DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and jbug

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_001261140.1	Gene:	jbug / 43997	FlyBaseID:	FBgn0028371	Length:	2990	Species:	Drosophila melanogaster

Alignment Length:	3040	Identity:	526/3040 - (17%)
Similarity:	916/3040 - (30%)	Gaps:	1141/3040 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  2472 CEILENTSNFTNPKGEVVNITEALN---TGLIDGRRGQVIDPQNNRVLNLRQAVE--------QK 2525
            |.|    :|.|......||:...|:   .||....|.  :||..: |.|..||::        .|
  Fly   188 CRI----TNLTTDWNSGVNLAALLDYCQPGLFPHWRS--LDPSQS-VRNCTQAMDLAQREFGVPK 245

  Fly  2526 IIDSEQTNHILMPLAKSLS------------------VPRLADQGLIDPQTQTIVHPESGYPLSI 2572
            :::.|   ::..|....||                  ..|..:..:.||..........|
  Fly   246 VLEPE---YLASPWLDELSGMTYLSYFMKPGGPGYNATMRWVNTQVKDPVKNFTTDWNDG----- 302

  Fly  2573 HEAIVCEVLDP-HSKLHKPEKCTLEEAITKGIINADDSTFNYKNKTLNITEAIEAKLFDPSYDQQ 2636
              .::||::.. ......|||.:.:             .|:|:|   ||.:|::|
  Fly   303 --RVMCEIIKGLGGSAPAPEKLSTD-------------PFHYEN---NIRKAVDA---------- 339

  Fly  2637 KSKVEIPPVGM---IFPVAVEKSLVEPSKRVVLHPSTKKALPIKQAIEENFIMSI--------PY 2690
                     |.   :.|:...|.:..|.                  :|...||:.        |.
  Fly   340 ---------GARLGVQPILTAKDMANPE------------------VEHLGIMAYAAHLQWVPPR 377

  Fly  2691 SPKPDAIEV----------------VTAMEQDLIDVAAQTLTVPSTGER--------------IP 2725
            .|..|.:.|                :..|.:|:...:.:...||.:|:.              :|
  Fly   378 PPLSDLVSVYLESTSGRVGEPTHFRIDVMSRDISLSSVRCHVVPPSGQPGQPVRLNAHGEGVFVP 442

  Fly  2726 LRQAMENGVL-----------------------------VVKNLSDFVITQKPIPKTEIMETVRA 2761
            .|..|...|:                             .:.:|.:.::.....||||.: .|.|
  Fly   443 ERYGMHEIVVEIGEDSLGGHFFRALPRLLQVAPPGMAPCALGSLVEVLVNATGAPKTEDI-LVTA 506

  Fly  2762 V------HTVTTKTIELMQGYVLISNNEV------------QNVNTGE-VCSLEEAKEL------ 2801
            |      |....|.|:  :|:..|...:.            :::..|. .|::.:|..:
  Fly   507 VSPTGISHNCPLKKID--EGHSAIFKPDEAGIWEIAITYQGRHIQGGPFTCAVFDASGVSVHGLD 569

  Fly  2802 GILREESTTRETKAAAGESPESVGDVGTSGDQTV---------------IVEERTQTVVVSSDTR 2851
            |.:...:.|.|..|..         ||.||:..|               |||.:.:...:.....
  Fly   570 GAMPLRAHTFEVDARG---------VGVSGELHVDIVHDKHSLVCSVEKIVENKYRVTFMPRQNG 625

  Fly  2852 KQEMQVVSTTQSTKDTSVPSVSEIETKGSKEPSKTLQNVKDAAKLGALGVIAAPVLAGGAIVSGV 2916
            |..:.:.......|.:  |.:..:.|||.                                 ||
  Fly   626 KYRVYIYFNGYDVKGS--PFIMRVGTKGR---------------------------------SG- 654

  Fly  2917 KSLIKSVKSPTEDAKSTEKPKEPQTSFIE-------------------QERRKELQPQQVPSEVD 2962
                |:..||..|:|  .:.:.|...|:.                   .||.....||..|.
  Fly   655 ----KTRSSPLHDSK--HRSESPSMHFVSTTNTRHNDYRNSSLSRHNTAERTNSYSPQYSPK--- 710

  Fly  2963 NLLSETENFISSTTANF--IANEKQQDKPDTLPQESNLP-LEVESTSTLTTTTVTTITTSSTTTE 3024
               .:|.::.||::..:  .:.|.....|...|..|..| ::..:::.|.|.|:.....|.|:..
  Fly   711 ---LDTTDYHSSSSRYYKRESEENHATPPPAPPPASGSPTVKYLNSADLYTETLNGRRDSKTSNS 772

