DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and csr-1

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_001040938.1	Gene:	csr-1 / 177591	WormBaseID:	WBGene00017641	Length:	1030	Species:	Caenorhabditis elegans

Alignment Length:	928	Identity:	211/928 - (22%)
Similarity:	320/928 - (34%)	Gaps:	289/928 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 IQPDKCPRKVNREIIETMVHAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDR 235
            :|.....|:.|:|.|.|.:.|            .||.|..|:.                   ||.
Worm   191 VQMKLIDRQHNKEYILTTMSA------------RGRGNRATKQ-------------------KDN 224

  Fly   236 IFRVTI---KWQAQ--------------VSLFNL-----------EEALEGRTRQIP------YD 266
            ...:.|   :|.|:              .|||.|           |:|||     ||      .|
Worm   225 FILLDILLKQWAAKKGQQNLPAFAYDGAQSLFTLEGISLMVDIKKEDALE-----IPELSNFLKD 284

  Fly   267 AI--LALDVVMR-----HLPSMTYTPVG--------------------RS--FFSSPEGYY---H 299
            :|  |:.|:.:.     ..||...|.:.                    ||  :.|..:|.|   .
Worm   285 SISFLSGDLEISCEPDLEKPSFVQTELNEWSDPRFYAYLDIVTSQSAIRSERYLSQSKGLYVHTQ 349

  Fly   300 PLGGGREVWF----GFHQSVR--------PSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDI 352
            .|...|..|.    |.|:..|        |     :|.:|..:|.:|.:.| :..|.:....||.
Worm   350 SLEELRVKWAVAAKGIHKGCRIVGANGPLP-----ILELDPQSTQYYASIP-LSQMLQYAFPRDF 408

  Fly   353 NEQR--KPLTDSQR-VKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVE 414
            ...|  .|....|| ||..  :|.||               ||......|:.:       ..|:.
Worm   409 PPNRIVNPNMKLQRAVKLL--LKDLK---------------CNPYYDDKQIWA-------TNTIT 449

  Fly   415 CTVAKY-------FLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTST 472
            .:...|       |..|| ..|::|.||.:|.|.......:|||...::..|.     .|.:...
Worm   450 VSDVDYNAPKDPEFRQKY-PNLKFPMLPAVQCGTGPHKRLMPLEYLKVLPYQS-----IDRRVLE 508

  Fly   473 MIKATARSAPDREREINNLVKRAD-FN-NDSYVQEFGLTIS----NSMMEVRG-RVLPPPKLQYG 530
            ..:.|.|:....|| .:.|.|..| |. ||..:::||:.|.    |::.|:.| |||.|
Worm   509 EFELTPRANAPNER-WSTLQKHYDQFGFNDQVMKDFGVQICNDPFNNVSEIDGERVLAP------ 566

  Fly   531 GRVSTGLTGQQLFPPQNKVSLASP-----NQGVWDMRGKQFFTGVEI------------RIWAIA 578
                             .|:.|.|     .:..|..:.|:|.|...|            |.|...
Worm   567 -----------------SVAYADPVHVDDEKRDWKAQDKKFVTPATIDHLMFVLVAGYTRTWDAD 614

  Fly   579 CFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQ----------VEPMFRYLK 633
            |         ||.:...:...:...|.||.|      ..|:.  ||          :..:|:.|
Worm   615 C---------DATKFVAKAFMQRCKDKGMHI------GSYSM--DQHNGERGSENFLTSVFKNL- 661

  Fly   634 ITFPGLQ-----LVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQ----------- 682
            :|.|..:     ..|:.:....|...|..:..:.:..:.||.|..|||.|....
Worm   662 VTHPNYRDSSFTPFVLFISDDVPNIHECLKFEERMSDIPTQHVLLKNVKKMRDNIEKKSQGGRRA 726

  Fly   683 ---TLSNLCLKINVKLGGINSILVPSIRPKVFNEPVIF-LGADVTHPP--AGDNKKPSIAAVVGS 741
               ||.|:.:|.|:|.||:|...........:||...| :|.||.||.  |.....||...:..:
Worm   727 YDLTLDNIVMKANIKCGGLNYTADIPRDLACWNEVSTFVIGMDVAHPDRNAAREGNPSTVGLSCN 791

  Fly   742 MDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMF-------YKSTGGYKPHRIILYRDGVSEG 799
            ...:|..:.........|:|.||:      |:|..|       :....|: |.::|::|||||.|
Worm   792 SAENPYSFIGDFLYTDPRREAIQD------EILRKFTDQSVRNFAEIRGF-PKKVIIFRDGVSFG 849

  Fly   800 QFPHVLQHELTAIREACIKL------EPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAG 858
            :....|:.  ..|.|..||.      ..:|.|.:..|||:||||||.:.     :.|..||:|..
Worm   850 EETAALKE--VEIIEQTIKTAAKSMGHSDYAPKVLAIVVKKRHHTRFYA-----KGGHHGNMPIN 907

  Fly   859 ----TTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCT 919
                |:|...|....:...::.:.:.:|||::...:.|:.||.....:.:..:...:|..:....
Worm   908 PLPDTSVGGDIAEYGKRQIFIQAFRPVQGTAKVPSFLVIRDDEEVSDEHVAKMVCAVCSLHQLVN 972

  Fly   920 RSVSIPAPAYYAHLVAFR 937
            ...|||.|.|.||.:|.|
Worm   973 SPTSIPTPVYVAHELAKR 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	30/139 (22%)
		ArgoL1	285..335	CDD:400854	15/86 (17%)
		PAZ_argonaute_like	336..456	CDD:239212	30/129 (23%)
		Piwi_ago-like	502..942	CDD:240015	120/507 (24%)
csr-1	NP_001040938.1	PAZ	399..521	CDD:198017	33/151 (22%)
csr-1	NP_001040938.1	Piwi-like	555..993	CDD:239208	116/491 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010