Protein Alignment AGO1 and alg-4

DIOPT Version :9

• Sequence 1: NP_001246314.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_499191.1
• Gene: alg-4 / 176400
• WormBaseID: WBGene00006449
• Length: 1040
• Species: Caenorhabditis elegans
• Alignment Length: 1076
• Identity: 357/1076 - (33%)
• Similarity: 520/1076 - (48%)
• Gaps: 194/1076 - (18%)

  Fly    59 TSF---DTLTSPPAPGS-SVNPTAVTSPSAQNVAAGGAT--VAGAAATAAQVASALGATTGSVTP 117
            |||   :||||....|| |::|...:.|     |:|.|:  .:..:.:..|.|...|:.:.::
 Worm     7 TSFVDNNTLTSSGISGSGSMSPPITSRP-----ASGQASPLTSNGSLSPPQYADDQGSVSYNL-- 64

  Fly   118 AIATATPATQPDMPVFTCP---------------RRPNLGREGRPIVLRANHFQVTM--PRGYVH 165
                       |.|....|               .||.||..||.|.:::|.|.:.:  |:..|.
 Worm    65 -----------DSPRDLSPLLLSELACLNMREVVARPGLGTIGRQIPVKSNFFAMDLKNPKMVVI 118

  Fly   166 HYDINIQPDKCPRKVNRE----IIETMVHAYSKIF-GVLKPVFDGRNNLYT----RDPLPIGNER 221
            .|.:.|....| ||::::    |....|..:..|| ......:||.:.|||    ..|...|:.|
 Worm   119 QYHVEIHHPGC-RKLDKDEMRIIFWKAVSDHPNIFHNKFALAYDGAHQLYTVARLEFPDDQGSVR 182

  Fly   222 LELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEAL--EGRTRQIPYD-----AILALDVVMRHLP 279
            |:.|.:||.:.:||.       :..:|:.|:...|  ..|||....|     .|..||::.|...
 Worm   183 LDCEASLPKDNRDRT-------RCAISIQNVGPVLLEMQRTRTNNLDERVLTPIQILDIICRQSL 240

  Fly   280 SMTYTPVGRSFFSSPEGYYH---------PLGGGREVWFGFHQSVR-PSQWKMMLNIDVSATAFY 334
            :........:|::.....|.         .|.||:|:|.||..|.. .|.::.:|||||:.||||
 Worm   241 TCPLLKNSANFYTWKSSCYRIPTAAGQALDLEGGKEMWTGFFSSAHIASNYRPLLNIDVAHTAFY 305

  Fly   335 KAQ-PVIDFMCEVLDIR----DINEQRKP------------------------------------ 358
            |.: .|:.|||:||:.|    :.|..|.|
 Worm   306 KTRITVLQFMCDVLNERTSKPNRNNPRGPGGPGGPGGYRGGRGGGRGGSYGNFGNRGPPGANVRD 370

  Fly   359 ------LT--------DSQRVKFTKE-----IKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFP 404
                  ||        |:|...|...     |:|:||...|.....|.|:| |..:.||....|.
 Worm   371 DFGGNGLTFTMDTLSRDTQLSSFETRIFGDAIRGMKIRAAHRPNAIRVYKV-NSLQLPADKLMFQ 434

  Fly   405 LQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQ 469
            ...|.|:.|.|:||.||.:||. .|:||.||||.||...::.:||:|.|.|.:.|:..||:::.|
 Worm   435 GIDEEGRQVVCSVADYFSEKYG-PLKYPKLPCLHVGPPTRNIFLPMEHCLIDSPQKYNKKMSEKQ 498

  Fly   470 TSTMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVS 534
            ||.:|||.|..|..||..|..|..:|.|..|.:::|||:.:|:.|::...||:.||.:.:||
 Worm   499 TSAIIKAAAVDATQREDRIKQLAAQASFGTDPFLKEFGVAVSSQMIQTTARVIQPPPIMFGG--- 560

  Fly   535 TGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQ 599
               ..:.:.|      :..|..|.|.|..:..:.....|.:::......|.  :.:|:.|.|.|.
 Worm   561 ---NNRSVNP------VVFPKDGSWTMDNQTLYMPATCRSYSMIALVDPRD--QTSLQTFCQSLT 614

  Fly   600 KISNDAGMPIIGQPCFCKYATGPDQVEPMFRYL----KITFPGLQLVVVVLPGK-TPVYAEVKRV 659
            ..:...||.....|...||....:.|..:|..:    ::|......::|||..| :.:|..||..
 Worm   615 MKATAMGMNFPRWPDLVKYGRSKEDVCTLFTEIADEYRVTNTVCDCIIVVLQSKNSDIYMTVKEQ 679

  Fly   660 GDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINS-ILVPSIRPK-VFNEPVIFLGADV 722
            .|.|.|:.:|||..|||::.:|.|.:|:.||:|:|:||||| |:...|..| :.::|.:.:|.||
 Worm   680 SDIVHGIMSQCVLMKNVSRPTPATCANIVLKLNMKMGGINSRIVADKITNKYLVDQPTMVVGIDV 744

  Fly   723 THPPAGDNK--KPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYK 785
            |||...:.:  .||:||:|.::|..|..|.|.|:||:..:|.:..|...:||.:|.||:.| ..|
 Worm   745 THPTQAEMRMNMPSVAAIVANVDLLPQSYGANVKVQKKCRESVVYLLDAIRERIITFYRHT-KQK 808

  Fly   786 PHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSG 850
            |.|||:||||||||||..||:.|:.:||.||:.:..::||.||:||||||||.|:||..:.:..|
 Worm   809 PARIIVYRDGVSEGQFSEVLREEIQSIRTACLAIAEDFRPPITYIVVQKRHHARIFCKYQNDMVG 873

  Fly   851 KSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTY 915
            |:.|:|.|||||.||..|..||||||||.|:||||||:.||||.|:..|.:||:|.:||.:||||
 Worm   874 KAKNVPPGTTVDTGIVSPEGFDFYLCSHYGVQGTSRPARYHVLLDECKFTADEIQSITYGMCHTY 938

  Fly   916 VRCTRSVSIPAPAYYAHLVAFRARYHLVEK-----EHD-------------------SGEGSHQS 956
            .|||||||||.|.|||.|||.|||.|:..|     .:|                   ||:|....
 Worm   939 GRCTRSVSIPTPVYYADLVATRARCHVKRKLGLADNNDCDTNSRSSTLASLLNVRTGSGKGKKSY 1003

  Fly   957 GCSEDRTPGAMARA---------ITVHADTKKVMYF 983
            ..|.|....:::.|         ::|..|.|..|||
 Worm  1004 APSVDDESYSLSDATSDQILQDCVSVATDFKSRMYF 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	39/146 (27%)
		ArgoL1	285..335	CDD:400854	19/59 (32%)
		PAZ_argonaute_like	336..456	CDD:239212	50/179 (28%)
		Piwi_ago-like	502..942	CDD:240015	186/448 (42%)
alg-4	NP_499191.1	PLN03202	67..959	CDD:215631	319/916 (35%)
		ArgoN	89..235	CDD:293095	44/153 (29%)
		ArgoL1	266..306	CDD:285861	17/39 (44%)
		PAZ_argonaute_like	374..484	CDD:239212	40/111 (36%)
		Piwi_ago-like	530..964	CDD:240015	186/448 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1910
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.970