  Fly  3025 TGNLEPVVVEDVSTTVKEDKVVVKPS-TVPEDKTEVSKITETITTVTSNE------TDTVPEKIS 3082
            :........:..:....:.:.|.||. |.|.::.|::..|.|.::.:..:      |.|:...:|
  Fly   773 SSTKNDYYYDKENELYSQRRAVTKPKLTPPREERELTSTTNTSSSSSFQQRHQQLATSTLTRSLS 837

  Fly  3083 Q------KSASEESAKKDPVVTKDTSSRPAETE---TSPK-----PVQKEPTPDPAQNTEFPE-- 3131
            .      .:.|.|.....|:..|.::...:.|.   :||:     |||:. :|:.|..|....
  Fly   838 PIPSPTLNTRSSEVHTHSPLTIKTSNQYESSTRNITSSPRHASVSPVQRY-SPNSAYITTATHRM 901

  Fly  3132 -SIKKDPTPEPDYKETATEAAQITPKEASPAPTNKNEQSAEPT--SKPEPMPRTAKKEEISEIEP 3193
             |....|..:..|:.:.|.....|.|..|...|:.|.: |.|:  ...|.:.||...|
  Fly   902 GSPLTSPVSKNGYESSRTVEKSSTYKSTSNYVTDSNIR-ASPSLYGTAERLRRTGSPE------- 958

  Fly  3194 PFTAPLAPFVDQLAETKITEIKTEFKEPVTSSQTITTITTTVKTVDEHPIVEEVDEVSKSE---- 3254
                   |.:|..:..:::.:|     |.::.:....:....|.:..|..:|.:..:::.:
  Fly   959 -------PRIDHSSNVRVSSMK-----PASARRDSWDVINKTKHMLSHNSLESLANMTEKQLNTE 1011

  Fly  3255 ---KIVDVEEPT----------VHQQEPIKVN---ETSDDSTRTEPTNEIVHEERVVTVEEPTIT 3303
               ...|::..|          :|:|:..:.:   ::.||..|.:|:        .:||:..:..
  Fly  1012 LQYNRPDLDHETHRNTQYNKFALHKQQQQQSDYRRDSPDDGERYKPS--------AITVKSHSNN 1068

  Fly  3304 ETTVTTTTITTTTTSSSEETLPQEN---------------------TAT------VKETP---LN 3338
            ..|..:...|.|...|||..:.:.|                     .||      |::.|   :.
  Fly  1069 TYTDKSGGYTKTVKESSEHVVTESNGHGPSPGYGYSSLSRFRPIDGNATGARAIRVQDIPNGSIG 1133

  Fly  3339 EPV----PSSPAETKEIEQTTNDDQKKPEEIVDTEKKTTEQKPV-------------------ET 3380
            .||    ..|.|.:..:|...|..:     :..:.:....|:.:                   ||
  Fly  1134 RPVEFEIDGSRAGSGNLEILVNGGR-----VTSSVRSLGGQRFIASFTPHEHGTHTVQITFNGET 1193

  Fly  3381 IPTEP-----ISTSETTTVTLTTK-----TTIVDEGKLHPPSD-------IEQIIQPHSTS---- 3424
            :|..|     :|:...|.:..:|:     |..|.| .|.||..       :..::.|..:.
  Fly  1194 VPGSPWHAEIMSSPGLTALGESTRLVPANTPAVFE-ILPPPGQSLSKGECVATVLTPSKSKLNAR 1257

  Fly  3425 DKHQSL-----VDFIEQEKGTQPAE--------GGSNILQNVKDAAKLGALAIVGAPV------- 3469
            ..|::.     ::|:..|.||...:        .|..::..|.|::.:....:.|..|
  Fly  1258 VTHEAANGAARIEFVPTEVGTHVIDASINGTKIAGGPLIAKVYDSSLIQVTEVNGGVVGQACQFR 1322

  Fly  3470 ----LAGKALVDALTTE----------------KTLKPEHSTSQVVT-----ETVE--------- 3500
                .||:..::....|                .:..||.:.|.::.     |||.
  Fly  1323 VDASAAGEGQLEISINEGEVPNHVQVVGGGRCLVSFTPEQAKSHLIDIKFNGETVRGCPFVCAVA 1387

