DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AGO1 and ppw-2

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_491535.1	Gene:	ppw-2 / 172152	WormBaseID:	WBGene00004094	Length:	975	Species:	Caenorhabditis elegans

Alignment Length:	1035	Identity:	246/1035 - (23%)
Similarity:	397/1035 - (38%)	Gaps:	248/1035 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TPSP--TRPQSPSQAQTSFDTLTSPPA--PGSSVNPTAV-TSPSAQNVAAGGATVAGAAATAAQV 104
            ||.|  |.|..|   ...|..:|:||.  |...|.|..| |.|
Worm     4 TPVPPVTMPPVP---PVGFPPVTAPPGLHPPPPVPPVPVPTLP---------------------- 43

  Fly   105 ASALGATTGSVTPAIATATPA---------TQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMP 160
                      ||....||..|         ..||..::..|..|  |..|....:..|.|.|.:.
Worm    44 ----------VTSEHKTAHDACIKRLEQLEIPPDPKIYPSPTEP--GTFGSVTEVLTNVFGVEVH 96

  Fly   161 R-GYVHHYDINIQPDKCPRKVNREIIET-------------------MVHAYSKIFGVLKP---- 201
            : ...:.|.::|..:...:|   |:..|                   :.||.::.....|.
Worm    97 KTSNFYQYSVHITAELSSKK---EVTFTKKGKEDFIVHDRHEKCSAILFHALNRFEDFFKSSENC 158

  Fly   202 -VFDGRNNLYTRDPLPIGNERLELEVTLP-GEGKDRIFRVT--------------IKWQA----- 245
             ::||::.|:|         .:.|...:| |:.|.::|::.              ||.:.
Worm   159 IIYDGQSILFT---------SMNLFEGIPTGKIKTKVFQINGADTNLKDLMVLPCIKLEVFPTKN 214

  Fly   246 QVSLFNLEEALEGR--------TRQIPYDAILALD------------VVMRHLPSMTYTPVGRSF 290
            .|..|:||:.  ||        :..:.|..||.|.            ||..|         |:.|
Worm   215 PVVNFSLEDI--GRRTSDSNIESVNMAYKQILDLAMSQYAIRETSKCVVFEH---------GKMF 268

  Fly   291 FSSP--EGY----YHPLGGGREVWFGFHQSVR-------PSQWKMMLNIDVSATAFYKAQPVIDF 342
            |.:|  |||    ...:|.|:::..|..::::       .:|....:.||....||:..|.|...
Worm   269 FINPLQEGYAPCDIVEVGDGKQMKPGLKKTLQFIEGPYGRNQNNPSIVIDGMKVAFHMEQLVFQK 333

  Fly   343 MCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQL 407
            :..:     .:.....:|.|:|.:....||||.....:.|:.|. :::.::....|....|  :|
Worm   334 LSSI-----TSNLANGITGSERERCAAVIKGLDCHSNYRGRTRH-HKIESIHHEGAATARF--EL 390

  Fly   408 ENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTST 472
            |.|.|  ||||.||.|||:::||||:...:...:.....:.|:|:..|...||.  ::|...:|.
Worm   391 EGGGT--CTVATYFKDKYKIQLRYPNANLIVCKERGALNFYPMELITISPNQRV--RITQQTSSQ 451

  Fly   473 MIKATARSA--PD-REREI--NNLVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGR 532
            ..:.|..||  || |:|.|  ..:..:....|: .:.:.|:|:.:..:.|:||.||      ..|
Worm   452 SQRTTKESAVLPDIRQRLIMTGKIAAKITAENE-VLGKMGVTVCDEPLVVKGRNLP------AIR 509

  Fly   533 VSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQF-FTGVEIRIWAI-ACFAPQRTVREDALRNFT 595
            :::..||:.|.         :|....|  |.::: .:.|..::||: ...:|...:..|.:|.|.
Worm   510 LASFETGEHLI---------NPRDCKW--RPQRYNRSAVAPKVWALYGVGSPGSQMNRDVMRRFC 563

  Fly   596 QQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVVVLPGK-TPVYAEVK-- 657
            .:...:|...|: :...|......| ||.:|...|  :....|...|:.:.... |.::.:.|
Worm   564 DEFMNMSRSKGI-LFPPPGDVNLLT-PDAIENRLR--EAANAGCTFVLCITEDNITCLHQKYKFI 624

  Fly   658 ------RVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPKVFNEPVI 716
                  .|.|..|..|...     ||.:...||.|:..|.||||||.|.:.:.:   |.|.:..:
Worm   625 EHHTQMIVQDMKLSKALSV-----VNASKKLTLENVINKTNVKLGGSNYVYLDT---KNFLQEHL 681

  Fly   717 FLGADVTHPPAGDN--------KKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVREL 773
            .:|..::.||.|..        ..|:|.....:.:. ...::....:....||.|..:..:|...
Worm   682 IIGVGISSPPPGTKYIMESRGILNPTIVGFAYNGNG-KQEFSGDFVLNAAGQETIAPIEDIVSYS 745

  Fly   774 LIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHT 838
            :..:.|...|..|.||.:||.|.|||....::.:|:...|.|.....|:.:  :.:|||.|.|..
Worm   746 IKGYKKFHDGKAPKRITIYRSGSSEGNHGPIISYEVPLARVAMRNFSPDTQ--LLYIVVSKEHTY 808

  Fly   839 RLFCAEKKEQSGKSG------------------------NIPAGTTVDVGITHPTEFDFYLCSHQ 879
            |.|   |||..|.|.                        ||..|.|||.|:|:|....|:|.||.
Worm   809 RFF---KKESGGSSSGGSNSAGASNSGTLTSAPPKPWELNIGPGLTVDYGVTNPACKQFFLNSHM 870

  Fly   880 GIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRAR 939
            .:||:::...|.||.||.:.....|:..|:.|||.:.......|||.|.|.|:..|.|.|
Worm   871 TLQGSAKTPLYTVLADDRNIGMSALEEFTFNLCHLHQIVGLPTSIPTPLYVANEYAKRGR 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	33/193 (17%)
		ArgoL1	285..335	CDD:400854	15/62 (24%)
		PAZ_argonaute_like	336..456	CDD:239212	32/119 (27%)
		Piwi_ago-like	502..942	CDD:240015	123/481 (26%)
ppw-2	NP_491535.1	PLN03202	64..919	CDD:215631	219/927 (24%)
		ArgoN	78..>189	CDD:293095	22/122 (18%)
		PAZ	334..461	CDD:198017	37/138 (27%)
		Piwi	604..934	CDD:280353	93/341 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910