DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and EPPK1

DIOPT Version :9

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:NP_112598.3 Gene:EPPK1 / 83481 HGNCID:15577 Length:5088 Species:Homo sapiens


Alignment Length:6494 Identity:1216/6494 - (18%)
Similarity:2081/6494 - (32%) Gaps:2237/6494 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1592 IKVNNTVTVEQTS------GELGSPENPRNIADAITAGSVDTKTGLYRVKSGQTISLAEAYERGY 1650
            :.|..|.:.||.|      ..||:...||..|.:|        .|:|...|||..|:..|.|:|.
Human     9 LPVPGTNSTEQASVPRAMAATLGAGTPPRPQARSI--------AGVYVEASGQAQSVYAAMEQGL 65

  Fly  1651 --------LIRHESVT------IKSNALCLSDAIAHGLVD-------------GAGWIADRNSGD 1688
                    |:..::.|      .:...|.:|.|:..|||.             ..|: .|...|:
Human    66 LPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQQGLVGLELKEKLLAAERATTGY-PDPYGGE 129

  Fly  1689 KFRLDSAIANQLIDASVRE-----------VVDAKRDTKITLQEALQSGVLNAKTG--------- 1733
            |..|..||..:::|.::.:           :||..:...:..:.|...|:|:.:|.         
Human   130 KLALFQAIGKEVVDRALGQSWLEVQLATGGLVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPG 194

  Fly  1734 ----RYVNEVTKEKLTFAEARNRQLIVKPYTLKDICDLNLLDKQAQITSPMRREKLSIMQAIEAG 1794
                |:::..|.|:||:.:...| .:..|.:     .|.||  ..:||.......:|..:.:|.|
Human   195 TGDLRFLDPNTLERLTYHQLLER-CVRAPGS-----GLALL--PLKITFRSMGGAVSAAELLEVG 251

  Fly  1795 VLDGNLLKCITKRKGELVTLQ-EAIAD------------GIVLPAECKYRDF------------- 1833
            :||...::.:  |:|.|..:. .|.|:            |:||..|...:.|             
Human   252 ILDEQAVQGL--REGRLAAVDVSARAEVRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGT 314

  Fly  1834 -----------------MTGELISIPEAVERGLISS-------VAQRSIFDIDGFKDLRSNDYVS 1874
                             :||:.:.:.|||..||:|.       ||:::   :.|..|..|...:.
Human   315 ALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQA---VTGHHDPFSGSQIP 376

  Fly  1875 FNVALSRDLLRRK----------STGFALETGRDSLVPLEVAVSEGLVRQEVYEMFSRGIGVQNA 1929
            ...|:.:.|:.|.          :||..:...|...:|||.|:..|.:.::.....|:.....:.
Human   377 LFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQAGSFSDG 441

  Fly  1930 SGKELSVFDLVYHNLIDPKTGYLL-----DPKTGETVPLDTAIERKFITPEGALLLSSLLNITLT 1989
            :...|....|:...:.||:||...     .|:.||              |:|...:.......|:
Human   442 THGGLRYEQLLALCVTDPETGLAFLPLSGGPRGGE--------------PQGPPFIKYSTRQALS 492

  Fly  1990 TETVTRTINRYVTIRAGSQEPVDSVLLTFTEAVRQGFIDEERQLFKDPKTGNIYSVQQALNYGLL 2054
            |.|.|.::.::      ...||....|.|:||:.    .|:|.:..........||:        
Human   493 TATATVSVGKF------RGRPVSLWELLFSEAIS----SEQRAMLAQQYQEGTLSVE-------- 539

  Fly  2055 VPDSNQTVPEPTNRKKTKSTITIVTKQIIPEAEPIKLNTQHTKYVEKSVEIPISQELVKPHRVVS 2119
                           |..:.::...:|....|.               |.....::.|.|..:: 
Human   540 ---------------KLAAKLSATLEQAAATAR---------------VTFSGLRDTVTPGELL- 573

  Fly  2120 EFINLEKSSYIEQNVTERQIMELPPGGWRLKD----AIEQRLFNPDTGVFHVQGTDRLVNFEECI 2180
                  |:..|:|::.||    |..|....||    |..||         ::|||.       ||
Human   574 ------KAEIIDQDLYER----LEHGQATAKDVGSLASVQR---------YLQGTG-------CI 612

  Fly  2181 NKQIINNLSLSVIDPNTGDKISVQSAFERDILDSYGNYTNSRKQVQGMRSAIDESKIILETVPAT 2245
                     ..::.|.:.:::|:..                                        
Human   613 ---------AGLLLPGSQERLSIYE---------------------------------------- 628

  Fly  2246 RGANQKTILRITKVNNIPDVLEVSTPLKDAPPKFVEVLTCQRELASPEPLQIAPGAIYDPSTALV 2310
              |..|.:||                                                 |.|||:
Human   629 --ARCKGLLR-------------------------------------------------PGTALI 642

  Fly  2311 IFTQTGETENIFDAARQGLVDEQLIKIVDPTTKQPISVTEAIARSIYDPKT-ATILDSE------ 2368
            :......|         |.       |:||...:..||.||:..::..|.. |.:|.:|      
Human   643 LLEAQAAT---------GF-------IIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGY 691

