Protein Alignment AGO1 and ago3

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: XP_004911628.1
• Gene: ago3 / 100486574
• XenbaseID: XB-GENE-6462752
• Length: 861
• Species: Xenopus tropicalis
• Alignment Length: 877
• Identity: 626/877 - (71%)
• Similarity: 717/877 - (81%)
• Gaps: 29/877 - (3%)

  Fly   119 IATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNRE 183
            |.||.|...  .|.|..||||..|..|:||.|.||.|||.:|:..|:.|:::|:||||||:||||
 Frog     3 IGTAGPVGA--QPFFMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNRE 65

  Fly   184 IIETMV-HAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGE-GKDRIFRVTIKWQAQ 246
            ::::|| |....|||..:||:||:.:|||.:|||:.:..::|:|||||| ||||.|:|:||:.::
 Frog    66 VVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVASTGVDLDVTLPGEGGKDRPFKVSIKFVSR 130

  Fly   247 VSLFNLEEALEGRT--------RQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGG 303
            :|...|.|.|.|||        :.|..:.:.|:|||:||||||.||||||||||:||||.|||||
 Frog   131 ISWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGG 195

  Fly   304 GREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFT 368
            ||||||||||||||:.|||||||||||||||||||||.||||||||.:|:||.:|||||.|||||
 Frog   196 GREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFT 260

  Fly   369 KEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPH 433
            |||||||:|:||||.|||||||||||||||..|:||||||||||||.|||:||.:||.::|:|||
 Frog   261 KEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYNLQLKYPH 325

  Fly   434 LPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFN 498
            |||||||||.||||||||||||||||||||||||.||||||||||||||||:.||:.||:.|:::
 Frog   326 LPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYD 390

  Fly   499 NDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRG 563
            .|.:||||...:.:.|..|.|||||.|.||||||..|               :|:|:.|||||||
 Frog   391 ADPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRT---------------VATPSHGVWDMRG 440

  Fly   564 KQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPM 628
            |||.|||||::|||||||.||..||:.|:.||.||:|||.||||||.|||||||||.|.|.||||
 Frog   441 KQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPM 505

  Fly   629 FRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINV 693
            ||:||.|:.||||::|:|||||||||||||||||:|||||||||.|||.||||||||||||||||
 Frog   506 FRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINV 570

  Fly   694 KLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQH 758
            ||||||:||||..||.||.:||||||||||||||||.|||||||||||||||||||.||||||:.
 Frog   571 KLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRP 635

  Fly   759 RQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQF-PHVLQHELTAIREACIKLEPE 822
            |||||.:|:||||||||.||||| .:||.|||.|||||||||| ..||.:||.|||||||.||.:
 Frog   636 RQEIIHDLASMVRELLIQFYKST-RFKPTRIIFYRDGVSEGQFRQQVLYYELLAIREACISLEKD 699

  Fly   823 YRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRP 887
            |:||||:||||||||||||||::.|:.|:|||||||||||..||||.|||||||||.||||||||
 Frog   700 YQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRP 764

  Fly   888 SHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEG 952
            ||||||||||.|.:||||.|||||||||||||||||||||||||||||||||||||:|||||.||
 Frog   765 SHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEG 829

  Fly   953 SHQSGCSEDRTPGAMARAITVHADTKKVMYFA 984
            ||.||.|..|.|.|:|:|:.:|.||.:.||||
 Frog   830 SHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	64/138 (46%)
		ArgoL1	285..335	CDD:462567	45/49 (92%)
		PAZ_argonaute_like	336..456	CDD:239212	97/119 (82%)
		Piwi_ago-like	502..942	CDD:240015	335/440 (76%)
ago3	XP_004911628.1	ArgoN	73..167	CDD:465134	40/93 (43%)
		ArgoL1	177..227	CDD:462567	45/49 (92%)
		PAZ_argonaute_like	228..348	CDD:239212	97/119 (82%)
		Piwi_ago-like	393..819	CDD:240015	335/441 (76%)