DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and LOC680875

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	XP_002729884.2	Gene:	LOC680875 / 680875	RGDID:	1587008	Length:	772	Species:	Rattus norvegicus

Alignment Length:	910	Identity:	179/910 - (19%)
Similarity:	303/910 - (33%)	Gaps:	297/910 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  7733 VSRASDKKIKLEIALKEATE-------------FHDTLQAFVEWLTQAEKLLSNAEPVSRVLETI 7784
            |:..::..:..|..:.||.|             |...|.....||...|:|.::..|::......
  Rat    60 VTEVTETVVVTETVVTEAVEMGPCKHRGQPVQVFLAPLDTLCSWLDGMEELQASQGPLAADATLA 124

  Fly  7785 QAQMEEHKVLQKDVSTHREAMLLLDKKGTHLKYFSQKQDVILIKNLLVSVQHRWERVVSKAAERT 7849
            .:|:.|.::|          :.||.::..|::  .:.::......|..    :|.|:|.:|..|.
  Rat   125 ASQLREQELL----------LRLLRERAPHME--PRLREAGSPSELCT----QWHRLVQQAETRW 173

  Fly  7850 RALDHGYKEAREFNDAWSGMMQYLQETEQVLDQIIEEATASKEPQKIKKYIGKLKETHRQLGAKQ 7914
            :.|:.....|:.|..|...::..|..|||:|      |.....|:.:::....|:|....:.|:.
  Rat   174 KLLEQLVPAAQSFETACKALLLQLSPTEQLL------AELRLRPKCLEESWPYLQEVCEGVVARA 232

  Fly  7915 SVYDGTMRTGKNLLERAPKGDRPVLDKMLIELKEQWTRVWSKSIDRQRKLEEALLLSGQFSDALG 7979
            ...:..::||:.|.|            :|...:.|..|...|....:.||.|:.:...|
  Rat   233 RDLERVLQTGQRLAE------------LLTSDQAQLVRQQLKQFQERVKLTESQIACAQ------ 279

  Fly  7980 ELLDWLKKAKSRLNENGPVHGDLET---VQGLCEHHKHIEQDLQKRAAQMQGVLKTGRDLERSGN 8041
            :.|.:.::.:|  ::..|..| ||.   ::|....|..: :||::.:.|:
  Rat   280 QKLLFTQRTES--SKPSPPAG-LEAQHELEGSASIHPGL-KDLKQLSVQL--------------- 325

  Fly  8042 NPEVGRQLDEMQSIWEEVKSAVAKRGERLQVALVDAEKLNARVQAL-FDWLDHAEHKLRYAKNAP 8105
             .::..:|:::.. |.|..|..|.....:....:.:..|.|.|:|| ..||
  Rat   326 -VQLAERLEKLAQ-WAETSSQAAAPTVTIWEQSLSSATLRADVKALEGHWL-------------- 374

  Fly  8106 DDEKVSREMMDIHMDFMKDLRVR------EREKTETFEYAEDIINKAYPDAIPIIKNWLSIIQQ- 8163
                   |..|..:..:.:..|:      |...||          |..|::     :|.|..|:
  Rat   375 -------ETQDAGLKAIWEPAVQTLCGLAEEAATE----------KLRPES-----DWNSGFQEF 417

  Fly  8164 RWEE---VRQWAINRESKLEQ----HLQSLKDLD--------DTIEELLAWLSGLEGTLLNLKH- 8212
            .|.:   ...| :.|......    ||....||.        .:.|.:..    |||.||.:.|
  Rat   418 LWGQQTLAVSW-LGRRGDTAYGSACHLGLRMDLQGCRAAMSRPSCERIYT----LEGMLLLVAHL 477

  Fly  8213 --------EQLPDEIPPVEKLIEDHKEFMENTARRQNEVDRACKPRQLPPGARKPSRSGKTP--- 8266
                    ::|....|...|:::.....:|..                 |||:.|....:.|
  Rat   478 VEKFVLCPQRLSQAEPLGTKVVQAQSWVLEEL-----------------PGAQTPKYWTQAPREI 525

  Fly  8267 VFKGSRDQGLNARKGSRITPTRDTPDRDRLPHYGPRFSPSTSG--PELEFRSPRAKLLWTKWRDV 8329
            :...|.|||               |..|    .|.|......|  ||        :|.|..|...
  Rat   526 LALRSLDQG---------------PPGD----LGSRAKACLLGKIPE--------ELSWRPWWAE 563

  Fly  8330 WMLSWERQRLLNDHLLYLKDVERARNFSWDDWRKRFLKYMNHKKSRLTDLFRKMDKDNN------ 8388
            .|.:|..::  .:|       .:......|:|.:   ....|::..|.:.|....:..|
  Rat   564 VMENWNHRK--PEH-------SKRNQEERDEWEQ---LEQGHQEQDLMESFLAAGEQGNIGQGWP 616

  Fly  8389 ----GMI-PRDVFIDGILNTKFD--TSGLEMKAVADLFDRNGEGLIDWQEFIAALRPDWQERKPA 8446
                |.. |...|     :|.|:  .|..:.:..:.:..||.||.   ...:|..||
  Rat   617 GCNWGRCGPHHKF-----STTFEPGLSSAQKQPSSVVRARNTEGT---STPVARGRP-------- 665

  Fly  8447 NDSDKIHDEVKRLVMLCTCRQKFRVFQVGEGKYRFGDSQKLRLVRILRSTVMVRVGGGWVALDEF 8511
                                                   |::...|.|..:||||||||.|||||
  Rat   666 ---------------------------------------KVQGALIARGAMMVRVGGGWAALDEF 691

  Fly  8512 LQKNDPCRAKGRTNIELREQFILADGVSQSMAAFTPRRSTP--------NAAATASSSPHAHNGG 8568
            |.||||.||||||:.::.|:|:          .:||....|        .:....||.|.:...|
  Rat   692 LVKNDPVRAKGRTSQKIHERFL----------CWTPSVPAPEVITLRLWTSIRMGSSRPQSPKTG 746

Fly 8569 8568
Rat 747 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068
		DUF4775	3026..3357	CDD:330579
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103	2/13 (15%)
		SPEC	7749..7968	CDD:238103	47/231 (20%)
		SPEC	7973..8181	CDD:238103	38/221 (17%)
		EF-hand_7	8373..8437	CDD:316058	14/76 (18%)
		GAS2	8450..8522	CDD:128539	23/71 (32%)
		Herpes_ICP4_C	8550..>8795	CDD:332854	5/27 (19%)
LOC680875	XP_002729884.2	SPEC	<157..282	CDD:295325	32/152 (21%)
LOC680875	XP_002729884.2	GAS2	<672..700	CDD:295345	20/27 (74%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900