DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and DST

DIOPT Version :9

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:XP_016866694.1 Gene:DST / 667 HGNCID:1090 Length:7827 Species:Homo sapiens


Alignment Length:9310 Identity:2222/9310 - (23%)
Similarity:3856/9310 - (41%) Gaps:2215/9310 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 EVVHSSRGPAITTNIDDSNLRYRHETKRERTVEAVITDYPGVS---PLGSVPHERTNFERTVTFQ 93
            ||.|.|.        .::::|.|...|..|..........|.|   |.......|.:...:..|.
Human   110 EVHHQSE--------QETSVRKRRIKKSSRVQPEFYHSVQGASIRRPSSGNASYRCSMSSSADFS 166

  Fly    94 DPTGNSRRLSETGALVPAGAIPTSSTHYQQVTRNKRISTEVLGSSV-----------------ES 141
            |....|:: |.:.:..|...:|.:...::   |:||   ::.|.||                 ..
Human   167 DEDDFSQK-SGSASPAPGDTLPWNLPKHE---RSKR---KIQGGSVLDPAERAVLRIADERDKVQ 224

  Fly   142 TKTSQRAPNGH-RRVTTHI------VRK----VTTLSRAEENAQPAE-DLLPPAKMIRSSE---- 190
            .||..:..|.| .:|..|:      :|.    ::.|.....:..|.| |.|...:::.::|    
Human   225 KKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRERDFLKTLRLVSATEACEY 289

  Fly   191 ------------------LEYRRALPPAIESSSTQRR---------------------------- 209
                              :.:.|.....|.....:||                            
Human   290 EQHEDVEDEDKGPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTII 354

  Fly   210 ---EISDI-VVGKEDNVSAREALLRWARRSTARYPGVRVNDFTSSWRDGLAFSALVHRNRPDLLD 270
               :|||| |.|:.:::||:|.||.|.:::|..|.|:|..:||:.||||..|:|::|:.||||:|
Human   355 LHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLID 419

  Fly   271 WRKARNDRPRERLETAFHIVEKEYGVTRLLDPEDVDTNEPDEKSLITYISSLYDVFPE-PPSIHP 334
            ............||.||::.|| .||.|||||||||.:.|||||:|||:|||||.||: |.....
Human   420 MNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEG 483

  Fly   335 LFDMESQRRVHEYRDLAQQFIYWCREKTAYLQERSFPPTLIEMKRLLSDLQRFRSDEVSARKREK 399
            :...:.:.:..||:::....|.|.|.....:.||:||...:|:|.|.:...:|:..|:..::.||
Human   484 IGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEK 548

  Fly   400 SKLIQIYKELERYFETVGEVDVEAELRPDAIEKAWYRMNTALQDREVILQQEIERLERLQRLADK 464
            ||:.::||.||.:.| .|.:.:.....|:.|||.|.::..|:.:||..|:.|:||||.||::|::
Human   549 SKIKRLYKLLEIWIE-FGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANR 612

  Fly   465 VQREIKHVDQKLTDLEGRIGEEGRRIE----------------------RLHPVDAKSIVEA--- 504
            |||:....:.||......:..:.:|:|                      |.|.:|.:.:::.   
Human   613 VQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYY 677

  Fly   505 ----LETEIRHLEEPIQDMNQDC-HVLNEGRYPHVSELHKKVN----KLHQRWAQ-LRTNFHTNL 559
                |...:..|.:.|..:..:| .|.::||.....:....::    .|:..:|| |..:..:.|
Human   678 QADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGL 742

  Fly   560 VQKL------------------------------------------SGLKYPVHETTVTRQTRM- 581
            .|.|                                          ||::....:|....|.|. 
Human   743 TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKP 807

  Fly   582 VVESRQIDTN-----PHFRDLQEHIEWCQNKLKQLLAADYGSDLPSVKEELDRQQHEHKIIDQFH 641
            :::|..:|.|     .:.:.:|:.:.|......||...::|||||||:..|:..::.|:.|::|.
Human   808 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFE 872

  Fly   642 TKILNDERQQTKFSGDELALYQQRLNQLQKVYAELLSTSTKRLSDLDSLQHFLGQASAELQWLNE 706
            :.:...:..:.:.:......|.::|::|:..||:||:||..:...||:|.:|:.:|:.||.||||
Human   873 SSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNE 937

  Fly   707 KEQVEITRDWADKQLDLPSVHRYYENLMSELEKREMHFATILDRGEALLNQQHPASKCIEAHLTA 771
            ||:.|:..||:::..::.....|:..||.||:::|.:..::.:..|.||.:.|||...|||:..|
Human   938 KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 1002

  Fly   772 LQQQWAWLLQLTLCLEVHLKHATEYHQFFGEIKDAEQWLAKRDEILNSKFS-QSDFGLDQGETLL 835
            :|.||:|:|||..|:|.|:|..|.|.:||.:.|:|..:|....:.:..|:| .....:.:.|.|:
Human  1003 MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLV 1067

  Fly   836 RGMQDLREELNAFGETVATLQRRAQTVVPLNKRRQ--PVNRQGPVQAICAYKQQGQLQIEKGETV 898
            :...:.:|||..:..|:|.|..:|:|::.|..|..  |:....|::|||.|:|. ::.|.|.:..
Human  1068 QESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI-EITIYKDDEC 1131

  Fly   899 TLLDNSGRVKWRVRTAKGQEGPIPGACLLLPPPDQEAIDAAERLKRLFDRSVALWQKKHL----- 958
            .|.:||.|.||:|.:..|.|..:|..|..:|||::||:|.|.|:::.:...:.||.:.|:     
Human  1132 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSV 1196

  Fly   959 -----------RLRQNMIFATIRVVKGWDFDQFLAMGPEQRTAIRRALNDDADKLLSEGDPNDPQ 1012
                       |:|.:.: |:|:.:...:..|.|:   ..::.....|.|..:..:..|.    .
Human  1197 VSWHYLINEIDRIRASNV-ASIKTMLPGEHQQVLS---NLQSRFEDFLEDSQESQVFSGS----D 1253

  Fly  1013 LRRLRREMDEVNRLFDEFEKRARAEEESKQASRIFTEECLAIKSKLEDMARELDQIILAPLPRDL 1077
            :.:|.:|::...:.:.|..|.|..||:.:....::..|...|:.:||:....|.:.|..||.|| 
Human  1254 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERD- 1317

  Fly  1078 DSLEHVLEIHSDYERRLHLLEPELKHLQETFRTIALK-------------TPVLKKSLDNLMELW 1129
            |..|.|..| ::.|:    |:.||:.|::...||..|             .|.|:..|:.:::..
Human  1318 DLHESVFRI-TEQEK----LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 1377