  Fly  3501 --------------------------------------------ELPTEIITTSTATLVTKVTTT 3521
                                                        |||..:.....|....:.|.|
  Fly  1388 DTSRVLLNLSNLELIPVNRPSSFHITVSGGGAAELAVSVRGPQGELPVRVTGDIHAGFTAEFTPT 1452

  Fly  3522 TTTTTTSTSE-------GTPD-DEALDVVKLPAELV-ESSVKREVPRTLAIGDA--------ISQ 3569
            |....:...|       |||. .::.|..|:....| ..::.|.|..|:..|||        ||.
  Fly  1453 TVGGHSINVEYNGFAVQGTPFLAKSYDASKVVVGSVSRGTMGRPVQFTVDAGDAGEGNLEITISA 1517

  Fly  3570 K-------------------LISPDECQ---------VIVDGEQQSQTVSTLLKEEQLS-----P 3601
            |                   .:..:.|:         :.|.|...:.::|..:...|:|     |
  Fly  1518 KGQNIPTQVHPQGSARFSVSFVPTESCEHTINVSFNKMPVPGCPITVSISGGVAGPQVSLGGPGP 1582

  Fly  3602 LDEVQIIDDKLIVLQQVSYLVDADTELTPQNLYELNIYDPENQ----------------YFIDPS 3650
            :.:.    :..::......|.|          .|:|:..|..|                .|:...
  Fly  1583 VHQT----NSFVINHNGGRLED----------IEVNVEGPAGQSVPAQVHQSADGVFKAEFVPRV 1633

  Fly  3651 TGQKISFHTLVFDMN------------VFNPETILVKNFSTGKY-ETLTAALERPLLDRHTGHMV 3702
            .|:    |.:...:|            |::...|.|||.|:|.. :.:|..:|..  ....|::.
  Fly  1634 VGE----HRVNVTVNGLPTAGSPYAAKVYDVSAIKVKNVSSGTVGKAVTFLVETS--QAGPGNLE 1692

  Fly  3703 DPKTGKKIPFFECVDRQ--WIIRANPEE------------------------------QKPSGIE 3735
            ....|.::|.......|  :.|...|.|                              |.|..::
  Fly  1693 VTVNGGRVPTSAQAQGQHTYAISFTPREAESHTVELRFNSQDVPGSPFTCRVAAAARIQSPETMD 1757

  Fly  3736 NVTI----------DTQTGQVVLDDGR--VCSIVEAINSGKLDI-----------QSISVRDPVS 3777
            .|::          ||:....||...|  |...::|:.|..|..           .|:.||.|..
  Fly  1758 KVSVGRLFEFVVESDTKPTVEVLGPARRSVPVKIDALGSSTLGYNVKFEPMEVGDHSVEVRLPGG 1822

  Fly  3778 GEV------IPLRMAIELGVVDMQAGTV-----------------IDIQTL---KEIPM------ 3810
            |.|      :....|.::.|.|::||.|                 ::|...   |.:|.
  Fly  1823 GHVEGSPFLLKAYSAEKVIVTDIRAGVVNKSVSFGINASQAGAGNLEIIVAVNGKNVPNFVQSEG 1887

  Fly  3811 ELAFQLGFLVPGARKPISLEAAVR------KGLYDPETGKLFDSESQNQVDVQKSIEIGLVDPKI 3869
            ...|::.|      ||  .|||..      .|  .|..|..|   |.:......|..:||  |:.
  Fly  1888 NARFKVNF------KP--TEAATHSLSVRFNG--HPVPGSPF---SCHIAAAAASPSMGL--PRA 1937

  Fly  3870 SLIVDTVTKKEVKLDCAIE---DDLVLP---ATGQIKDNKNNTLVPFDVGVQQCLLKTDNVTWSL 3928
            ..:.:.:.:..||:|...|   .|.|.|   .|....||::..|...|.|......:...|...|
  Fly  1938 MAMGECLKQAAVKMDNTFELEGFDGVEPQIFVTSPSGDNEHCQLSQHDGGSYSASFRPTTVGRHL 2002

  Fly  3929 PELLQREYY---TPSTGKVLN----PVTGEEILLQQAIEMGFVELETTLVKDVDHDKILPGKEAA 3986
            ..:...:.:   :|.:..|.:    .::|    |:|  :.|...|...:...||         ||
  Fly  2003 ISVTANDQHINGSPFSCNVFDVSRVSISG----LEQ--QYGPANLGVPVTFSVD---------AA 2052

