Protein Alignment AGO1 and C04F12.1

DIOPT Version :9

• Sequence 1: NP_001246314.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_492573.1
• Gene: C04F12.1 / 172816
• WormBaseID: WBGene00007297
• Length: 944
• Species: Caenorhabditis elegans
• Alignment Length: 1011
• Identity: 223/1011 - (22%)
• Similarity: 366/1011 - (36%)
• Gaps: 271/1011 - (26%)

  Fly    82 PSAQN--VAAGGATVAGAAATAAQVA--------------SALGATTGSVTP-AIATATPATQPD 129
            ||.:|  .||...:...:|:.:.|||              |.:..::...|| ||....|...|.
 Worm     2 PSKKNKKAAAAERSATLSASASQQVAKDEQSAPVVPTPELSRVSVSSNPPTPSAIEKPVPLPVPS 66

  Fly   130 MPVFTC--PRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAY 192
            .|:|..  |.:.....:.:|:.:..|.:::.:....|..||::
 Worm    67 KPLFEYEPPAQLEALAKNKPVKVTTNSYELELKPTPVFRYDVS---------------------- 109

  Fly   193 SKIFGVLKPVFDGRNNLYTRDPLPI----GNER---------LELEVTLPGEGKDRIF------- 237
                 |||...|.     ||||:.:    |.:|         :::.:||.|.|...||
 Worm   110 -----VLKSFDDS-----TRDPIELAGSKGGDRQRQADLTEIVKVALTLEGLGNLNIFYDGAAML 164

  Fly   238 ----RVTIKWQAQVSLF------------NLEEALEGR------------TRQIPYDAILALDVV 274
                :...|.:.|.::|            :|:|:..||            ::|...:.|   |::
 Worm   165 FTTQKFETKTEKQQAIFMPIPSDHPKLSTSLKESQFGRASGKFHVSIELNSKQSELNTI---DLL 226

  Fly   275 MRHL-----PSMTYTPVGRSFFSSPEGYYHPLGGGREVW-----------------FGFHQSVRP 317
            ...|     |......:..|..:...|:. .|.||.|::                 .|...|::.
 Worm   227 NERLDSAACPVTQMAQIALSAEAKQNGFI-ILDGGHELFDQKNTRRTIGKDGVEDMDGVAASIKM 290

  Fly   318 SQWKMM-----LNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIE 377
            :|....     |.:|.....|:|..|:.|.      |:.||..          :....:|||::.
 Worm   291 AQGNKKTGSAHLVMDYKKKQFFKTGPLKDL------IKGINPN----------QLRSYLKGLRVH 339

  Fly   378 ITHCGQMRRKYRVCNVTRRPAQMQSFP---LQLENGQTV--ECT----VAKYFLDKYRMKLRYPH 433
            .|:..|......:.||          |   ::|.:|..:  :|.    ..|.|.|..:
 Worm   340 TTYSHQSIFIDGISNV----------PIGEIKLPDGTPLLDDCARVSGKPKSFFDASK------- 387

  Fly   434 LPCLQVGQEHKH-----TY-LPLEVCNIVAGQRCIKKLTDM--QTSTMIKATARSAPDREREINN 490
             |.:||.|.:|.     .| .|:|...:...|    |||..  :....||...|.  |..|::..
 Worm   388 -PAVQVNQYNKREGRRMVYSFPIENLLVKPNQ----KLTQNHGEPPRSIKPELRF--DLIRKVGE 445

  Fly   491 LVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASP- 554
            ..|....|..  ::..|:.|:...:.|....:|.|.:.|.....|                 ||
 Worm   446 SAKLLSPNQT--LKSIGIAINPEPIVVEAMTVPKPTILYKDGAFT-----------------SPD 491

  Fly   555 --NQGVWDM--RGKQFFTG--VE-IRIWAIACFAPQRTVREDALRNFTQQLQKI----SNDAGMP 608
              |:..||:  |..|...|  || ::|..|......::..:.:.:....:||.|    :.|.||
 Worm   492 LLNRTSWDVQARNHQSLKGGFVEPMKINKILILYNSQSYSQASPKEAVVELQSILSKKAKDVGM- 555

  Fly   609 IIGQPCFCKYATGPD---------------QVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKR 658
            .||| ...:....||               ||:|:..|...|..|....:              :
 Worm   556 TIGQ-IDVEDLNDPDIIGAIENKMTILKTSQVKPIVIYADHTSEGTHSTL--------------K 605

  Fly   659 VGDTVLGMATQCVQAKNVNKTSP--QTLSNLCLKINVKLGGIN-SILVPSIRPKVFNEP--VIFL 718
            :.:.:..:.||.|......|.:|  .|.:||.:|:|:|.||:| .:.|.:....::.:.  .:.:
 Worm   606 LQERLCEVITQQVALDKSLKRTPGKVTANNLLMKLNLKYGGVNHKVRVDNSISHLWGDTSNTLII 670

  Fly   719 GADVTHPPAGDNKKPSIA---AVVG---SMDAHPSRYAATVRVQQHRQEIIQE--LSSMVRELLI 775
            ..||.|......||..|.   :.||   :..|.|..:......|..|.|.:.|  |....|.:|.
 Worm   671 SYDVCHSSGKVYKKDEICDEPSCVGFGFNGTACPEAFIGDFHYQLPRHEQVDEHLLKLRARFMLN 735

  Fly   776 MFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYR---PGITFIVVQKRHH 837
            .:..|...| |.::::.||||||||...|...|..||:::.:.:..|.:   |....:||.|||.
 Worm   736 HYITSRKKY-PQQVVILRDGVSEGQHKMVRNEEFQAIKQSIMNVFNEKKAKAPSFALLVVTKRHA 799

  Fly   838 TRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHF-DS 901
            .||..   |:|:|.: |:|..|.:|..|......:....||..:.||::|...:.|.:|..| .:
 Worm   800 NRLLI---KDQNGYT-NVPPLTAIDQTIVKKQGNEVIFVSHCPLNGTAQPIVINTLVNDGIFKTN 860

  Fly   902 DELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFR 937
            |:|......||..:.:.|..||:|...|.|...|.|
 Worm   861 DQLVQFITALCCAHQKSTNIVSLPESIYAADEYAKR 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	31/176 (18%)
		ArgoL1	285..335	CDD:400854	12/71 (17%)
		PAZ_argonaute_like	336..456	CDD:239212	27/134 (20%)
		Piwi_ago-like	502..942	CDD:240015	120/480 (25%)
C04F12.1	NP_492573.1	PRK14971	<13..231	CDD:237874	45/252 (18%)
		Piwi	589..902	CDD:214930	87/327 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810