  Fly  1130 KELNTQSGLHKDRLKLLEASLAGLEDNEHVISELENELARHQ-------DLPSTAEGLQQVFKQL 1187
            .::.:.|..:.|:||.:...|...:..|.::...|.:|...:       ::.:....|:|...::
Human  1378 NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV 1442

  Fly  1188 NHMQDIITQQQPQMDKMNDAADQLGRMGVPTKVLGDLKRLHSNVERLNTRWSAVCNQLGERMRSC 1252
            :..:.:....:.::.|....:|::.:......:  |........::|..||..|..|:..|:|..
Human  1443 DEKRQVFHALEDELQKAKAISDEMFKTYKERDL--DFDWHKEKADQLVERWQNVHVQIDNRLRDL 1505

  Fly  1253 ETAIGLMKNLQSSVQVEESWVD--GTTER--LSAMP--TATSAYELD--KLLGAAIERK-PKIEN 1308
            |.....:|..:.:....:.|:.  .||:|  ....|  :.|.|.:|:  |:|.:.||.| .|::.
Human  1506 EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1570

  Fly  1309 VNVAGGRLIREAKIYDSKCLRFVDWLVEARPSFSPPRRDLRPADSDPGATQYYSQRLDNLNTKND 1373
            ......:.....|.|:.:.:.: ..:|:::.. ||.:|....:.:|     ...|...:|.|:..
Human  1571 CQKYAEQYSATVKDYELQTMTY-RAMVDSQQK-SPVKRRRMQSSAD-----LIIQEFMDLRTRYT 1628

  Fly  1374 RLLEQLSQRLKTAIEVNGSDGLQYAESLQKPLKTFRVDFSAGSVPTGDGYAARQEDLYTTTYSTT 1438
            .|:..::|.:|.|     .|.|:..|..:|.|:..:.:           :..:.::|...   .:
Human  1629 ALVTLMTQYIKFA-----GDSLKRLEEEEKSLEEEKKE-----------HVEKAKELQKW---VS 1674

  Fly  1439 QISST-KTTKSSTKSVYSSDGLDAASQEVSTAGLPQSQIQFNEIRTLKRSQQLGGHSVLDIAGIR 1502
            .||.| |..:.:.|..:|...:  :|:|:||                |:.|              
Human  1675 NISKTLKDAEKAGKPPFSKQKI--SSEEIST----------------KKEQ-------------- 1707

  Fly  1503 DPRTGRVLTIGEAIQ-LRILDVRTGEMLVGDRRITLEQAA-----DQGLIDLQLAKQLLEPGAGR 1561
                     :.||:| :::...:.|:.:..:.|..||:..     ...|:..:..|||.|.....
Human  1708 ---------LSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1763

  Fly  1562 DASGRELSLLEVIQREISEAESGYETAEKRIKVNNTVTVEQTSGELGSPENPRNIADAITAGSVD 1626
            |..         ::.::.:..:|              |::||:||:.|      :..|:..|.:|
Human  1764 DVK---------VEEKLDKVIAG--------------TIDQTTGEVLS------VFQAVLRGLID 1799

  Fly  1627 TKTGLYRVKSGQTIS------LAEAYERGYLIRHESVTIKSNALCLSDAIAHGLVDGAGWIADRN 1685
            ..||:..:::...||      |.:.::                  |.||.:|||:          
Human  1800 YDTGIRLLETQLMISGLISPELRKCFD------------------LKDAKSHGLI---------- 1836

  Fly  1686 SGDKFRLDSAIANQLIDAS-VREVVDAKRDTKITLQEALQSGVLN-----------AKTGRYVNE 1738
                   |..|..||.:.| .:|::.|...|.|.:.:||...::.           ..||..|..
Human  1837 -------DEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIP 1894

  Fly  1739 VTKEKLTFAEARNRQLIVKPYTLKDICDLNLLDKQ---AQITSPMRREKLSIMQAIEAGVLDGNL 1800
            .|.|:||..:|..:.|:......|      :|::|   ..:..|...||:|::..::...|..|.
Human  1895 ATGEQLTLQKAFQQNLVSSALFSK------VLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENT 1953

  Fly  1801 ---LKCITKRKGELVTLQEAIADGIVLPAECKYRDFMTGELISIPEAVERGLISSVAQRSIFDID 1862
               |..:..::|..:||            :|       |..|||..|...|||.   :.::|.: 
Human  1954 GMWLLPVRPQEGGRITL------------KC-------GRNISILRAAHEGLID---RETMFRL- 1995

  Fly  1863 GFKDLRSNDYVSFNVALSRDLLRRKSTGFALETGRDSLVPLEVAVSEGLVRQE------VYEMFS 1921
                            ||..||    :|..:.:.....:.:|.||.||::.::      .|::.:
Human  1996 ----------------LSAQLL----SGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQT 2040

  Fly  1922 RGIGVQNASGKELSVFDLVYHNLI---------DPKTGY--LLDPKTGETVPLDTAIERKFITPE 1975
            .|| :|:...|.|:|.:.|..:||         :.:.||  |:.|.:||..|..::::::.||.|
Human  2041 GGI-IQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNE 2104

  Fly  1976 GALLLSSLLNITLTTETVTRTINRYVTIRAGSQE------PVDSVLLTFTEAVRQGFIDEERQLF 2034
               |...:||                    |.|:      |..|.::....|.:.|.||......
Human  2105 ---LAYKILN--------------------GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASI 2146

  Fly  2035 --------KDPKTGNIYSVQQALNYGLLVPDSNQTVPEPTNRKKTKSTITIVTKQIIPEAEPIKL 2091
                    |.|..|::.:.:.|..:.........||.:....           :.:....||:..
Human  2147 LKNITLPDKMPDLGDLEACKNARRWLSFCKFQPSTVHDYRQE-----------EDVFDGEEPVTT 2200

  Fly  2092 NTQHTKYVEKSVEIPISQELVKPHRVVSEFINLEKSSYIEQNVTERQIMELPPGGWRLKDAIEQR 2156
            .|.     |::.::.:|..::              :||::.|..:|.:  |..|.  |.:|:...
Human  2201 QTS-----EETKKLFLSYLMI--------------NSYMDANTGQRLL--LYDGD--LDEAVGML 2242

  Fly  2157 L------FNPDTGVFHVQGTDRLVNFEECI-----NKQIINNLSLSVIDPNTGDKISVQSAFERD 2210
            |      |:.:|.:            :||:     :...:||.|....|..|    :..|:|.: 
Human  2243 LEGCHAEFDGNTAI------------KECLDVLSSSGVFLNNASGREKDECT----ATPSSFNK- 2290

