DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and Cpn

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster

Alignment Length:	836	Identity:	184/836 - (22%)
Similarity:	290/836 - (34%)	Gaps:	195/836 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  2638 SKVEIPPVGMI-FPVAVEKSLVEPSKRVVLHPSTKKALPIKQAIEENFIMSIPY---SPKPDAIE 2698
            |.|..|||.:. .||||...:..|   |...|:....:|:...:    |.:.|.   :|.|.|:.
  Fly    95 SPVSTPPVAVAQIPVAVSAPVAPP---VAATPTPVAPIPVAAPV----IATPPVAASAPTPAAVT 152

  Fly  2699 VVTA---------MEQDLIDVAAQTLTVPSTGERIP-----LRQAMENGVLVVKNLSDFVITQKP 2749
            .|.:         .....:.|||....||:.   :|     |..|:...|..       |:.:.|
  Fly   153 PVVSPVIATPPVVPANTTVPVAAPVAAVPAA---VPVVAPVLAPAVAPAVAP-------VVAETP 207

  Fly  2750 -------IPKTEIMETVR----AVHTVTTKTIELMQGYVL----ISNNEVQNVNTGEVCSLEEAK 2799
                   ||...|.|.|.    .|..|.||.:...:..|:    .....|.........|:..|.
  Fly   208 APPPVAEIPVATIPECVAPLIPEVSVVATKPLAAAEPVVVAPPATETPVVAPAAASPHVSVAPAV 272

  Fly  2800 ELGILREESTTRETKAAAG---ESPESVGDVGTSGDQTVIVEER--TQTVVVSSDTRKQEMQVVS 2859
            |..::...|.:.|...||.   .:||      |.....|:.|.:  ..|||.:..|...|.:.::
  Fly   273 ETAVVAPVSASTEPPVAAATLTTAPE------TPALAPVVAESQVAANTVVATPPTPAPEPETIA 331

  Fly  2860 TTQSTKDTSVPSVSEIETKGSKEPSKTLQNVKDAAKLGALGVIAAPVLAGGAIVSGVKSLIKSVK 2924
            .....:...|.||:..||.....|....::            |.|||:|...:.:.:     :|.
  Fly   332 PPVVAETPEVASVAVAETTPPVVPPVAAES------------IPAPVVATTPVPATL-----AVT 379

  Fly  2925 SPTEDAKSTEKPKEPQTSFIEQERRKELQPQQVPSEVDNLLSETENFISSTTANFIANEK----- 2984
            .|  |..::..|              ||.|...||.|.:.::||...::......:|.|.
  Fly   380 DP--DVTASAVP--------------ELPPVIAPSPVPSAVAETPVDLAPPVLPPVAAEPVPAVV 428

  Fly  2985 QQDKPDTLPQESNLPLEVESTSTLTTTTVTTITTSSTTTETGNLEPVVVEDVSTTVKEDKVVVKP 3049
            .::.|:| |..::.|:.:.:........|.. ..|....|..:....:|....||....:....|
  Fly   429 AEETPET-PAPASAPVTIAALDIPEVAPVIA-APSDAPAEAPSAAAPIVSTPPTTASVPETTAPP 491

  Fly  3050 STVPEDKTEVSKITETITTVTSNETDTVPEKISQKSASEESAKKDPVVTKDTSSRPAETETSPKP 3114
            :.||.:..:||.::|     .:.||...|                ||   :.::..|..:.:|..
  Fly   492 AAVPTEPIDVSVLSE-----AAIETPVAP----------------PV---EVTTEVAVADVAPPE 532

  Fly  3115 VQKEPTPDPAQNTEFPESIKKDPTPEPDYKETAT-----EAAQIT----PKEASPAPTN---KNE 3167
            ...:...:|.:          .|.|.||..|..|     |||:.|    |:.:.|.|..   ..|
  Fly   533 AAADLIIEPVE----------PPAPIPDLLEQTTSVPAVEAAESTSSPIPETSLPPPNEAVASPE 587

  Fly  3168 QSAEPTSKPEPMPRTAKKEEISEIEPPFTAPLAPFVDQLAETKITEIKTEFKEPVTSSQTITTIT 3232
            .:..|.:.|||:|         |.||....|..| :...|...|.|.....:.|||.     |.|
  Fly   588 VAVAPITAPEPIP---------EPEPSLATPTEP-IPVEAPVVIQEAVDAVEVPVTE-----TST 637

  Fly  3233 TTVKTVDEHPIVEEVDEVSKSEKIVDVEEPTVHQQEPIKVNETSDDSTRTEPTNEI------VHE 3291
            :..:|..|:|:.|:|.:.:.:|..|..:||.|     ..:|:.:..:..|.|..||      |.:
  Fly   638 SIPETTVEYPVAEKVLDPAITEAPVTTQEPDV-----ANINDGAPATEITTPAVEIVTAAAEVSD 697

  Fly  3292 ERVVTVEEPTITETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPS---------SPAE 3347
            ..:..::.|...|..|.....|        ||.|.|........|:..|||.         |.|.
  Fly   698 TAIPLIDPPVPQEIAVAEIPET--------ETKPAEVIVEQSTIPIEAPVPEVSKYAEPVISEAP 754

  Fly  3348 TKEIEQTTNDDQKKP----EEIVDT-EKKTTEQKPVETIPTEPISTSETTTVTLTT 3398
            ..|:..|..|:....    .|:|.| .:|..|:.|...||.:..|.|::..|...|
  Fly   755 AAEVPITAGDNPDNTSVGISEVVPTIAEKAVEEVPTSEIPEQSSSPSDSVPVAKIT 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068	103/508 (20%)
		DUF4775	3026..3357	CDD:330579	81/357 (23%)
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
Cpn	NP_731674.1	rne	<9..167	CDD:236766	19/78 (24%)
		rne	<109..300	CDD:236766	44/213 (21%)
		rne	<228..409	CDD:236766	46/219 (21%)
		rne	<331..594	CDD:236766	64/331 (19%)
		rne	<501..763	CDD:236766	75/323 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900