Protein Alignment AGO1 and wago-10

DIOPT Version :9

• Sequence 1: NP_001246314.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_503177.1
• Gene: wago-10 / 178560
• WormBaseID: WBGene00020707
• Length: 990
• Species: Caenorhabditis elegans
• Alignment Length: 1006
• Identity: 213/1006 - (21%)
• Similarity: 380/1006 - (37%)
• Gaps: 218/1006 - (21%)

  Fly    76 PTAVTSPSAQNVAAGGATVAGAAATAAQVASALGATTGSVTPAIATATP-----ATQPDMPVFTC 135
            ||.|.:||                           .||.: |.|....|     :::.|:|....
 Worm     2 PTTVQNPS---------------------------PTGFL-PQIPFRIPKRTRRSSEVDVPATKR 38

  Fly   136 PRRPNLGREGRPI-----VLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYS-K 194
            |..|.......|.     ::.....|:.|       :.:||  ...|||:.|..::|::...: |
 Worm    39 PAPPLTSSTSLPTRDSFSIIETRDVQLNM-------FALNI--SGMPRKIQRFHVDTLIKGKNGK 94

  Fly   195 IFGVLKPV----------------------------------------FDGRNNLYTRDPLPIGN 219
            ||.|...|                                        :|..|.||..|.:.:|
 Worm    95 IFNVNHGVLANSGDINSHNKRLAQHALMQKFHKKRRELFGQHDYHILAYDCANTLYLPDGVYLG- 158

  Fly   220 ERLELEVTLPGEG---------------KDRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAIL 269
             |.|.|.|...:.               ||..:.:.|:....:.... |||.|...|.   :...
 Worm   159 -RNEEECTFKSDDFSPEQWNITSKLSRKKDYTYVMKIRPSGFIYTSG-EEASEVANRM---ELTR 218

  Fly   270 ALDVV-MRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQ-----SVRPSQWKMMLNIDV 328
            .:::| .:.|.:..|...|...||.............|:..||.:     ..|..:.:|::.||.
 Worm   219 CVEIVTSQKLNNSDYCQFGNDTFSFRAQPVSEPDATSEIRSGFAKVSRIVEGRNGKNEMLMAIDT 283

  Fly   329 SATAFYKAQPVIDFMC------------------------------EVLDIRDINEQRKPLT-DS 362
            .|:.|||:..|::|:|                              :..|.:|:.|..:.|. ..
 Worm   284 KASPFYKSTSVLNFVCGKYLEKRGSSRNDYRGRGDYNRKKTGGGSTDAPDHQDVAEVERSLEYRE 348

  Fly   363 QRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRM 427
            .|.:..:.:|||.:...|.........:..|....::...|  ...||:. |.:||.::|:.|..
 Worm   349 NRQQIEEALKGLLVSAAHLKNSTNLIMISRVAETNSETTKF--MTNNGER-EISVADHYLEAYNY 410

  Fly   428 KLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREI--NN 490
            :|:||.:|.:...:.....:.|:|:..:..|||.............:|....:.|.:..::  :.
 Worm   411 RLKYPKMPLVVSKRFRDECFYPMELLQVAPGQRIKDHKMSAAVQMAMKGQKSTLPQKHVDLVKHV 475

  Fly   491 LVKRADFNNDSYVQEFGLTI-SNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQ-------- 546
            |.:....:.:.|:..||:.: |..:::::.::||||::::...|.....|..:|...
 Worm   476 LSRNLKLDRNLYMDAFGIKLESAELVKLQSKILPPPQIKFKDEVYMPKMGNPVFRTNGRFVDPAD 540

  Fly   547 -NKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPII 610
             |.|::...::.: |||..:.|..      .::|:.     ||:.:     .::|.|.|  .||
 Worm   541 INAVAIVVFDRAI-DMRQAENFCD------RLSCYC-----RENGI-----TVKKSSRD--WPI- 585

  Fly   611 GQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMAT--QCVQA 673
                  :.....|.|.......|....|:.::|.:...|.|...:|.:..:..:|:.|  .|.|.
 Worm   586 ------REINSEDSVAIKNAMEKWFSKGVNILVAIAKEKKPDVHDVLKYYEASVGLQTIQVCKQT 644

  Fly   674 KNVNKTS--PQTLSNLCLKINVKLGGIN-SILVPS-------------IRPKVFNEPVIFLGADV 722
            .::..:|  .||..|:..|.|:|.||.| .:.:|.             :..|:| |.|.|:|.|:
 Worm   645 VDMMLSSGGRQTADNVMRKFNLKCGGTNFFVQIPRSVNGRTVCADAHLLNEKLF-ERVQFIGFDI 708

  Fly   723 THPPA------GDNKKPSIAAVVG---SMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFY 778
            :|..:      ...|.....::||   |: :|.:.......:|..::..:|:|..:..: .:..|
 Worm   709 SHGASRTLFDRSTGKMDGEVSIVGVSYSL-SHSTHLGGFAYMQTQKEYKLQKLDEVFPK-CVDSY 771

  Fly   779 KSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCA 843
            ::..|..|.:|::||.|..||.|..| :.|:..||....:::|:|||.:..|:.|:..|.|:|.|
 Worm   772 RNHTGRLPSKIVIYRIGAGEGDFKRV-KEEVDKIRGTFNRIQPDYRPQLVVIIAQRDSHVRVFPA 835

  Fly   844 EKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLT 908
            ..........|:.:||.||..||.....:|.|.|...:.||.||..|.:|.:|.::...|:..||
 Worm   836 HITGSKAGQQNVTSGTCVDSVITSLGHQEFILSSQMPLLGTVRPCKYTILTNDPNWTKTEITHLT 900

  Fly   909 YQLCHTYVRCTRSVSIPAPAYYAHLVAFRAR 939
            |.....:....:..|.|...|.|..:|.|.|
 Worm   901 YFRAFGHQVSYQPPSFPDVLYAAENLAKRGR 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	34/190 (18%)
		ArgoL1	285..335	CDD:400854	12/54 (22%)
		PAZ_argonaute_like	336..456	CDD:239212	27/150 (18%)
		Piwi_ago-like	502..942	CDD:240015	116/475 (24%)
wago-10	NP_503177.1	PAZ_argonaute_like	347..439	CDD:239212	20/94 (21%)
		ArgoL2	478..515	CDD:293097	8/36 (22%)
		Piwi-like	499..932	CDD:239208	112/463 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910