  Fly  2211 ILDSYGNYTNSRKQVQGMRSAIDES-----KIILETVPATRGANQKTILRITKVNNIPDVLEVST 2270
               .:.......:..:..:.||||.     ..::.:..:..|....||....|||:.|.|     
Human  2291 ---CHCGEPEHEETPENRKCAIDEEFNEMRNTVINSEFSQSGKLASTISIDPKVNSSPSV----- 2347

  Fly  2271 PLKDAPPKFVEVLTCQRELASPEPLQIAPGAIYDPSTALVIF-----TQTGETENIFDAAR---- 2326
                ..|..:..|| |.|||....|:      .|....|..:     .:|.|..|....::    
Human  2348 ----CVPSLISYLT-QTELADISMLR------SDSENILTNYENQSRVETNERANECSHSKNIQN 2401

  Fly  2327 --QGLVDEQLIKI-------VDPTTKQ-------PISVTEAIARSIYDPKTATILD------SEG 2369
              ..|::..::|.       |:.|..:       ||        ..|.|:.:.:|.      |:|
Human  2402 FPSDLIENPIMKSKMSKFCGVNETENEDNTNRDSPI--------FDYSPRLSALLSHDKLMHSQG 2458

  Fly  2370 QPVDLITATKLGLLSVVGAPLVAAEGALRTVRFVTDPRTGEQ--------------IPVEVAYER 2420
            ...|..|....|  :...||.::...  :|:  ::..|.||:              :|.|...::
Human  2459 SFNDTHTPESNG--NKCEAPALSFSD--KTM--LSGQRIGEKFQDQFLGIAAINISLPGEQYGQK 2517

  Fly  2421 GI--VSRD---QLHRGRSFDSEPATVEDKVVVLQRMRKVILKPKDALRKGIIDEETCEILENTSN 2480
            .:  :|.:   |.|..:...:.....|......|:|      |:|...:..|:|.:|.:      
Human  2518 SLNMISSNPQVQYHNDKYISNTSGEDEKTHPGFQQM------PEDKEDESEIEEYSCAV------ 2570

  Fly  2481 FTNPKGEVVNITEALN--TGLIDG-------RRGQVIDPQNNRVLNLRQAVEQKIIDS---EQTN 2533
              .|.|:..|...:|.  |.|:|.       ....:.|.|||...:...  :....|:   |..:
Human  2571 --TPGGDTDNAIVSLTCATPLLDETISASDYETSLLNDQQNNTGTDTDS--DDDFYDTPLFEDDD 2631

  Fly  2534 HILMPLAKSLSVPRLADQGLIDPQTQTIVHPESGYPLSIHEAIVCEVLDPHSKLHKPEKCTLEEA 2598
            |               |..|:|...:..:|||....|.....   |...|....:...|......
Human  2632 H---------------DSLLLDGDDRDCLHPEDYDTLQEEND---ETASPADVFYDVSKENENSM 2678

  Fly  2599 ITKGIINADDSTFNYKNKTLNITEAIEAKLFDPSYDQQKS--KVEIPPVGMIFPVAVEK----SL 2657
            :.:|   |...:.:.|||    ...::..|.|...|:..|  |:.:.|||.      :|    ||
Human  2679 VPQG---APVGSLSVKNK----AHCLQDFLMDVEKDELDSGEKIHLNPVGS------DKVNGQSL 2730

  Fly  2658 VEPSKRV---VLHPSTKKALPIKQAI--EENFIMSIPY----SPKPDAIEVVTAME----QDLID 2709
            ...|:|.   :|......:|.....:  :|:|..|:.:    |.:....|.||..|    .|.:|
Human  2731 ETGSERECTNILEGDESDSLTDYDIVGGKESFTASLKFDDSGSWRGRKEEYVTGQEFHSDTDHLD 2795

  Fly  2710 VAAQTLTVPSTGERI-------------------PLRQAMENGVLVVKNLSDFVITQKPIPKTEI 2755
               ...:..|.|:.|                   .:|.  |||              ||      
Human  2796 ---SMQSEESYGDYIYDSNDQDDDDDDGIDEEGGGIRD--ENG--------------KP------ 2835

  Fly  2756 METVRAVHTVTTKTIELMQGYVLISNNEVQNVNT-------GEVCSLEEAKELGILREESTTRET 2813
                |..:......|:|....:..:::|.:|:||       ....|||:.:.:.:::        
Human  2836 ----RCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNVVQ-------- 2888

  Fly  2814 KAAAGESPESVGDVGTSGDQTVIVEERTQTVVVSSDTRKQEMQVVSTTQSTKDTSVPSVSEIE-- 2876
                         :.:..:..::.|:.......:....|.:..:::.....||...|.:.:.|  
Human  2889 -------------LASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHEMVLKDVLPPIIKDTESE 2940

  Fly  2877 -TKGSKEPSKTLQNVKDAAKLGA-LGVIAAPVLAGGAIVSGVKSLIKSVKSPTEDAKSTEKPKEP 2939
             |.|....|....|:...::||. |......::.|    |.:..|..|||.              
Human  2941 KTFGPASISHDNNNISSTSELGTDLANTKVKLIQG----SELPELTDSVKG-------------- 2987

  Fly  2940 QTSFIEQERRKELQPQQVPSEVDNLLSETENFISSTTANFIANEKQQDKPDTLPQESNLPLEVES 3004
                 :.|..|.:.| :|.|.:|:::....:.|.              ||   .:||:|.|    
Human  2988 -----KDEYFKNMTP-KVDSSLDHIICTEPDLIG--------------KP---AEESHLSL---- 3025

  Fly  3005 TSTLTTTTVTTITTSSTTTETGNL-------EPVVVEDVSTTVK----EDKVVVK---------- 3048
                    :.::|.........:|       ..:::||.::..|    |.:|:|:          
Human  3026 --------IASVTDKDPQGNGSDLIKGRDGKSDILIEDETSIQKMYLGEGEVLVEGLVEEENRHL 3082

  Fly  3049 ---PSTVPEDKTEVSKITETITTVTSNETDTVPEKISQKSASEESAKKDPVVTKDTSSRPAETET 3110
               |.....|..::.........:|:|      |:::||.    |.||..|..||..:. .:...
Human  3083 KLLPGKNTRDSFKLINSQFPFPQITNN------EELNQKG----SLKKATVTLKDEPNN-LQIIV 3136

  Fly  3111 SPKPVQKEPTPDPAQNTE--FPESIKKDPTPEPDYKETATEAAQITPKEASPAPTNKNEQSAEPT 3173
            |..|||.|       |.|  |..|:.|                                      
Human  3137 SKSPVQFE-------NLEEIFDTSVSK-------------------------------------- 3156

