DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and ZAN

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_003377.2	Gene:	ZAN / 7455	HGNCID:	12857	Length:	2812	Species:	Homo sapiens

Alignment Length:	1026	Identity:	233/1026 - (22%)
Similarity:	346/1026 - (33%)	Gaps:	316/1026 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  2839 ERTQTVVVSSDTRKQEMQVV-STTQSTKDTSVPSVSEIETKGSKEPSKTLQNVKDAAKLGALGVI 2902
            :.|...|.|.  .:|.||:: ...|.:...||.::..|.......|.|.|..:...:.:.:.|..
Human   492 QNTSVTVPSG--HQQPMQLIFKGIQGSNTASVVAMGFILINPGTCPVKVLPELPPVSPVSSTGPS 554

  Fly  2903 AAPVLAGGAIVSGVKSLIKSVKSPTEDAKSTEKPKEPQTSFIEQERRKELQPQQVPSEVDNLLSE 2967
            ....|.....:|..|..: |::.|:...:....|||..|...|:......:| .:|||..|:.||
Human   555 ETTGLTENPTISTKKPTV-SIEKPSVTTEKPTVPKEKPTIPTEKPTISTEKP-TIPSEKPNMPSE 617

  Fly  2968 TENFISSTTANFIANEKQQDKPDTLPQESNLPLE---VESTSTLTTTTVTTITTSSTTTETGNLE 3029
            .....|             :||..|.::..:|.|   :.|.....:|...|:.|...||.|
Human   618 KPTIPS-------------EKPTILTEKPTIPSEKPTIPSEKPTISTEKPTVPTEEPTTPT---- 665

  Fly  3030 PVVVEDVSTTVKEDKVVVKPSTVPEDKTEVSKITETIT---TVTSNETDTV-PEKISQKSASEES 3090
                |:.:|:::|..:..:..::|.:|..:.....||:   |:.|.|..|: |||
Human   666 ----EETTTSMEEPVIPTEKPSIPTEKPSIPTEKPTISMEETIISTEKPTISPEK---------- 716

  Fly  3091 AKKDPVVTKDTSSRPAETET-SPKPVQKEPTPDPAQNTEFPESIKKDPTPEPDYKETATEAAQIT 3154
                |.:..:..:.|.|..| ||   :|..||     ||.|....:.||..|:...|.||...|:
Human   717 ----PTIPTEKPTIPTEKSTISP---EKPTTP-----TEKPTIPTEKPTISPEKPTTPTEKPTIS 769

  Fly  3155 PKEASPAPTNKNEQSAEPTSKPEPMPRTAKKEEISEIEPPFTAPLAPFVDQLAETKITEIKTEFK 3219
            |::.: .||   |:...||.|| .:|  .:|..||..||  |.|          |:.|.|.||..
Human   770 PEKLT-IPT---EKPTIPTEKP-TIP--TEKPTISTEEP--TTP----------TEETTISTEKP 815

  Fly  3220 EPVTSSQTITTITTTVKTVDEHPIVEEVDEVSKSEKIVDVEEPTVHQQEPIKVNETSDDSTRTEP 3284
            .......|:.|..||. :|:|..|..|...:...:..:..|:||:..::|     |......|.|
Human   816 SIPMEKPTLPTEETTT-SVEETTISTEKLTIPMEKPTISTEKPTIPTEKP-----TISPEKLTIP 874

  Fly  3285 TNEIVHEERVVTVEEPTITETTVTTTTITTTTTSSSEETLPQENTATVKETP-LNEPVPSSPAET 3348
            |     |:..:..|:|||        .|..||.|:.:.|:|.|......|.| ::...|:.|.|.
Human   875 T-----EKLTIPTEKPTI--------PIEETTISTEKLTIPTEKPTISPEKPTISTEKPTIPTEK 926

  Fly  3349 KEI--EQTTNDDQKKPEEIVDTEKKTTEQKPVETIPTE-PISTSETTTVTLTTKTTIVDEGKLHP 3410
            ..|  |:||...:|.   .:.|||.|...:.: ||||| |..::|..|:. |.|.||..|    .
Human   927 PTIPTEETTISTEKL---TIPTEKPTISPEKL-TIPTEKPTISTEKPTIP-TEKLTIPTE----K 982