  Fly  2369 -----GQPVDLITATKLGLLSVVGAPLVAAEGALRTVRF------VTDPRTGEQIPVEVAYERG- 2421
                 ||.:.|..|.:.|        |:..|..:|.:..      |.||....::||:|||.|| 
Human   692 TDPYTGQQISLFQAMQKG--------LIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGY 748

  Fly  2422 ------IVSRDQLHRGRSFDSEPATVEDKVVVLQRMRKVILKPKDAL--------RKGIIDEETC 2472
                  ::..|.....:.| .:|.|.|: :..||.:.:.:..|:..|        :..::|..|.
Human   749 FDQMLNLILLDPSDDTKGF-FDPNTHEN-LTYLQLLERCVRDPETGLYLLPLSSTQSPLVDSATQ 811

  Fly  2473 EILEN---TSNFTNPKGEVVNITEALNTGLI-DGRRGQVIDPQNNRVLNLRQAVEQKIIDSEQTN 2533
            :..:|   :..:...:|:.|:..|.:|:... :|||.|::.....|.:.|.|..:....::::..
Human   812 QAFQNLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQREVTLGQVAKLLEAETQRQA 876

  Fly  2534 HILMPLAKS-LSVPRLADQGLIDPQ--TQTI---VHPE-------------------------SG 2567
            .|::|..:| ::|.:|.:.|:||.|  .|.:   :.||                         ||
Human   877 DIMLPALRSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSG 941

  Fly  2568 YPLSIHEAIVCEVLDPHSKL---------------HKPEKCTLEEAITKGIINADDSTFNYKNKT 2617
            ..||:::|:..::|.|...|               |.||..:::||:.:|::..:      ....
Human   942 QRLSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPE------LYGR 1000

  Fly  2618 LNITEAIEAKLFDPSYDQQKSKVEIPPVGMIFPVAVEKSLVEPSKRV--VLHPSTKKALPIKQAI 2680
            |...|...|...||...:|.|..:....|:| |......|:|.....  ::.|::...||:..||
Human  1001 LKRAEGAIAGFRDPFSGKQVSVFQAMKKGLI-PWEQAARLLEAQVATGGIIDPTSHHHLPMPVAI 1064

  Fly  2681 EENFI---MSIPYS------PKPDAIEVVTAMEQDLIDV------AAQTLTVPSTGERIPLRQAM 2730
            :..::   |....|      |.||. :..|:..|.|.:.      ....|.:|.:...:|..:.:
Human  1065 QRGYVDQEMETALSSSSETFPTPDG-QGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQV 1128

  Fly  2731 ENGVLVVKN----------LSDFVITQKPIPKTEIMETVRAVHTVTTKTIELMQGYV----LISN 2781
            :..:..|..          ||....|::  .:..::|.|:...|...:.:..:|.:|    |::.
Human  1129 QRSLQAVPGAKDGTSLWDLLSSCHFTEE--QRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQ 1191

  Fly  2782 NEVQNVN-TGEVCSLEEAKELGILREESTTRETKAAAGESPESVGDVGTSGDQTVIVEERTQTVV 2845
            ..|.... .|||.:: ...:.||:.:|  |.|..|...:||..|      .:|..:......|..
Human  1192 ARVMVPGPRGEVPAV-WLLDAGIITQE--TLEALAQGTQSPAQV------AEQPAVKACLWGTGC 1247

  Fly  2846 VSSDTRKQEMQVVSTTQSTKDTSVPS-------VSEIETKGSKEPSKTLQ-NVKDAAKLGALGVI 2902
            |:....:......|..|:.:|..:|:       .:::.:....:|....: :|:||.|:|.:|  
Human  1248 VAGVLLQPSGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVG-- 1310

  Fly  2903 AAPVLAGGAIVSGVKSLIKSVKSPTEDAKSTEKPKEPQTSFIEQERRKELQPQ------------ 2955
                          :.|.:.:......|.....|....:..:.|...|.|.||            
Human  1311 --------------RELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLA 1361

  Fly  2956 -----------------------------QVPSEVDNLLSETENFISSTTANFIANEKQQDK--- 2988
                                         ||.:.||   .:.:.|...:..:.:..::.:::   
Human  1362 TGGVVDPVHGVHLPQAAACRLGLLDTQTSQVLTAVD---KDNKFFFDPSARDQVTYQQLRERCVC 1423

  Fly  2989 -PDT----LPQESNLPLEVESTSTLTTTTVTTITTSSTTTETGNLEPVVVEDVSTTVKEDKVVVK 3048
             .:|    ||..|:..|||:.      .|...:........||..:...|......:.|      
Human  1424 DSETGLLLLPLPSDTVLEVDD------HTAVALRAMKVPVSTGRFKGCSVSLWDLLLSE------ 1476

  Fly  3049 PSTVPEDKTEVSKITETITTVTSNETDTVPEKISQKSASEESAKKDPV------VTKDTSSRPAE 3107
              .|..||..     |.:....|.....:.:.:|..:...|:|::.|:      :.|..|:|.. 
Human  1477 --YVGADKRR-----ELVALCRSGRAAALRQVVSAVTTLVEAAERQPLQATFRGLRKQVSARDL- 1533

  Fly  3108 TETSPKPVQKEPTPDPAQNTEFPESIKKDPTPEPDYKETATEAAQITPKEASPAPTN-----KNE 3167
              ...:.:.::...:.:|.|                 .|..|.|::...:.|....|     ..:
Human  1534 --FRAQLISRKTLDELSQGT-----------------TTVKEVAEMDSVKRSLEGGNFIAGVLIQ 1579

