DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and Syne1

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	XP_036011805.1	Gene:	Syne1 / 64009	MGIID:	1927152	Length:	8820	Species:	Mus musculus

Alignment Length:	10095	Identity:	1897/10095 - (18%)
Similarity:	3516/10095 - (34%)	Gaps:	3027/10095 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 TSQRAP--NGHRRVTTHIVRKVTTLSRAEE----------------NAQPAEDLLPPA------K 184
            :.|:.|  .|||....|.|..:.|..:..|                ||....|..|..      .
Mouse    71 SGQKLPCEQGHRVKRIHAVANIGTALKFLEGRKSMYRGSPIKLVNINATDIADGRPSIVLGLMWT 135

  Fly   185 MIRSSELEYRRALPPAIESSSTQRREISDIV------------VGKEDNVSAREALLRWARRSTA 237
            :|...::|...:..|.::|.|:....:..:|            |..:...:|::.||:|.:.:..
Mouse   136 IILYFQIEELTSNLPQLQSLSSSASSVDSMVSTETASPPSKRKVAAKIQGNAKKTLLKWVQHTAG 200

  Fly   238 RYPGVRVNDFTSSWRDGLAFSALVHRNRPDLLDWRKARNDRPRERLETAFHIVEKEYGVTRLLDP 302
            :..|:.|.||..|||.||||.:::|..:|:|:|..|.:....||.||.||.|.|.:.|:.|||||
Mouse   201 KQMGIEVKDFGKSWRTGLAFHSVIHAIQPELVDLEKVKTRSNRENLEDAFTIAETQLGIPRLLDP 265

  Fly   303 EDVDTNEPDEKSLITYISSLYDVFP----------EPPSIHPLFD-----MESQRRVHEYRDLAQ 352
            ||||.::|||||::||::.....:|          |...|.|::.     ::|:|   :.|.:.:
Mouse   266 EDVDVDKPDEKSIMTYVAQFLTQYPDIHGAGCDGQEDDEIFPVYSSFANYIQSKR---DDRLILK 327

  Fly   353 QFIYWCREKTAYLQERSFPPTLIEMKRLLSDLQRFRSDEVSARKREKSKLIQIYKELERYFETVG 417
            :...|..:     .||.|....:....|....|.|:...|....:.| ::..|.:.|:|
Mouse   328 ETKVWIEQ-----FERDFTRAQMTESSLQDKYQAFKHFRVQYEMKRK-QVEHIIQPLQR------ 380

  Fly   418 EVDVEAELRPDAIEKAWYRMNTALQD----------------------REVILQQEIERLERLQR 460
              |.:..|....:::.|.|:::.|.|                      .||.|::||...:..:.
Mouse   381 --DGKLTLDQALVKQCWERVSSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITIQQVHEE 443

  Fly   461 LADKVQREI-KHVD-QKLTDLEGRIGEEGRRIERLHPVDAKSIVEALETEIRHLEEPIQDMNQDC 523
            .|:.:||:: :|.| .:.||...|...|   |.:...|:.          |....:.::||.:..
Mouse   444 TANTIQRKLEQHKDLLQNTDAHKRAFHE---IYQTRSVNG----------IPMPPDQLEDMAERF 495

  Fly   524 HVLNEGRYPHVSELHKKVNKLHQRWAQLRTNFHTNLVQKLSGLKYPVHETTVTRQTRMVVESRQI 588
            |.::.     .||||    .:...:.:|:....:.||...|.||     :.:.:..|.  ||.::
Mouse   496 HFVSS-----TSELH----LMKMEFLELKYRLLSLLVLAESKLK-----SWIIKYGRR--ESVEL 544

  Fly   589 DTNPHFRDLQEHIEWCQNKLKQLLAADYGSDLPSVKEELDRQQHEHKIIDQFHTKILNDERQQTK 653
                   .||.:|.:.:|.                           |..:|:....
Mouse   545 -------LLQSYISFIENS---------------------------KFFEQYEVTY--------- 566

  Fly   654 FSGDELALYQQRLNQLQKVYAELLSTSTKRLSDLDSLQHFLGQASAELQWLNEKEQV-------- 710
                          |:.|..|::...:...:.:.:::..|:.:|:|  ||.|...:|
Mouse   567 --------------QILKQTADIYVKAEGSVEEAENVMKFMSEATA--QWRNLSVEVRSVRSMLE 615

  Fly   711 EITRDW---ADKQLDLPSVHRYYENLMSELEKREMHF-----------ATILDRGEALLNQ-QHP 760
            |:..:|   .|....|.:.....|.::|:.|..:..|           ..:.|.|..|:.. ...
Mouse   616 EVISNWDRYGDTVASLQAWLEDAEKMLSQSEHAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEI 680

  Fly   761 ASKCIEAHLTALQQQWAWL--------------------LQLTLCLEVHLKHATEYHQFFGE--- 802
            .|:.::..|..|..:|..|                    :.:|..|   ...|||.|:...|
Mouse   681 VSRDLKQQLLLLNGRWRELFMEVKQYARADEMDRMKKEYIDVTTTL---FGFATEAHRKLSEPLE 742

  Fly   803 ---------IKDAEQWLAKRDEILNSKFSQ---------SDFGLDQGETLLRGMQDLREELNAFG 849
                     |:|.|. |.||..::::::..         .:...::...:|..|..|:|:|:...
Mouse   743 VSFINVKLLIQDLED-LEKRVPVMDAQYKMIAKKAHLFAKESPQEEANEMLTTMSKLKEQLSKVK 806

  Fly   850 ETVATLQRRAQTV-VPLNKRRQPVNR---------------QGPVQAICAYKQQGQLQIEKGE-- 896
            |..:.|...||.: |||.:....:..               :...|:...:||:.|..:...|
Mouse   807 ECCSPLLYEAQQLTVPLEELETQITSFYDSLGKINEILSVLEQEAQSSTLFKQKHQELLASQENC 871

  Fly   897 --TVTLLDNSGRVKWRVRTAKGQEGPIPGACLLLPPPDQEAIDAAERLKRLFDRSVALWQKKHLR 959
              ::||::...:...::.|:.....|.....|      |:.|.......:...:....| |||:.
Mouse   872 KKSLTLIEKGSQSVQKLVTSSQARKPWDHTKL------QKQIADVHHAFQSMIKKTGDW-KKHVE 929

  Fly   960 LRQNMIFATIRVVKGWDFDQFLAMGPEQRTAIRRALNDDADKLLSEGDPNDPQLRR--------- 1015
                   |..|::|.::         |.|..:.:.|....:.|..:|||.: .|||
Mouse   930 -------ANSRLMKKFE---------ESRAELEKVLRVAQEGLEEKGDPEE-LLRRHTEFFSQLD 977

  Fly  1016 ------LRREMDEVNRLFDEFEKRARAEEESK----------QASRIFTEECLAIK-----SKLE 1059
                  ..:..||:..:..|.|::...|...|          :|........:|::     :.:|
Mouse   978 QRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIAVEKDRFSAAVE 1042

  Fly  1060 DMARELDQ-IILAPLPRDLDSLEHVLEIH----SDYERRLHLLEPELKHLQETFRTIALKTPV-- 1117
            :...||:| ..|||    .:..|.:::.|    || :...||.|..|:.::|....:.::.||
Mouse  1043 ECRAELEQETKLAP----QEGSEKIIKEHRVFFSD-KGPHHLCEKRLQLIEELCGKLPVQDPVRD 1102

  Fly  1118 -----------LKKSLDNLMEL-------WKELNTQSGLHKDRLKLLEASLAGLEDN-------- 1156
                       ||.|:||...:       ||:..::.......:...:|.|..::|.
Mouse  1103 TCGACHTALKELKASIDNTYTMLVDDPDKWKDYTSRFSEFSSWVSAKKACLKKIKDEPIDTGNHD 1167

  Fly  1157 --EHVISELENELARHQDLPSTAEGLQQVFKQLNHMQDIITQQQPQMDKMNDAADQLGRMGVPTK 1219
              :|::.|:.|      |:....|.|..:..:|.::.||.::.:.|     ...|:|..:....|
Mouse  1168 EVKHMVDEIRN------DITKKGESLSWLKSRLKYLIDISSENEAQ-----KRGDELAELSSSFK 1221

