DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and ago4

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	XP_004911629.1	Gene:	ago4 / 100495218	XenbaseID:	XB-GENE-1006882	Length:	890	Species:	Xenopus tropicalis

Alignment Length:	870	Identity:	625/870 - (71%)
Similarity:	718/870 - (82%)	Gaps:	27/870 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 PDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMV-HA 191
            |...:|..||||.||..|:||.|.||||||.:|:..|:|||::|:|:|.||:||||:::||| |.
Frog    35 PPTNLFQPPRRPGLGTLGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHF 99

  Fly   192 YSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEAL 256
            ...|||..:|.:||:.|:||..|||||.:|::|||||||||||:.|:|||:|.:.|||..|.|||
Frog   100 KMPIFGDRQPGYDGKRNMYTAHPLPIGRDRVDLEVTLPGEGKDQTFKVTIQWVSVVSLQLLLEAL 164

  Fly   257 EGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWK 321
            .|...::|.|::.||||:.||||||.||||||||||.||||||||||||||||||||||||:.|.
Frog   165 AGHLSEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWN 229

  Fly   322 MMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRR 386
            |||||||||||||:|||||:|||||||:::||||.|||||||||||||||:|||:|:||||||:|
Frog   230 MMLNIDVSATAFYRAQPVIEFMCEVLDVQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKR 294

  Fly   387 KYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLE 451
            ||||||||||||..|:|||||||||.:|||||:||..||.::|:||||||||||||.||||||||
Frog   295 KYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLE 359

  Fly   452 VCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADF--NNDSYVQEFGLTISNSM 514
            ||||||||||||||||.||||||||||||||||:.||:.|||....  ..|.|::|||:.:.|.|
Frog   360 VCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEM 424

  Fly   515 MEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIAC 579
            .|:.|||||.|.||||||||            || ::|:|||||||||||||:.|:||::||:||
Frog   425 TELTGRVLPAPMLQYGGRVS------------NK-TVATPNQGVWDMRGKQFYAGIEIKVWAVAC 476

  Fly   580 FAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVV 644
            ||||:..|||.|::||.||:|||.||||||.|||||||||.|.|.|||||::||:|:.||||:||
Frog   477 FAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKLTYVGLQLIVV 541

  Fly   645 VLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPK 709
            :|||||||||||||||||:|||||||||.|||.|||||||||||||||.||||||::|||..||.
Frog   542 ILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPS 606

  Fly   710 VFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHR----------QEIIQ 764
            ||.:||||||||||||||||.|||||||||||||.|||||.||||||..|          ||:||
Frog   607 VFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQETTQELLYSQEVIQ 671

  Fly   765 ELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITF 829
            :||:|||||||.||||| .:||.|||.||.||||||...|...||.|||:|||.||.:||||||:
Frog   672 DLSNMVRELLIQFYKST-RFKPTRIIYYRGGVSEGQMKQVAWPELMAIRKACISLEEDYRPGITY 735

  Fly   830 IVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLW 894
            ||||||||||||||:|.|:.|||||:|||||||..||||:|||||||||.|||||||||||.|||
Frog   736 IVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLW 800

  Fly   895 DDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCS 959
            |||.|.:||||.|||||||||||||||||||||||||.|||||||||||:|:|||.||||.||.|
Frog   801 DDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQS 865

  Fly   960 EDRTPGAMARAITVHADTKKVMYFA 984
            ..|.|.|:|:|:.:|.||:..||||
Frog   866 NGRDPQALAKAVQIHHDTQHTMYFA 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	72/129 (56%)
		ArgoL1	285..335	CDD:400854	45/49 (92%)
		PAZ_argonaute_like	336..456	CDD:239212	97/119 (82%)
		Piwi_ago-like	502..942	CDD:240015	332/449 (74%)
ago4	XP_004911629.1	PLN03202	42..889	CDD:215631	620/860 (72%)
		ArgoN	45..182	CDD:293095	76/136 (56%)
		ArgoL1	194..243	CDD:285861	44/48 (92%)
		PAZ_argonaute_like	244..364	CDD:239212	97/119 (82%)
		Piwi_ago-like	411..848	CDD:240015	332/450 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	156	1.000	Domainoid score	I4126
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1302	1.000	Inparanoid score	I155
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	1	1.000	-	-		otm48767
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X379
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080