  Fly  3168 QSAEPTSKPEPMPRTAKKEEISEIEPPFTAPLAPFVDQLAETKITEIKTEFKEPVTSSQTITTIT 3232
            .:.|..|.||.:.|...:...:.:.....|.....:|.:...|:| ::..||..:...:|...: 
Human  1580 GTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPVENRKLT-VEEAFKAGMFGKETYVKL- 1642

  Fly  3233 TTVKTVDEHPIVEEVDEVSKSEKIVDVEEPTVHQQEPIKVNETSDDSTRTEPTNEIVHEERVVTV 3297
                             :|....:....:|...||..:               .:.:.::.:|..
Human  1643 -----------------LSAERAVTGYTDPYTGQQISL---------------FQAMQKDLIVRE 1675

  Fly  3298 EEPTITETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPSSPA--------ETKEIEQT 3354
            ....:.|..:.|..|.....|                    ..||...|        |...|...
Human  1676 HGIRLLEAQIATGGIIDPVHS--------------------HRVPVDVAYRCGYFDEEMNRILAD 1720

  Fly  3355 TNDDQK---KPEEIVDTEKKTTEQKPVETIPTEP----------------ISTSETTTVTLTTKT 3400
            .:||.|   .|    :|.:..|..:.:|....:|                :..:|.|...|.::|
Human  1721 PSDDTKGFFDP----NTHENLTYLQLLERCVEDPETGLYLLQIIKKGENYVYINEATRHVLQSRT 1781

  Fly  3401 TIVDEGKLHPPSDIEQII-------QPHSTSDKHQSLVDFIEQEKGTQPAEGGSNILQNVKDAAK 3458
            ..:..|:.     .:|::       .|:.|.|:.:.|:    ||.|.|  .||            
Human  1782 AKMRVGRF-----ADQVVSFWDLLSSPYFTEDRKRELI----QEYGAQ--SGG------------ 1823

  Fly  3459 LGALAIVGAPVLAGKALVDALTTEKTLKPEHSTSQVVTETVEELPTEIITTSTATLVTKVTTTTT 3523
                                  .||.|       :::|.|:||..|:......|.:..:||.   
Human  1824 ----------------------LEKLL-------EIITTTIEETETQNQGIKVAAIRGEVTA--- 1856

  Fly  3524 TTTTSTSEGTPDDEALDVVKLPAELVESSV-KREVPRTLAIGDAISQKLISPDECQVIVDGEQQS 3587
                                  |:|..|.| .::...||.:|....|.|.:.:..:..::|....
Human  1857 ----------------------ADLFNSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSGCI 1899

  Fly  3588 QTVSTLLKEEQLSPLDEVQIIDDKLIVLQQVSYLVDADTELTPQNLYELNIYDPENQYFIDPSTG 3652
            ..|:.....|.:| |.|..  ..:||.....::|::|..               ...:.:||.|.
Human  1900 AGVTVPSTREVMS-LHEAS--RKELIPAAFATWLLEAQA---------------ATGFLLDPCTR 1946

  Fly  3653 QKISFHTLVFDMNVFNPETILVKNFSTGKYETLTAALERPLLDRHTGHMVDPKTGKKIPFFECVD 3717
            ||:|....| |:.:.|.|.          .|.|..| ||..    ||:. ||.||..||.|:.:.
Human  1947 QKLSVDEAV-DVGLVNEEL----------RERLLKA-ERAA----TGYR-DPATGDTIPLFQAMQ 1994

  Fly  3718 RQWIIRANPEEQKPSGIENVTIDTQTGQVVLDDGRVCSIVEAINSGKLDIQSISVRDPVSGEVIP 3782
            :|.|.:|.                                                         
Human  1995 KQLIEKAE--------------------------------------------------------- 2002

  Fly  3783 LRMAIELGVVDMQAGTVIDIQTLKEIPMELAFQLGFLVPGARKPISLEAAVRKGLYDPET-GKLF 3846
               |:.|..|.:..|.|||.|....:|:|.|::.|.|.......||.:..:||...||.| .|:.
Human  2003 ---ALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVS 2064

  Fly  3847 DSESQNQVDVQKSIEIG-LVDP-----KISLIVDTVTKKEVKLDCAIEDDLVLPATGQIKDNKNN 3905
            ..|.|.:...|:  :.| |:.|     :.|..:|..|::      |:|.:.|....|:.:..| .
Human  2065 YRELQERCRPQE--DTGWLLFPVNKAARDSEHIDDETRR------ALEAEQVEITVGRFRGQK-P 2120

  Fly  3906 TLVPFDVGVQQCLLKTDNVTWSLPELLQREYYTPSTGKVLNPVTGEEILLQQAIEMGFVELETT- 3969
            ||        ..||.::.||......|.|.|.| .|.:.|..|.  :::|:      .:|.:.| 
Human  2121 TL--------WALLNSEYVTEEKKLQLVRMYRT-HTRRALQTVA--QLILE------LIEKQETS 2168

  Fly  3970 --------LVKDVDHDKILPGKEAAKVGLLDTVRGTLSSPNISLDEAFVKGYLIST--------- 4017
                    :.:.:...::|......:..|.|...|..::..:..|:. ||.||..|         
Human  2169 NKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDR-VKRYLEGTSCIAGVLVP 2232