  Fly  1220 VLGDLKRLHSNVERLNTRWSAVCNQLGERMRSCETAIGLMKNLQSSVQVEESWVDG--------- 1275
            .   |..|.|.||:|.:.:.. |.|..|.::|  :..||:...|.|.:..|..:|.
Mouse  1222 A---LVALLSEVEKLLSNFGE-CVQYKEIVKS--SLEGLISGPQESKEEAEMILDSKNLLEAQQL 1280

  Fly  1276 ------TTERLSA--------MPTATSA-------YELDK----LLGAAIERKPKIENVNVAGGR 1315
                  .|:.:||        |..|...       .||.|    |.|....|:.:...:.|:
Mouse  1281 LLHHQQKTKMISAKKRDLQEQMEQAQQGGQAGPGQEELRKLESTLTGLEQSRERQERRIQVS--- 1342

  Fly  1316 LIREAKIYDSKCLRFVDWLVEARP------SFSPPRRDLRPADSDPGATQYYSQRLDNLNT---- 1370
             :|:.:.:::.....|.:|.:...      |||    .|....|:...|:.:|:|.:::.|
Mouse  1343 -LRKWERFETNKETVVRYLFQTGSSHERFLSFS----SLESLSSELEQTKEFSKRTESIATQAEN 1402

  Fly  1371 ------------KNDRLLEQLSQRLK---TAIEVNGSDGLQYAESLQKPLKTFRVDFSAGSVPTG 1420
                        :|.|:|::.::.:|   |.:|....:.::..|.::.....|..:|...|:
Mouse  1403 LVKEAAELPLGPRNKRVLQRQAKSIKEQVTTLEDTLEEDIKTMEMVKSKWDHFGSNFETLSI--- 1464

  Fly  1421 DGYAARQEDLYTTTYSTT----QISSTKTTKSSTKS-VYSSDGLDAASQE----VST-------A 1469
             ....::.:|.:...|.:    |||..|.|....:| :.|..||:..:|.    |:|       |
Mouse  1465 -WILEKENELSSLEASASAADVQISQIKVTIQEIESKIDSIVGLEEEAQSFAQFVTTGESARIKA 1528

  Fly  1470 GLPQSQIQFNEIRTLKRSQQ--LGGH----------------SVLDIA-GIRDP--------RTG 1507
            .|.|.:..:.|::...|..:  :.||                ||.:.| .:.||        .|.
Mouse  1529 KLTQIRRYWEELQEHARGLEGTILGHLSQQQKFEENLRKIRQSVSEFAERLADPIKICSSAAETY 1593

  Fly  1508 RVL----TIGEAIQLRILDV----RTGEMLVGDRRITLEQAADQ---------------GLIDLQ 1549
            :||    .:.:|::.....|    .:.:..|.....|.|.||.|               .|.||.
Mouse  1594 KVLQEHMDLCQAVESLSSTVTMFSASAQKAVNRESCTQEAAALQQQYEEILHKAKEMQTALEDLL 1658

  Fly  1550 LAKQLLEPG-----------------------AGRDASGRELSLLEVIQREISEAESGY------ 1585
            ...|.||.|                       |.|.....||.|::.:|.|:....|.|
Mouse  1659 ARWQRLEKGLSPFLTWLERCEAIASSPEKDISADRGKVESELQLIQALQNEVVSQASLYSNLLQL 1723

  Fly  1586 -----------ETAEKRIKVNN------------------------------------TVTVEQT 1603
                       :.|..::::..                                    :|.::|.
Mouse  1724 KEALFSVASKEDVAVMKLQLEQLDERWGDLPQIISKRMHFLQSVLAEHKQFDELLFSFSVWIKQF 1788

  Fly  1604 SGEL--GSPENPRNIADAIT-----AGSVDTKTG--------LYRVKS-GQTISL---------- 1642
            .|||  .|..|.|:...|:|     |..::.|.|        |.:::| |:...|
Mouse  1789 LGELQRTSEINLRDHQVALTRHKDHAAEIEKKRGEITHLQGHLSQLRSLGRAQDLHPLQSKVDDC 1853

  Fly  1643 -------AEAYERG---------------------YLIRHESVTIKSNALCLSDAIAHGL----- 1674
                   ::..||.                     |.:|......||.:...||::...|
Mouse  1854 FQLFEEASQVVERRKLALAQLAEFLQSHACMSTLLYQLRQTVEATKSMSKKQSDSLKTDLHSAIQ 1918

  Fly  1675 -----------VDGAGWIAD--------------RNSGDKFRLD-SAIANQL------IDA---- 1703
                       :||....|.              |.:.|:..|: ..|.|.|      .||
Mouse  1919 DVKTLESSAISLDGTLTKAQCHLKSASPEERTSCRATTDQLSLEVERIQNLLGTKQSEADALVAL 1983

  Fly  1704 ----------------SVREVVDAKRDTKITLQEALQSGV---------LNA------------- 1730
                            .:.|.:|.:| .|:..::|||..:         ||:
Mouse  1984 KEAFREQKEELLRSIEDIEERMDRER-LKVPTRQALQHRLRVFNQLEDELNSHEHELCWLKDKAK 2047

  Fly  1731 ----KTGRYVNEVTKE----KLTFAEARNRQL------------IVKPY---------------- 1759
                |...:..||.:|    :.|:.:.| ||:            :|:.|
Mouse  2048 QIAQKDVAFAPEVDREINGLEATWDDTR-RQIHENQGQCCGLIDLVREYQSLKSTVCNVLEDASN 2111

  Fly  1760 ------TLKDICDL------------NLLDKQAQITSPMRREK--LSIMQAIEAGVLDGNLLKC- 1803
                  |:||..||            .:..||.::.|...:.|  ||.::.|.:|  |.:|:|.
Mouse  2112 VVVMRATIKDQGDLKWAFSKHETSRNEMNSKQKELDSFTSKGKHLLSELKKIHSG--DFSLVKTD 2174

  Fly  1804 ----------ITKRKGE---LVTLQEAIADGIVLPAECKYRDFMTG-ELISIPEAVERGLISSVA 1854
                      :::|..|   ::.:..:|.|.::     ..:|.:.| ...|:|:..|.  ||::
Mouse  2175 MESTLDKWLDVSERIEENMDMLRVSLSIWDDVL-----SRKDEIEGWSNSSLPKLAEN--ISNL- 2231

  Fly  1855 QRSIFDIDGFKDLRSNDYVSFNVALSRDLLRRKSTGFALETGRDSLVPLEVAVSEGLVRQEVYEM 1919
            ..|:...:..|:|.|...:.   ||..:.|..|..... |..::...|.|:...|..:||::..
Mouse  2232 NNSLRAEELLKELESEVKIK---ALKLEDLHSKINNLK-ELTKNPETPTELQFIEADLRQKLEH- 2291

  Fly  1920 FSRGIGVQNASG--KELSVFDLVYHNLIDPKTGYLLD-----PKTGETVPLDTAIERKFITPEGA 1977
             ::.| .:.|.|  |:.:.........:...|.:|::     .:..:|...:...:.|.|..|
Mouse  2292 -AKEI-TEEARGTLKDFTAQRTQVERFVKDITAWLINVEESLTRCAQTETCEGLKKAKDIRKE-- 2352

  Fly  1978 LLLSSLLNITLTTETVTRTINRYVTIRAGS----------QEPVDSVLLTFTEAVRQ-------- 2024
             |.|...:||.|.|.:.....::.::...|          :....|.|.:.|:|..|
Mouse  2353 -LQSQQNSITSTQEELNSLCRKHHSVELESLGRAMTGLIKKHEATSQLCSQTQARIQDSLEKHFS 2416

  Fly  2025 GFIDEERQLFKDPK---------TG----------NIYSVQQALNYGL----LVPDSNQTVPEPT 2066
            |.:.|.::.|...|         ||          |:..|..:|:.|.    :|....||:....
Mouse  2417 GSMKEFQEWFLGAKAAARESSNLTGDSQILEARLHNLQGVLDSLSDGQSKLDVVTQEGQTLYAHL 2481

  Fly  2067 NRKKTKSTITIVT----------KQIIPEAEPIK--------LNTQHTK---YVEKSVEIPISQE 2110
            .::...|....:|          ||.:.|.:.::        ...||.|   ::.:..|...::.
Mouse  2482 PKQIVSSIQEQITKANEEFQAFLKQCLKEKQALQDCVSELGSFEDQHRKLNLWIHEMEERLKTEN 2546