  Fly  3174 SKPEPMPRTAKKEEISEIEPPFTAPLAPFVDQLAETKITEIKTEFKEPVTSSQTITTITTTVKTV 3238
                         |||:             |..::....|..|.|:|..|....        |.:
Human  3157 -------------EISD-------------DITSDITSWEGNTHFEESFTDGPE--------KEL 3187

  Fly  3239 DEHPIVEEVDEVSKSEKIVDVEEPTVHQQEPIKVNETSDDSTRTEPTNEIVHEERVVTVEEPTIT 3303
            |   :...:...:|:.|..||.:|                       ||.|....::|.  |.:.
Human  3188 D---LFTYLKHCAKNIKAKDVAKP-----------------------NEDVPSHVLITA--PPMK 3224

  Fly  3304 ETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPSSPAETK--------EIEQTTNDDQK 3360
            |........|           .:::|:|.|::|||:.:.|:...:|        ||.|.|     
Human  3225 EHLQLGVNNT-----------KEKSTSTQKDSPLNDMIQSNDLCSKESISGGGTEISQFT----- 3273

  Fly  3361 KPEEIVDTEKKTTEQKPVETIPTEPISTSE---------TTTVTLTTKTTIVD----EGKLHPPS 3412
             ||.| :.......:|.||.:.......||         .::.||.|..:.::    :.::....
Human  3274 -PESI-EATLSILSRKHVEDVGKNDFLQSERCANGLGNDNSSNTLNTDYSFLEINNKKERIEQQL 3336

  Fly  3413 DIEQIIQPHSTSDKHQSLVDFIEQEKGTQPAEGGSNILQNVKDAAKLGALAIVGAPVLAGKALVD 3477
            ..||.:.|.|             |||..|..|.....:::|||..|                   
Human  3337 PKEQALSPRS-------------QEKEVQIPELSQVFVEDVKDILK------------------- 3369

  Fly  3478 ALTTEKTLKPEHSTSQVVTETVEELPTEIITTSTATLVTKVTTTTTTTTTSTSEGTPDDEALDVV 3542
                 ..||..|...|.|.|......|:|:..:   |:.::||:......||   .|.|..:...
Human  3370 -----SRLKEGHMNPQEVEEPSACADTKILIQN---LIKRITTSQLVNEAST---VPSDSQMSDS 3423

  Fly  3543 KLPAELVESS-VKREVPRTLAIGDAISQKLISPDECQVIVDGEQQSQTVSTLLKEEQLSPLDEVQ 3606
            ...:.:..|| :|.|                |.|:...|  |..:|:.:..:||::|.|      
Human  3424 SGVSPMTNSSELKPE----------------SRDDPFCI--GNLKSELLLNILKQDQHS------ 3464

  Fly  3607 IIDDKLIVLQQVSYLVDADTELTPQNLYELNIYDPENQYFIDPSTGQKISFHTLVFDMNVFNPET 3671
                     |:::.:.:...|||... |:|                :|....:.|..:.:   |.
Human  3465 ---------QKITGVFELMRELTHME-YDL----------------EKRGITSKVLPLQL---EN 3500

  Fly  3672 ILVKNFSTGKYETLTAALERPLLDRHTGHMVDPKTGKKIPFFECVDRQWIIRANPEEQKPSGIEN 3736
            |..|..:.|..|.:          .|.|..                                   
Human  3501 IFYKLLADGYSEKI----------EHVGDF----------------------------------- 3520

  Fly  3737 VTIDTQTGQVVLDDGRVCSIVEAINSGKLDIQSISVRDPVSGEVIPLRMAIELGVVDMQAGTVI- 3800
                         :.:.||..|.:.. |..|                     ||.:..:.|... 
Human  3521 -------------NQKACSTSEMMEE-KPHI---------------------LGDIKSKEGNYYS 3550

  Fly  3801 -DIQTLKEIPMELAFQLGFLVPGARK--------PISLEAAVRKGLYDPETGKLFDSESQNQVDV 3856
             :::|:|||.:|.:......:|...|        |..||.                         
Human  3551 PNLETVKEIGLESSTVWASTLPRDEKLKDLCNDFPSHLEC------------------------- 3590

  Fly  3857 QKSIEIGLVDPKISLIVDTVTKKEVKLDCAIEDDLVLPATGQIKDNKNNTLVPFDVGVQQCLLKT 3921
                              |...||:             |:|      :::...|...:||||..|
Human  3591 ------------------TSGSKEM-------------ASG------DSSTEQFSSELQQCLQHT 3618

  Fly  3922 DNVTWSLPELLQREYYTPSTGKVLNPVTGEEILLQQAIEMGFVELETTLVKDVDHDKILPGKEAA 3986
            :.:         .||                               .||::|:            
Human  3619 EKM---------HEY-------------------------------LTLLQDM------------ 3631

  Fly  3987 KVGLLDTVRGTLSSPNISLDEAFVKGYLISTKKPLSLVDCLLRGLYDPSTAKFTIDDKQLDLKAA 4051
                                           |.||...:.|               |..|     
Human  3632 -------------------------------KPPLDNQESL---------------DNNL----- 3645

  Fly  4052 IAQKLINPEELVLLDPKTESIISITEAIAKGYLDPIEGYVINPYASTKLSLHEALENRILIPPKR 4116
                                                                |||:|::      
Human  3646 ----------------------------------------------------EALKNQL------ 3652

  Fly  4117 KRSLPDAVYRGLYDPKTGQFSNTVTREKLTTERAIRRGILDPDSTVVNVGSGQIIPFGVATETGI 4181
             |.|                                                             
Human  3653 -RQL------------------------------------------------------------- 3655

  Fly  4182 VDSKHGTVRDADDHPIDFKEAFDRG---ILVEAKKPLRLIEAVVKNV-YDEVDGHFVDPKSGEKL 4242
                               |.|:.|   |.|..:|.::|.|..:|:: .|...||          
Human  3656 -------------------ETFELGLAPIAVILRKDMKLAEEFLKSLPSDFPRGH---------- 3691

  Fly  4243 NFAEALNTNLLDEHSVQIRDFKTGLYKQLNLTHAKDTGI---IDAQNSKLLYNNQTMTLKHAFDI 4304
                      ::|.|:..:..||......|::..:...|   ||::.|||               
Human  3692 ----------VEELSISHQSLKTAFSSLSNVSSERTKQIMLAIDSEMSKL--------------- 3731