  Fly  4018 -------KKPLSLVDCLLRGLYDPSTAKFTIDDKQLDLKAAIAQKLINPEELVLLDPKTESIISI 4075
                   ::.:|:...:.:|:..|.||...     |:.:||..         .::||.....:|:
Human  2233 AKDQPGRQEKMSIYQAMWKGVLRPGTALVL-----LEAQAATG---------FVIDPVRNLRLSV 2283

  Fly  4076 TEAIAKGYLD------------PIEGYVINPYASTKLSLHEALENRIL----------------- 4111
            .||:|.|.:.            .:.||. :||...::||.:|::..::                 
Human  2284 EEAVAAGVVGGEIQEKLLSAERAVTGYT-DPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 2347

  Fly  4112 -IPPKRKRSLP-DAVYRGLY----------DPK--TGQFSNTVTREKLTTERAIRRGILDPDSTV 4162
             |.|.....:| |..||..|          ||.  |..|.:..|.|.||..:.:||.:.|||:.:
Human  2348 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGL 2412

  Fly  4163 VNVGSGQIIPFGVATETGIVDSKHGTVRDADDHPIDFKEAFDRGILVEAKKPLRLIEAVVKNVYD 4227
            ..:   |:...|.|... :.:.....:|||...|   .....:|..|...:.|...|.......|
Human  2413 YML---QLAGRGSAVHQ-LSEELRCALRDARVTP---GSGALQGQSVSVWELLFYREVSEDRRQD 2470

  Fly  4228 EVDGHFVDPKSGEKLNFAEALNTNLLDEHSVQIRDFKTGLYKQLNLTHAKDTGIIDAQNSKLLYN 4292
            .:..:.....:.|:|.   |..|:||.:...|.|              |:........:.:....
Human  2471 LLSRYRAGTLTVEELG---ATLTSLLAQAQAQAR--------------AEAEAGSPRPDPREALR 2518

  Fly  4293 NQTMTLKHAFDIGIL-------MDVNAPISIQRAIHQGLFDD-KTGKLSDPRTGRQITLL--ESM 4347
            ..||.:|    :|.|       .||.|...:.||..:.|..: .:|.|..|...|::|.:  |:.
Human  2519 AATMEVK----VGRLRGRAVPVWDVLASGYVSRAAREELLAEFGSGTLDLPALTRRLTAIIEEAE 2579

  Fly  4348 RSFVVNPHLPCYF-------------------------DEQTEQMYTLS---------ETCRNGI 4378
            .:....|.|...:                         :.:|::....:         :|.|:..
Human  2580 EAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAAAARRQEQTLRDAT 2644

  Fly  4379 INRREGVFR-EPGS------NSFVPLGEALSLGLIVDIENAGFGLYELLS--------------- 4421
            :..:.|.|: .|.|      :|:  |.||....|:........||.:|::               
Human  2645 MEVQRGQFQGRPVSVWDVLFSSY--LSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSK 2707

  Fly  4422 ---------MGFYETSTRKVLHPVTNRKLNLNEACVEDVVSLSSSLVKHHETGKYLRLANAIKEQ 4477
                     :...|..|..:|.|.|.|.|......:::|..:.|  ||     :||...:.|...
Human  2708 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDS--VK-----RYLEGTSCIAGV 2765

  Fly  4478 LV--DDSRGCYNLGNEQLDLQAARARGLIVSNRRLLSLELVLRQQLYRPETGKFCDPTTGEYLDL 4540
            ||  .|..|    ..|::.:..|..:|::.....|:.||.       :..||...||.....|.:
Human  2766 LVPAKDQPG----RQEKMSIYQAMWKGVLRPGTALVLLEA-------QAATGFVIDPVRNLRLSV 2819

  Fly  4541 IEAIHSGFI-----------DPATTVFKNQLTGKELPLTEAIENGDIDVSKGRVFDPKSKSAYNY 4594
            .||:.:|.:           :.|.|.:.:..||:::.|.:|::                      
Human  2820 EEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQ---------------------- 2862

  Fly  4595 DVALSRGILVTITRPLTDRNDVVRRQDSVELLNQTPVSVVISKPREMSLEEAIRYNIIDPKTALV 4659
                               .|::.|:..:.||.                .:.....:|||     
Human  2863 -------------------KDLIVREHGIRLLE----------------AQIATGGVIDP----- 2887

  Fly  4660 RDFDSFKFLPYSVAVERGLVD-TTKRTLVDP----KALYFAFDPTLIVYVREPVTFDQAAESKCL 4719
              ..|.: :|..||.:||..| ...|.|.||    |..   |||.    ..|.:|:.|.......
Human  2888 --VHSHR-VPVDVAYQRGYFDEEMNRVLADPSDDTKGF---FDPN----THENLTYVQLLRRCVP 2942

  Fly  4720 DLQTGLLTYVPASVPGSATAAPASDDSANDSLTVIE-TPKVYTLKEAASAGVVDPDSALVKDLAK 4783
            |..|||  |: ..:.|..:|.....:....:|.... ||         .:|.:...|..|.:|..
Human  2943 DPDTGL--YM-LQLAGRGSAVHQLSEELRCALRDARVTP---------GSGALQGQSVSVWELLF 2995

  Fly  4784 AKLVRLPEAFRKGLMDANKANVLN------TQTSKLCTLQ-----EAYESGLICTPKRSFGLLEA 4837
            .:  .:.|..|:.|:...:|..|.      |.||.|...|     || |:|   :|:.       
Human  2996 YR--EVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEA-EAG---SPRP------- 3047