  Fly  2111 LVKPHRVVSEFIN------------------LEKSSYIEQNVTERQIMELPPGGWR--------- 2148
            |.:....:||..|                  |:|.|...|.::| :......||.|
Mouse  2547 LGESKHHISEKKNEVRKVEMFLGELLAARESLDKLSQRGQLLSE-ESHSAGKGGCRSTQLLTSYQ 2610

  Fly  2149 ----------------LK--DAIEQRLFNPDTGVFHVQGTDRLVNFEECI-NKQIIN-------- 2186
                            ||  :|:|:...:....|..||  |||...|..: ||:.:.
Mouse  2611 SLLRVTKEKLRSCQLALKEHEALEEATQSMWARVKDVQ--DRLACAESTLGNKETLEGRLSQIQD 2673

  Fly  2187 ----------NLSLSVIDPNTGDK-------------------------------ISVQSAFERD 2210
                      .|:|::   ..||:                               :..||..| .
Mouse  2674 ILLMKGEGEVKLNLAI---GKGDQALRSSNKEGQQAIQDQLEMLKKAWAEAMNSAVHAQSTLE-S 2734

  Fly  2211 ILDSYGNYTNSRKQVQGMRSAIDE----------------------SKIILETVPAT-------- 2245
            ::|.:.:|...:.|::....::|:                      ..|:.|....|
Mouse  2735 VIDQWNDYLEKKSQLEQWMESVDQRLEHPLQLQPGLKEKFSLLDHFQSIVSEAEDHTGALQQLAA 2799

  Fly  2246 --RGANQKT-------------------ILRIT--KVNNIPDVLEVSTPLKDAPPKFVEVLTCQR 2287
              |...|||                   |:.:.  |:..:.|:::......||..:|.:.|.
Mouse  2800 KSRELYQKTQDESFKEAGQEELRTQFQDIMTVAKEKMRTVEDLVKDHLMYLDAVQEFADWLH--- 2861

  Fly  2288 ELASPEPLQIAPGAIYDPSTALVIFTQTGETENIFDAARQGLVDEQLIKIVDPTTKQPI-----S 2347
              ::.|.|........|||.     ||                 ::|:||.:....:.|     |
Mouse  2862 --SAKEELHRWSDTSGDPSA-----TQ-----------------KKLLKIKELIDSREIGAGRLS 2902

  Fly  2348 VTEAIARSIYDPKTAT---ILDSEGQPV--------DLITATKLGLLSVVGAPLVAAEGALRTVR 2401
            ..|::|.::.....|:   :|:||.|.:        |.:..|:..|.|:|      :|.||....
Mouse  2903 RVESLAPAVKQNTAASGCELLNSEMQALRADWRQWEDCLFQTQSSLESLV------SEMALSEQE 2961

  Fly  2402 FVTDPRTGEQIPVEVAYER----------------GIVSRDQL----HRGRSF-----DSEPATV 2441
            |.     |:...:|.|.|:                |..|.:::    |:||..     .:||.|
Mouse  2962 FF-----GQVTQLEQALEQFCTLLKTWAQQLTLLEGKNSDEEILECWHKGREILDALQKAEPMT- 3020

  Fly  2442 EDKVVVLQRMRKVI--LKPKDALRKGIIDEETCEILENTSNFTNPKGEVV-----NITEALNTGL 2499
            ||....|..:.:..  |.|......|:|.|..|..|:.:....| |.:::     ..:......|
Mouse  3021 EDLKSQLNELCRFSRDLSPYSEKVSGLIKEYNCLCLQASKGCQN-KEQILQERFQKASRGFQQWL 3084

  Fly  2500 IDGR--RGQVID-PQN-NRVLNLRQAVEQKIIDSEQTNHILMPLAKSLSVPRLADQGLIDPQTQT 2560
            ::.:  ..:..| ||| :.|.:..|.:::.:.:||...|.|..:   |....|....|.:.:.|
Mouse  3085 VNAKITTAKCFDLPQNLSEVSSSLQKIQEFLSESENGQHKLNTM---LFKGELLSSLLTEEKAQ- 3145

  Fly  2561 IVHPESGYPLSIHEAIVCEVLDP-------HSKLHKPEKCTLEEAI-TKGIINADDSTFNYKNKT 2617
                          |:..:||..       |:.||:.|.......| .|....:.:...|:.:||
Mouse  3146 --------------AVQAKVLTAKEEWKSFHANLHQKESALENLKIQMKDFEVSAELVQNWLSKT 3196

  Fly  2618 LNITEAIEAKLFD-PSYDQQKSKVEIPPVGMIFPVAVEKSLVEPSKRVVLHPSTKKALPI--KQA 2679
            ..:.:....:|:| |:..:::.|::        .|..|....||.    ||...:||..:  .||
Mouse  3197 ERLVQESSNRLYDLPAKRREQQKLQ--------SVLEEIQCYEPQ----LHRLKEKARQLWEGQA 3249

  Fly  2680 IEENFIMSI-PYSPKPDAIEVVTAMEQDLIDVAAQTLTVPSTGERIPLRQAMENGVLVVKN---- 2739
            ..::|:..: ..|.:..|:..||..:...:|.........|.|.: .|:..|.:.|.::.:
Mouse  3250 ASKSFVHRVSQLSSQYLALSNVTKEKVSRLDRIIAEHNRFSQGVK-ELQDWMSDAVHMLDSYCLP 3313

  Fly  2740 LSDFVITQKPIPKTEIMETVRAVHTVTTKTIELMQGYVLISNNEVQNVNTGEVCSLEEAKELGIL 2804
            .||..:....:.|.|.:.:||....:..|.:.....|||
Mouse  3314 TSDKSVLDSRMLKLEALLSVRQEKEIQMKMVVTRGEYVL-------------------------- 3352

  Fly  2805 REESTTRETKAAAGESPESVGDVGTSGDQTVIVEERTQTVVVSSDTR-KQEMQ-VVSTTQSTKD- 2866
              :||:.|..||..:..::|.|:..|              ::|:..| |.::: .:|...|.:|
Mouse  3353 --QSTSLEGSAAVQQQLQAVKDMWES--------------LLSAAIRCKSQLEGALSKWTSYQDD 3401

  Fly  2867 -----TSVPSVSEIETKGSKEPSKTLQNVKDAAKLGALGVIAAPVLAGGAIVSGVKSLIKSVKSP 2926
                 :.:.||....|:..|:.::..:.:   ..||...::...||:.       .||:::::
Mouse  3402 VRQFSSWMDSVEVSLTESEKQHTELREKI---TALGKAKLLNEEVLSH-------SSLLETIE-- 3454

  Fly  2927 TEDAKSTEKPKEPQTSFIEQERRKELQP--QQVPSEVDNLLSETENFISSTTANFIANEKQQDKP 2989
            .:.|..||       .::.|...::||.  |.:..:....:::.|..:         ...|:.:.
Mouse  3455 VKRAAMTE-------HYVTQLELQDLQERHQALKEKAKEAVTKLEKLV---------RLHQEYQR 3503

  Fly  2990 DTLPQESNLPLEVESTSTLTTTTVTTITTSSTTTETGNLEPVVV-----EDVSTTVKEDKVVVKP 3049
            |....||.|..|.|.   |...:|....|::..|...:|:.:.|     :.:..:|...:..|.|
Mouse  3504 DLKAFESWLEQEQEK---LDRCSVHEGDTNAHETMLRDLQELQVRCAEGQALLNSVLHTREDVIP 3565

  Fly  3050 STVPEDKTEV------------SKITETITTVTS--NETDTVPEKISQKSASEESAKKDPVVTKD 3100
            |.:|:.:..|            .::.|....:.:  |:...:.:|..|   ::|..|:  :..|.
Mouse  3566 SGLPQAEDRVLESLRQDWQVYQHRLAEARMQLNNVVNKLRLMEQKFQQ---ADEWLKR--MEEKI 3625

  Fly  3101 TSSRPAETETSPKPVQKEPTPDPAQNTEFPESIKKDPTPEPDYKETATEAAQITPKEASPAPTNK 3165
            ......::..|.|.:|.      .|..::.|.:.   ....:.:|..|.|..|.  :.:...:..
Mouse  3626 NFRSECQSSRSDKEIQL------LQLKKWHEDLS---AHRDEVEEVGTRAQGIL--DETHISSRM 3679

  Fly  3166 NEQSAEPTSKPEPMPRTAK------KEEISEIEPPFTAPLAPFVDQLAETKITEIKTEFKEPVTS 3224
            ..|:.:.||:.:.:.....      :||:..:|.. .:.|:.:.|....|     ...||...|.
Mouse  3680 GCQATQLTSRYQALLLQVLEQIKFFEEELQCLEET-ESSLSSYSDWYGST-----HKNFKNVATK 3738

