DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and ago1

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_001304144.1	Gene:	ago1 / 100302589	XenbaseID:	XB-GENE-5933499	Length:	857	Species:	Xenopus tropicalis

Alignment Length:	869	Identity:	635/869 - (73%)
Similarity:	727/869 - (83%)	Gaps:	17/869 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PAIATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVN 181
            |:.|..:....|...||..||||.:|..|:||.|.||:|:|.:|:..|:||:::|:||||||:||
Frog     5 PSSAAPSGYVPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVN 69

  Fly   182 REIIETMV-HAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQA 245
            ||::|.|| |...:|||..|||:||:.|:||...||||:||::.|||:|||||||||:|:|||.|
Frog    70 REVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGHERVDFEVTIPGEGKDRIFKVSIKWVA 134

  Fly   246 QVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFG 310
            .||...|.|||.....|:|.:::.||||.||||.||.||||||||||.|||||||||||||||||
Frog   135 VVSWRMLHEALGSGRIQLPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFG 199

  Fly   311 FHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLK 375
            |||||||:.|.|||||||||||||||||||:|||||||||:|:||.|||||||||:|||||||||
Frog   200 FHQSVRPAMWNMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLK 264

  Fly   376 IEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVG 440
            :|:||||||:|||||||||||||..|:||||||:|||||||||:||..||.::|:||||||||||
Frog   265 VEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVG 329

  Fly   441 QEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYVQE 505
            ||.||||||||||||||||||||||||.||||||||||||||||:.||:.|:|.|.:|.|.|:||
Frog   330 QEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQE 394

  Fly   506 FGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGV 570
            ||:.:.:.|.||.|||||.|.||||||              |: ::|:|||||||||||||:.|:
Frog   395 FGIKVKDDMTEVTGRVLPAPILQYGGR--------------NR-AIATPNQGVWDMRGKQFYNGI 444

  Fly   571 EIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKIT 635
            ||::|||||||||:..||:.|:|||.||:|||.||||||.|||||||||.|.|.||||||:||.|
Frog   445 EIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNT 509

  Fly   636 FPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINS 700
            :.||||::|:|||||||||||||||||:|||||||||.|||.||||||||||||||||||||||:
Frog   510 YSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINN 574

  Fly   701 ILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQE 765
            ||||..|..||.:||||||||||||||||.|||||.|||||||||||||.||||||:.|||||::
Frog   575 ILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIED 639

  Fly   766 LSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFI 830
            ||.|||||||.||||| .:||.|||.|||||.|||.|.:|.:||.|||:||||||.:|:||||:|
Frog   640 LSYMVRELLIQFYKST-RFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYI 703

  Fly   831 VVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWD 895
            |||||||||||||::.|:.|||||||||||||..||||.|||||||||.|||||||||||:||||
Frog   704 VVQKRHHTRLFCADRSERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWD 768

  Fly   896 DNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCSE 960
            ||.|.:||||.|||||||||||||||||||||||||.|||||||||||:||||||||||.||.|.
Frog   769 DNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSN 833

  Fly   961 DRTPGAMARAITVHADTKKVMYFA 984
            .|.|.|:|:|:.||.||.:.||||
Frog   834 GRDPQALAKAVQVHQDTLRTMYFA 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	72/129 (56%)
		ArgoL1	285..335	CDD:400854	45/49 (92%)
		PAZ_argonaute_like	336..456	CDD:239212	99/119 (83%)
		Piwi_ago-like	502..942	CDD:240015	333/439 (76%)
ago1	NP_001304144.1	PLN03202	26..856	CDD:215631	625/845 (74%)
		ArgoN	26..164	CDD:293095	76/137 (55%)
		ArgoL1	175..224	CDD:285861	44/48 (92%)
		PAZ_argonaute_like	225..345	CDD:239212	99/119 (83%)
		Piwi_ago-like	390..815	CDD:240015	333/440 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	528	1.000	Domainoid score	I292
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1302	1.000	Inparanoid score	I155
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	1	1.000	-	-		otm48767
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X379
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060