  Fly  4305 GILMDVNAPISIQRAIHQ-GLFDDKTGKLSDPRTGRQITLLESMRSFVVNPHLPCYFDEQTEQMY 4368
                    .:|.:..:|: ..|.|...:.|  ::.:.|.::....|..|...|            
Human  3732 --------AVSHEEFLHKLKSFSDWVSEKS--KSVKDIEIVNVQDSEYVKKRL------------ 3774

  Fly  4369 TLSETCRNGIINRREGVFREPGSNSFVPLGEALSLGLIVDIENAGFGLYELLSMGFYETS---TR 4430
               |..:|        |.::.|...             :.:|...|.:...:|....:.|   ::
Human  3775 ---EFLKN--------VLKDLGHTK-------------MQLETTAFDVQFFISEYAQDLSPNQSK 3815

  Fly  4431 KVLHPVTNRKLNLNEACVEDVVSLSSSLVKHHETGKYLRLANAIKEQLVDDSRGCYNLGNEQLDL 4495
            ::|     |.||..:.|..||....::.|:..||..:|       ||.:||.:            
Human  3816 QLL-----RLLNTTQKCFLDVQESVTTQVERLETQLHL-------EQDLDDQK------------ 3856

  Fly  4496 QAARARGLIVSNRRLLSLELVLRQQLYRPETGKFCDPTTGEYLDLIEAIHSGFIDPATTVFKNQL 4560
                    ||:.          |||.|:.:....||                    ..|..:|:|
Human  3857 --------IVAE----------RQQEYKEKLQGICD--------------------LLTQTENRL 3883

  Fly  4561 TGKELPLTEA--IENGDIDVSKGRVFDPKSKSAYNYDVALSRGILVTITRPLTDRNDVVRRQDSV 4623
            .|.:    ||  |.:|.:::.|   :..|.:.... |:..|...|..:.     :|.....:::.
Human  3884 IGHQ----EAFMIGDGTVELKK---YQSKQEELQK-DMQGSAQALAEVV-----KNTENFLKENG 3935

  Fly  4624 ELLNQTPVSVVISKPREMSLEEA-IRYNIIDPKTALVRDFDSFKFLPYSVAVERGLVDTTKRTLV 4687
            |.|:|...:::     |..|.|| |:...::.|                       .:.:|:.| 
Human  3936 EKLSQEDKALI-----EQKLNEAKIKCEQLNLK-----------------------AEQSKKEL- 3971

  Fly  4688 DPKALYFAFDPTLIVYVREPVTFDQAAESKCLDLQTGLLTYVPASVPGSATAAPASDDSANDSLT 4752
                     |..:...::|                                              
Human  3972 ---------DKVVTTAIKE---------------------------------------------- 3981

  Fly  4753 VIETPKVYTLKEAASAGVVDPDSALVKDL--AKAKLVRLPEAFRKGLMDANKANVLNTQTSKLCT 4815
              ||.||                |.||.|  :|.|:..|.:.......|:.:|..          
Human  3982 --ETEKV----------------AAVKQLEESKTKIENLLDWLSNVDKDSERAGT---------- 4018

  Fly  4816 LQEAYESGLICTPKRSFGLLEAITFNLYNPTNGCLVDPFQMHPDIIRRRKFTLAEAIGSGLVDPS 4880
                                                    .|..:|.:......|..|...:   
Human  4019 ----------------------------------------KHKQVIEQNGTHFQEGDGKSAI--- 4040

  Fly  4881 STVVRDPSTGVIVPLTAAISSGLIDATEGRLTDANEPKNNIDLVKAAEKGLLLPAEQRQAVFEKF 4945
                                 |..|...|                                    
Human  4041 ---------------------GEEDEVNG------------------------------------ 4048

  Fly  4946 NMCEENVNDLLKWVTTVEQKISSVGGPREKIDELRNQINALKQIKDEIESQQRPVATCLEQIRQI 5010
            |:.|.:|:             ..||..:|.:::   |...:|...::|.||.:.|....:..:.:
Human  4049 NLLETDVD-------------GQVGTTQENLNQ---QYQKVKAQHEKIISQHQAVIIATQSAQVL 4097

  Fly  5011 VLTGGDVLSAPEVTTLENSGRELRSRVDRVNDRTVRLLRRLEAGRDELTKLRSELDVFSDWLQVA 5075
            :...|..||..|...|:.:.:||:...:.....:.:.::...:.::||.|..::...|..|||.:
Human  4098 LEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQS 4162

  Fly  5076 RRTLEDKERSLSDLTRLPSQADSVREFVSDVIGHQADLRFITMAAQKFVDESKEFLAILNDFRTS 5140
            .:.||:.|....|:..|.::....:.|..|||.|:.|||:||::..:.::.:|           |
Human  4163 EQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK-----------S 4216

  Fly  5141 LPERLPHVEPLSSAESPIRQEVSLVSAQYKDLLNRVNALQDRVSGLGGRQREYQDALDKANEWLR 5205
            ..:|.......|:....:::::...:.:::.|.::.|.|.:.:..|..:.:.|:||.......|:
Human  4217 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQ 4281

  Fly  5206 SVHPRVSRIISEPIAGDPKGVQDQMNEAKALHNELLSSGRLVDNAQQALDNLLRSLGGQLSPMEI 5270
            :.....|:.:|||||.|||.:|.|:.|.|||..::.|....|:..::..:.|| ...|.|.|.: 
Human  4282 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-DARGSLLPAK- 4344

  Fly  5271 NQLELPIADLKNNYQQLLDNLGEHCKTLDKTLVQSQGVQDALDSLVGWVNQAEDKFKMNLRPASL 5335
            |.::..:.|:...|:.|..::.|..:.|..||.:|..|||.||.::.|:...|...| ......|
Human  4345 NDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-EQGQVPL 4408

  Fly  5336 IKERLQEQIREHKVLLADLQSHQASIDSVQVSAKHLLASASNARIAKKVESNLNDVTVKFEKLYE 5400
            ....||:.|.::.:|..|:...|:||:::....|..: ..::...|..:::.:.|::.:|.   |
Human  4409 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM-ETTDPSTASSLQAKMKDLSARFS---E 4469

  Fly  5401 KANKRGEFLDDVYNRLSRYLDEISTVEQRMASLQEALDSRETSLLSTEELARRMNELSRDKDQLA 5465
            .::|..|.|    .::.....::...|.....||..|:::..:|...:...:.:.|||:...:..
Human  4470 ASHKHKETL----AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQEST 4530

  Fly  5466 PQFEDCVRSGKDLIS-LRDVTDTGVLRDRIKALESQWRNINISIDERAKLSKQKAE------QQL 5523
            .:|.:..:..:.|.| |::::..|:..|:...|| :..|::....|.....|:|.|      :||
Human  4531 SEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE-KTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 4594

