DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and alg-2

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_871992.1	Gene:	alg-2 / 173468	WormBaseID:	WBGene00000106	Length:	910	Species:	Caenorhabditis elegans

Alignment Length:	929	Identity:	613/929 - (65%)
Similarity:	734/929 - (79%)	Gaps:	53/929 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 PGSSVNPTAVTSPSAQNVAAGGATVAGAAATAAQVASALGATTGSVTPAIATATPATQPDMPV-F 133
            ||.|:.       |:..:..|||..:.::........|:|                |:||..| |
Worm    21 PGDSLT-------SSSFMPDGGAETSSSSQLGGSAHGAIG----------------TKPDAGVQF 62

  Fly   134 TCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGV 198
            .||.|||.|.|||.|:||||||.|.:|.|.|.||.|::.||||||:||||:|..::.::||.|..
Worm    63 QCPVRPNHGVEGRSILLRANHFAVRIPGGSVQHYQIDVFPDKCPRRVNREVIGCLISSFSKYFTN 127

  Fly   199 LKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGK-DRIFRVTIKWQAQVSLFNLEEALEGRTRQ 262
            ::||:||:.|:|||:|||||.|.:..||||||:.. :|.|.||:||..||.|..|::|:|||.||
Worm   128 IRPVYDGKRNMYTREPLPIGTEPMNFEVTLPGDSAVERKFSVTMKWIGQVCLSALDDAMEGRVRQ 192

  Fly   263 IPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHP---------LGGGREVWFGFHQSVRPS 318
            :|::|:.::||::|||||:.||||||||| :|.|...|         ||||||||||||||||||
Worm   193 VPHEAVQSIDVILRHLPSLKYTPVGRSFF-TPPGVMKPGMQMHQESKLGGGREVWFGFHQSVRPS 256

  Fly   319 QWKMMLNIDVSATAFYKAQPVIDFMCEVLDIR-DINEQRKPLTDSQRVKFTKEIKGLKIEITHCG 382
            ||||||||||||||||:|.|||:|:.|||::. ....:|:.|:|:|||||||||:||||||||||
Worm   257 QWKMMLNIDVSATAFYRAMPVIEFVAEVLELPVQALAERRALSDAQRVKFTKEIRGLKIEITHCG 321

  Fly   383 QMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTY 447
            .:|||||||||||||||.|:||||||.|||:||||||||.||||::|:||||||||||||.||||
Worm   322 AVRRKYRVCNVTRRPAQTQTFPLQLETGQTIECTVAKYFFDKYRIQLKYPHLPCLQVGQEQKHTY 386

  Fly   448 LPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLTISN 512
            ||.|||:||.||||:|||||:||||||||||||||:|||||..||.:|:.:.|.:..|||:||:.
Worm   387 LPPEVCDIVPGQRCLKKLTDVQTSTMIKATARSAPEREREICKLVSKAELSADPFAHEFGITINP 451

  Fly   513 SMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAI 577
            :|.||:||||..|||.||||              ::.:.|.|||||||||||||.||:|:|.|||
Worm   452 AMTEVKGRVLSAPKLLYGGR--------------HRATTALPNQGVWDMRGKQFHTGMEVRTWAI 502

  Fly   578 ACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLV 642
            ||||.|..|:|:.||.||.|||:||.||||||||.|.|||||:|.:||||||:|||.|:..:||:
Worm   503 ACFAQQSHVKENDLRMFTTQLQRISTDAGMPIIGTPMFCKYASGVEQVEPMFKYLKQTYSAIQLI 567

  Fly   643 VVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIR 707
            |||||||||:|||||||||||||:|||||||||..:|:||||||||||:||||||:||||:|::|
Worm   568 VVVLPGKTPIYAEVKRVGDTVLGIATQCVQAKNAIRTTPQTLSNLCLKMNVKLGGVNSILLPNVR 632

  Fly   708 PKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRE 772
            |::|||||||||.|:|||.|||.:||||||||||||||||||||||||||||||||.:|:.||||
Worm   633 PRIFNEPVIFLGCDITHPAAGDTRKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIITDLTYMVRE 697

  Fly   773 LLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHH 837
            ||:.||::| .:||.||::|||||||||..:|||:||.||||||:.||..|:||||||.||||||
Worm   698 LLVQFYRNT-RFKPARIVVYRDGVSEGQLFNVLQYELRAIREACVMLESGYQPGITFIAVQKRHH 761

  Fly   838 TRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSD 902
            ||||.|:|.:|.||:.|||.||||||||||||||||:||||.||||||||||||||||||...:|
Worm   762 TRLFAADKADQVGKAFNIPPGTTVDVGITHPTEFDFFLCSHAGIQGTSRPSHYHVLWDDNDLTAD 826

  Fly   903 ELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSG-EGSHQSG-CSEDRTPG 965
            |||.||||:||||||||||||||||||||||||||||||||:::|.|| |||..|| .|||.|..
Worm   827 ELQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDRDHGSGEEGSQPSGTSSEDTTLS 891

  Fly   966 AMARAITVHADTKKVMYFA 984
            :||:|:.||.|:..|||||
Worm   892 SMAKAVQVHPDSNNVMYFA 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	69/129 (53%)
		ArgoL1	285..335	CDD:400854	43/58 (74%)
		PAZ_argonaute_like	336..456	CDD:239212	89/120 (74%)
		Piwi_ago-like	502..942	CDD:240015	322/439 (73%)
alg-2	NP_871992.1	PLN03202	67..859	CDD:215631	564/807 (70%)
		ArgoN	67..205	CDD:293095	75/137 (55%)
		ArgoL1	216..273	CDD:285861	42/57 (74%)
		PAZ_argonaute_like	274..395	CDD:239212	89/120 (74%)
		Piwi_ago-like	440..866	CDD:240015	322/440 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165240
Domainoid	1	1.000	511	1.000	Domainoid score	I159
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81825
Inparanoid	1	1.050	1279	1.000	Inparanoid score	I73
Isobase	1	0.950	-	0	Normalized mean entropy	S1910
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	1	1.000	-	-		otm14497
orthoMCL	1	0.900	-	-		OOG6_100361
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3246
SonicParanoid	1	1.000	-	-		X379
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890