DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and ergo-1

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_503362.2	Gene:	ergo-1 / 178602	WormBaseID:	WBGene00019971	Length:	1121	Species:	Caenorhabditis elegans

Alignment Length:	1036	Identity:	249/1036 - (24%)
Similarity:	412/1036 - (39%)	Gaps:	228/1036 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SPSAQNVAAGGATVAGAAATAAQVASALGATTGSVTPAIATATPATQPDMPVFTCPRRPNLGRE- 144
            |.:..|...||..| |...|||.:::......|:..|..:.:..:.:.:...|..  ||....:
Worm   121 SQNGGNRGGGGGRV-GGGRTAAGMSNPGDLVGGADQPIHSVSKKSLRHNAQEFAV--RPKTMVQD 182

  Fly   145 ---GRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGVLKPVFDGR 206
               |:...|..||..|.:|:..:..:..||:.....:..|:.  |.....:.:|....||.| |.
Worm   183 KGLGQKTTLLTNHTLVQLPQEPITLHVFNIEVFINGKSSNKR--ELCGPRFWEILKENKPTF-GM 244

  Fly   207 NNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQ--AQVSL-FNLEEALEGRTRQIPYDAI 268
            .|.|..:.:   |...........||:....|:...|:  .|:.. .|:|:.   .|.|:....|
Worm   245 PNQYIFNDV---NMMWSTNKLRQSEGRTNNRRMNFVWKYVKQIKFGGNIEDE---ETMQLLSTLI 303

  Fly   269 LALDVVMRHLP--SMTYTPVGR-SFFSSPEGY---------YHPLGGGREVWFGFHQSVRPS-QW 320
            .|:......||  ...||...| ::....|.|         .|.|..|.:...|...::|.: :.
Worm   304 DAIATQRARLPLAPPKYTVFKRLTYLICEEAYEPELPDVSLCHKLRIGTDARVGVSIAIRTNLRA 368

  Fly   321 KMMLNIDVSATAFYK-AQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQM 384
            .:....|:..|.|.: |.|::..:|      ||.|....|.::..:|:...:
Worm   369 GITACFDLGHTLFTRPAYPLVRLLC------DIIEHSVVLDEAFEMKYDAAL------------- 414

  Fly   385 RRKYRVCNVTRRPAQMQS-----FPLQL---------ENGQT----------------------- 412
                |.|||:....::.:     ..|||         |:|:.
Worm   415 ----RACNVSDENLRVMTQILTKMTLQLSTETGDYVGEDGEVIVRPAPTIRNPGRNFKFVGLGAP 475

  Fly   413 ----------VECTVAKYFLDKYRMKLRYPHLPCL------QVGQEHKHTYLPLEVCNIVAGQRC 461
                      ||.|||.|:|.||.::||||:|||:      |.|  :||:.:|||:.:.:.....
Worm   476 ADRYYFTSDGVELTVADYYLQKYNIRLRYPNLPCVLKKAPEQCG--NKHSAMPLELVSYIVVPTR 538

  Fly   462 IKKLT--DMQTSTMIKATARSAPDREREINNLVKRADF--------NNDSYVQEFGLTISNSMME 516
            ....|  ||: :.||..|..:|..|.:.:.:::.:...        |||.|:::..|.:....:.
Worm   539 YGGFTMPDMR-ADMINKTTYTAQQRGKLLQHIIAQKSLSGIEPPVSNNDDYMKKHKLVMKREPIR 602

  Fly   517 VRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDM----RGKQFFTGVEIR---- 573
            |:..:||||.|.||..|         |..::.:       |.|:.    ..:|...|...|
Worm   603 VKATILPPPTLVYGDSV---------FHDEHHI-------GEWEAVTHDPPRQVLDGAVFRRKLY 651

  Fly   574 -----------IWAIACFAPQRTVREDALRNFTQQ----LQKISNDAGMPII------------G 611
                       :.:|......|..|:   .::.||    :.:...|:|.|::            |
Worm   652 KSSEQPLMKRLMGSILLIQSPRQCRD---FDYNQQGYHAIMRAIEDSGQPVLWADENKHSAVIQG 713

  Fly   612 QPCFCKYATGPDQVEPMFRYLKITFPGLQ--------LVVVVLPGKTPVYA----------EVKR 658
            :..|.:...|.:.:|...:.:|.|....:        :|..|...:..||:          .:|.
Worm   714 ELQFNQNQHGIEVIEQFLQNIKSTIGEYERDGEVIVPIVFAVFQARATVYSGNNNEYNDYNVLKY 778

  Fly   659 VGDTVLGMATQCVQAKNVNKTSPQ----TLSNLCL-KINVKLGGINSILVPSIRPKVFN------ 712
            :.|...|:.||.:..|::....|.    .|:.|.: |:..|:|..:..|......|.:.
Worm   779 LADNKYGIHTQGILEKSLGVVGPSPKNCALTRLMVEKVLGKVGTTHRKLERGGAHKTWTIFTDPA 843

  Fly   713 EPVIFLGADVTHPPAGDN------KKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVR 771
            :|.:.||.||:||...|.      :|.|.|.|||::|...:.:.|:.|:|....|.:.:.|..:.
Worm   844 KPTLVLGIDVSHPSTRDRETGNVLQKMSAATVVGNIDLDVTEFRASSRIQDTGVECLIDFSKEID 908

  Fly   772 ELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRH 836
            |.:..|...| |.:|..|::||||:|||.|...|..|...|.|.|:|::..::|.||:|||.|||
Worm   909 ERIGEFIDHT-GKRPAHIVVYRDGLSEGDFQKYLFEERVCIEERCLKIDTSFQPSITYIVVTKRH 972

  Fly   837 HTRLFCAEKKEQSGKSG-NIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWD----- 895
            ||:.|..:..:.....| |:..||.::..:|....:||:|.:..|.:|..||:||:||.|
Worm   973 HTQFFLEDPSQGYESQGYNVLPGTLIEDAVTTNKYYDFFLSTQIGNEGCFRPTHYYVLHDTWTGK 1037

  Fly   896 DNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQS 956
            .:.|.......|||..|    |.|.:|::|||..||||.|.||      ||...|..:::|
Worm  1038 PDSFWPTVTHALTYNFC----RSTTTVALPAPVLYAHLAAKRA------KETLDGINTYKS 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	28/131 (21%)
		ArgoL1	285..335	CDD:400854	11/60 (18%)
		PAZ_argonaute_like	336..456	CDD:239212	40/172 (23%)
		Piwi_ago-like	502..942	CDD:240015	136/515 (26%)
ergo-1	NP_503362.2	PAZ	421..557	CDD:198017	34/138 (25%)
ergo-1	NP_503362.2	Piwi_ago-like	588..1080	CDD:240015	138/521 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1910
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870