  Fly  3225 SQTITTITTTVKTVDEHPIVEEVDEVSKSEKIVDVEEPTVHQQEPIKVNETSDDSTRTEPTNEIV 3289
                               :::|||....:|:..:|......::...:.:::.:...........
Mouse  3739 -------------------IDKVDESMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAMKFLAE 3784

  Fly  3290 HEERVVTVEEPTITETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPSSPAETKEIEQT 3354
            ||...:..|..|..|.....|:.......|.|:.|......:.|...|.:.:    ||.:||..|
Mouse  3785 HEAEALRKEIHTYMEQLKNLTSTVRKECMSLEKGLHLAKEFSDKYKVLAQWM----AEYQEILCT 3845

  Fly  3355 TNDDQKKPEEIVDTEKKTTEQKPVETIPTEPISTSETTTVTLTTKTTIVDEGKLHPPSDIEQIIQ 3419
            ..:.:.   |:.:.:.:.::.|.::    :.:.:.|.:..::..|:..:.|           ::|
Mouse  3846 PEEPKM---ELYEKKAQLSKYKSLQ----QMVLSHEPSVTSVQEKSEALLE-----------LVQ 3892

  Fly  3420 PHSTSDKHQSL-VDF-----------IEQEKGTQPAEGGSNILQNVK-------------DAAKL 3459
            ..|..||.|.| .||           ...|...:..|..:..||.|:             |..::
Mouse  3893 DQSLKDKIQKLQSDFQDLCSRAKERVFSLEAKVKDHEDYNTELQEVEKWLLQMSGRLVAPDLLEM 3957

  Fly  3460 GALAIVGAPVLAGKALVDALTTEK----TLKPEHSTSQVVTETVEELPTEIITTSTATLVTKVTT 3520
            .:|..:...:...||:::.:...:    .||.:..|  ::.:..|.|..:...|..|.|
Mouse  3958 SSLETITQQLAHHKAMMEEIAGFEDRLDNLKAKGDT--LIGQCPEHLQAKQKQTVQAHL------ 4014

  Fly  3521 TTTTTTTSTSEGTPDDEALDVVKLPAELVESSVKREVPRTLAIGDAISQKLISPDECQVIVDGEQ 3585
                      :||.|  :...:...|:.|..|::.|:.:.::..|.:.|       ||..:...|
Mouse  4015 ----------QGTKD--SYSAICSTAQRVYRSLEYELQKHVSSQDTLQQ-------CQAWISAVQ 4060

  Fly  3586 ------------QSQTVSTL-----LKEEQLSPLDEV----------------------QIIDDK 3611
                        :::.|..:     |:|:..:.||.:                      |:|:.:
Mouse  4061 PDLKPSPQPPLSRAEAVKQVKHFRALQEQARTYLDLLCSMCDLSNSSVKNTAKDIQQTEQLIEQR 4125

  Fly  3612 LIVLQQVS---------------YLVDADTELTPQNL----YELNIYDPENQY-----FIDPSTG 3652
            |:..|.::               ||.|||.:|  ||:    .||.|...:|..     ||.....
Mouse  4126 LVQAQNLTQGWEEIKSLKAELWIYLQDADQQL--QNMKRRHTELEINIAQNMVMQVKDFIKQLQC 4188

  Fly  3653 QKISFHTLVFDMNVFNPETILVKNFSTGKYETLT-----------------AALERPLLDRHTGH 3700
            :::|..|:|..::.      |.||..:.:::.:|                 |..|:.|....:.|
Mouse  4189 KQVSVSTIVEKVDK------LTKNQESPEHKEITHLNDQWQDLCLQSDKLCAQREQDLQRTSSYH 4247

  Fly  3701 ----MVDPKTGKKIPFFECVDRQW--IIRANPEEQ--KPSGIENVTIDTQTGQVVLDDGRVC--S 3755
                :|:       .|.|....:|  :.|:|.|..  ....::.:.:..|.....:||.:.|  .
Mouse  4248 DHMRVVE-------AFLEKFTTEWDSLARSNAESTAIHLEALKKLALALQEEMYAIDDLKDCKQK 4305

  Fly  3756 IVEAI----------NSGKLDIQSISVRDPVSGEV-IPLRMAIELGVVDMQAGTVID-------- 3801
            ::|.:          .:..|:.:...::|.|..:: :.:....||.|:..:...:::
Mouse  4306 LIEQLGLDDRELVREQTSHLEQRWFQLQDLVKRKIQVSVTNLEELNVIQSRFQELMEWAEEQQPN 4370

  Fly  3802 -IQTLKEIPMELAFQLGFLVPGARKPI---------SLEA--AVRKGLYDPETGKLFDSESQNQV 3854
             ::.||:.|          .||..:.:         .|||  .:.|.|.......:.|.....:.
Mouse  4371 IVEALKQSP----------PPGMAQHLLMDHLAICSELEAKQVLLKSLMKDADRVMADLGLNERK 4425

  Fly  3855 DVQKSIEIGLVDPKISLIVDTVTKKEVKLDCAIEDD-----LVLPATGQIKDNKNN-------TL 3907
            .:||:  :......:|.:.|.|.::...|:.|:.:.     .|..||.||:.::..       .|
Mouse  4426 VIQKA--LSEAQKHVSCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIVFREYICL 4488

  Fly  3908 VPFDVGVQ-------QCLLKT--DNVTW------SLPELLQREYYTPSTGKVLNPVTGEEILLQQ 3957
            :|.||..|       |..|||  :.||.      .|.:.:.::......||:....|..:.:||:
Mouse  4489 LPDDVSKQVKTCKTAQASLKTYQNEVTGLCAQGRELMKGITKQEQEEVLGKLQELQTVYDTVLQK 4553

  Fly  3958 AIEMGFVELETTLVK----DVDHDKILPGKEAAKVGLLDTVRGTLSSPNISLDEAFVKGYLISTK 4018
            .... ..|||.:||.    ..|.||.....:.|.:         ::.|.|:         |::.|
Mouse  4554 CSHR-LQELEKSLVSRKHFKEDFDKACHWLKQADI---------VTFPEIN---------LMNEK 4599

  Fly  4019 KPLSLVDCLLRGLYDPSTAKFTIDDKQLDLKAAIAQKLINPEELVLLDPKTESIISITEAIAKGY 4083
            ..|                     ..|||...:|.::          .|:.|:::...:...:..
Mouse  4600 TEL---------------------HAQLDKYQSILEQ----------SPEYENLLLTLQTTGQAM 4633

  Fly  4084 LDPIEGYVINPYASTKLSLHEALENRI--------------LIPPKRKRSLPDAVYRGLYDPKTG 4134
            | |....|.:.|.|.|||......|.|              ::..|...||.:...:.|.|.: .
Mouse  4634 L-PSLNEVDHSYLSEKLSALPQQFNVIVALAKDKFYKTQEAILARKEYTSLIELTTQSLGDLE-D 4696

  Fly  4135 QF-------SNTVTREKLTTERAIRRGILDPDSTVVNVGSGQIIPFGVATETGIVDSKHGTVRDA 4192
            ||       |:.:..|.::.:::.        |.::    |:::..|.|...  ::.|
Mouse  4697 QFLKMRKMPSDLIVEESVSLQQSC--------SALL----GEVVALGEAVNE--LNQK------- 4740

  Fly  4193 DDHPIDFKEAF-DRGILVEAKKPLRLIEAVVKNVYDEVDGHFVDPKSGEKLNFAEALNTNLLDEH 4256
                   ||:| ..|...:.:|.|:|     ..:|     |.:..::.::::|.|. .|::..||
Mouse  4741 -------KESFRSTGQPWQPEKMLQL-----ATLY-----HRLKRQAEQRVSFLED-TTSVYKEH 4787

  Fly  4257 SVQIRDFKTGLYKQLNLTHAKDTGIIDAQNSKLLYNNQTMTLKHAF-----DIGILMDVNAPISI 4316
            :...|.    |..||.:...:...:    |.:.|...:.:.:.|:.     |.|||:.
Mouse  4788 AQMCRQ----LESQLEVVKREQAKV----NEETLPAEEKLKVYHSLAGSLQDSGILLK------- 4837

