DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and MUC6

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_005952.2	Gene:	MUC6 / 4588	HGNCID:	7517	Length:	2439	Species:	Homo sapiens

Alignment Length:	1564	Identity:	278/1564 - (17%)
Similarity:	432/1564 - (27%)	Gaps:	559/1564 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  2292 PEPLQIAPGAIYDPSTALVIFTQTGETENIFDAARQGLVDEQ---LIKIVDPTTKQPISVTEAIA 2353
            |...|..||:               ..|..::.::....|.:   .:..:.|||.||
Human  1163 PSQPQSVPGS---------------NIEGCYNCSQDEYFDHEEGVCVPCMPPTTPQP-------- 1204

  Fly  2354 RSIYDPKTATILDSEGQPVDLI----TATKLGLLSVVG--------------APLV--------- 2391
                 |.|..:..:..:|..:.    |:|.:||||..|              .||:
Human  1205 -----PTTPQLPTTGSRPTQVWPMTGTSTTIGLLSSTGPSPSSNHTPASPTQTPLLPATLTSSKP 1264

  Fly  2392 -AAEGALRTVRFVTDPRTGEQIPVEVAYERGIVSRDQL----HRGRSFDSEPATVEDKVVVLQRM 2451
             |:.|..........|:....:| ..|..|...::..:    .|..:..:.|||. .......|.
Human  1265 TASSGEPPRPTTAVTPQATSGLP-PTATLRSTATKPTVTQATTRATASTASPATT-STAQSTTRT 1327

  Fly  2452 RKVILKPKDALRKGIIDEETCEILENT--SNFTNPKGEVVNITEALNTGLIDGRRGQVIDPQNNR 2514
            ...:..|..:.....:.:.|.:.|..|  :..|.|:.     |.|..||....:.||...|....
Human  1328 TMTLPTPATSGTSPTLPKSTNQELPGTTATQTTGPRP-----TPASTTGPTTPQPGQPTRPTATE 1387

  Fly  2515 VLNLRQAVEQKIIDSEQTNHILMPLAKSLSVPRLADQGLIDPQTQTIVHPESGYPLSIHEAIVCE 2579
            ....|...|.....:..|.|  .|......||...      |.|.|..|..:.||
Human  1388 TTQTRTTTEYTTPQTPHTTH--SPPTAGSPVPSTG------PVTATSFHATTTYP---------- 1434

  Fly  2580 VLDPHSKLHKPEKCTLEEAITKGIINADDSTFNYKNKTLNITEAIEAKLFDPSYDQQKSKVEIPP 2644
                                                              .||:.:......:||
Human  1435 --------------------------------------------------TPSHPETTLPTHVPP 1449

  Fly  2645 VGMIFPVAVEKSLVEPSKRVVLHPSTKKALPIKQAIEENFIMSIPYSPKPDAIEVVTAMEQDLID 2709
                    ...|||.||...|:.|:..:                              |.....:
Human  1450 --------FSTSLVTPSTHTVITPTHAQ------------------------------MATSASN 1476

  Fly  2710 VAAQTLTVPSTGERIPLRQAMENGVLVVKNLSDFVITQKPIPKTEIMETVRAVHT---VTTKTIE 2771
            .:|.|.|:|                                |.|.:..| .:.||   :|..|..
Human  1477 HSAPTGTIP--------------------------------PPTTLKAT-GSTHTAPPITPTTSG 1508

  Fly  2772 LMQGYVLISNNEVQNVNTGEVCSLEEAKELGILREESTTRETKAAAGESPESVGDVGTSGDQTVI 2836
            ..|.:...|.|:.                       .|:..:..::...||             :
Human  1509 TSQAHSSFSTNKT-----------------------PTSLHSHTSSTHHPE-------------V 1537

  Fly  2837 VEERTQTVVVSSDTRKQEMQVVSTTQSTKDTSVPSVSEIETKGSKEPSKTLQNVKDAAKLGALGV 2901
            ....|.|:..:..:.:....|..|..:|.....|            |..|......::...:.|.
Human  1538 TPTSTTTITPNPTSTRTRTPVAHTNSATSSRPPP------------PFTTHSPPTGSSPFSSTGP 1590

  Fly  2902 IAAPVLAGGAIVSGVKSLIKSVKSPTEDAKSTEKPKEPQTSFIEQERRKELQPQQVPSEVDNLLS 2966
            :.|                .|.|:.|    :...|..|||:.          |..||....:|::
Human  1591 MTA----------------TSFKTTT----TYPTPSHPQTTL----------PTHVPPFSTSLVT 1625

  Fly  2967 -ETENFISSTTANFIANEKQQDKP-DTLPQESNLPLEVESTSTLTTTTVTTITTSSTTTETGNLE 3029
             .|...|:.|.|....:......| .|:|.    |..:::|.:..|....|:|||.|:....:|.
Human  1626 PSTHTVITPTHAQMATSASIHSMPTGTIPP----PTTLKATGSTHTAPTMTLTTSGTSQALSSLN 1686

  Fly  3030 PVVVEDVSTTVKEDKVVVKPSTVPEDKTEVSKITETITTVTSN------ETDTVPEKI-----SQ 3083
                            ..|.||.....|..:...|..:|.|:|      .|.|.|..:     ||
Human  1687 ----------------TAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVTTSGTSQ 1735