  Fly  4838 ITFNLYNPTNGCLVDPFQMHPDIIRRRKFTLAEAIGSGLVDPSSTVVRDPSTGVIVPLTAAISSG 4902
                  :|.........::....:|.|...:.:.:.||.|   |...|:       .|.|...||
Human  3048 ------DPREALRAATMEVKVGRLRGRAVPVWDVLASGYV---SRAARE-------ELLAEFGSG 3096

  Fly  4903 LID--ATEGRLT----DANEPKNNIDLVKAAEKGLLLPA-----------EQRQAVFEKFNMCEE 4950
            .:|  |...|||    :|.|.......::.|.:|...|.           .||:...|       
Human  3097 TLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGE------- 3154

  Fly  4951 NVNDLLKWVTTVEQKISSVGGPREKIDELRNQINALKQIKDEIES---QQRPV-------ATCLE 5005
                               |..:|.....|.|...|:....|::.   |.|||       ::.|.
Human  3155 -------------------GETQEAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSSYLS 3200

  Fly  5006 QIRQ---IVLTGGDVLSAPE-VTTLENSGRELRSRVDRVNDRTVRLLRRLEAGRDELTKLRSELD 5066
            :.|:   :.......|..|: |..|.....|...|:.:|:.|.:|.  ::.|         |||.
Human  3201 EARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRC--QVSA---------SELH 3254

  Fly  5067 VFSDWLQVARRTLEDKERSLSDLTRLPSQADSVREFV-------------SDVIGHQADLRFITM 5118
            ..........|.|....::|.::|.:    |||:.::             .|..|.|..:. |..
Human  3255 TSGILGPETLRDLAQGTKTLQEVTEM----DSVKRYLEGTSCIAGVLVPAKDQPGRQEKMS-IYQ 3314

  Fly  5119 AAQKFVDESKEFLAIL-------------NDFRTSLPERLPH-------VEPLSSAESPIR---- 5159
            |..|.|......|.:|             .:.|.|:.|.:..       .|.|.|||..:.    
Human  3315 AMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTD 3379

  Fly  5160 ----QEVSLVSAQYKDLLNR---VNALQDRVSGLGG---------------RQREYQDALDKANE 5202
                |::||..|..|||:.|   :..|:.::: .||               .:|.|.|       
Human  3380 PYTGQQISLFQAMQKDLIVREHGIRLLEAQIA-TGGVIDPVHSHRVPVDVAYRRGYFD------- 3436

  Fly  5203 WLRSVHPRVSRIISEPIAGDPKGVQDQMNEAKALHNELLSSGRLVDNAQQALDNLLRSLGGQLSP 5267
                  ..::|::::| :.|.||..|........:.:||.  |.|.:....|  .:..|.|:.|.
Human  3437 ------EEMNRVLADP-SDDTKGFFDPNTHENLTYVQLLR--RCVPDPDTGL--YMLQLAGRGSA 3490

  Fly  5268 MEINQLELPIADLKNNYQQLLDNLGEHCKTLDKTLVQS----QGVQDALDSLVGWVNQAEDKFKM 5328
            :                .||.:.|  .|...|..:...    ||...::..|:.:...:||: :.
Human  3491 V----------------HQLSEEL--RCALRDARVTPGSGALQGQSVSVWELLFYREVSEDR-RQ 3536

  Fly  5329 NL----RPASLIKERLQEQIREHKVLLADLQSH---QASIDSVQVSAKHLLASASNARIAKKVES 5386
            :|    |..:|..|.|...:..   |||..|:.   :|...|.:...:..|.:|:          
Human  3537 DLLSRYRAGTLTVEELGATLTS---LLAQAQAQARAEAEAGSPRPDPREALRAAT---------- 3588

  Fly  5387 NLNDVTVKFEKLYEKANKRGEFLDDVYNRLSRYLDEISTVEQRMASLQEALDSRETSLLSTEELA 5451
                :.||..:|..:|....:.|...|  :||            |:.:|.|....:..|....|.
Human  3589 ----MEVKVGRLRGRAVPVWDVLASGY--VSR------------AAREELLAEFGSGTLDLPALT 3635

  Fly  5452 RRMNELSRDKDQ---LAPQFEDCVR--------------SGKDLISLRDVTDTGVLRDRIKALES 5499
            ||:..:..:.::   ..||.:|..|              ||:   |.|:....|..::...|..:
Human  3636 RRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGR---SQREGQGEGETQEAAAATAA 3697

  Fly  5500 QWRNINISIDERAKLSKQKAEQQ-----------LAY--EGLKDQVLSWLASTEARVNGLPPVAI 5551
            ..|......|  |.:..|:.:.|           .:|  |..:|::   ||...|...|||.:..
Human  3698 ARRQEQTLRD--ATMEVQRGQFQGRPVSVWDVLFSSYLSEARRDEL---LAQHAAGALGLPDLVA 3757

  Fly  5552 DLDRIKQQHDELKPICKDYRDYAPTIDKINDIGAQYDALIRPESPARKRSTYSPIKRTSPLRRMS 5616
            .|.|:.::.:|             .:.|::..|                           |||  
Human  3758 VLTRVIEETEE-------------RLSKVSFRG---------------------------LRR-- 3780