  Fly  4317 QRAIHQGLFDDKTGKLSDPRTGRQITLLESMRSFVVNPHLPCYFDEQTEQMYT----LSETCRNG 4377
            :.|.|   .:|.:..| ||      |..|..:|.|.:      :.|:.:||.:    |...|.:.
Mouse  4838 RVATH---LEDLSPHL-DP------TAYEKAKSQVQS------WQEELKQMTSDVGELVTECESR 4886

  Fly  4378 IINRREGVFREPGSNSFVPLGEALSLGLIVDIENAGFGLYELLSMGFYETSTRKVLHPVTNRKLN 4442
            ::...:  |:...|.|...|....:               ||......:.|.:.:...:  ||:.
Mouse  4887 MVQSID--FQTEMSRSLDWLRRVKA---------------ELSGPVCLDLSLQDIQEEI--RKIQ 4932

  Fly  4443 LNEACVEDVVSLSS----SLVKHHETGKYLRLANAIKEQLVDDSRGCYNLGNEQLDLQAARARGL 4503
            :::   |:|  |||    |.:.|.|..|:.:....|...|.........|..   |:|.|
Mouse  4933 IHQ---EEV--LSSLRIMSALSHKEQEKFTKAKELISADLEHTLAELQELDG---DVQEA----- 4984

  Fly  4504 IVSNRRLLSLELVLRQQLYRPETGKFCDPTTGEYLDLIEAIHSGFIDPATTVFKNQLTGKELPLT 4568
             :..|:....|:..|.|               .|..:.:|.:. ::|.|..:.  ||.|..|.:.
Mouse  4985 -LRTRQATLTEIYSRCQ---------------RYYQVFQAAND-WLDDAQEML--QLAGNGLDVE 5030

  Fly  4569 EAIEN---------------GDIDVSKGRV--FDPKSKSAYNYDVA--------LSRGILVTITR 4608
            .|.||               .:::..:|.|  .||..|:....::|        .|:||   |..
Mouse  5031 SAEENLRSHMEFFKTEGQFHSNMEELRGLVARLDPLIKATGKEELAQKMASLEKRSQGI---IQE 5092

  Fly  4609 PLTDRNDVVR-----------RQDSVELLNQTPVSV-VISKPREMSLEEAIRYNIIDPKTALVRD 4661
            ..|.|:.:.|           |:..:||:|.....: ..:..:..|:.||  ...:....|||..
Mouse  5093 SHTQRDLLQRCMVQWQEYQKAREGVIELMNDAEKKLSEFAVLKTSSIHEA--EEKLSKHKALVSV 5155

  Fly  4662 FDSFKFLPYSVAVERGLV-------DTTKRTLVDPKALYFAFDPTL--IVYVREPVTFDQAAESK 4717
            .|||.  ...||:|....       ||:|.||.......:.....|  :...:|.:..|...|.|
Mouse  5156 VDSFH--EKIVALEEKASQLEQTGNDTSKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWK 5218

  Fly  4718 CLDLQ----TGLLTYVPASVPGSATAAPASDDSANDSLTVIETPKVYTLKEAASAGVVDPDSALV 4778
            .|..:    |.::..:...:|||:|                         |.||
Mouse  5219 RLSAKVKETTEVINQLQGRLPGSST-------------------------EKAS----------- 5247

  Fly  4779 KDLAKAKLVRLPEAFRKGLMDANKANVLNTQTSKLCTLQEAYESGLICTPKRSFGLLEAITFNLY 4843
                ||:|:.|.|:....|||      |.:|...|..||:           |:..:|:...|
Mouse  5248 ----KAELMTLLESHDTYLMD------LESQQLTLGVLQQ-----------RALSMLQDRAF--- 5288

  Fly  4844 NPTNGCLVDPFQMHPDIIRRRKFTLAEAIGSGLVDPSSTVVRDPSTGVIVPLTAAISSGLIDATE 4908
                                                       |.|...||:..||:     |.:
Mouse  5289 -------------------------------------------PGTEEEVPILRAIT-----ALQ 5305

  Fly  4909 GRLTDANEP-KNNIDLVKAAEKGLLLPAEQRQAVFEKFNMCEENVNDLLKWVTTVEQKISSVGGP 4972
            .:..:..|. ||:..|||.       ..::|:||       |..:|.:..|   |::....:|.|
Mouse  5306 DQCLNMQEKVKNHGKLVKQ-------ELQEREAV-------ETRINSVKSW---VQETKDYLGNP 5353

  Fly  4973 REKIDELRNQINALKQIKDEIESQQRPVATCLEQIRQIVLTGGDVLSAPEVTTLENSGRELRSRV 5037
            ..:||   .|:..||::..|..|.|..:....|:.:...|....||.:.....|.....:|
Mouse  5354 TIEID---TQLEELKRLLAEATSHQESIEKIAEEQKNKYLGLYTVLPSEISLQLAEVALDL---- 5411

  Fly  5038 DRVNDRTVRLLRRLEAGRDELTKLRSELDVFSDWLQVARRTLEDKERSLSDLTRLPSQADSVREF 5102
             :::|:....::.:|.|     |..|:  .||..:|...:.|      .:.||:|.::.|
Mouse  5412 -KIHDQIQEKVQEIEEG-----KAMSQ--EFSCKIQKVTKDL------TTILTKLKAKTD----- 5457

  Fly  5103 VSDVIGHQADLRFITMAAQKFVDESKEFLAILNDFRTSLPERLPHVEPLSSAES----PIRQEVS 5163
              |::..:|:        .|.:.|.      |:...:.|.|....::..|...|    |:.:::.
Mouse  5458 --DLVHAKAE--------HKMLGEE------LDGCNSKLMELDAAIQTFSERHSQLGQPLAKKIG 5506

  Fly  5164 LVSAQYKDLL----NRVNALQDRVSGLGGRQREYQDALDKANEWLRSVHPRVSRIISEPIAGDPK 5224
            .::..::..:    ||::.|...:|    ...||.:.|:...:|:......|...|:...|
Mouse  5507 KLTELHQQTIRQAENRLSKLNQALS----HMEEYNEMLETVRKWIEKAKVLVHGNIAWNSA---- 5563

  Fly  5225 GVQDQMNEAKALHNELLSSGRLVDNAQQALDNLLRSLG-----GQLSPMEINQLELPIADLKNNY 5284
               .|:.|...||..||.....:|:..:|:...::.|.     |:|| .::.|....:.:|:...
Mouse  5564 ---SQLQEQYILHQTLLEESGEIDSDLEAMAEKVQHLANVYCTGKLS-QQVTQFGREMEELRQAI 5624

  Fly  5285 QQLLDNLGEHCKTLDKTLVQSQGVQDALDSLVGWVNQAEDKFKMNLRPASLIKERLQEQIREHKV 5349
            :..|.||.:..|.:.|...:.:.:|.||:       ||:    ..|....:.:..|:||:...:.
Mouse  5625 RVRLRNLQDAAKDMKKFEGELRNLQVALE-------QAQ----TILTSPEVGRRSLKEQLCHRQH 5678

  Fly  5350 LLADLQSHQASIDSVQVSAKHL------LASASNARIAKKVESNLNDVTVKFEKLYEKANKRGEF 5408
            ||::::|.:..:.:||:....|      :||......|.:::...:       :|...|.::...
Mouse  5679 LLSEMESLKPKMQAVQLCQSALRIPEDVVASLPLCHAALRLQEEAS-------QLQHTAIQQCNI 5736

  Fly  5409 LDDVYNRLSRYLDEISTVEQRMASLQEALDSRETSLLSTEELARRMNELSRDKDQLAPQFEDCVR 5473
            :.:...:..:|..|:..::|.:......::.:..:..:.:||..:
Mouse  5737 MQEAVVQYEQYKQEMKHLQQLIEEAHREIEDKPVATSNIQELQAQ-------------------- 5781

  Fly  5474 SGKDLISLRDVTDTGVLRDRIKALESQWRNINISIDERAKLSKQKAEQQLAYEGLKDQVLSWLAS 5538
                 |||.:     .|..:||..:.|..::|    .:.|:...||:.            :.:..
Mouse  5782 -----ISLHE-----ELAQKIKGYQEQIDSLN----SKCKMLTMKAKH------------ATMLL 5820

  Fly  5539 TEARVNGLPPVAIDLDR----------------IKQQHDELKPI------------------CKD 5569
            |...|.||.....||||                ..:.|..|.|:                  |:.
Mouse  5821 TVTEVEGLAEGTEDLDRELHPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRS 5885