  Fly  5524 -AYEGLKDQVLSWLASTEARVNGLPPVAIDLDRIKQQHDELKPICKDYRDYAPTIDKINDIGAQY 5587
             |::.|...:.||:..|..:|..:.| :...:.:.:..::.|.:.:.:....|.|.|:|:.|...
Human  4595 DAFQVLVKSLKSWIKETTKKVPIVQP-SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISL 4658

  Fly  5588 DALIRPESPARKRSTYSPIKRTSPLRRMSGDARSPSPTKGGILSPLSTGSSGFGSRRSSQDGFQL 5652
            ..||        .:..:|.|..:.::  ||         |.:|       :|.|:..::::.:..
Human  4659 CNLI--------SAVTTPAKAIAAVK--SG---------GAVL-------NGEGTATNTEEFWAN 4697

  Fly  5653 SELSPVQQQLSEINNRYGLIGVRLNDRQHELDNLNEELRKQYENLKGLAQFLERI--------QR 5709
            ..|:.:::.:::|::.|..:|:.|.|:..||:....:|:|..|....:.|:|:::        |.
Human  4698 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQT 4762

  Fly  5710 QLPKESVSNKDEAERCIKQARKILEDMYEKQSLLDTTKAQVKDILRRKSDVPGAEQLRQENDSIQ 5774
            ..|.::.:.|.:.|:......::.:::.:.|.|.|    ::.::|....|.|.|.:.:|....|.
Human  4763 PAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKD----KLTELLEENPDTPEAPRWKQMLTEID 4823

  Fly  5775 EKWKNLNDICKNR----IAFSEKLRDFLDTHGNLKSWLDSKERMLTVLGPISSDPRMVQSQVQQV 5835
            .||:.||.:..:|    ...|..|..|......||.||..||.|::||||:|.||.|:.:|.|||
Human  4824 SKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 4888

  Fly  5836 QVLREEFRTQQPQLKHFQELGHDVVDHLAGTPDAQA-VEIKLKDILGKWDDLVGKLDDRANSLGG 5899
            |:|.:||.|::||.:.....|..::......|..:. |:.:|..:..|||.|.|:|.||.:.:..
Human  4889 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 4953

  Fly  5900 AADSSKEFDAAVNRLREALQNISDNLDTLPTDGDHQENLRKIENLERQLEGQRPLLADVEQS--- 5961
            |...|.::.:.:..|.:.|.::.:.|.:......|.      :.:.:|||..:.:..:::|.   
Human  4954 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP------DAMNQQLETAQKMKQEIQQEKKQ 5012

  Fly  5962 ---AATLCN----ILGDPASRADVNSRVAALEKQYLALQKKLDTKKAETEASLRDGRHFAENCSK 6019
               |..||.    ::.:...:|:::.::..:.|.:..:::|.:......:::......|.:....
Human  5013 IKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 5077

  Fly  6020 TLGWLGGELSNLTDRLLVSAHKPTLQHQIDTHEPIYREVMAREHEVIMLINKGKDL---TDRQQD 6081
            ...||..:.........:||....|:..|..|:...:.:.|:.|.....|.:|::|   |...:.
Human  5078 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEK 5142

  Fly  6082 RGVKRDLDRIQQQWEKLRREAVDRHTRLQTCMEHCKKYSQTSETFLAWLRTAEDKLADLTPGVLS 6146
            ..::..|:.|:..|:...::..:|..:|:..:|...||.:..||...|:...::.|.:: ...|.
Human  5143 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEI-KFCLD 5206

  Fly  6147 KAKLETRLRDLQTFRSEVWKHSGEFENTKGLGETFLSSCDIDKEPIKAELQDIRDRWERLNNDLI 6211
            .|:.|..:..|::.:.|:.:|.|..|.......:.||.|:||||.:..|.:.:..:.:.:...|.
Human  5207 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLH 5271

  Fly  6212 ARAHEIENCSRRLDDFNDELRNLDHSLGRCEDRLAAHDALGGAAKDPKLLERVKAIREELTNLSK 6276
            ::...:||.:::..:|.:..:.....|...:::|..||:||..|...|.|..::..::.|..|..
Human  5272 SKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 5336

  Fly  6277 PLQSLKALAKDISAEARAAGGDADHLTSEVDGLADRMSELQGRLDDRCGELQSAATAVSQFNEQM 6341
            .:...|.||:|:..||..:.|.:|.|. :|:.:|...|.|..::|::|..|::....:..|...:
Human  5337 QVDLAKRLAQDLVVEASDSKGTSDVLL-QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 5400

  Fly  6342 KSLGIDLNDLETEIEKLSPPGREIKIVQVQIDDVGKIQTKLDRLVGRLEDAERAAD-VLVDAGFA 6405
            :.:.....:.:.|::.::|.||:.:.:|.|.:.:.....||:.|:...::|.:... :|.....:
Human  5401 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 5465

  Fly  6406 ADTTQTREQISTLRKTLGRLDNRVRDHEDNLHSTLKALREFYDHQSQTLDDIQDVSDEFKRMKPV 6470
            .|....:..:..|.|...:|.:|.:..|:.:..|:|.|.|||....:....:|...:..:...||
Human  5466 PDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV 5530

  Fly  6471 GSELDQIRRQQEDFRNFRERKVEPLAINVDKVNVAGRDLVRSAGSGVSTTAIEKDLEKLNDRWND 6535
            |.|.:.|.:|...|:.|::.::|||......||..|:.|::||....||..:|.||:.:|.||..
Human  5531 GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKT 5595

  Fly  6536 LKERMNERDRRLDVALLQSGKFQEALAGLSKWLSDTEEMVANQKPPSSDYKVVKAQLQEQKFLKK 6600
            |.:::.:|..:|..|||..|:||:||..|..|:.||||:||||||||:::||||||:||||.|::
Human  5596 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQR 5660

  Fly  6601 MLLDRQNSMGSLANLGKEVANHCEPGERASIEKQLNDLMKRFDALTDGAEQRELDLEEAMEVAKR 6665
            :|.||::::..:...|:::|...||.::..|.|||:.|..|::||.:.||.|...||....||::
Human  5661 LLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 5725

  Fly  6666 FHDKISPLELWLDNTERSVKAMELIPTDEEKIQQRIREHDRLHDEILGKKPDFSDLADVTAQLMH 6730
            ||:.:.||..||...|:.:...|.|.|...|::::|.:|..|.|:|:...             .|
Human  5726 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN-------------KH 5777

