DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and ppw-1

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_491323.2	Gene:	ppw-1 / 172013	WormBaseID:	WBGene00004093	Length:	887	Species:	Caenorhabditis elegans

Alignment Length:	917	Identity:	203/917 - (22%)
Similarity:	359/917 - (39%)	Gaps:	164/917 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 AAGGATVAGAAATAA-QVASALGATTGSVTPAIATATPATQPDMPVFTCP-------RRPNLGRE 144
            ||..|...|.|..|| :..:....|..::...|...|  .:|:.|::...       |:|: |.|
Worm    15 AAPAAQKLGTAPLAAKKTRNVERGTKVNIDTNIRKLT--IKPNQPIYKYAVQVNYVFRKPD-GTE 76

  Fly   145 GRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGVLK---PVF-DG 205
            .      ......:..:|..|..|    ..:|.:..|..|         |.:..||   |.| |.
Worm    77 A------TIEMSKSAKKGTEHDND----KTRCQKVYNEAI---------KRYDELKTGGPFFYDR 122

  Fly   206 RNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALEG-------RTRQI 263
            :.:|||...|.  ||.:...||      |:|.:.....:||..|..::::.:.       .|...
Worm   123 QASLYTLTKLK--NESISFVVT------DKICKRQNFKEAQFVLKKVDQSFQSTSNDVIRTTNSC 179

  Fly   264 PYDA---------------------ILALDVVMRHLPSMTYTPVGRSFFSSPEG-YYHPLGGGRE 306
            |.:|                     ::.:...:.:|...|...|....::  || .|..:|..:.
Worm   180 PANADKTLLEAMNIIVSGPAFENKNVITVGACVHYLIDPTVVDVAYKEYA--EGQLYSGVGASKS 242

  Fly   307 V--WFGFHQSVRPSQWKMMLNIDVSATAFY-KAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFT 368
            |  ..|..:.| ||   :.:..::..|.|: ...|:::.:..........:...|.  :||::
Worm   243 VKTLEGTDKKV-PS---LFMTTEMKTTLFHPDYAPLVELLQTFRGFSTTLKANSPA--AQRIE-- 299

  Fly   369 KEIKGLKIEI---THCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLR 430
            |...||.:.:   .|.| :.....|..:.|.....:....::|........|..||..||.:.|:
Worm   300 KAFVGLDVVLNYGVHKG-LGEDGVVMKIRRFHTSAKETCFEVEKSTREFTNVFDYFKKKYGITLK 363

  Fly   431 YPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIK-KLTDMQTSTMIKATARSAPDREREINNLVKR 494
            ||.|..::...:....:.|.||..:...|.... ::.:.:.:.|||.:|.....|:...:.:|:.
Worm   364 YPDLFTIEAKGKQGKIHFPAEVLLLCPNQTVTNDQMINNEQADMIKMSAAQPHIRKTTTDTIVRN 428

  Fly   495 ADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTG-QQLFPPQNKVSLASPNQGV 558
            ....:::.   :|.......:.:.|.|||.||:.:.|.....|.. :..||....
Worm   429 VGLASNNI---YGFIKVEDPVNLEGMVLPKPKIAFAGNQLADLANPKSRFPTDFN---------- 480

  Fly   559 WDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQL--QKISNDAGMPIIGQPCFCKYATG 621
               |..|::...|:..|.:.      .|:.:.::...:||  :.::|       |..|     :.
Worm   481 ---RAGQYYDAKELTKWELV------FVQNEEVQGLAKQLADEMVNN-------GMKC-----SN 524

  Fly   622 P-------DQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKT 679
            |       ..:||:|:..|..  |.||:..|:..:...:.::|.: :....:.||.::|:...|.
Worm   525 PTMSFIIRGDLEPIFKKAKAA--GTQLLFFVVKSRYNYHQQIKAL-EQKYDVLTQEIRAETAEKV 586

  Fly   680 --SPQTLSNLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVG-- 740
              .|||..|:..|.|:||||:|.    :|..:.||:|...:...||....|.|  |.....||
Worm   587 FRQPQTRLNIINKTNMKLGGLNY----AIGSEAFNKPNRLIVGFVTSQRVGGN--PDYPISVGFA 645

  Fly   741 -SMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGY--KPHRIILYRDGVSEGQFP 802
             :|..|..::|... |..||...:  ..|::::.|:..:|:....  :|..|:||.:|||||||.
Worm   646 ANMLKHHQKFAGGY-VYVHRDRDV--FGSIIKDTLLAIFKTCTEQRGRPDDILLYFNGVSEGQFS 707

  Fly   803 HVLQHELTAIREACIKLE----PEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDV 863
            .:.:.....::|||:..:    |.:||.||.|...|.|:.||:    |...|:..|:..||.||.
Worm   708 MINEEFSARVKEACMAFQKEGTPPFRPHITIIASSKAHNERLY----KSDKGRIVNLEPGTVVDH 768

  Fly   864 GITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDE----LQCLTYQLCHTYVRCTRSVSI 924
            .|......::|..|....|||::.:.:.:::........|    |:.||..||:.:......|.:
Worm   769 TIVSNVYTEWYHASAVARQGTAKATKFTLIFTTKAGPQAEPLWHLEQLTNDLCYDHQIVFHPVGL 833

  Fly   925 PAPAYYA 931
            |.|.|.|
Worm   834 PVPLYIA 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	28/160 (18%)
		ArgoL1	285..335	CDD:400854	12/53 (23%)
		PAZ_argonaute_like	336..456	CDD:239212	24/122 (20%)
		Piwi_ago-like	502..942	CDD:240015	114/455 (25%)
ppw-1	NP_491323.2	PAZ_argonaute_like	272..389	CDD:239212	24/121 (20%)
ppw-1	NP_491323.2	Piwi-like	444..849	CDD:239208	113/444 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010