  Fly  5570 YRDYAPTIDKIN-DI---------GAQYDALIRPESPARKRSTYSPIKRTSPLRRMSGDARSPSP 5624
            ....|.|...:| ||         |.|.||...|.|.|..:..|.|....|...::....||...
Mouse  5886 PSPVANTEAAVNQDIAYYQALSAEGLQTDAARIPPSAAVSQELYEPGLEPSATAKLGDLQRSWET 5950

  Fly  5625 TKGGILSPLSTGSSGFGSRRSSQDGFQ--LSELSPVQQQLSEINNRYGLIGVRLNDRQHELDNLN 5687
            .|..|.....|.......::..||..|  .:::..::.:|.|..........::.:.|.....|.
Mouse  5951 LKNVISEKQRTLYEVLERQQKYQDSLQSISTKMEAMEMKLGESLEPSRSPESQMAEHQSSPQALM 6015

  Fly  5688 EELRKQYENLKGLAQFLERIQRQLPKESVSNKDEAERCIKQARKILEDMYEKQSLLDTTKAQVKD 5752
            :|::...:.:.||       |..|.:|.|:...|::..         :....||.| |..|:...
Mouse  6016 DEVQMLQDEINGL-------QVSLAEELVAESQESDPA---------EQLALQSTL-TVLAERMS 6063

  Fly  5753 ILRRKSDVPGAEQLRQE--NDSIQEKWKNLNDICKNRIAFSEKLRDFLDTHGNLKSW-LDSKERM 5814
            .:|.|:  .|..||.:|  :|.::|:.:            .:.|:.:......|..| |::|..:
Mouse  6064 TIRMKA--AGKRQLLEEKLSDQLEEQRQ------------EQALQRYRCEADELDHWLLNTKATL 6114

  Fly  5815 LTVLG----PISSDPRMVQSQVQQVQVLREEFRTQQPQLKHFQELGHDVVDHLAGT-PDAQAVEI 5874
            ...||    |:..|.::|..|...|::.::.....|..: |.:.|   :::..|.| .:|:.:.:
Mouse  6115 DVALGTSQEPMDMDAQLVDCQNMLVEIEQKVVALSQLSV-HNENL---LLEGKAHTKEEAEQLAV 6175

  Fly  5875 KLKDILGKWDDLVGKLDDRANSLGGAADSSKEFDAAVNRLREALQNISDNLDT-----------L 5928
            ||:.:.|...:|...|.||...:.......||            :|..|..||           .
Mouse  6176 KLRLLKGSLGELQRALHDRQLDMQQGVTQEKE------------ENDVDFTDTQSPGVQEWLAQA 6228

  Fly  5929 PTDGDH--QENLRKIENLERQLEGQRPLLADVEQSAATLCNILGDPASRADVNSRVAALEKQYLA 5991
            .|...|  |.:|::.:..|::|..|:.||..|              |||.:
Mouse  6229 RTTRTHQRQSSLQQQKEFEQELAEQKSLLRSV--------------ASRGE-------------- 6265

  Fly  5992 LQKKLDTKKAETEASLRDGRHFAENCSKTLGWLGGELSNLTDRLLVSAHK-----PTLQHQIDTH 6051
               ::.|:.:..|.|               |.||.:...|:..|.::..:     .:|..:....
Mouse  6266 ---EILTQHSTAEGS---------------GGLGEKPDVLSQELGIAEDQMRVKWESLHQEFSAK 6312

  Fly  6052 EPIYREVMAREHEVIMLINKGKDLTD--------RQQDR-GVKRDLDRIQQQWEKLRREA--VDR 6105
            :.:.:.::.:|.|.::..:..:.|:.        :.||: .|...||.:.|.:.:...::  .||
Mouse  6313 QKLLQNILEQEQEQVLYSSPNRLLSGVLPFRGEAQTQDKTSVTSLLDGLSQAFGEASSQSGGTDR 6377

  Fly  6106 HTRLQTCMEHCKKYSQTSETFLAWLRTAEDKLADLTPGVLSKAKLETRLRDLQTFRSEVWKHSGE 6170
                |:.....|.|...|.| ..||...|::|...|..:  ..:.|..|.:.:....::.:.|.|
Mouse  6378 ----QSIHLEQKLYDGVSAT-STWLNDVEERLFVATAPL--PEETEACLFNQEALAKDIKEMSEE 6435

  Fly  6171 FENTKGL-GETFLSSCDIDKEPIKAELQDIRDRWERLNNDLIARAHEIENCSRRLDDFNDELRNL 6234
            .:..|.| .:.|....| :::.|:..|..:..|...|::.:..|.|:::...:::..|.::|:.|
Mouse  6436 MDKNKNLFSQAFPEDSD-NRDVIEDTLGCLLGRLSLLDSVVDQRCHQMKERLQQILRFQNDLKVL 6499

  Fly  6235 DHSLGRCEDRLAAHDALGGAAKDPKLLERVKAIR---EELTNLSKPLQSLKALAKDISAEARAAG 6296
            ..||  .:.:......|....:.| ::|:::||:   |.|.:|...:..||..|..:..|..|
Mouse  6500 FTSL--ADSKYIILQKLANVFEQP-IVEQMQAIQQAEEGLRDLEGGISELKRWADKLQVEQSA-- 6559

  Fly  6297 GDADHLTSEVDGLADRMSELQGRLDDRCGELQSAATAVSQFNEQMKSLGIDLNDLETEIEKLSPP 6361
                  ..|:..|.|...||...:..|...|.......||:::.::.| :||  |:|..||::
Mouse  6560 ------VQELSKLQDMYDELLMTVSSRRSSLHQNLALKSQYDKALQDL-VDL--LDTGQEKMT-- 6613

  Fly  6362 GREIKIVQVQIDDVGKIQTKLDRLVGRLEDAERAADVLVD--AGFAA--DT---TQTREQISTL- 6418
             .:.||:....:::.::..|.......||......::|..  .||||  :|   |....|.|.:
Mouse  6614 -GDQKIIVCSKEEIQQLLGKHKEYFQGLESHMILTEILFRKIVGFAAVKETQFHTDCMAQASAVL 6677

  Fly  6419 -----------------------RKTLGR----LDNR------VRDHED------NLHSTLK-AL 6443
                                   |:.|.|    ::|.      |.:.||      ||:..|| :|
Mouse  6678 KQAHKRGVELEYILEMWSHLDENRQELSRQLEVIENSIPSVGLVEESEDRLVERTNLYQHLKSSL 6742

  Fly  6444 REFYDHQSQTLDD---------------------------IQDVSDEFKRMK------------- 6468
            .|:.....|.|||                           ...||.|..|::
Mouse  6743 NEYQPKLYQALDDGKRLLMSVSCSELESQLNQLGEHWLSNTNKVSKELHRLETILKHWTRYQSEA 6807

  Fly  6469 ----------------------PVGSELDQIRRQQEDFRNFRERKVEPLAINVDKVNVAGRDLVR 6511
                                  .|..||:.:|.....|..| .::|:..:.....|...|..|:|
Mouse  6808 AALNHWLQCAKDRLAFWTQQSVTVPQELEMVRDHLSAFLEF-SKEVDAKSALKSSVTSTGNQLLR 6871

  Fly  6512 SAGSGVSTTAIEKDLEKLNDRWNDL-------KERMNERDRRLDVALLQSGKF--QEALAGLSKW 6567
            .  ..|.|.|:..:|.:::.:|.||       :|::::         ||..|.  :.|::.:..|
Mouse  6872 L--KKVDTAALRAELSRMDSQWTDLLTGIPVVQEKLHQ---------LQMDKLPSRHAISEVMSW 6925

  Fly  6568 LSDTEEMVANQKPP---SSDYKVVKAQLQEQKFLKKMLLDRQNSMGSLANLGKEVAN---HCEPG 6626
            :|..|.::...:..   :..||.:...||:.|..|..|..:|.:...:.....::::   ..:..
Mouse  6926 ISLMESVILKDEEDIRNAIGYKAIHEYLQKYKGFKIDLNCKQLTADFVNQSVLQISSQDVESKRS 6990

  Fly  6627 ERASIEKQLNDLMKRFDALTDGAEQRELDLEEAMEVAKRFHDKISPLELWLDNTERSVKAMELIP 6691
            ::....:||..:.|.:..|.....::...||..:|....:.:.:..|:.|..|.||.:|...|:
Mouse  6991 DKTDFAEQLGAMNKSWQLLQGRVGEKIQMLEGLLESWSEYENSVQSLKAWFANQERKLKEQHLL- 7054