  Fly  6731 LVSDEEAVNLGEKVRGVTER----------------YTGLVDASDNIGALLAESRQGLRHLVLSY 6779
            |   .:||::|:.::.::.|                |..:.:.|.:...||   :|.|.:..:..
Human  5778 L---HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL---QQALCNAKIFG 5836

  Fly  6780 QD---LVAWMESMEAELKRFKSVPVYAEKLLEQMDHLLELNENIAGHASNVESTVESGAELMKHI 6841
            :|   |:.|:..:..:|.:........|.|.:|...|..|.|:|.....||:..:.:|.||:|..
Human  5837 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 5901

  Fly  6842 SNDEAIQLKDKLDSLQRRYGDLTNRGGDLLKSAQNALPLVQQFHEAHNRLVEWMQSAEAALAPSE 6906
            :.||.:.::|||::::.||.|:|....|:.|:.:.||.|.::.|..|..|..|:...|..|...|
Human  5902 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 5966

  Fly  6907 PRQADVLR-LEGELADMRP------------ILDSINQVGPQLCQLSPGEGAATIESIVTRDNRR 6958
               ..||: .|...|.|||            :|||:|:|...|.:|.|......:|.:|..||.|
Human  5967 ---TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNER 6028

  Fly  6959 FDSIVEQIQRKAERLHLSNQRAKEVTGDIDELLEWFREMDTTLREADLPAMEPKLVRAQLQEHRS 7023
            :..:.:.|.:|.|.:..:..|:::.....|..|.|..|.:..|.......:|.....||||..::
Human  6029 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT 6093

  Fly  7024 INDDISSQKGRVRDVTAASKKVLRESPQSENTATLREKLDDLKEIVDTVAQLCSERLGILEQALP 7088
            ...:|...|..:.|:..:..|::....:.|. .::::|||.:.:..||:.|:.|||...||:|..
Human  6094 FTMEILRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 6157

  Fly  7089 LSEHFADSHQGLTAWLDDMEQQISRLSMPALRPDQITLQQDKNERLLQSIAEHKPLLDKLNKTGE 7153
            |...|.::::.|..||.:.:..||:|..|||..:.:..||:::.:|.:.||||||.:||:||||.
Human  6158 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 6222

  Fly  7154 ALGALVADDDGAKINEILDTDNARYAALRLELRERQQALESALQESSQFSDKLEGMLRALANTVD 7218
            .|..| :..:|..|.|.....:..|:.::.::::|..||:.|:.:|:||.||::.:|.:|...|:
Human  6223 QLLEL-SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 6286

  Fly  7219 QVNQLDPLSALPQKIREQIEDNDALMDDLDKRQDAFSAVQRAANDVIAKA-GNKADPAVRDIKAK 7282
            ::.|...:||..:||:|||.:|..:..|::|.|..:..:::...::||:: |...|.:.:.::.|
Human  6287 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 6351

  Fly  7283 LEKLNNLWNDVQNATKKRGSSLDDILSVAEPFWKQLNSVMKTLKDLEETLSCQEPPAAQPQDIKK 7347
            |:::..:|.::....::|.:.|.|::.:||.||....|::.|:||.::.:...|.|...|..:|:
Human  6352 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ 6416

  Fly  7348 QQVALQEIRHEIDQTKPEVEQVRRHGSNLMNMCGEPDKPEVKKHIEDLDNAWDNITALYAKREEN 7412
            ||.|.:.||.|||..:.|::.|...||.|:..|||||||.|||.|::|::|||::...:..|.:.
Human  6417 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 6481

  Fly  7413 LIDAMEKAMEFHETLQNLLKFLTKAEDKFAHLGAVGSDIDAVKRQIEQLKSFKDEVDPHMVEVEA 7477
            |.:||:.|:::.:.||.:..::..|..|.|.:..:|:|::.||:|||:||.||.|.....:|:|.
Human  6482 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 6546

  Fly  7478 LNRQAVELTERTSPE-QAASIREPLSVVNRRWEALLRGMVERQKQLEHALLHLGQFQHALNELLV 7541
            ||.||..|.::.:.| ...::::||..:...|::|...::.||.:||.|||.||||||||:|||.
Human  6547 LNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 6611

  Fly  7542 WINKTDSTLDQLKPIPGDPQLLEVELAKLKVLANDIQAHQNSVDTLNDAGRQLIETEKGSVEAST 7606
            |:..|:..|.:.||:.|||:.:|:||||..||.||:.|||::|:.:|.||..|||:..|. |||.
Human  6612 WLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGE-EASN 6675

  Fly  7607 TQEKLRKLNNEWKQLLQKASDRQHELEEALREAHGYIAEVQDILGWLGDVDAVIGASKPVGGLPE 7671
            .|.||..||..|:.:|:|...|:.:|:.|||:|.|:..|::|:..||.|.:..:.||||:|||||
Human  6676 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 6740

  Fly  7672 TATEQLERFMEVYNELDENRPKVETIQAQGQEYIKRQNQMKVSSSNLQHTLRTLKQRWDAVVSRA 7736
            ||.|||...|||....:......:::..:||:.:.|  ..|.:.:|:...:..||::|::|.::.
Human  6741 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNIDQDINNLKEKWESVETKL 6803

  Fly  7737 SDKKIKLEIALKEATEFHDTLQAFVEWLTQAEKLLSNAEPVSRVLETIQAQMEEHKVLQKDVSTH 7801
            :::|.|||.||..|.|||::||.|:.||||||:.|:.|...|.:|:|:..|::||||...:|::|
Human  6804 NERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 6868

  Fly  7802 REAMLLLDKKGTHLKYFSQKQDVILIKNLLVSVQHRWERVVSKAAERTRALDHGYKEAREFNDAW 7866
            ||.::.|||.|||||||||||||:||||||:|||.|||:||.:..||.|:||...|.|::|::||
Human  6869 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAW 6933

  Fly  7867 SGMMQYLQETEQVLDQIIEEATASKEPQKIKKYIGKLKETHRQLGAKQSVYDGTMRTGKNLLERA 7931
            |.:|::|:|:|:.||..:|.|   .:|.|||..:.:.||..:.||||.||||.|.|||::|.|:.
Human  6934 SKLMEWLEESEKSLDSELEIA---NDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT 6995

  Fly  7932 PKGDRPV-LDKMLIELKEQWTRVWSKSIDRQRKLEEALLLSGQFSDALGELLDWLKKAKSRLNEN 7995
            ...|..: ||.||.||:::|..:..||::||.|||||||.||||:|||..|:|||.:.:.:|.|:
Human  6996 SLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAED 7060

