DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and VIT

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_444506.2	Gene:	VIT / 5212	HGNCID:	12697	Length:	693	Species:	Homo sapiens

Alignment Length:	737	Identity:	132/737 - (17%)
Similarity:	235/737 - (31%)	Gaps:	227/737 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  3365 IVDTEKKTTEQKPVETIPTEPISTSETTTVTLTTKTTI------VDEGKLHPPSDIEQIIQ-PHS 3422
            :|.|.|.:..:..:..:.|...|..||.......|.|:      |..||:..|   |.|:: |..
Human     4 VVLTMKASVIEMFLVLLVTGVHSNKETAKKIKRPKFTVPQINCDVKAGKIIDP---EFIVKCPAG 65

  Fly  3423 TSDK---------------------HQSLVD------FIEQEKGTQPAEGG-SNILQNVKDAAKL 3459
            ..|.                     |..::|      .:.:..|....:|. ||.:|::......
Human    66 CQDPKYHVYGTDVYASYSSVCGAAVHSGVLDNSGGKILVRKVAGQSGYKGSYSNGVQSLSLPRWR 130

  Fly  3460 GALAIVGAPVLAGKALVDALTTEKTLKPEHSTSQVVTETVEELPTEIITTSTATLVTKVTTTTTT 3524
            .:..::.:....|.....|||...:..|.....: .|:..:..|....|....||: ::...|..
Human   131 ESFIVLESKPKKGVTYPSALTYSSSKSPAAQAGE-TTKAYQRPPIPGTTAQPVTLM-QLLAVTVA 193

  Fly  3525 TTTSTSEGTPDDEALDVVKLP---------AEL----------------VESSVKREVPRTLAIG 3564
            ..|.|:...|...|.....:|         .|:                .:..::|:.|     .
Human   194 VATPTTLPRPSPSAASTTSIPRPQSVGHRSQEMDLWSTATYTSSQNRPRADPGIQRQDP-----S 253

  Fly  3565 DAISQKLISPDECQVIVDGEQQSQTVSTLLKEEQLSP--------LDEVQIIDDKLIVLQQVSYL 3621
            .|..||.:..|    :..||..|....::|.:|.|.|        |:.|.:.|....:  .:|:|
Human   254 GAAFQKPVGAD----VSLGEMDSWKPGSVLLDEGLVPKEELSTQSLEPVSLGDPNCKI--DLSFL 312

  Fly  3622 VDADT-----------ELTPQNLYELNIYDPEN------QYFIDPSTGQKISFHTLVFDM----- 3664
            :|..|           :|.......|:| .|..      ||..:|:|...:..||...|:
Human   313 IDGSTSIGKRRFRIQKQLLADVAQALDI-GPAGPLMGVVQYGDNPATHFNLKTHTNSRDLKTAIE 376

  Fly  3665 --------------------NVF-----------NPETILVKNFSTGKYETLTAALERPLLDRHT 3698
                                |.|           |...::|..:.|.|.|      |...|.|.:
Human   377 KITQRGGLSNVGRAISFVTKNFFSKANGNRSGAPNVVVVMVDGWPTDKVE------EASRLARES 435

  Fly  3699 GHMVDPKTGKKIPFFECV------DRQWIIR---ANPEEQKPSGIENVTIDT-----QTGQVVLD 3749
            |..:         ||..:      ::|:::.   ||....:.:|..::.:.:     :|.|.::.
Human   436 GINI---------FFITIEGAAENEKQYVVEPNFANKAVCRTNGFYSLHVQSWFGLHKTLQPLVK 491

  Fly  3750 DGRVCSIVEAINSGKLDIQSISVRDPVSGE--------------VIPLRMAIELGVVDMQAGTVI 3800
              |||. .:.:...|..:.|..:...:.|.              |..|....|:...|.:.|.|
Human   492 --RVCD-TDRLACSKTCLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEISDTDTRIGAV- 552

  Fly  3801 DIQTLKEIPMELAFQLGFLVPGARKPISLEAAVRKGLYDPETG----------KLFDSESQNQVD 3855
              |...|..:|..|.     ..:.||..|.|..|.|.:...|.          :||.....|
Human   553 --QYTYEQRLEFGFD-----KYSSKPDILNAIKRVGYWSGGTSTGAAINFALEQLFKKSKPN--- 607

  Fly  3856 VQKSIEIGLVD---------PKISLIVDTVTKKEVKLDCAIEDDLVLPATGQIKDNKNNTLVPFD 3911
             ::.:.|.:.|         |.::..:..|....:.:..|.:::|.:.||...:|:.      |.
Human   608 -KRKLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIATHPARDHS------FF 665

  Fly  3912 VGVQQCLLKTDNVTWSLPELLQ 3933
            |.      :.||:...:|.::|
Human   666 VD------EFDNLHQYVPRIIQ 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068
		DUF4775	3026..3357	CDD:330579
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
VIT	NP_444506.2	LCCL	44..133	CDD:281766	15/91 (16%)
		vWFA	308..471	CDD:294047	31/178 (17%)
		vWA_collagen	509..669	CDD:238749	32/183 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900