHVLWDDNNLTADELQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVD 983

  Fly   945 KEHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA 984
            :||||||||..||.|||.|...||||:.||.|...|||||
 Worm   984 REHDSGEGSQPSGTSEDTTLSNMARAVQVHPDANNVMYFA 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	71/129 (55%)
		ArgoL1	285..335	CDD:462567	45/78 (58%)
		PAZ_argonaute_like	336..456	CDD:239212	91/120 (76%)
		Piwi_ago-like	502..942	CDD:240015	326/439 (74%)
alg-1	NP_001367206.1	ArgoN	170..300	CDD:465134	71/129 (55%)
		ArgoL1	310..389	CDD:462567	45/78 (58%)
		PAZ_argonaute_like	390..511	CDD:239212	91/120 (76%)
		Piwi_ago-like	556..981	CDD:240015	326/440 (74%)