Protein Alignment AGO1 and ppw-1

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_491323.2
• Gene: ppw-1 / 172013
• WormBaseID: WBGene00004093
• Length: 887
• Species: Caenorhabditis elegans
• Alignment Length: 917
• Identity: 203/917 - (22%)
• Similarity: 359/917 - (39%)
• Gaps: 164/917 - (17%)

  Fly    88 AAGGATVAGAAATAA-QVASALGATTGSVTPAIATATPATQPDMPVFTCP-------RRPNLGRE 144
            ||..|...|.|..|| :..:....|..::...|...|  .:|:.|::...       |:|: |.|
 Worm    15 AAPAAQKLGTAPLAAKKTRNVERGTKVNIDTNIRKLT--IKPNQPIYKYAVQVNYVFRKPD-GTE 76

  Fly   145 GRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGVLK---PVF-DG 205
            .      ......:..:|..|..|    ..:|.:..|..|         |.:..||   |.| |.
 Worm    77 A------TIEMSKSAKKGTEHDND----KTRCQKVYNEAI---------KRYDELKTGGPFFYDR 122

  Fly   206 RNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALEG-------RTRQI 263
            :.:|||...|.  ||.:...||      |:|.:.....:||..|..::::.:.       .|...
 Worm   123 QASLYTLTKLK--NESISFVVT------DKICKRQNFKEAQFVLKKVDQSFQSTSNDVIRTTNSC 179

  Fly   264 PYDA---------------------ILALDVVMRHLPSMTYTPVGRSFFSSPEG-YYHPLGGGRE 306
            |.:|                     ::.:...:.:|...|...|....::  || .|..:|..:.
 Worm   180 PANADKTLLEAMNIIVSGPAFENKNVITVGACVHYLIDPTVVDVAYKEYA--EGQLYSGVGASKS 242

  Fly   307 V--WFGFHQSVRPSQWKMMLNIDVSATAFY-KAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFT 368
            |  ..|..:.| ||   :.:..::..|.|: ...|:::.:..........:...|.  :||::
 Worm   243 VKTLEGTDKKV-PS---LFMTTEMKTTLFHPDYAPLVELLQTFRGFSTTLKANSPA--AQRIE-- 299

  Fly   369 KEIKGLKIEI---THCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLR 430
            |...||.:.:   .|.| :.....|..:.|.....:....::|........|..||..||.:.|:
 Worm   300 KAFVGLDVVLNYGVHKG-LGEDGVVMKIRRFHTSAKETCFEVEKSTREFTNVFDYFKKKYGITLK 363

  Fly   431 YPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIK-KLTDMQTSTMIKATARSAPDREREINNLVKR 494
            ||.|..::...:....:.|.||..:...|.... ::.:.:.:.|||.:|.....|:...:.:|:.
 Worm   364 YPDLFTIEAKGKQGKIHFPAEVLLLCPNQTVTNDQMINNEQADMIKMSAAQPHIRKTTTDTIVRN 428

  Fly   495 ADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTG-QQLFPPQNKVSLASPNQGV 558
            ....:::.   :|.......:.:.|.|||.||:.:.|.....|.. :..||....
 Worm   429 VGLASNNI---YGFIKVEDPVNLEGMVLPKPKIAFAGNQLADLANPKSRFPTDFN---------- 480

  Fly   559 WDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQL--QKISNDAGMPIIGQPCFCKYATG 621
               |..|::...|:..|.:.      .|:.:.::...:||  :.::|       |..|     :.
 Worm   481 ---RAGQYYDAKELTKWELV------FVQNEEVQGLAKQLADEMVNN-------GMKC-----SN 524

  Fly   622 P-------DQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKT 679
            |       ..:||:|:..|..  |.||:..|:..:...:.::|.: :....:.||.::|:...|.
 Worm   525 PTMSFIIRGDLEPIFKKAKAA--GTQLLFFVVKSRYNYHQQIKAL-EQKYDVLTQEIRAETAEKV 586

  Fly   680 --SPQTLSNLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVG-- 740
              .|||..|:..|.|:||||:|.    :|..:.||:|...:...||....|.|  |.....||
 Worm   587 FRQPQTRLNIINKTNMKLGGLNY----AIGSEAFNKPNRLIVGFVTSQRVGGN--PDYPISVGFA 645

  Fly   741 -SMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGY--KPHRIILYRDGVSEGQFP 802
             :|..|..::|... |..||...:  ..|::::.|:..:|:....  :|..|:||.:|||||||.
 Worm   646 ANMLKHHQKFAGGY-VYVHRDRDV--FGSIIKDTLLAIFKTCTEQRGRPDDILLYFNGVSEGQFS 707

  Fly   803 HVLQHELTAIREACIKLE----PEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDV 863
            .:.:.....::|||:..:    |.:||.||.|...|.|:.||:    |...|:..|:..||.||.
 Worm   708 MINEEFSARVKEACMAFQKEGTPPFRPHITIIASSKAHNERLY----KSDKGRIVNLEPGTVVDH 768

  Fly   864 GITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDE----LQCLTYQLCHTYVRCTRSVSI 924
            .|......::|..|....|||::.:.:.:::........|    |:.||..||:.:......|.:
 Worm   769 TIVSNVYTEWYHASAVARQGTAKATKFTLIFTTKAGPQAEPLWHLEQLTNDLCYDHQIVFHPVGL 833

  Fly   925 PAPAYYA 931
            |.|.|.|
 Worm   834 PVPLYIA 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	28/160 (18%)
		ArgoL1	285..335	CDD:462567	12/53 (23%)
		PAZ_argonaute_like	336..456	CDD:239212	24/122 (20%)
		Piwi_ago-like	502..942	CDD:240015	114/455 (25%)
ppw-1	NP_491323.2	PAZ_argonaute_like	272..389	CDD:239212	24/121 (20%)
		Piwi-like	444..849	CDD:239208	113/444 (25%)