  Fly  7996 GPVHGDLETVQGLCEHHKHIEQDLQKRAAQMQGVLKTGRDLERSGNNPE--VGRQLDEMQSIWEE 8058
            .|||||::.|..|.::||..:::|.||.:.:|.:.::.|:|.....:..  |..|:.|:.:.||.
Human  7061 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWET 7125

  Fly  8059 VKSAVAKRGERLQVALVDAEKLNARVQALFDWLDHAEHKLRYAKNAPDDEKVSREMMDIHMDFMK 8123
            |.:....:..||:.||..||:.::.|.||.:||..||..||:....||||...|.::|.|.:|||
Human  7126 VCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMK 7190

  Fly  8124 DLRVREREKTETFEYAEDIINKAYPDAIPIIKNWLSIIQQRWEEVRQWAINRESKLEQHLQSLKD 8188
            .|..:..|..:.....:.::...:||:|..||:|::||:.|:|||..||...:.:|...|..|..
Human  7191 KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA 7255

  Fly  8189 LDDTIEELLAWLSGLEGTLLNLKHEQLPDEIPPVEKLIEDHKEFMENTARRQNEVDRACKP---R 8250
            ..:.:|.|||||...|.||.:...|.:|.||..|:.||.:|:.|||...|:|.:||:..|.   |
Human  7256 KQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 7320

  Fly  8251 QLPPGARKPSRSGKTPVFKGSRDQGLNARKGSRITPTRDTPDRDRLPHYGPRFSPSTSGPELEFR 8315
            ...|.    |.....||.    |:|...||              |.|  .....||.|..::|.:
Human  7321 AADPS----SLQSHIPVL----DKGRAGRK--------------RFP--ASSLYPSGSQTQIETK 7361

  Fly  8316 SPRAKLLWTKWRDVWMLSWERQRLLNDHLLYLKDVERARNFSWDDWRKRFLKYMNHKKSRLTDLF 8380
            :||..||.:||:.||:|:.||:|.|||.|..|:::....||.:|.|||:::::|||||||:.|.|
Human  7362 NPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFF 7426

  Fly  8381 RKMDKDNNGMIPRDVFIDGILNTKFDTSGLEMKAVADLFDRNGEGLIDWQEFIAALRPDWQERKP 8445
            |::|||.:|.|.|..||||||::||.||.|||.||||:|||:|:|.||:.||:|||.|:....||
Human  7427 RRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKP 7491

  Fly  8446 ANDSDKIHDEVKRLVMLCTCRQKFRVFQVGEGKYR------FGDSQKLRLVRILRSTVMVRVGGG 8504
            ..|:|||.|||.|.|..|.|.::|:|.|:|:.|||      |||||:||||||||||||||||||
Human  7492 ITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGG 7556

  Fly  8505 WVALDEFLQKNDPCR------------------------AKGRTNIELREQFILADGVSQSMAAF 8545
            |:||||||.||||||                        ||||||:||||:||||||.||.||||
Human  7557 WMALDEFLVKNDPCRVHHHGSKMLRSESNSSITTTQPTIAKGRTNMELREKFILADGASQGMAAF 7621

  Fly  8546 TP--RRSTPNAAATASSSPHAHNGGSSNLPPYMSGQGP------IIKVRERS-----VRSIPMSR 8597
            .|  |||.|   ::..:||:.....||......|.|.|      |:....|:     :.:..||.
Human  7622 RPRGRRSRP---SSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMST 7683

  Fly  8598 PSRSSLSASTPDSLSD----------------NEGSHGG-PSGRYTP-----RKVTYTSTRTGLT 8640
            |.:::..:..|...::                .:|.|.| .||..|.     |.....|.:|...
Human  7684 PCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR 7748

  Fly  8641 PGGSRAGSKPNSRPLSRQGSKPPSRHGSTLSLDSTDDHTPSRIPQRKPSTGSTASGTTPRPARLS 8705
            | |||||||..||..||:||.......|.:....:|..|..:..:..|..||..|  |.:|:::.
Human  7749 P-GSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPS--TAKPSKIP 7810

  Fly  8706 VTTTTTPGSRLNGTS 8720
            .....:|.|:|:.:|
Human  7811 TPQRKSPASKLDKSS 7825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401 89/248 (36%)
CH 223..327 CDD:306753 54/103 (52%)
SPEC 471..689 CDD:238103 54/300 (18%)
SPEC 690..866 CDD:238103 60/176 (34%)
SH3 885..922 CDD:327375 12/36 (33%)
SPEC 1047..1250 CDD:238103 44/222 (20%)
SPEC 1153..1390 CDD:238103 45/252 (18%)
PLEC <1498..1526 CDD:197605 3/28 (11%)
Plectin 1949..1981 CDD:307019 11/33 (33%)
DNA_pol3_delta2 <2711..3178 CDD:331068 82/522 (16%)
DUF4775 3026..3357 CDD:330579 65/364 (18%)
SMC_N <4904..5566 CDD:330553 142/669 (21%)
SPEC 5304..5513 CDD:238103 44/209 (21%)
SPEC <5658..5787 CDD:321951 29/136 (21%)
SPEC 5793..6007 CDD:238103 56/224 (25%)
SPEC 6011..6220 CDD:238103 44/211 (21%)
SPEC 6118..6330 CDD:238103 53/211 (25%)
PRK09039 <6279..6441 CDD:332967 35/162 (22%)
SPEC 6443..6660 CDD:238103 86/216 (40%)
SPEC 6663..6878 CDD:238103 57/233 (24%)
SPEC 6880..7087 CDD:238103 58/219 (26%)
SPEC 6986..7196 CDD:238103 62/209 (30%)
SPEC 7196..7417 CDD:238103 72/221 (33%)
SPEC 7314..7526 CDD:238103 76/212 (36%)
SPEC 7528..7747 CDD:238103 92/218 (42%)
SPEC 7749..7968 CDD:238103 112/219 (51%)
SPEC 7973..8181 CDD:238103 74/209 (35%)
EF-hand_7 8373..8437 CDD:316058 40/63 (63%)
GAS2 8450..8522 CDD:128539 54/101 (53%)
Herpes_ICP4_C 8550..>8795 CDD:332854 51/204 (25%)
DSTXP_016866694.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 153 1.000 Domainoid score I4281
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H134369
Inparanoid 1 1.050 2383 1.000 Inparanoid score I34
Isobase 1 0.950 - 0 Normalized mean entropy S7584
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17559at33208
OrthoFinder 1 1.000 - - FOG0003564
OrthoInspector 1 1.000 - - otm40714
orthoMCL 1 0.900 - - OOG6_101076
Panther 1 1.100 - - LDO PTHR23169
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3145
SonicParanoid 1 1.000 - - X2438
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.850

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