  Fly  6692 TDEEKIQQRIREHDRLHDEILGKKPDFSDLADVTAQLMHLVSDEEAVNLGEKVRGVTERYTGLVD 6756
            .|...::..:::...|.|.|..|:.:...:......|:.        |..|:|.|
Mouse  7055 GDRNSVENALKDCQELEDLIKAKEKEVEKIEQNGLALIQ--------NKREEVSG---------- 7101

  Fly  6757 ASDNIGALLAESRQGLRHLVLSYQDLVAWMESMEAELKRFKSVPVYAEKLLEQMDHLLELNENIA 6821
               ::.:.|.|.||             .|: |::..:::.|   :.....|.|..:.....:.|.
Mouse  7102 ---SVMSTLQELRQ-------------TWI-SLDRTVEQLK---IQLTSALGQWSNHKAACDEIN 7146

  Fly  6822 GHASNVESTVESGAELMKHISNDEAIQLKDKLDSLQRRYGDLTNRGGDLLKSAQNALPLVQQFHE 6886
            ||......:: |...|:  ..:.||:|:  ::|:||..:.:|..:.|.|           |:|..
Mouse  7147 GHLMEARYSL-SRFRLL--TGSSEAVQV--QVDNLQNLHDELEKQEGGL-----------QKFGS 7195

  Fly  6887 AHNRLVEWMQSAEAALAPSEPRQADVLRLEGELADMRPILDSINQVGPQLCQLSPGEGAATIESI 6951
            ..|:|                           |.:..|.:                  |.|:.|.
Mouse  7196 ITNQL---------------------------LKECHPPV------------------AETLSST 7215

  Fly  6952 VTRDNRRFDSIVEQIQRKAERLHLSN--------------------QRAKEVTG---------DI 6987
            :...|.|:::::|:|   ||:||.|.                    ||.:|.|.         ||
Mouse  7216 LQEVNMRWNNLLEEI---AEQLHSSKALLQLWQRYKDYSKQCASAIQRQEEQTSVLLKAATNKDI 7277

  Fly  6988 --DELLEWFREMDTTLREADLPAMEPKLVRAQLQEHRSINDDISSQKGRVRDVTAASKKVLRESP 7050
              ||:.:|.::.:..|:..:           .:::...|..::..|.|:..||:||:      :.
Mouse  7278 ADDEVTKWIQDCNDLLKGLE-----------TVKDSLFILRELGEQLGQQVDVSAAA------AI 7325

  Fly  7051 QSENTATLREKLDDLKEIVDTVAQLC-SERLGILEQALPLS-----------EHFADSHQGLTAW 7103
            |.|                    ||| |:|||.|||||...           |.||.|.:.|..|
Mouse  7326 QCE--------------------QLCFSQRLGALEQALCKQQAVLQAGVVDYETFAKSLEALEVW 7370

  Fly  7104 LDDMEQQISRLSMPALRPDQITLQQDKNE---RLLQ--SIAEHKPLLDKLNKTGEALGALVADDD 7163
            :.:.| .|.:...|....|..|:|:...|   ::|:  |:|   |.||:||:.|..|.  :.|.:
Mouse  7371 MVEAE-GILQGQDPTHSSDLSTIQERMEELKGQMLKFSSLA---PDLDRLNELGYRLP--LNDKE 7429

  Fly  7164 GAKINEILDTDNARYAALRLELRERQQALESALQESSQFSDKLEGMLRALANTVDQVNQLDPLSA 7228
            ..::..:    |..::....:..||...|:|.|.:...|.:|.|..:..|..|
Mouse  7430 IKRMQNL----NRHWSLTSSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQT------------ 7478

  Fly  7229 LPQKIREQIEDNDALMDDLDKRQDAFSAV----QRAANDVIAKAGNKADPAVRD----IKAKLEK 7285
             ..|:..:|..|...:.:..:..:.|.|.    |:..:.:|....|..:....|    ...||..
Mouse  7479 -EHKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIVDGQNLLEQGQVDDREEFSLKLTL 7542

  Fly  7286 LNNLWNDVQNATKKRGSSLDDILSVAEPFWKQLNSVMKTLKDLEETLSCQEPPAAQPQDIKKQQV 7350
            |:|.|..|....::|...:|..:...:.:.:....:.|.|.::...      |.:...:|   .|
Mouse  7543 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLAEVSHL------PLSGLGNI---PV 7598

  Fly  7351 ALQEIRHEIDQTK-PEVEQVRRHGSNLMNM-CGEPDKPEVKKHIEDLDNAWDNITALYAKREENL 7413
            .||::|...|:.: .|...:|:.||.::.: .|       |:.:...|:..:  .||.|:    |
Mouse  7599 PLQQVRMLFDEVQFKEKVFLRQQGSYILTVEAG-------KQLLLSADSGAE--AALQAE----L 7650

  Fly  7414 IDAME--KAMEFH-ETLQNLLKFLTKAEDKFAHLGAVGSDIDAVKRQIEQLKSFKDEV-----DP 7470
            .|..|  ||...| |..:..|.||.|..:|...         .:...:|:|:.||..:     |.
Mouse  7651 TDIQEKWKAASMHLEEQKKKLAFLLKDWEKCER---------GIANSLEKLRMFKKRLSQPLPDH 7706

  Fly  7471 H---------MVEVE-ALNRQAVELTE----------RTSPEQAASIREPLSVVNRRWEALLRGM 7515
            |         ..|:| |:.|...:|||          ..|.|..:.::|.:.::.|:||.|...:
Mouse  7707 HEELHAEQMRCKELENAVGRWTDDLTELMLVRDALAVYLSAEDISMLKERVELLQRQWEELCHQV 7771

  Fly  7516 VERQKQLEHALLHLGQFQHALNELLVWINKTDSTLDQLKPIPGDPQLLEVELAKLKVLANDIQ-- 7578
            ..|::|:...|.....|.....||..|:.:.:|.:.|...|     |:|..:.|||   .|.|
Mouse  7772 SLRRQQVSERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLK---KDYQEE 7828

  Fly  7579 ---AHQNSVDTLNDAGRQLIETEKGSVEASTTQEKLRKLNNEWKQLLQKASDRQHELEEALREAH 7640
               |.:|.:. |.:.|.:|.:....| :||..|.||.::.:.|:.||...:.|..:|:|.|....
Mouse  7829 IAVAQENKIQ-LQEMGERLAKASHES-KASEIQYKLSRVKDRWQHLLDLMAARVKKLKETLVAVQ 7891

  Fly  7641 GYIAEVQDILGWLGDVDAVIGASKPVGGLPETATEQLERFMEVYNELDENRPKVETIQAQGQEYI 7705
            .....:..:..||..:::.:  :||: ......:|:::|.:....||..:..|..|    |...:
Mouse  7892 QLDKNMGSLRTWLAHMESEL--AKPI-VYDSCNSEEIQRKLNEQQELQRDIEKHST----GVASV 7949

  Fly  7706 KRQNQM----------KVSSSNLQHTLRTLKQRWDAVVSRASDKKIKLEIALKEATEFHDTLQAF 7760
            ....::          .....::|...|.|.:||..:.:.:.::::|:|...:...:|.|....|
Mouse  7950 LNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRF 8014

  Fly  7761 VEWLTQAEKLLSNAEPVSR-VLETI-QAQMEEHKVLQKDVSTHREAMLLLDKKGTHLKYFSQKQD 7823
            .:||..:|:  :.|.|.|. ||.|: :.::::.:..|:.|......:.|::|:...|...::...
Mouse  8015 EDWLEVSER--TAAFPSSSGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDS 8077

  Fly  7824 VILIKNLLVSVQHRWERVVSKAAERTRALDHGYKEAREFNDAWSGMMQYLQETEQVLDQIIEEAT 7888
            ...::.::.....||:.:..:.....|.|.|...:..||..|...::.:|.|.:..|.. ||..:
Mouse  8078 ACSLRQMVHGGNQRWDDLQKRVTSILRRLKHFISQREEFETARDSILVWLTEMDLQLTN-IEHFS 8141

  Fly  7889 ASKEPQKIKKYIGKLKETHRQLGAKQSVYDGTMRTGKNLLERAPKGDRPVLDKMLIELK----EQ 7949
            ......|||    :||...:::....:..:..:..|:.|:|::...|..|:::.|.||:    |.
Mouse  8142 ECDVQAKIK----QLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEV 8202