  Fly  3987 KVGLLDTVRGTLSSPNISLDEAFVKGYLISTKKPLSLVDCLLRGLYD---------PSTAKFTID 4042
            ..|     .|||... :|.|.:.||.         .:|.| .|||||         |.....|.:
  Fly  2053 GAG-----EGTLELV-VSTDSSTVKA---------EVVAC-ARGLYDVTFVPQSTEPHYVNITFN 2101

  Fly  4043 DKQLD---LKAAIAQ--KLINPEELVLLD-PKTESIISITEAIAKGYLDPIEGYVINPYASTKLS 4101
            :..:|   .:..|.|  :.|....|..:| |..:.|:.|
  Fly  2102 EVAVDGSPFRVDIQQHTQHIQIGSLAAIDFPADDQIVEI-------------------------- 2140

  Fly  4102 LHEALENRILIPPKRKRSLPDAVYRGLYDPKTGQFSNTVTR--EKLTTERAIRRGILDPDSTVVN 4164
                      ..|.:| |:|.::.|...:.:|....|...|  ::.|.:....|.:...|.|:|.
  Fly  2141 ----------FSPDQK-SVPYSINRQTAEFRTHMTGNYTLRFIDRETRQHIGSRTLCVFDPTLVK 2194

  Fly  4165 V---------------------GSGQIIPFGVATETGIVDSKHGTVRDADDHPIDFKEAFDRGIL 4208
            :                     |.|.:   ......|..:..| |:|...          ..|:.
  Fly  2195 ITEVSEAFCHRPASIGVSLNEAGQGDL---SALVRCGATEVPH-TIRGPS----------KTGVY 2245

  Fly  4209 VEAKKPLRLIEAVVKNVYDEVDGHFVDPKSGEKLNFAEALNTNLLDEHS-VQIRDFKTGLYKQ-- 4270
            ....:|.|:....:..:::||      |.|      .:.|..|:|...: .:|.....|||:.
  Fly  2246 EIVYQPTRVAPHKISILFNEV------PIS------LKPLEINVLPASAGKEISVSGLGLYQSRV 2298

  Fly  4271 -LNLTHAKDT---------GIIDAQNSKLL----YNNQTMTLKHAFDIGILMDVNAP-ISIQRAI 4320
             ...:.|.||         .::.....:.|    |..:...|:..|.|      |.| ..:...:
  Fly  2299 GKTTSFAIDTVKRPAREFDVVVSGPGGQALPVRCYQTKNGHLQAEFTI------NKPGQCVIEVL 2357

  Fly  4321 HQG-----------LFDDKTGKLSDPRTGRQITLLESMRSFVV------------------NPHL 4356
            ||.           .||  :.|:|.....::...|.|..||.|                  |..:
  Fly  2358 HQSKPLPGSPFTCESFD--SSKVSTQGVTKEPLALHSPNSFTVRTDNAGTAELEAFAISPSNQSI 2420

  Fly  4357 PCYFDEQTEQMYTLSETCRNGIINRREGVFREPGSNSFV-----------PLG-EALSLGLIVDI 4409
            |....||::.:|.:            |.|..:||:....           ||. .|.|.|:..|.
  Fly  2421 PVLISEQSDGVYNV------------EFVPSQPGNYKLTLMYGGETIPSSPLNFTASSSGVRNDA 2473

  Fly  4410 ENAGFGL------------------------------------------------YELLSMGFYE 4426
            ..||.||                                                |.:||:|.||
  Fly  2474 RAAGHGLEVCHRNKEASFVVYCPIAPNVQIERLDEYGERIEPKIKALGNNEWRISYTILSVGKYE 2538

  Fly  4427 TSTRKVLHPVTNRKLNL-----NEACVED----VVSLSSSLVKHHETGKYLRLANAIKEQLVDDS 4482
                 :.....||. :|     :.:|||.    .|....:||.|  .|:.:..|..|
  Fly  2539 -----IRASCPNRG-SLPGSPWHISCVESNKVTPVGGWGTLVDH--DGRLILPARII-------- 2587

  Fly  4483 RGCYNLGNEQLDLQAARARGLIVSNRRLLSLELVLRQQLYRPETGKFCDPTTGEY---------- 4537
                      .|::.|....|:.|   :..:|:.:.:.:    .||.|...|||.
  Fly  2588 ----------FDVENAGPGKLVCS---IDGIEIPVDKLV----DGKMCLNITGENLAAGEHDLDL 2635