  Fly  3084 KSASEESAKKDPVVTKDTSSRPAETETSPKPVQKEPTPDPAQNTEFPESIKKDPTPEPDYKETAT 3148
            ..:|..:||....:...|||                       |..||             .|:|
Human  1736 SRSSFSTAKTSTSLHSHTSS-----------------------THHPE-------------VTST 1764

  Fly  3149 EAAQITPKEASPAPTNKNEQSAEPTSKPEPMPRTAKKEEISEIEPPFTAPLAPFVDQLAETKITE 3213
            ....|||...|             |....|:..|..... |.:..|||....|       |..|.
Human  1765 STTSITPNHTS-------------TGTRTPVAHTTSATS-SRLPTPFTTHSPP-------TGTTP 1808

  Fly  3214 IKTEFKEPVTSSQTITT-----------------ITTTVKTVDEHP-IVEEVDEVSKSEKIVDVE 3260
            |.:......||.||.||                 .:|::.|...|. |:....:::.|..|..:.
Human  1809 ISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHTQMATSASIHSMP 1873

  Fly  3261 EPTVHQQEPIKVNETSDDSTRTEPTNEIVHEE---------------RVVTVEEPTITETTVT-- 3308
            ..|:.....||...::..:....||.....:.               ...:...|.:|.|:.|
Human  1874 TGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPYHTSSTHHPEVTPTSTTNI 1938

  Fly  3309 ----TTTITTT----TTSSSEETLPQENTATVKETPL---NEPVPSSP-AETKEIEQTTNDDQKK 3361
                |:|.|.|    |||:|...||         ||.   :.|..||| :.|..:..|:
Human  1939 TPKHTSTGTRTPVAHTTSASSSRLP---------TPFTTHSPPTGSSPFSSTGPMTATS------ 1988

  Fly  3362 PEEIVDTEKKTTEQKPVETIPTE--PISTS----ETTTVTLTTKTTIVDEGKLH--------PPS 3412
               ...|....|...|..|:||.  |.|||    .|.||.:||.|.:.....:|        ||:
Human  1989 ---FQTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVIITTHTQMATSASIHSTPTGTVPPPT 2050

  Fly  3413 DIEQIIQPHS----------TSDKHQSLVDFIEQEKGTQPAEGGSNILQNVKDAAKLGALAIVGA 3467
            .::.....|:          ||..|.|.          ..|...|:.:
Human  2051 TLKATGSTHTAPPMTVTTSGTSQTHSSF----------STATASSSFI----------------- 2088

  Fly  3468 PVLAGKALVDALTTEKTLKPEHSTSQVVTETVEELPTEIITTSTATLVTKVTTTTTTTTTSTSEG 3532
                         :..:..|::|:|:.        |:..|||....| :..||..:||...:|..
Human  2089 -------------SSSSWLPQNSSSRP--------PSSPITTQLPHL-SSATTPVSTTNQLSSSF 2131

  Fly  3533 TPDDEALDVVKLPAELVESSVKREVPRTLAIGDAISQKLIS-PDECQVIVDGEQQSQTVSTLLKE 3596
            :|...|...|   :..|.||  ...|:|.:.....|...:| |.....:..|...|.:.......
Human  2132 SPSPSAPSTV---SSYVPSS--HSSPQTSSPSVGTSSSFVSAPVHSTTLSSGSHSSLSTHPTTAS 2191

  Fly  3597 EQLSPLDEVQIIDDKLIVLQQVSYLVDADTELTPQNLYELNIYDPENQYFIDPSTGQKISFHTLV 3661
            ...|||....         ...|..:.|....|..:.:.|:...|.:...:.|:....::..|:.
Human  2192 VSASPLFPSS---------PAASTTIRATLPHTISSPFTLSALLPISTVTVSPTPSSHLASSTIA 2247

  Fly  3662 F-----------------DMNVFNPETILVKNFSTGKYETLTAALE-------RPLLDRHTGHMV 3702
            |                 ..:..:..|.|.....|..:.:||:.:.       ..|..||.|..:
Human  2248 FPSTPRTTASTHTAPAFSSQSTTSRSTSLTTRVPTSGFVSLTSGVTGIPTSPVTNLTTRHPGPTL 2312

  Fly  3703 DPKT 3706
            .|.|
Human  2313 SPTT 2316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068	83/482 (17%)
		DUF4775	3026..3357	CDD:330579	79/388 (20%)
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
MUC6	NP_005952.2	VWD	40..192	CDD:214566
		C8	228..297	CDD:285899
		TIL	302..357	CDD:280072
		VWC_out	359..>403	CDD:214565
		VWD	386..549	CDD:214566
		C8	588..660	CDD:285899
		TIL	664..721	CDD:280072
		TIL	782..827	CDD:280072
		VWC	829..886	CDD:302663
		VWD	868..1017	CDD:278521
		C8	1057..1127	CDD:285899
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1455		56/348 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1471..1626		38/265 (14%)
		1, truncated	1561..1738		47/238 (20%)
		Approximate repeats	1607..1953		87/432 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1642..1834		57/268 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1868..1983		27/123 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2033..2077		7/43 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2090..2196		26/119 (22%)
		PHA03255	2188..>2343	CDD:165513	22/138 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2233..2278		5/44 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2348
		CT	2351..2434	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900