  Fly  3411 PSDIEQIIQPHSTSDKHQSLVDFIEQEKGTQPAEGGSNILQNVKDAAKLGALAIVGAPVLAGKAL 3475
            |:                     |..||.|.|.|             ||.|
Human   983 PT---------------------IPTEKPTIPTE-------------KLTA-------------- 999

  Fly  3476 VDALTTEKTLKPEHSTSQVVTETVEELPTEIITTSTATLV----------TKVTTTTTTTTTSTS 3530
                     |:|.|.:           ||   .|..|.||          |.|...||||:.|::
Human  1000 ---------LRPPHPS-----------PT---ATGLAALVMSPHAPSTPMTSVILGTTTTSRSST 1041

  Fly  3531 EGTPDDEALDVVKLPAELVESSVKREVPRTLAIGDAISQK-------LISPDECQVIVDGEQQSQ 3588
            |..|.:...:....||     |.|...|   :.|....:.       |.|.:.|
Human  1042 ERCPPNARYESCACPA-----SCKSPRP---SCGPLCREGCVCNPGFLFSDNHC----------- 1087

  Fly  3589 TVSTLLKEEQLSPLDEVQIIDDKLIVLQQVSYLVDADTELTPQNLYELNIYDPENQYFIDPST-- 3651
                                      :|..|.          ...|..:.|:|..::|....|
Human  1088 --------------------------IQASSC----------NCFYNNDYYEPGAEWFSPNCTEH 1116

  Fly  3652 -----GQKISFHTLVFDMNVFNPETILVKNFSTGKYETLTAALERPLL-----------DRHTGH 3700
                 |.::       :..:....|..|.....|:|.....|.....|           .||.|.
Human  1117 CRCWPGSRV-------ECQISQCGTHTVCQLKNGQYGCHPYAGTATCLVYGDPHYVTFDGRHFGF 1174

  Fly  3701 M-------VDPKTGKKIPFFECVDRQWIIRANPEEQKPSGIE-----NVTIDTQTGQVVLDDGRV 3753
            |       ..|......|||.       :.|..|||...|:.     .||:...|  |.|..||
Human  1175 MGKCTYILAQPCGNSTDPFFR-------VTAKNEEQGQEGVSCLSKVYVTLPEST--VTLLKGR- 1229

  Fly  3754 CSIVEAINSGKLDIQSISVRDPVSGEVIPLRMAIELGVVDMQAGTVIDIQT 3804
                               |..|.|:.:.|......||....:|..:::||
Human  1230 -------------------RTLVGGQQVTLPAIPSKGVFLGASGRFVELQT 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068	85/347 (24%)
		DUF4775	3026..3357	CDD:330579	91/338 (27%)
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
ZAN	NP_003377.2	MAM	41..203	CDD:306977
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..84
		MAM	211..367	CDD:306977
		MAM	373..535	CDD:306977	10/44 (23%)
		Atrophin-1	<540..1022	CDD:331285	159/644 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..884		102/413 (25%)
		66 X heptapeptide repeats (approximate) (mucin-like domain)	573..1041		162/629 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	904..929		6/24 (25%)
		TIL	1044..1093	CDD:307783	11/93 (12%)
		TILa	1095..1148	CDD:315397	10/59 (17%)
		VWD	1156..1308	CDD:306577	30/135 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1302..1323
		C8	1349..1423	CDD:214843
		TIL	1426..1479	CDD:307783
		TILa	1481..1535	CDD:315397
		VWD	1542..1695	CDD:306577
		C8	1742..1808	CDD:312319
		TILa	1869..1924	CDD:315397
		VWD	1931..2084	CDD:306577
		C8	2149..2207	CDD:312319
		TIL	2211..2267	CDD:307783
		TILa	2269..2320	CDD:315397
		VWD	2331..2484	CDD:306577
		C8	2543..>2597	CDD:214843
		TILa	2654..2707	CDD:315397
		EGF	2712..2740	CDD:306513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810