Protein Alignment AGO1 and csr-1

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_001040938.1
• Gene: csr-1 / 177591
• WormBaseID: WBGene00017641
• Length: 1030
• Species: Caenorhabditis elegans
• Alignment Length: 928
• Identity: 211/928 - (22%)
• Similarity: 320/928 - (34%)
• Gaps: 289/928 - (31%)

  Fly   171 IQPDKCPRKVNREIIETMVHAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDR 235
            :|.....|:.|:|.|.|.:.|            .||.|..|:.                   ||.
 Worm   191 VQMKLIDRQHNKEYILTTMSA------------RGRGNRATKQ-------------------KDN 224

  Fly   236 IFRVTI---KWQAQ--------------VSLFNL-----------EEALEGRTRQIP------YD 266
            ...:.|   :|.|:              .|||.|           |:|||     ||      .|
 Worm   225 FILLDILLKQWAAKKGQQNLPAFAYDGAQSLFTLEGISLMVDIKKEDALE-----IPELSNFLKD 284

  Fly   267 AI--LALDVVMR-----HLPSMTYTPVG--------------------RS--FFSSPEGYY---H 299
            :|  |:.|:.:.     ..||...|.:.                    ||  :.|..:|.|   .
 Worm   285 SISFLSGDLEISCEPDLEKPSFVQTELNEWSDPRFYAYLDIVTSQSAIRSERYLSQSKGLYVHTQ 349

  Fly   300 PLGGGREVWF----GFHQSVR--------PSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDI 352
            .|...|..|.    |.|:..|        |     :|.:|..:|.:|.:.| :..|.:....||.
 Worm   350 SLEELRVKWAVAAKGIHKGCRIVGANGPLP-----ILELDPQSTQYYASIP-LSQMLQYAFPRDF 408

  Fly   353 NEQR--KPLTDSQR-VKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVE 414
            ...|  .|....|| ||..  :|.||               ||......|:.:       ..|:.
 Worm   409 PPNRIVNPNMKLQRAVKLL--LKDLK---------------CNPYYDDKQIWA-------TNTIT 449

  Fly   415 CTVAKY-------FLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTST 472
            .:...|       |..|| ..|::|.||.:|.|.......:|||...::..|.     .|.:...
 Worm   450 VSDVDYNAPKDPEFRQKY-PNLKFPMLPAVQCGTGPHKRLMPLEYLKVLPYQS-----IDRRVLE 508

  Fly   473 MIKATARSAPDREREINNLVKRAD-FN-NDSYVQEFGLTIS----NSMMEVRG-RVLPPPKLQYG 530
            ..:.|.|:....|| .:.|.|..| |. ||..:::||:.|.    |::.|:.| |||.|
 Worm   509 EFELTPRANAPNER-WSTLQKHYDQFGFNDQVMKDFGVQICNDPFNNVSEIDGERVLAP------ 566

  Fly   531 GRVSTGLTGQQLFPPQNKVSLASP-----NQGVWDMRGKQFFTGVEI------------RIWAIA 578
                             .|:.|.|     .:..|..:.|:|.|...|            |.|...
 Worm   567 -----------------SVAYADPVHVDDEKRDWKAQDKKFVTPATIDHLMFVLVAGYTRTWDAD 614

  Fly   579 CFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQ----------VEPMFRYLK 633
            |         ||.:...:...:...|.||.|      ..|:.  ||          :..:|:.|
 Worm   615 C---------DATKFVAKAFMQRCKDKGMHI------GSYSM--DQHNGERGSENFLTSVFKNL- 661

  Fly   634 ITFPGLQ-----LVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQ----------- 682
            :|.|..:     ..|:.:....|...|..:..:.:..:.||.|..|||.|....
 Worm   662 VTHPNYRDSSFTPFVLFISDDVPNIHECLKFEERMSDIPTQHVLLKNVKKMRDNIEKKSQGGRRA 726

  Fly   683 ---TLSNLCLKINVKLGGINSILVPSIRPKVFNEPVIF-LGADVTHPP--AGDNKKPSIAAVVGS 741
               ||.|:.:|.|:|.||:|...........:||...| :|.||.||.  |.....||...:..:
 Worm   727 YDLTLDNIVMKANIKCGGLNYTADIPRDLACWNEVSTFVIGMDVAHPDRNAAREGNPSTVGLSCN 791

  Fly   742 MDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMF-------YKSTGGYKPHRIILYRDGVSEG 799
            ...:|..:.........|:|.||:      |:|..|       :....|: |.::|::|||||.|
 Worm   792 SAENPYSFIGDFLYTDPRREAIQD------EILRKFTDQSVRNFAEIRGF-PKKVIIFRDGVSFG 849

  Fly   800 QFPHVLQHELTAIREACIKL------EPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAG 858
            :....|:.  ..|.|..||.      ..:|.|.:..|||:||||||.:.     :.|..||:|..
 Worm   850 EETAALKE--VEIIEQTIKTAAKSMGHSDYAPKVLAIVVKKRHHTRFYA-----KGGHHGNMPIN 907

  Fly   859 ----TTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCT 919
                |:|...|....:...::.:.:.:|||::...:.|:.||.....:.:..:...:|..:....
 Worm   908 PLPDTSVGGDIAEYGKRQIFIQAFRPVQGTAKVPSFLVIRDDEEVSDEHVAKMVCAVCSLHQLVN 972

  Fly   920 RSVSIPAPAYYAHLVAFR 937
            ...|||.|.|.||.:|.|
 Worm   973 SPTSIPTPVYVAHELAKR 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	30/139 (22%)
		ArgoL1	285..335	CDD:462567	15/86 (17%)
		PAZ_argonaute_like	336..456	CDD:239212	30/129 (23%)
		Piwi_ago-like	502..942	CDD:240015	120/507 (24%)
csr-1	NP_001040938.1	PAZ_argonaute_like	361..497	CDD:239212	38/166 (23%)
		Piwi-like	555..993	CDD:239208	116/491 (24%)