Protein Alignment shot and MICAL1

DIOPT Version :10

• Sequence 1: NP_725339.1
• Gene: shot / 36542
• FlyBaseID: FBgn0013733
• Length: 8805
• Species: Drosophila melanogaster
• Sequence 2: NP_001273542.1
• Gene: MICAL1 / 64780
• HGNCID: 20619
• Length: 1086
• Species: Homo sapiens
• Alignment Length: 716
• Identity: 153/716 - (21%)
• Similarity: 227/716 - (31%)
• Gaps: 267/716 - (37%)

  Fly   145 SQRAP-NGHRRVTTHIVRKVTTLSRAEENAQPAEDLLPPAKMIRSSELEYRRALPPAIESSSTQR 208
            ||.:| |.||.|             |:....||         .|...|..|...|       .|.
Human   463 SQTSPENMHRNV-------------AQYGLDPA---------TRYPNLNLRAVTP-------NQV 498

  Fly   209 REISDIVVGKE----------------DNVSAREALLRWARRSTARYPGVRVNDFTSSWRDGLAF 257
            |::.| |:.||                .:...:|.||||.:..||.||||.|:|.:|||.||||.
Human   499 RDLYD-VLAKEPVQRNNDKTDTGMPATGSAGTQEELLRWCQEQTAGYPGVHVSDLSSSWADGLAL 562

  Fly   258 SALVHRNRPDLLDWRKARNDRPRERLETAFHIVEKEYGVTRLLDPEDVDTNEPDEKSLITYISSL 322
            .|||:|.:|.||:..:.:.....|....|..:.|.|.|:|.::..:.|.... |...||.|:|..
Human   563 CALVYRLQPGLLEPSELQGLGALEATAWALKVAENELGITPVVSAQAVVAGS-DPLGLIAYLSHF 626

  Fly   323 YDVF------PEPPSIHPLFDMESQRRVHEYRDLAQQFIYWCREKTAYLQERSFPPT---LIEMK 378
            :..|      |.|.|                                    ::.|.|   ::.:.
Human   627 HSAFKSMAHSPGPVS------------------------------------QASPGTSSAVLFLS 655

  Fly   379 RLLSDLQRFRSDEVSARKREKSKLIQIYKELERYFETVG-EVDVEAE----LRPDAIEKAWYRMN 438
            :|...|||.|:.| :|......||     .||...||.. ||..:.|    |.|.:     ....
Human   656 KLQRTLQRSRAKE-NAEDAGGKKL-----RLEMEAETPSTEVPPDPEPGVPLTPPS-----QHQE 709

  Fly   439 TALQDREVILQQEIERLERL---------------------------QRLADKVQREIKHVDQKL 476
            ....|...:..:.:..||||                           |...|.....::|:.|
Human   710 AGAGDLCALCGEHLYVLERLCVNGHFFHRSCFRCHTCEATLWPGGYEQHPGDGHFYCLQHLPQ-- 772

  Fly   477 TDLEGRIGEEGRRIERLHPVDAKSIVEALETEIRHLE--EPIQDMNQ------------------ 521
            ||.:....:.|.....|......|:...|.|.....|  .|:.|.:|
Human   773 TDHKAEGSDRGPESPELPTPSENSMPPGLSTPTASQEGAGPVPDPSQPTRRQIRLSSPERQRLSS 837

  Fly   522 -----------------DCHVL---------------------------NEGRYPHVSE------ 536
                             .|..|                           .|...|..||
Human   838 LNLTPDPEMEPPPKPPRSCSALARHALESSFVGWGLPVQSPQALVAMEKEEKESPFSSEEEEEDV 902

  Fly   537 -LHKKVNKLHQRWAQLRTNFHTNLVQKLSGL--KYPVHETTVTRQTRMVVESRQIDTNPHFRDLQ 598
             |...|.:..|.:|            |.||.  .||....|:.|:.:.                :
Human   903 PLDSDVEQALQTFA------------KTSGTMNNYPTWRRTLLRRAKE----------------E 939

  Fly   599 EHIEWC-----QNKLKQLLAADYGSDLPSVKEELD-RQQHEHKIIDQFHTKILNDERQQTKFSGD 657
            |...:|     |.:|.::.||....:...||.||. |:|..            :.|:|:..:.|.
Human   940 EMKRFCKAQTIQRRLNEIEAALRELEAEGVKLELALRRQSS------------SPEQQKKLWVGQ 992

  Fly   658 ELALYQQRLNQLQKVYAELLSTSTKRLSDLDSLQHFLGQASAELQ-WLNEKEQVEITRDWADKQL 721
            .|.|..:: |.|....|||:.|    :.:| :|:....|...||: ::|.:|.::..   ||:|.
Human   993 LLQLVDKK-NSLVAEEAELMIT----VQEL-NLEEKQWQLDQELRGYMNREENLKTA---ADRQA 1048

  Fly   722 D 722
            :
Human  1049 E 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401	65/241 (27%)
		CH_PLEC-like_rpt2	223..327	CDD:409038	40/109 (37%)
		SPEC	471..689	CDD:238103	54/296 (18%)
		SPEC	690..866	CDD:238103	9/34 (26%)
		SH3_10	864..929	CDD:407754
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1980	CDD:459901
		DUF5585	2860..>3198	CDD:465521
		SMC_prok_B	<4936..>5564	CDD:274008
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:413338
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:181619
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		FRQ1	<8375..8444	CDD:444056
		GAS2	8450..8522	CDD:128539
		PHA03307	8550..>8795	CDD:223039
MICAL1	NP_001273542.1	UbiH	102..>218	CDD:440419
		CH_MICAL1	526..631	CDD:409045	39/105 (37%)
		LIM_Mical_like	716..769	CDD:188744	6/52 (12%)
		bMERB_dom	953..1079	CDD:463467	30/118 (25%)