DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and NEFM

DIOPT Version :9

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:NP_005373.2 Gene:NEFM / 4741 HGNCID:7734 Length:916 Species:Homo sapiens


Alignment Length:1144 Identity:218/1144 - (19%)
Similarity:391/1144 - (34%) Gaps:386/1144 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  2527 IDSEQTNHILMP-LAKSLSVPRLADQGLIDPQTQTIVHPESG----YPLS-IHEAIVCEVLDPH- 2584
            :.|.....:|.| ||.|.::...|:..|...|:.::::..||    |.|| .:|....:.|:.. 
Human    48 VSSSYKRSMLAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRF 112

  Fly  2585 ----SKLHKPEKCTLEEAITKGIINADDSTFNYKNKTLNITEAIEAKLFDPSYDQ---------- 2635
                .|:|..|:...|       |.|:......|       :|..|:|.| :|||          
Human   113 AGYIEKVHYLEQQNKE-------IEAEIQALRQK-------QASHAQLGD-AYDQEIRELRATLE 162

  Fly  2636 ----QKSKVEIPPVGMIFPVAVEKSLVEPSKRVVLHPSTKKAL-PIKQAIEENFIMSIPYSPKPD 2695
                :|::|::....:...:...|...|...|  |...|:.|: .:::.|||..::.:....|..
Human   163 MVNHEKAQVQLDSDHLEEDIHRLKERFEEEAR--LRDDTEAAIRALRKDIEEASLVKVELDKKVQ 225

  Fly  2696 AIEVVTAM-----EQDLIDVAAQTLTVPSTGERIPLRQAMENGVLVVKNLSDFVITQKPIPKTEI 2755
            :::...|.     |:::.|:.||.             ||           |...:.:|...||:|
Human   226 SLQDEVAFLRSNHEEEVADLLAQI-------------QA-----------SHITVERKDYLKTDI 266

  Fly  2756 METVRAVHTVTTKTIELMQGYVLISNNEVQNVNTGE------VCSLEEAKELGILREESTTRETK 2814
            ...::.:.:             .:.::..||::..|      ...|.||.|           :.|
Human   267 STALKEIRS-------------QLESHSDQNMHQAEEWFKCRYAKLTEAAE-----------QNK 307

  Fly  2815 AAAGESPESVGDVGTSGDQTVIVEERTQTVVVSSDTRKQEMQVVSTTQSTKDTSVPSVSEIETKG 2879
            .|...:.|.:.:.                        ::::|                       
Human   308 EAIRSAKEEIAEY------------------------RRQLQ----------------------- 325

  Fly  2880 SKEPSKTLQNVKDAAKLGALGVIAAPVLAGGAIVSGVKSLIKSVKSPTEDAKSTEKPKEPQTSFI 2944
                ||:::                                      .|..:.|::..|.|.|.|
Human   326 ----SKSIE--------------------------------------LESVRGTKESLERQLSDI 348

  Fly  2945 EQERRKELQPQQVPSEVDNLLSETENFISSTTANFIANEKQQDKPDTLPQESNLPLEVESTSTLT 3009
            |:....:|      |...:.:.:.||.:..|......:.::..  |.|..:..|.:|:.:...|.
Human   349 EERHNHDL------SSYQDTIQQLENELRGTKWEMARHLREYQ--DLLNVKMALDIEIAAYRKLL 405

  Fly  3010 TTTVTTITTSSTTTETGNL---EPVVVEDVSTTVKEDKV--------------VVKPSTVPEDKT 3057
            ....|..:|.:.:. ||.|   .|.:.  :|:.:::.||              :::.:.|.::|:
Human   406 EGEETRFSTFAGSI-TGPLYTHRPPIT--ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKS 467

  Fly  3058 EVSKITETIT-----TVTSNETDTVPEKISQKSASEE--SAKKDPVVTKDTSSRPAETETSPKPV 3115
            |:.:....||     ::...:.:...||..:..|.||  :|||.||  |.|:....|.|.     
Human   468 EMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV--KATAPEVKEEEG----- 525

  Fly  3116 QKEPTPDPAQNTEFPESIKKDPT-------------PEPDYKETATEAAQITPKEASPAPTNKNE 3167
            :||......:..|..|..|.|..             .|.:.:|..|| |:...:||......|.|
Human   526 EKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE-AEAEGEEAEAKEEKKVE 589

