DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and rde-1

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_741611.1	Gene:	rde-1 / 179393	WormBaseID:	WBGene00004323	Length:	1020	Species:	Caenorhabditis elegans

Alignment Length:	983	Identity:	229/983 - (23%)
Similarity:	399/983 - (40%)	Gaps:	203/983 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 RPIVLRANHFQVT---MPRGYVHHYDINIQPDKCPRKVNREI---IETMVHAYSKIFG------- 197
            :.::|..|.|:.:   ..|.| :.|::.:..:...||..:..   .|..:...:|:|.
Worm    38 KKVLLLVNWFKFSSKIYDREY-YEYEVKMTKEVLNRKPGKPFPKKTEIPIPDRAKLFWQHLRHEK 101

  Fly   198 -----VLKP-VFDGRNNLYTRDPLPIGNERL---ELEVTLPGEGKDR-----------IFRVTIK 242
                 :|:. |||.::.:|:...|.....::   |..|....|.||.           |.....|
Worm   102 KQTDFILEDYVFDEKDTVYSVCRLNTVTSKMLVSEKVVKKDSEKKDEKDLEKKILYTMILTYRKK 166

  Fly   243 WQAQVSLFNLEEALEGR----------TRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGY 297
            :....|..|.|:..|..          |:::.|...:..::.::...:..|.  ..|....||.:
Worm   167 FHLNFSRENPEKDEEANRSYKFLKNVMTQKVRYAPFVNEEIKVQFAKNFVYD--NNSILRVPESF 229

  Fly   298 YHP--------LGGGREVWFGFHQSVRP-SQWKMMLNIDVSATAFYKA--QPVIDFMCEVLDIRD 351
            :.|        :....|.|||.:..::. ...:.:||..:....||.|  ..::|::..::|.:.
Worm   230 HDPNRFEQSLEVAPRIEAWFGIYIGIKELFDGEPVLNFAIVDKLFYNAPKMSLLDYLLLIVDPQS 294

  Fly   352 INEQ-RKPL-----------TDSQRVKFTKEIKGLKIEITH-------------------CGQMR 385
            .|:. ||.|           ..:.|.:..:.::.||::...                   |.:..
Worm   295 CNDDVRKDLKTKLMAGKMTIRQAARPRIRQLLENLKLKCAEVWDNEMSRLTERHLTFLDLCEENS 359

  Fly   386 RKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPL 450
            ..|:|...:.|.          .|.:..:.|:.|.: ::.:..:.:||||.::|....|...:|:
Worm   360 LVYKVTGKSDRG----------RNAKKYDTTLFKIY-EENKKFIEFPHLPLVKVKSGAKEYAVPM 413

  Fly   451 EVCNIVAGQRCIKKLTD--MQTSTMIKATARSAPDREREINNLVKRADFNND--SYVQEFGLTIS 511
            |...:....:..|...|  ||...:.:|| |...|.:.....::|..||:::  ::|:.|||...
Worm   414 EHLEVHEKPQRYKNRIDLVMQDKFLKRAT-RKPHDYKENTLKMLKELDFSSEELNFVERFGLCSK 477

  Fly   512 NSMMEVRGRVLPPPKLQYGGR-------VSTGLTGQQL-FPPQNKVSLA-------SPNQGVWDM 561
            ..|:|..|:||..|.|.....       |..|...:|| ..|:.::..|       :.|..:.:.
Worm   478 LQMIECPGKVLKEPMLVNSVNEQIKMTPVIRGFQEKQLNVVPEKELCCAVFVVNETAGNPCLEEN 542

  Fly   562 RGKQFFTGV-------EIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYA 619
            ...:|:|.:       .|||.|......| ::..||.:|.....:..:.:.|   ||     ::.
Worm   543 DVVKFYTELIGGCKFRGIRIGANENRGAQ-SIMYDATKNEYAFYKNCTLNTG---IG-----RFE 598

  Fly   620 TGPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKT----- 679
            ....:.:.||..|......:.:.:::...:...|..||...|..:|:|.|.:.::.|.|.
Worm   599 IAATEAKNMFERLPDKEQKVLMFIIISKRQLNAYGFVKHYCDHTIGVANQHITSETVTKALASLR 663

  Fly   680 ----SPQTLSNLCLKINVKLGGINSIL----VPSIRPKVFNE----PV-IFLGADVTHPPAGDNK 731
                |.:....:.||||.||||||..|    :..|.|:....    |: :::|.|||||.:....
Worm   664 HEKGSKRIFYQIALKINAKLGGINQELDWSEIAEISPEEKERRKTMPLTMYVGIDVTHPTSYSGI 728

  Fly   732 KPSIAAVVGSMDAHPSRYAATVRVQQ----------HRQEIIQELSSMVRELLIMFYKSTGGYKP 786
            ..||||||.|::...:.|...:..|:          |.:|....|.:...:||..|.::.....|
Worm   729 DYSIAAVVASINPGGTIYRNMIVTQEECRPGERAVAHGRERTDILEAKFVKLLREFAENNDNRAP 793

  Fly   787 HRIILYRDGVSEGQFPHVLQHELTAIREACIKL-------EPEYRPGITFIVVQKRHHTRLFCAE 844
            ..|::||||||:.:...|...||.:::....:.       :||  |..||||:||||:|||....
Worm   794 AHIVVYRDGVSDSEMLRVSHDELRSLKSEVKQFMSERDGEDPE--PKYTFIVIQKRHNTRLLRRM 856

  Fly   845 KKE----------------------------QSGKSG--NIPAGTTVDVGITHPTEFDFYLCSHQ 879
            :|:                            :|.::|  |..:|||||..|....:|||:|.||.
Worm   857 EKDKPVVNKDLTPAETDVAVAAVKQWEEDMKESKETGIVNPSSGTTVDKLIVSKYKFDFFLASHH 921

  Fly   880 GIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRAR-YHLV 943
            |:.|||||.||.|::||.....||:..:||.|.....||.:.:|:|.|.:||||...:|: .:..
Worm   922 GVLGTSRPGHYTVMYDDKGMSQDEVYKMTYGLAFLSARCRKPISLPVPVHYAHLSCEKAKELYRT 986

  Fly   944 EKEHDSGE 951
            .|||..|:
Worm   987 YKEHYIGD 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	30/171 (18%)
		ArgoL1	285..335	CDD:400854	11/58 (19%)
		PAZ_argonaute_like	336..456	CDD:239212	25/152 (16%)
		Piwi_ago-like	502..942	CDD:240015	146/527 (28%)
rde-1	NP_741611.1	PAZ_argonaute_like	280..419	CDD:239212	24/149 (16%)
rde-1	NP_741611.1	Piwi_ago-like	467..982	CDD:240015	146/525 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1910
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870