  Fly  5617 GDARSPSPTKGGILSPLSTGSSGFGSRRSSQDGFQLSELSPVQQQLSEINNRYGLIGVRLNDRQH 5681
                                                      |...||::.. |::|.       
Human  3781 ------------------------------------------QVSASELHTS-GILGP------- 3795

  Fly  5682 ELDNLNEELRKQYENLKGLAQFLERIQRQLPKESVSNKDEAERCIKQARKILEDMYEKQSLLDTT 5746
                         |.|:.|||..:.:|.....:||....|...||.......:|...:|..:...
Human  3796 -------------ETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIY 3847

  Fly  5747 KAQVKDILRRKSDVPGAEQLRQENDS----IQEKWKNLNDICKNRIAFSEKLRDFLDTHGNLKSW 5807
            :|..|.:||     ||...:..|..:    :.:..:||      |::..|.:...: ..|.::..
Human  3848 QAMWKGVLR-----PGTALVLLEAQAATGFVIDPVRNL------RLSVEEAVAAGV-VGGEIQEK 3900

  Fly  5808 LDSKERMLTVLGPISSDPRMVQSQVQQVQVLREEFRTQQPQLKHFQELGHDVV--DHLAGTPDAQ 5870
            |.|.||.:|..    :||...|                  |:..||.:..|::  :|.....:||
Human  3901 LLSAERAVTGY----TDPYTGQ------------------QISLFQAMQKDLIVREHGIRLLEAQ 3943

  Fly  5871 AVEIKLKDILGKWDDLVGKLDDRANSLGGAADSSKE---FDAAVNRLREALQNISDNLDTLPTDG 5932
            ..              .|.:.|..:|.....|.:..   ||..:||:   |.:.||:.... .|.
Human  3944 IA--------------TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV---LADPSDDTKGF-FDP 3990

  Fly  5933 DHQENLRKIENLERQLEGQRPLLADVEQSAATLCNILGDPASRADVNSRVAALEKQYLALQKKLD 5997
            :..|||..::.|.|                   |  :.||    |....:..|..:..|:.:..:
Human  3991 NTHENLTYVQLLRR-------------------C--VPDP----DTGLYMLQLAGRGSAVHQLSE 4030

  Fly  5998 TKKAETEASLRDGRHFAENCSKTLGWLGGELSNLTDRLLVSAHKPTLQHQIDTHEPIYREVMARE 6062
                |...:|||.|     .:...|.|.|:..::.:.|                  .||||.   
Human  4031 ----ELRCALRDAR-----VTPGSGALQGQSVSVWELL------------------FYREVS--- 4065

  Fly  6063 HEVIMLINKGKDLTDRQQDRGVKRDLDRIQQQWEKLRREAVDRHTRLQTCMEHCKKYSQTSETFL 6127
                         .||:||.     |.|                                   :.
Human  4066 -------------EDRRQDL-----LSR-----------------------------------YR 4077

  Fly  6128 AWLRTAEDKLADLTPGVLSKAKLETRLRDLQTFRSEVWKHSGEFENTKGLGETFLSSCDID-KEP 6191
            |...|.|:..|.|| .:|::|:.:.|                        .|....|...| :|.
Human  4078 AGTLTVEELGATLT-SLLAQAQAQAR------------------------AEAEAGSPRPDPREA 4117

  Fly  6192 IKAELQDI-----RDR----WERLNNDLIARAHEIENCSRRLDDFNDELRNLDHSLGRCEDRLAA 6247
            ::|...::     |.|    |:.|.:..::||..                         |:.|| 
Human  4118 LRAATMEVKVGRLRGRAVPVWDVLASGYVSRAAR-------------------------EELLA- 4156

  Fly  6248 HDALGGAAKD-PKLLERVKAIREELTNLSKPLQSLKALAKDISAEARAAGGDADHLTSEVDGLAD 6311
              ..|....| |.|..|:.||.||..........|:...:.......|..||.|...|:.:|   
Human  4157 --EFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREG--- 4216

  Fly  6312 RMSELQGRLDDRCGELQSAATAVSQFNEQMKSLGIDLNDLETEIEKLSPPGREIKIVQVQIDDVG 6376
                 ||.     ||.|.||.|.:....|.::    |.|...|:::....||.:.:..|..... 
Human  4217 -----QGE-----GETQEAAAATAAARRQEQT----LRDATMEVQRGQFQGRPVSVWDVLFSSY- 4266

  Fly  6377 KIQTKLDRLVGRLEDAERAADVLVDAGFAADTTQTREQISTLRKTLGRLDNRVRDHEDNLHSTLK 6441
                        |.:|.|  |.|: |..||......:.::.|.:.:...:.|:.      ..:.:
Human  4267 ------------LSEARR--DELL-AQHAAGALGLPDLVAVLTRVIEETEERLS------KVSFR 4310

  Fly  6442 ALREFYD----HQSQTL--DDIQDVSDEFKRMKPVGSELDQIRRQQEDFRNFRERKVEPLAINVD 6500
            .||....    |.|..|  :.::|::...|.::.| :|:|.::|..|.                 
Human  4311 GLRRQVSASELHTSGILGPETLRDLAQGTKTLQEV-TEMDSVKRYLEG----------------- 4357

  Fly  6501 KVNVAGRDLVRSAGSGVSTTAIEKD----LEKLNDRWNDLKERMNERDRRLDVALLQSGKFQEAL 6561
                      .|..:||...|  ||    .||::     :.:.|.:...|...||:    ..||.
Human  4358 ----------TSCIAGVLVPA--KDQPGHQEKMS-----IYQAMWKGVLRPGTALV----LLEAQ 4401