  Fly  7950 WTRV--WSKSI------------DRQRKLEEALLLSGQFSDALGELLDWLKKAKSRLNENGP-VH 7999
            :.||  :.|.:            ||:..||::..||.         |.|...:...:....| .:
Mouse  8203 FGRVERYHKKLIRLPLPDDHDLSDRELDLEDSTALSD---------LRWQDPSADGMPSPQPSSN 8258

  Fly  8000 GDLETVQGLCEHHKHIEQDLQKRAAQMQGV-LKTGRDLERSGNNPEVGRQLDEMQSIWEEVKSAV 8063
            ..|...|.|     ..|:..:...|.:..: |:...|.:.|.:.....|.|.......||.|...
Mouse  8259 PSLSLPQPL-----RSERSGRDTPASVDSIPLEWDHDYDLSRDLESASRTLPSEDEEGEEDKEFY 8318

  Fly  8064 AKRGERLQVALV--------------------DAEKLNARVQALFDWLDHAEHKLRYAKNAPDDE 8108
            .:....|...::                    |...|.::::.|...||.:..:::...|....:
Mouse  8319 LRGAVGLSDVVIPENPEAYVKLTENAIRNTSGDPSSLESQMRQLDKALDDSRFQIQQTANILRSK 8383

  Fly  8109 KVSREMMDI-HMDFMKDL--------RVREREKTETFEYAEDIINKAYPDAIPI--IKNWLSIIQ 8162
            ..:...:|. :..:||.|        .||..|    .:.||:   :::|..:.:  .:...:.:.
Mouse  8384 TPTGPDLDTSYKGYMKLLGECSGSIDSVRRLE----HKLAEE---ESFPGFVNLNSTETQTAGVI 8441

  Fly  8163 QRWEEVRQWAINRESKLEQHLQSLKDLDDTIEELLAWLSGLEGTLLNLKHEQLPDEIPPVEKLIE 8227
            .|||.::..|:::|.:::|:||..:..:..:..:.|||...|..|..|:|..|..:|..:|..|:
Mouse  8442 DRWELLQAQAMSKELRMKQNLQKWQQFNSDLNNIWAWLGETEEELDRLQHLALSTDIHTIESHIK 8506

  Fly  8228 DHKEFMENTARRQNEVDRACKPRQLPPGARKPSRSGKTPVFKGSRDQGLNARK---------GSR 8283
            ..||.       |..||.                                 ||         .|.
Mouse  8507 KLKEL-------QKAVDH---------------------------------RKAIILSINLCSSE 8531

  Fly  8284 IT--PTRDTPD-RDRLPHYGPRFSPSTSGPELEFRSPRAKLLWTKWRDVWMLSWERQRLLNDHLL 8345
            .|  .::::.| :|||.....|:.             |...|...||.          ||.|.|:
Mouse  8532 FTQADSKESHDLQDRLSQMNGRWD-------------RVCSLLEDWRG----------LLQDALM 8573

  Fly  8346 YLKDVERARNFSWDDWRKRFLKYMNHKKSRLTDLFRKMDKDNNGMIPRDVFID---------GIL 8401
            ..::...                |:|   .|..:...:|:..|.::|.|..:|         .::
Mouse  8574 QCQEFHE----------------MSH---ALLLMLENIDRRKNEIVPIDSTLDPETLQDHHKQLM 8619

  Fly  8402 NTKFDTSGLEMKAVADLFDRNGEGLIDWQEFIAALRPDWQERKPANDSDKIHDEVKRLVMLCTCR 8466
            ..|.:....::: ||.|.|.:.:.|::      |...|..|.|     :|:|....||.:|
Mouse  8620 QIKQELLKSQLR-VASLQDMSRQLLVN------AEGSDCLEAK-----EKVHVIGNRLKLL---- 8668

  Fly  8467 QKFRVFQVGEGKYRFGDSQKLRLVRILRSTVMVRVGGGWVALDEFLQKNDPCRAKGRTNIELREQ 8531
                   :.|..:...|.:||     |..:...:....|.:.||.
Mouse  8669 -------LKEVSHHIKDLEKL-----LDMSSSQQDLSSWSSADEL-------------------- 8701

  Fly  8532 FILADGVSQSMAAFTPRRSTPNAAATASSSPHAHNGGSSNLPPYMSGQGPIIKVRERSVRSIPMS 8596
                 ..|.|::. |..|||||    ...||.    |..:|    |..||.:        |.|.|
Mouse  8702 -----DTSGSVSP-TSGRSTPN----RQKSPR----GKCSL----SQPGPSV--------SSPKS 8740

  Fly  8597 RPSRSSLSASTPDSLSDNEG 8616
            |.:|....:|..|...:..|
Mouse  8741 RSTRDGSDSSRSDPRPERVG 8760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401	67/242 (28%)
		CH	223..327	CDD:306753	45/103 (44%)
		SPEC	471..689	CDD:238103	34/218 (16%)
		SPEC	690..866	CDD:238103	47/240 (20%)
		SH3	885..922	CDD:327375	8/40 (20%)
		SPEC	1047..1250	CDD:238103	51/242 (21%)
		SPEC	1153..1390	CDD:238103	60/305 (20%)
		PLEC	<1498..1526	CDD:197605	8/44 (18%)
		Plectin	1949..1981	CDD:307019	7/36 (19%)
		DNA_pol3_delta2	<2711..3178	CDD:331068	85/499 (17%)
		DUF4775	3026..3357	CDD:330579	57/355 (16%)
		SMC_N	<4904..5566	CDD:330553	129/697 (19%)
		SPEC	5304..5513	CDD:238103	33/214 (15%)
		SPEC	<5658..5787	CDD:321951	25/130 (19%)
		SPEC	5793..6007	CDD:238103	46/232 (20%)
		SPEC	6011..6220	CDD:238103	41/225 (18%)
		SPEC	6118..6330	CDD:238103	47/215 (22%)
		PRK09039	<6279..6441	CDD:332967	44/208 (21%)
		SPEC	6443..6660	CDD:238103	50/293 (17%)
		SPEC	6663..6878	CDD:238103	40/214 (19%)
		SPEC	6880..7087	CDD:238103	47/238 (20%)
		SPEC	6986..7196	CDD:238103	56/228 (25%)
		SPEC	7196..7417	CDD:238103	44/230 (19%)
		SPEC	7314..7526	CDD:238103	53/241 (22%)
		SPEC	7528..7747	CDD:238103	50/233 (21%)
		SPEC	7749..7968	CDD:238103	51/238 (21%)
		SPEC	7973..8181	CDD:238103	38/240 (16%)
		EF-hand_7	8373..8437	CDD:316058	13/72 (18%)
		GAS2	8450..8522	CDD:128539	13/71 (18%)
		Herpes_ICP4_C	8550..>8795	CDD:332854	19/67 (28%)
Syne1	XP_036011805.1	CH_SYNE1_rpt1	24..143	CDD:409090	14/71 (20%)
		CH_SYNE1_rpt2	182..290	CDD:409092	45/107 (42%)
		SMC_prok_B	<753..>1006	CDD:274008	50/277 (18%)
		SMC_prok_B	<1167..2008	CDD:274008	156/869 (18%)
		SPEC	1983..2200	CDD:413338	37/220 (17%)
		SMC_prok_B	2281..3120	CDD:274008	157/891 (18%)
		Smc	2879..3662	CDD:224117	172/935 (18%)
		SbcC	3815..4377	CDD:223496	104/625 (17%)
		SPEC	3821..4036	CDD:238103	43/256 (17%)
		SPEC	4349..4565	CDD:413338	46/228 (20%)
		SPEC	4490..4666	CDD:413338	46/226 (20%)
		SMC_prok_B	4967..5802	CDD:274008	205/1095 (19%)
		EnvC	6078..>6336	CDD:227278	58/331 (18%)
		SMC_prok_B	6532..7402	CDD:274008	202/1036 (19%)
		SPEC	7027..7235	CDD:238103	55/310 (18%)
		SPEC	7164..7352	CDD:413338	58/285 (20%)
		SPEC	7356..7558	CDD:238103	50/224 (22%)
		SPEC	7460..7671	CDD:238103	48/245 (20%)
		SPEC	7784..7999	CDD:238103	49/231 (21%)
		SPEC	8003..8213	CDD:238103	47/216 (22%)
		SPEC	8464..8683	CDD:238103	60/328 (18%)
		KASH	8763..8819	CDD:402255
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810