DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and nrde-3

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_508092.1	Gene:	nrde-3 / 180392	WormBaseID:	WBGene00019862	Length:	1057	Species:	Caenorhabditis elegans

Alignment Length:	1058	Identity:	216/1058 - (20%)
Similarity:	399/1058 - (37%)	Gaps:	273/1058 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 QVASALGATTGSVT--PAI-ATATPAT-------------QPDMPVFTCP--RRPNLGREGRPIV 149
            :|...:|:..||..  ||. |::||.|             ||..|:||.|  ::.:||  ||  :
Worm     6 KVMGEMGSKPGSTAKKPATSASSTPRTNVWGTAKKPSSQQQPPKPLFTTPGSQQGSLG--GR--I 66

  Fly   150 LRANHFQVTMP----------------------RGYVHHYDINIQPDKCPRKVNREIIE-TMVHA 191
            .:..|...|.|                      |..::.::::|  .|...:::|.:.. |:||.
Worm    67 PKREHTDRTGPDPKRKPLGGLSVPDSFNNFGTFRVQMNAWNLDI--SKMDERISRIMFRATLVHT 129

  Fly   192 YSKIF----GVLKPVFDGRNNLYTR-----------------------DP----------LPIGN 219
            ..:.|    ||  ..|.|..|...|                       ||          :.:|.
Worm   130 DGRRFELSLGV--SAFSGDVNRQQRRQAQCLLFRAWFKRNPELFKGMTDPAIAAYDAAETIYVGC 192

  Fly   220 ERLELEVT-----------LPGEGK---------DRIFRVTIKWQAQV-----SLFNLEEALEGR 259
            ...::|:|           .|.|.|         ...|.:.||....:     :...||...| .
Worm   193 SFFDVELTEHVCHLTEADFSPQEWKIVSLISRRSGSTFEIRIKTNPPIYTRGPNALTLENRSE-L 256

  Fly   260 TRQIPYDAILALDVVMRHLPSMTYT----PVGRSFFSSPEGYYHPLGGGREVWF---GFHQSV-- 315
            ||.|  :||  .|..:.:...:.|:    |......:||:          ||..   ||.::.
Worm   257 TRII--EAI--TDQCLHNEKFLLYSSGTFPTKGGDIASPD----------EVTLIKSGFVKTTKI 307

  Fly   316 --RPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLD------------------------IRDINE 354
              |......::.:|.:.:.|||...::.|....:|                        .|..::
Worm   308 VDRDGVPDAIMTVDTTKSPFYKDTSLLKFFTAKMDQLTNSGGGPRGHNGGRERRDGGGNSRKYDD 372

  Fly   355 QRKP-----------------------LTDSQRVKFTKEIKGLKIEITHC--GQMRRKYRVCNVT 394
            :|.|                       ::|.......:.:|||..:..|.  .:..|...:..:.
Worm   373 RRSPRDGEIDYDERTVSHYQRQFQDERISDGMLNTLKQSLKGLDCQPIHLKDSKANRSIMIDEIH 437

  Fly   395 RRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQ 459
            ...|...:|..:|.:|:....::.:|:|.:|..:|::||||.:...:...:.:.|:|:.:|:.||
Worm   438 TGTADSVTFEQKLPDGEMKLTSITEYYLQRYNYRLKFPHLPLVTSKRAKCYDFYPMELMSILPGQ 502

  Fly   460 RCIKKLTDMQTSTMIKATARSAPDREREINNLV-----KRADFNNDSYVQEFGLTI-SNSMMEVR 518
            |..:....:...:.:.....|.||:..:.:.||     |..|...:..:..|.::: |...:...
Worm   503 RIKQSHMTVDIQSYMTGKMSSLPDQHIKQSKLVLTEYLKLGDQPANRQMDAFRVSLKSIQPIVTN 567

  Fly   519 GRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFAPQ 583
            ...|.||.:::.               .|::...:|.:||......:|.....::...|..:..:
Worm   568 AHWLSPPDMKFA---------------NNQLYSLNPTRGVRFQTNGKFVMPARVKSVTIINYDKE 617

  Fly   584 RTVREDALRNFTQQLQKISNDAGMPIIGQP-CFCKYATGPD-------QVEPMFRYLKITFPGLQ 640
            .....|.   |.:.|.|..::.||....:| .:.|...|..       ::|...|      .|:.
Worm   618 FNRNVDM---FAEGLAKHCSEQGMKFDSRPNSWKKVNLGSSDRRGTKVEIEEAIR------NGVT 673

  Fly   641 LVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNK-----TSPQTLSNLCLKINVKLGGINS 700
            :|..::..|.|...::.:..:..||..|..:.::..:|     ...||:.|:..|:|.|.||.|.
Worm   674 IVFGIIAEKRPDMHDILKYFEEKLGQQTIQISSETADKFMRDHGGKQTIDNVIRKLNPKCGGTNF 738

  Fly   701 IL-VP-------------SIRPKVFNEPVIFLGADVTHPPA------------GDNKKPSIAAVV 739
            :: ||             .:|.|::.: ..|:|.:::|..|            ||   |::..|.
Worm   739 LIDVPESVGHRVVCNNSAEMRAKLYAK-TQFIGFEMSHTGARTRFDIQKVMFDGD---PTVVGVA 799

  Fly   740 GSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMF--YKSTGGYKPHRIILYRDGVSEGQFP 802
            .|: .|.::.......|:.|   :.:|:::..::.|..  |:.:..|.|..:::||.|..||.:|
Worm   800 YSL-KHSAQLGGFSYFQESR---LHKLTNLQEKMQICLNAYEQSSSYLPETVVVYRVGSGEGDYP 860

  Fly   803 HVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKS--GNIPAGTTVDV-G 864
            .:: :|:..::.|..|.:..|.|....|..|:..|.|:| .|...:.|||  .|:.:||.||| |
Worm   861 QIV-NEVNEMKLAARKKKHGYNPKFLVICTQRNSHIRVF-PEHINERGKSMEQNVKSGTCVDVPG 923

  Fly   865 ITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAY 929
            .:|..| :|.||....:.||.:|:.|.::.:|..:..:|:..:||.|...:.......:||..:|
Worm   924 ASHGYE-EFILCCQTPLIGTVKPTKYTIIVNDCRWSKNEIMNVTYHLAFAHQVSYAPPAIPNVSY 987

  Fly   930 YAHLVAFRARYHLVEKEH 947
            .|..:|.|.  |...|.|
Worm   988 AAQNLAKRG--HNNYKTH 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	38/213 (18%)
		ArgoL1	285..335	CDD:400854	10/56 (18%)
		PAZ_argonaute_like	336..456	CDD:239212	25/168 (15%)
		Piwi_ago-like	502..942	CDD:240015	107/484 (22%)
nrde-3	NP_508092.1	PAZ_argonaute_like	385..499	CDD:239212	20/113 (18%)
nrde-3	NP_508092.1	Piwi	673..1001	CDD:280353	85/340 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910