  Fly  6562 AGLSKWLS-------DTEEMVANQKPPSSDYKVVKAQLQEQKFLKKMLLDRQNSMGSLANLGKEV 6619
            |.....:.       ..||.||        ..||..::||:                |.:..:.|
Human  4402 AATGFVIDPVRNLRLSVEEAVA--------AGVVGGEIQEK----------------LLSAERAV 4442

  Fly  6620 ANHCEP--GERASI-EKQLNDLMKRFDALTDGAEQRELDLEEAM-EVAKRFHDKISPLEL----- 6675
            ..:.:|  |::.|: :....||:.|...:      |.|:.:.|. .|....|....|:::     
Human  4443 TGYTDPYTGQQISLFQAMQKDLIVREHGI------RLLEAQIATGGVIDPVHSHRVPVDVAYRRG 4501

  Fly  6676 WLDNTERSVKAMELIPTDEEKIQQRIREHDRL-HDEILGK-KPDFSDLADVTAQLMHLVSDEEAV 6738
            :.|.....|.|.   |:|:.|.......|:.| :.::|.: .||    .|....::.|.....||
Human  4502 YFDEEMNRVLAH---PSDDTKGFFDPNTHENLTYVQLLRRCVPD----PDTGLYMLQLAGRGSAV 4559

  Fly  6739 N-LGEKVRGVTERYTGLVDA--SDNIGALLAESRQGLRHLVLSYQDLVAWMESMEAE----LKRF 6796
            : |.|::|      ..|.||  ....|||..:|        :|..:|:.:.|..|..    |.|:
Human  4560 HQLSEELR------CALRDARVMPGSGALQGQS--------VSVWELLFYREVSEDRRQDLLSRY 4610

  Fly  6797 KSVPVYAEKLLEQMDHLLELNENIAGHASNVESTVESGAELMKHISNDEAIQLKDKLDSLQRRYG 6861
            ::..:..|:|                           ||.|.                       
Human  4611 RAGTLTVEEL---------------------------GATLT----------------------- 4625

  Fly  6862 DLTNRGGDLLKSAQNALPLVQQFHEAHNRLVEWMQSAEAALAPSEPRQA--------DVLRLEGE 6918
                   .||..||     .|...||         .|||.....:||:|        .|.||.|.
Human  4626 -------SLLAQAQ-----AQARAEA---------EAEAGSPRPDPREALRAATMEVKVGRLRGR 4669

  Fly  6919 LADMRPILDSINQVGPQLCQLSPGEGAATIESIVTRDNRRFDSIVEQIQR-KAERLHLS------ 6976
            ...:..:|.|....|....:|....|:.|::  :....||..:|:|:.:. ...|..|.      
Human  4670 AVPVWDVLASGYVSGAAREELLAEFGSGTLD--LPALTRRLTAIIEEAEEAPGARPQLQDAWRGP 4732

  Fly  6977 ---------------NQRAKEVTGDIDELLEWFREMDTTLREADLPAMEPKLVRAQLQEHRSIND 7026
                           :||..:..|:..|.....|..:.|||:|.:     ::.|.|.|       
Human  4733 REPGPAGRGDGDSGRSQREGQGEGETQEAAAAARRQEQTLRDATM-----EVQRGQFQ------- 4785

  Fly  7027 DISSQKGR---VRDVTAASKKVLRESPQSENTATLREKLDDLKEIVDTVAQLCSERLGILEQALP 7088
                  ||   |.||..:|  .|.|:.:.|                 .:||..:..||     ||
Human  4786 ------GRPVSVWDVLFSS--YLSEAHRDE-----------------LLAQHAAGALG-----LP 4820

  Fly  7089 LSEHFADSHQGLTAWLDDMEQQISRLSMPALR---------------PDQITLQQ-DKNERLLQS 7137
                  |....||..:::.|:::|::|...||               |:  ||:. .:..:.||.
Human  4821 ------DLVAVLTRVIEETEERLSKVSFRGLRRQVSASELHTSGILGPE--TLRDLAQGTKTLQE 4877

  Fly  7138 IAEHKPLLDKLNKTGEALGALVADDDGAKINEILDTDNARY-AALR----LELRERQQA------ 7191
            :.|...:...|..|....|.||...|.....|.:....|.: ..||    |.|.|.|.|      
Human  4878 VTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVID 4942

  Fly  7192 ----LESALQES-------SQFSDKLEGMLRALANTVDQVNQLDPLSALPQKIREQIEDNDALMD 7245
                |..:::|:       .:..:||....||:      ....||.:.      :||....|:..
Human  4943 PVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAV------TGYTDPYTG------QQISLFQAMQK 4995