  Fly  3168 QSAEPTSKPEPMPRTAKKEEISEIEPPFTAPLAPFVDQLAETKI--TEIKTEFKEPVTSSQTITT 3230
            :.:|..:..|.:...||.|:..:.:.|  .|.:| |::..::.:  :.::.:.|.||..|     
Human   590 EKSEEVATKEELVADAKVEKPEKAKSP--VPKSP-VEEKGKSPVPKSPVEEKGKSPVPKS----- 646

  Fly  3231 ITTTVKTVDEHPI----VEEVDE--VSKSEKIVDVEEPTVHQQEPIKVNETSDDSTRTEPTNEIV 3289
               .|:...:.|:    |||..:  ||||    .|||..   :.|:..:...:..::.|      
Human   647 ---PVEEKGKSPVPKSPVEEKGKSPVSKS----PVEEKA---KSPVPKSPVEEAKSKAE------ 695

  Fly  3290 HEERVVTVEEPTITETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPSSPAETKEIEQT 3354
                                       ....|:  .:|....|||.|..|.|     |.||    
Human   696 ---------------------------VGKGEQ--KEEEEKEVKEAPKEEKV-----EKKE---- 722

  Fly  3355 TNDDQKKPEEIVDTEKKTTEQKPVETIPTEPISTSETTTVTLTTKTTIVDEGKLHPPSDIEQIIQ 3419
                 :||:::  .|||..|....|....|.::.:::..|.|..:|.  :|||     .::|   
Human   723 -----EKPKDV--PEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK--EEGK-----PLQQ--- 770

  Fly  3420 PHSTSDKHQSLVDFIEQEKGTQPAEGGSNILQNVKDAAKLGA----LAIVGAPVLAGKALVDALT 3480
                           |:||.....||||.  :...|....|:    :|:.|.  :.||..|:..|
Human   771 ---------------EKEKEKAGGEGGSE--EEGSDKGAKGSRKEDIAVNGE--VEGKEEVEQET 816

  Fly  3481 TEK---------------TLKP--------EHSTSQVVTETVEELPTEIITTSTATLVTKVTTTT 3522
            .||               .|.|        :.....|||:|||:     ||:......||..|.:
Human   817 KEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEK-----ITSEGGDGATKYITKS 876

  Fly  3523 TTTTTSTSEGTPD-DEALDVVKLPAELVESSVKREVPRT 3560
            .|.|....|.... :|.|...|...::...::.:||.::
Human   877 VTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQS 915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401
CH 223..327 CDD:306753
SPEC 471..689 CDD:238103
SPEC 690..866 CDD:238103
SH3 885..922 CDD:327375
SPEC 1047..1250 CDD:238103
SPEC 1153..1390 CDD:238103
PLEC <1498..1526 CDD:197605
Plectin 1949..1981 CDD:307019
DNA_pol3_delta2 <2711..3178 CDD:331068 83/509 (16%)
DUF4775 3026..3357 CDD:330579 78/375 (21%)
SMC_N <4904..5566 CDD:330553
SPEC 5304..5513 CDD:238103
SPEC <5658..5787 CDD:321951
SPEC 5793..6007 CDD:238103
SPEC 6011..6220 CDD:238103
SPEC 6118..6330 CDD:238103
PRK09039 <6279..6441 CDD:332967
SPEC 6443..6660 CDD:238103
SPEC 6663..6878 CDD:238103
SPEC 6880..7087 CDD:238103
SPEC 6986..7196 CDD:238103
SPEC 7196..7417 CDD:238103
SPEC 7314..7526 CDD:238103
SPEC 7528..7747 CDD:238103
SPEC 7749..7968 CDD:238103
SPEC 7973..8181 CDD:238103
EF-hand_7 8373..8437 CDD:316058
GAS2 8450..8522 CDD:128539
Herpes_ICP4_C 8550..>8795 CDD:332854
NEFMNP_005373.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 0/2 (0%)
Head 2..104 15/55 (27%)
Filament_head 10..78 CDD:282575 8/29 (28%)
Filament 100..411 CDD:278467 70/472 (15%)
Coil 1A 105..136 7/37 (19%)
Linker 1 137..149 5/19 (26%)
Coil 1B 150..248 18/99 (18%)
Linker 12 249..265 5/39 (13%)
Coil 2A 266..287 3/33 (9%)
Linker 2 288..291 1/2 (50%)
Coil 2B 292..412 28/227 (12%)
Tail 413..916 133/617 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..851 101/471 (21%)
6 X 13 AA approximate tandem repeats of K-S-P-V-[PS]-K-S-P-V-E-E-[KA]-[GAK] 614..691 21/94 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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