DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and HPF1

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_014487.1	Gene:	HPF1 / 854010	SGDID:	S000005515	Length:	967	Species:	Saccharomyces cerevisiae

Alignment Length:	1055	Identity:	201/1055 - (19%)
Similarity:	328/1055 - (31%)	Gaps:	365/1055 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2780 SNNEVQNVNTGEVCSLEEAKELGILREESTTRETKAAAGESPESVGDVGTSGDQTVIVEERTQTV 2844
            |:..|.:.::|.| |:..:.||     .|:|.:..::..|...|..:|.:|...:....|.:.::
Yeast    36 SSTAVSSTSSGSV-SISSSIEL-----TSSTSDVSSSLTELTSSSTEVSSSIAPSTSSSEVSSSI 94

  Fly  2845 VVSSDTRKQEMQVVSTTQSTKDTSVPSVSEIETKGSKEPSKTLQNVKDAAKLGALGVIAAPVLAG 2909
            ..|..:......:.|:..|...:|..:.|.....||...:::..:|..::.....|  ::.....
Yeast    95 TSSGSSVSGSSSITSSGSSVSSSSSATESGSSASGSSSATESGSSVSGSSTSITSG--SSSATES 157

  Fly  2910 GAIVSGVKSLIKSVKSPTEDAKSTEKPKEPQTSFIEQERRKELQPQQVPSEVDNLLSETENFISS 2974
            |:.|||..|..:|..|.:..:.:||.......|....|.         .|.|....|.||   |.
Yeast   158 GSSVSGSTSATESGSSASGSSSATESGSSASGSSSATES---------GSSVSGSSSATE---SG 210

  Fly  2975 TTANFIANEKQQDKPDTLPQESNLPLEVESTSTLTTTTVT---TITTSSTTTETGNLEPVVVEDV 3036
            ::.:..::..:.....::|..|....|..|:|:.:.:::|   |.:.||.::.:|:     |...
Yeast   211 SSVSGSSSATESGSASSVPSSSGSVTESGSSSSASESSITQSGTASGSSASSTSGS-----VTQS 270

  Fly  3037 STTVKEDKVVVKP---STVPEDKTEVSKITETITTVT--------SNETDTVPEKISQKSAS--- 3087
            .::|........|   |::|:..:..|..:.:||:.|        |:.|.|....:|....:
Yeast   271 GSSVSGSSASSAPGISSSIPQSTSSASTASGSITSGTLSSITSSASSATATASNSLSSSDGTIYL 335

  Fly  3088 -EESAKKDPVVTKDT-SSRPAETETSPKP---------------------VQKEPTPDPAQNTEF 3129
             ..:...|..:|... ::...|.....|.                     |:|.....|  .|||
Yeast   336 PSTTISGDITLTGSVIATEAVEVAAGGKLTLLDGDKYVFSADFIIHGGVFVEKSKPTYP--GTEF 398

  Fly  3130 PESIKK-DPTPEPDYKETATEAA---QITPK--------EASPAPTNKNEQSAEPTSKP------ 3176
            ..|.:. |.:...:.:|.|..:|   ..||.        ..|.:.:.|.|.:..|.|..
Yeast   399 DISGENFDVSGTFNAEEPAASSASAYSFTPGSFDNSGDISLSLSESTKGEVTFSPYSNSGAFSFS 463

  Fly  3177 ---------EPMPRTAKKEEISEIEPPFTAPLAPFVDQLAETKITEIKTE------FKEPVTSSQ 3226
                     ..:.|.|:...::.                     .||..|      ..|||:.|.
Yeast   464 NAILNGGSVSGLQRRAESGSVNN---------------------GEINLENGSTYVVVEPVSGSG 507

  Fly  3227 TITTI----------TTTVKTVDEHPIVEEVDEVSKSEKIVDVEEPTVHQQEPIKV------NE- 3274
            ||..|          |.|.:||           |.|.|.::.| :||.....||.|      |:
Yeast   508 TINIISGNLYLHYPDTFTGQTV-----------VFKGEGVLAV-DPTETNTTPIPVVGYTGENQI 560

  Fly  3275 --TSD------DS-----TRTEPTNEI--------------VHEER--------------VVTVE 3298
              |:|      ||     |.|:..::.              |.|..              |.:..
Yeast   561 AITADVTALSYDSATGVLTATQGNSQFSFSIGTGFSSSGFNVSEGTFAGAYAYYLNYGGVVASSA 625

  Fly  3299 EPTITETT--------------------------------------------VTTTTITTTTTSS 3319
            .|:.|.||                                            |.|||:|..||:|
Yeast   626 TPSSTSTTSGATNSTSGSTSFGASVTGSTASTSFGASVTGSTASTLISGSPSVYTTTLTYATTTS 690

  Fly  3320 ------SEETLPQENTATVKETPLNEPVPSSPAETKEIEQTTNDDQKKPEEIVDTEKKTTEQKPV 3378
                  ||.|....|..|:..|     ||.| :.|..|   |:.|:........|
Yeast   691 TVVVSCSETTDSNGNVYTITTT-----VPCS-STTATI---TSCDETGCHVTTST---------- 736

  Fly  3379 ETIPTEPISTSETTTVTLT--------TKTTIVDEGKLHPPSDIEQIIQPHSTSDKHQSLVDFIE 3435
            .|:.||.:|:...||||:|        |||.         .|:..:.....:||.|..:.|..
Yeast   737 GTVATETVSSKSYTTVTVTHCDNNGCNTKTV---------TSECPEETSATTTSPKSYTTVTV-- 790

  Fly  3436 QEKGTQPAEGGSNILQNVKDAAKLGALAIVGAPVLAGKALVDALTTEKTLKPEHSTSQVVTE--- 3497
                |...:.|.|......:|.                   :|.||  |:.|:..|:..||:
Yeast   791 ----THCDDNGCNTKTVTSEAP-------------------EATTT--TVSPKTYTTATVTQCDD 830

  Fly  3498 -------TVEELPTEIITTSTATLVTKVTTTTTTT------------------------------ 3525
                   ...|.|.|...||..:...|..||.|.|
Yeast   831 NGCSTKTVTSEAPKETSETSETSAAPKTYTTATVTQCDDNGCNVKIITSQIPEATSTVTATSASP 895

  Fly  3526 ---TTSTSEGTPDDEALDVVKLPAELVESSVKREVPRTLAIGDAISQKLISPDECQVIVDGEQQS 3587
               ||.||||:........:...:..:.:..|...|...:.|              :||    ||
Yeast   896 KSYTTVTSEGSKATSLTTAISKASSAISTYSKSAAPIKTSTG--------------IIV----QS 942

  Fly  3588 QTVSTLLKEEQLSPL 3602
            :.::..|....|:.|
Yeast   943 EGIAAGLNANTLNAL 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068	85/464 (18%)
		DUF4775	3026..3357	CDD:330579	95/508 (19%)
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
HPF1	NP_014487.1	Hyphal_reg_CWP	337..617	CDD:403079	56/314 (18%)
HPF1	NP_014487.1	Herpes_BLLF1	<643..937	CDD:282904	69/348 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900