  Fly  7246 DLDKRQDAFSAV--QRAANDVIAKAGNKADPAVRDIKAKL----EKLNNLWNDVQNATK 7298
            ||..|:.....:  |.|...||....:...|.  |:..:.    |::|.:..|..:.||
Human  4996 DLIVREHGIRLLEAQIATGGVIDPVHSHRVPV--DVAYRRGYFDEEMNRVLADPSDDTK 5052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401
CH 223..327 CDD:306753
SPEC 471..689 CDD:238103
SPEC 690..866 CDD:238103
SH3 885..922 CDD:327375
SPEC 1047..1250 CDD:238103
SPEC 1153..1390 CDD:238103
PLEC <1498..1526 CDD:197605
Plectin 1949..1981 CDD:307019 7/36 (19%)
DNA_pol3_delta2 <2711..3178 CDD:331068 87/549 (16%)
DUF4775 3026..3357 CDD:330579 48/349 (14%)
SMC_N <4904..5566 CDD:330553 155/792 (20%)
SPEC 5304..5513 CDD:238103 45/236 (19%)
SPEC <5658..5787 CDD:321951 27/132 (20%)
SPEC 5793..6007 CDD:238103 40/218 (18%)
SPEC 6011..6220 CDD:238103 35/218 (16%)
SPEC 6118..6330 CDD:238103 44/222 (20%)
PRK09039 <6279..6441 CDD:332967 32/161 (20%)
SPEC 6443..6660 CDD:238103 45/236 (19%)
SPEC 6663..6878 CDD:238103 42/228 (18%)
SPEC 6880..7087 CDD:238103 50/239 (21%)
SPEC 6986..7196 CDD:238103 54/243 (22%)
SPEC 7196..7417 CDD:238103 24/116 (21%)
SPEC 7314..7526 CDD:238103
SPEC 7528..7747 CDD:238103
SPEC 7749..7968 CDD:238103
SPEC 7973..8181 CDD:238103
EF-hand_7 8373..8437 CDD:316058
GAS2 8450..8522 CDD:128539
Herpes_ICP4_C 8550..>8795 CDD:332854
EPPK1NP_112598.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 3/10 (30%)
Plectin 1 34..71 13/44 (30%)
Interaction with KRT5. /evidence=ECO:0000250|UniProtKB:Q8R0W0 42..1115 248/1317 (19%)
Plectin 74..113 CDD:307019 8/38 (21%)
Plectin 151..189 CDD:307019 6/37 (16%)
Plectin 317..357 CDD:307019 8/39 (21%)
Plectin 393..433 CDD:307019 8/39 (21%)
Plectin 604..644 CDD:307019 16/155 (10%)
Plectin 643..682 CDD:307019 11/54 (20%)
PLEC 679..716 CDD:197605 10/44 (23%)
Plectin 718..758 CDD:307019 11/39 (28%)
Plectin 969..1001 CDD:307019 6/37 (16%)
PLEC 1000..1036 CDD:197605 10/36 (28%)
Plectin 1038..1078 CDD:307019 8/39 (21%)
Plectin 21 1239..1276 6/36 (17%)
Plectin 22 1277..1314 7/52 (13%)
Plectin 1278..1317 CDD:307019 8/54 (15%)
Plectin 23 1315..1352 7/36 (19%)
Plectin 24 1353..1390 0/36 (0%)
Plectin 1354..1393 CDD:307019 1/38 (3%)
Plectin 25 1391..1428 5/39 (13%)
Plectin 26 1564..1601 7/36 (19%)
Plectin 1565..1605 CDD:307019 7/39 (18%)
Interaction with KRT5. /evidence=ECO:0000250|UniProtKB:Q8R0W0 1572..5085 875/4617 (19%)
Plectin 1603..1643 CDD:307019 7/58 (12%)
PLEC 1641..1677 CDD:197605 5/68 (7%)
Plectin 1679..1718 CDD:307019 8/58 (14%)
Plectin 1891..1931 CDD:307019 8/42 (19%)
Plectin 1930..1969 CDD:307019 13/64 (20%)
Plectin 2005..2045 CDD:307019 12/39 (31%)
Plectin 2218..2263 CDD:307019 8/49 (16%)
Plectin 2261..2301 CDD:307019 10/53 (19%)
PLEC 2299..2335 CDD:197605 7/36 (19%)
Plectin 2337..2376 CDD:307019 7/38 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2578..2637 3/58 (5%)
Plectin 2754..2799 CDD:307019 11/48 (23%)
Interaction with KRT14. /evidence=ECO:0000250|UniProtKB:Q8R0W0 2761..2953 55/277 (20%)
Plectin 2797..2837 CDD:307019 10/46 (22%)
PLEC 2835..2871 CDD:197605 8/76 (11%)
Plectin 2873..2912 CDD:307019 13/62 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3114..3168 11/79 (14%)
Plectin 3285..3330 CDD:307019 8/45 (18%)
Plectin 3328..3368 CDD:307019 5/39 (13%)
PLEC 3366..3402 CDD:197605 12/35 (34%)
Plectin 3404..3443 CDD:307019 7/52 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3645..3702 11/59 (19%)
Plectin 3819..3864 CDD:307019 11/49 (22%)
Plectin 3862..3902 CDD:307019 6/46 (13%)
PLEC 3900..3936 CDD:197605 12/57 (21%)
Plectin 3938..3977 CDD:307019 10/55 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4179..4236 15/69 (22%)
Plectin 4353..4398 CDD:307019 14/82 (17%)
Plectin 4396..4436 CDD:307019 11/67 (16%)
PLEC 4434..4470 CDD:197605 8/51 (16%)
Plectin 4472..4511 CDD:307019 7/38 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4715..4769 7/53 (13%)
Plectin 4886..4931 CDD:307019 11/44 (25%)
Plectin 4929..4969 CDD:307019 7/39 (18%)
PLEC 4967..5003 CDD:197605 12/47 (26%)
Plectin 5005..5044 CDD:307019 8/40 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101076
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.800

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