  Fly  4538 ----LDLIEAIHSGFIDPATTVFKNQLTGKELPLTEAIENGDIDVSKGRVFDPKSKSAYNYDVAL 4598
                |.:.:...|.|:.......|.||.|:.|...:|.|.....:      |..:..|...:|.|
  Fly  2636 TWSGLTITQCPRSAFVTGQQAADKVQLMGRGLAAAQAGEAAHFTI------DASNAPAGRPEVIL 2694

  Fly  4599 ----SRGILVTITRPLTDRNDVVRRQDSVELLNQTPVSVVISKPREMSLEEAIRYN--IID--PK 4655
                :..:.|::.:|        |..:::.|.:.||:     |....:|..::::|  ::.  |.
  Fly  2695 TSQDNTSLPVSLAQP--------RPSENIWLASYTPL-----KSTTGTLNLSVKWNGRLVKGCPL 2746

  Fly  4656 TALV-RDFDSFKFLPYSVAVERGLVDTTKRTLVDPK--------------------ALYFAFDPT 4699
            |..| ...|:.|.:.....:..|:|....::.:|.:                    .||...|.|
  Fly  2747 TVAVGSSMDASKVIVSGEGLRHGIVGKDIKSWIDTRRAGPGELTAHCAGVRKVAYCELYDHGDAT 2811

  Fly  4700 LIVYVREPVTFDQAAESKCLDLQTGLLTYVPASVPGSATA---APASDDS 4746
            ..:.::     .|.:....|.::     |...:||||..|   |.|.|.|
  Fly  2812 FTLNIK-----PQESGRHILTIK-----YGGQNVPGSPFALKVAGAPDAS 2851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068	103/597 (17%)
		DUF4775	3026..3357	CDD:330579	72/410 (18%)
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
jbug	NP_001261140.1	CH	60..165	CDD:237981
		CH	172..269	CDD:278723	21/90 (23%)
		CH	281..371	CDD:278723	23/149 (15%)
		IG_FLMN	468..560	CDD:214720	15/94 (16%)
		Filamin	468..554	CDD:279024	14/88 (16%)
		Filamin	557..644	CDD:279024	16/97 (16%)
		IG_FLMN	560..648	CDD:214720	16/98 (16%)
		Filamin	1116..1200	CDD:279024	15/88 (17%)
		IG_FLMN	1119..1198	CDD:214720	12/83 (14%)
		Filamin	1210..1294	CDD:279024	15/84 (18%)
		Filamin	1299..1383	CDD:279024	13/83 (16%)
		IG_FLMN	1310..1389	CDD:214720	11/78 (14%)
		Filamin	1386..1473	CDD:279024	10/86 (12%)
		IG_FLMN	1399..1480	CDD:214720	11/80 (14%)
		Filamin	1477..1563	CDD:279024	15/85 (18%)
		IG_FLMN	1480..1569	CDD:214720	15/88 (17%)
		Filamin	1570..1653	CDD:279024	13/100 (13%)
		IG_FLMN	1575..1659	CDD:214720	13/101 (13%)
		Filamin	1657..1741	CDD:279024	16/85 (19%)
		IG_FLMN	1661..1747	CDD:214720	15/87 (17%)
		Filamin	1756..1830	CDD:279024	16/73 (22%)
		Filamin	1834..1919	CDD:279024	19/94 (20%)
		IG_FLMN	1837..1926	CDD:214720	21/101 (21%)
		IG_FLMN	1936..2023	CDD:214720	17/86 (20%)
		Filamin	1941..2017	CDD:279024	15/75 (20%)
		Filamin	2021..2111	CDD:279024	28/120 (23%)
		IG_FLMN	2025..2114	CDD:214720	27/119 (23%)
		Filamin	2187..2268	CDD:279024	14/100 (14%)
		Filamin	2279..2369	CDD:279024	16/95 (17%)
		IG_FLMN	2285..2375	CDD:214720	18/97 (19%)
		Filamin	2372..2459	CDD:279024	18/100 (18%)
		IG_FLMN	2376..2465	CDD:214720	18/100 (18%)
		IG_FLMN	2474..2561	CDD:214720	15/92 (16%)
		Filamin	2474..2555	CDD:279024	13/86 (15%)
		IG_FLMN	2657..2751	CDD:214720	22/112 (20%)
		Filamin	2657..2745	CDD:279024	20/106 (19%)
		Filamin	2755..2840	CDD:279024	16/94 (17%)
		IG_FLMN	2756..2847	CDD:214720	17/100 (17%)
		Filamin	2847..2937	CDD:279024	3/5 (60%)
		IG_FLMN	2850..2944	CDD:214720	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439924
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930