Protein Alignment AGO1 and PIWIL4

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_689644.2
• Gene: PIWIL4 / 143689
• HGNCID: 18444
• Length: 852
• Species: Homo sapiens
• Alignment Length: 845
• Identity: 208/845 - (24%)
• Similarity: 362/845 - (42%)
• Gaps: 153/845 - (18%)

  Fly   137 RRPNLGREGRPIVLRANHFQVTMPRGY-VHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGVLK 200
            |....|..|.|:.|..|.|.:..|:.: ::.|.:...||...|::.    ..:::::|::....|
Human    95 RNCKTGSSGIPVKLVTNLFNLDFPQDWQLYQYHVTYIPDLASRRLR----IALLYSHSELSNKAK 155

  Fly   201 PVFDGRNNLYTRDPLPIGNERLELEVT-LPGE---GKDRIFRVTIKWQAQVSLFNLEEALEGRTR 261
             .|||        .:...:::||.:|| |..|   |:.....:|:|                  |
Human   156 -AFDG--------AILFLSQKLEEKVTELSSETQRGETIKMTITLK------------------R 193

  Fly   262 QIPYDA---ILALDVVMRH-LPSMTYTPVGRSFFSSPEGY---YHPLGGGREVWFGFHQSVRPSQ 319
            ::|..:   |...:::.|. |..::...:||:|::..|..   .|.|    .:|.||..||...:
Human   194 ELPSSSPVCIQVFNIIFRKILKKLSMYQIGRNFYNPSEPMEIPQHKL----SLWPGFAISVSYFE 254

  Fly   320 WKMMLNIDVSATAFYKA---QPVIDFMCEVLDIRDINEQRKPLTDSQRVKFT----KEIKGLKIE 377
            .|::.:.|||    ||.   :.|::||..:.       ||..|:     .||    |::.|| |.
Human   255 RKLLFSADVS----YKVLRNETVLEFMTALC-------QRTGLS-----CFTQTCEKQLIGL-IV 302

  Fly   378 ITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRM---KLRYPHLPCL-- 437
            :|...  .|.|.:.::........:|  |..:|  .|.|...|:..:|.:   .|..|.|..|
Human   303 LTRYN--NRTYSIDDIDWSVKPTHTF--QKRDG--TEITYVDYYKQQYDITVSDLNQPMLVSLLK 361

  Fly   438 ---QVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTS--TMIKATA---RSAPD-REREINNLVK 493
               ....|.:..:|..|:|.:..       |||..||  .::||.|   |.:|. |::.:..||.
Human   362 KKRNDNSEAQLAHLIPELCFLTG-------LTDQATSDFQLMKAVAEKTRLSPSGRQQRLARLVD 419

  Fly   494 RADFNNDS--YVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQ 556
            ....|.::  .::.:||.. .|.:.:.||::|..|:         |....:..|   ||.|.
Human   420 NIQRNTNARFELETWGLHF-GSQISLTGRIVPSEKI---------LMQDHICQP---VSAAD--- 468

  Fly   557 GVW--DMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYA 619
              |  |:|..:......:..|.|.|  ..||  |....:|...|::::...|.. :..|...|..
Human   469 --WSKDIRTCKILNAQSLNTWLILC--SDRT--EYVAESFLNCLRRVAGSMGFN-VDYPKIIKVQ 526

  Fly   620 TGPDQ-VEPMFRYLKITFPGLQLVVVVLPGKTPVYAE-VKRVGDTVLGMATQCVQAKNVNKTS-- 680
            ..|.. |..:.:|:.   |.:|||:.:||.....|.: :|:...:...:.:|||.|:.:||..
Human   527 ENPAAFVRAIQQYVD---PDVQLVMCILPSNQKTYYDSIKKYLSSDCPVPSQCVLARTLNKQGMM 588

  Fly   681 PQTLSNLCLKINVKLGG-INSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDA 744
            ....:.:.:::..|||| :.::.:|.       :.::.:|.||.....  :|...:...|.|::.
Human   589 MSIATKIAMQMTCKLGGELWAVEIPL-------KSLMVVGIDVCKDAL--SKDVMVVGCVASVNP 644

  Fly   745 HPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYK---PHRIILYRDGVSEGQFPHVLQ 806
            ..:|:.:...:|:...::...|...:...|..:||    |.   |.|||:||.||.:||...:::
Human   645 RITRWFSRCILQRTMTDVADCLKVFMTGALNKWYK----YNHDLPARIIVYRAGVGDGQLKTLIE 705

  Fly   807 HELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEF 871
            :|:..:..:..:........::.|||:|:...|.|    .|.:....|.|.||.||...|....:
Human   706 YEVPQLLSSVAESSSNTSSRLSVIVVRKKCMPRFF----TEMNRTVQNPPLGTVVDSEATRNEWY 766

  Fly   872 DFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAF 936
            ||||.|....:||..|::|:|::|||....|.:|.||::|||.|......||:|||..|||.:.|
Human   767 DFYLISQVACRGTVSPTYYNVIYDDNGLKPDHMQRLTFKLCHLYYNWPGIVSVPAPCQYAHKLTF 831

  Fly   937  936
            Human   832  831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	26/136 (19%)
		ArgoL1	285..335	CDD:462567	15/52 (29%)
		PAZ_argonaute_like	336..456	CDD:239212	30/134 (22%)
		Piwi_ago-like	502..942	CDD:240015	116/445 (26%)
PIWIL4	NP_689644.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		PAZ_piwi_like	270..386	CDD:239211	30/141 (21%)
		Piwi_piwi-like_Euk	394..835	CDD:240016	125/481 (26%)