DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and FCGBP

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_003881.2	Gene:	FCGBP / 8857	HGNCID:	13572	Length:	5405	Species:	Homo sapiens

Alignment Length:	810	Identity:	141/810 - (17%)
Similarity:	235/810 - (29%)	Gaps:	339/810 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  3324 LPQENTATVKETPLNE-----------------------PVPSSPAETKEIEQTTNDDQK---KP 3362
            |.||.:..:|.|...|                       .:..|||....:.|..|..:|   :|
Human    20 LTQEASVDLKNTGREEFLTAFLQNYQLAYSKAYPRLLISSLSESPASVSILSQADNTSKKVTVRP 84

  Fly  3363 EEIV-------------------------------------DTEKKTTEQKPVETIPTE-----P 3385
            .|.|                                     ||.:.|. .:|::.:.||     |
Human    85 GESVMVNISAKAEMIGSKIFQHAVVIHSDYAISVQALNAKPDTAELTL-LRPIQALGTEYFVLTP 148

  Fly  3386 ISTSET-------------TTVTLTTKTTIVDEGKLHPPSDIEQI-IQPHSTSDKHQSLVDFIEQ 3436
            ..||..             .:|::|.|.::...||.:|..|:.:: :||::.: :.||.||.
Human   149 PGTSARNVKEFAVVAGAAGASVSVTLKGSVTFNGKFYPAGDVLRVTLQPYNVA-QLQSSVDL--- 209

  Fly  3437 EKGTQPAEGGSNILQNVKDAAKLGALAIVGAPVLAGKALVDALTTEKTLKPEHSTSQVVTETVEE 3501
                    .||.:              ...:||        |:.:..:...:|:|...|.|.:
Human   210 --------SGSKV--------------TASSPV--------AVLSGHSCAQKHTTCNHVVEQL-- 242

  Fly  3502 LPTEIITTS--TATLVTK-------VTTTTTTTTTSTSEGTPDDEALDVVKLPAELVESSVKREV 3557
            |||....|.  ..||.::       |..:..|..|....|......|..    .::||..|:...
Human   243 LPTSAWGTHYVVPTLASQSRYDLAFVVASQATKLTYNHGGITGSRGLQA----GDVVEFEVRPSW 303

  Fly  3558 PRTLAIGDAISQKLISPDECQVIVDGEQQSQTVSTLLKEEQLSPLDEVQIIDDKLIVLQQVSYLV 3622
            |..|:....|          ||::.|....:
Human   304 PLYLSANVGI----------QVLLFGTGAIR---------------------------------- 324

  Fly  3623 DADTELTPQNLYELNIYDPENQYFIDPSTGQKISFHTLVFDMNVFNPETILVKNFSTGKYETLTA 3687
               .|:|         |||   |.:            |:.|:..:.|..::
Human   325 ---NEVT---------YDP---YLV------------LIPDVAAYCPAYVV-------------- 348

  Fly  3688 ALERPLLDRHTGHMVDPKTGKKIPFFECVDRQWIIRANPEEQKPSGIENVTIDTQTGQVVLDDGR 3752
                                |.:|                     |.|.|.:
Human   349 --------------------KSVP---------------------GCEGVAL------------- 359

  Fly  3753 VCSIVEAINSGKLDIQSISVRDPVSGEVIPLRMAIELGVVDMQAGTVIDIQTLKEIPMELAFQLG 3817
            |.:..:||:...:|..::..:  ::.|.:|   ..|....:::.||...|.|     .|....||
Human   360 VVAQTKAISGLTIDGHAVGAK--LTWEAVP---GSEFSYAEVELGTADMIHT-----AEATTNLG 414

  Fly  3818 FLVPGARKPISLEAAVRKGLYDPETGKLFDSESQNQVDVQKSIEIGLVDPKISLIVDTVTKK-EV 3881
            .|..|..|.|....|                     .|..::: :..|:|....:.....:: :|
Human   415 LLTFGLAKAIGYATA---------------------ADCGRTV-LSPVEPSCEGMQCAAGQRCQV 457

  Fly  3882 ---KLDCAIEDDLVLPATGQIKDNKNNTLVPFDVGVQQCLLKTDNVTWSLPELLQREYYTPS-TG 3942
               |..|..|...|..|.|   |....|   || |.:..::.|  .::::.||...:...|: :.
Human   458 VGGKAGCVAESTAVCRAQG---DPHYTT---FD-GRRYDMMGT--CSYTMVELCSEDDTLPAFSV 513

  Fly  3943 KVLNPVTGEEILLQQAIEMGFVELETTLVKDVDHDKILPGKEAAKVGLLDTVRGTLSSPNISLDE 4007
            :..|...|..       .:.:|.|.|  |:...|...|...|...| |:|..|..|.   :||.|
Human   514 EAKNEHRGSR-------RVSYVGLVT--VRAYSHSVSLTRGEVGFV-LVDNQRSRLP---VSLSE 565

  Fly  4008 AFVKGYLISTKKPLSLV---------DCLL 4028
            ..::.|....:..:.||         ||.|
Human   566 GRLRVYQSGPRAVVELVFGLVVTYDWDCQL 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068
		DUF4775	3026..3357	CDD:330579	10/55 (18%)
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
FCGBP	NP_003881.2	IgGFc-binding	24..450		99/637 (16%)
		VWD	472..627	CDD:278521	34/146 (23%)
		C8	667..742	CDD:214843
		TIL	745..799	CDD:280072
		VWD	864..1019	CDD:278521
		C8	1060..1133	CDD:214843
		TIL	1136..1189	CDD:280072
		VWC	1194..1245	CDD:302663
		VWD	1252..1407	CDD:278521
		C8	1454..1529	CDD:214843
		TIL	1532..1585	CDD:280072
		VWC	1587..1640	CDD:302663
		VWD	1673..1832	CDD:278521
		C8	1871..1946	CDD:214843
		TIL	1950..2004	CDD:280072
		VWD	2072..2222	CDD:278521
		C8	2260..2334	CDD:214843
		TIL	2337..2390	CDD:280072
		VWC	2398..2446	CDD:302663
		VWD	2453..2608	CDD:278521
		C8	2655..2730	CDD:214843
		TIL	2733..2786	CDD:280072
		VWC	2788..2841	CDD:302663
		VWD	2874..3033	CDD:278521
		C8	3072..3147	CDD:214843
		TIL	3151..3205	CDD:280072
		VWD	3273..3423	CDD:278521
		C8	3461..3535	CDD:214843
		TIL	3538..3591	CDD:280072
		VWC	3599..3647	CDD:302663
		VWD	3654..3809	CDD:278521
		C8	3856..3931	CDD:214843
		TIL	3934..3987	CDD:280072
		VWC	3989..4042	CDD:302663
		VWD	4075..4234	CDD:278521
		C8	4273..4348	CDD:214843
		TIL	4352..4406	CDD:280072
		VWD	4474..4624	CDD:278521
		C8	4662..4736	CDD:214843
		TIL	4739..4792	CDD:280072
		VWC	4797..4849	CDD:302663
		VWD	4856..5003	CDD:278521
		C8	5044..5118	CDD:214843
		TIL	5121..5174	CDD:280072
		VWD	5235..5382	CDD:295339
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900