DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and alpha-Spec

DIOPT Version :9

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster


Alignment Length:2827 Identity:536/2827 - (18%)
Similarity:1037/2827 - (36%) Gaps:835/2827 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  5977 DVNSRVAALEKQYLALQKKLDTKKAETEASLRDGR---HFAENCSKTLGWLGGELSNLTDRLLVS 6038
            |:..|    .:|.|:.......:..:....|.|.|   :|..:..:...|:..:|...::.   |
  Fly    17 DIQER----REQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEE---S 74

  Fly  6039 AHKPT-LQHQIDTHEPIYREVMAREHEVIMLINKGKDLTDRQQ--DRGVKRDLDRIQQQWEKLRR 6100
            ...|| ||.:|..|:....||.|..:.::.|.|.|:::.::|.  ...::..||.:.:.||.|..
  Fly    75 YRDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLS 139

  Fly  6101 EAVDRHTRLQTC------MEHCKK---YSQTSETFLAWLRTAEDKLADLTPGVLSKAKLETRLRD 6156
            ...::..:||..      :..|::   :.:..|||:    ||::...||       ..:|...|.
  Fly   140 RLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFV----TADEFGQDL-------EHVEVLQRK 193

  Fly  6157 LQTFRSEVWKHSGEFENTKGLGETFLSSCDIDKEPIKAELQDIRDRWERLNNDLIAR------AH 6215
            ...|:.::............|.:..:.....:::.|....:::.:.|:||....|.|      ||
  Fly   194 FDEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAH 258

  Fly  6216 EIENCSRRLDDFNDELRNLDHSLGRC--EDRLAAHDALGGAAKDPKLLERVKAIREELTNLSKPL 6278
            ||:.       ||   |:.|.::...  :|.:.:.|..|   :|   |..|:|::.:...:.:.|
  Fly   259 EIQR-------FN---RDADETVAWIAEKDVVLSSDDYG---RD---LASVQALQRKHEGVERDL 307

  Fly  6279 QSLKALAKDISAEA-RAAGGDADHLTSEVDGLADRMSELQGRLDDRCGELQSAATAVSQFNEQMK 6342
            .:|:.....:.||| |.....|||    .|.:.|:.:|:       ....||..|...:..:::.
  Fly   308 AALEDKVSTLGAEAQRLCSIHADH----SDQIRDKQAEI-------ANYWQSLTTKARERKQKLD 361

  Fly  6343 S------LGIDLNDLETEIEKLSPPGREIKIVQVQIDDVGKIQTKLDRLVGRLEDAERAADVLVD 6401
            .      ...|..||.:.|..:       |.: :..|::.|.....:.|:.|.::.:        
  Fly   362 ESYYLHRFLADFRDLVSWINGM-------KAI-ISADELAKDVAGAEALLERHQEHK-------- 410

  Fly  6402 AGFAADTTQTREQISTLRKTLGRLDNRVRDHEDNLHSTLKALREFYDHQSQTLDDIQDVSDEFKR 6466
                                 |.:|.|    ||:...|.::.::..:.:.....:||        
  Fly   411 ---------------------GEIDAR----EDSFKLTTESGQKLLEREHYAAAEIQ-------- 442

  Fly  6467 MKPVGSELDQIRRQQEDFRNFRERKVEPLAINVDKVNVAGRDLVRSAGSGVSTTAIEKDLEKLND 6531
                                      |.||                        |:|.|...|..
  Fly   443 --------------------------EKLA------------------------ALENDKSSLLS 457

  Fly  6532 RWNDLKERMNERDRRLDVALLQSGKFQEALAGLSKWLSDTEEMVANQKPPSSDYKVVKAQLQEQK 6596
            .|.|   |....::.:|:.|     |.........|::..|..:||:....| ...|:|.:::.:
  Fly   458 LWED---RRILYEQCMDLQL-----FYRDTEQADTWMAKQEAFLANEDLGDS-LDSVEALIKKHE 513

  Fly  6597 FLKKMLLDRQNSMGSLANLGKEV--ANHCEPGERASIEKQLNDLMKRFDALTDGAEQRELDLEEA 6659
            ..:|.|..::..:.:|.....::  ..|....:.|. .:|:  |:.|..||.:.:.:|...||::
  Fly   514 DFEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQ-RRQM--LLARRAALQEKSSKRRQLLEDS 575

  Fly  6660 MEVAKRFHDKISPLELWLDNTERSVKAMELIPTDEEKIQQRIREHDRLHDEILGKKPDFSDLADV 6724
            ... ::|.......:.|:  :|:...|.:....|...:..::::|.....|:...|....|:.:|
  Fly   576 NRY-QQFERDCDETKGWI--SEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNV 637

  Fly  6725 TAQLM---HLVSDEEAVNLGEKVRGVTERYTGLVDASDNIGALLAESRQGLRHLVLSYQDLVAWM 6786
            ..:|:   |..:|:    :..:::.:...:..||.|||..|..|.|:.| .:....:.:|:..|:
  Fly   638 GTELIEKQHYAADQ----INTRMQEIVVLWETLVQASDKKGTKLNEACQ-QQQFNRTIEDIELWL 697

  Fly  6787 ESMEAEL------KRFKSVPVYAEKLLEQMDHLLELNENIAGHASNVEST-------VESGAELM 6838
            ..:|.:|      |...||....:|      |.| |..::..|...:||.       :|||    
  Fly   698 SEIEGQLLSEDHGKDLTSVQNLQKK------HAL-LEADVMAHQDRIESIKVAANKFIESG---- 751

  Fly  6839 KHISNDEAIQLKDKLDSLQRRYGDLTNRGGDLLKSAQNALPLVQQFHEAHNRLVEWMQSAEAALA 6903
             |...|   .:::|..:|..||.                                      |..|
  Fly   752 -HFDAD---NIRNKEGNLSARYA--------------------------------------ALAA 774

  Fly  6904 PSEPRQADVLRLEGELADMRPILDSINQVGPQLCQLSPGEGAATIESIVTRDNRRFDSIVEQIQR 6968
            |...|:             :.:|||:.                                |:|:.|
  Fly   775 PMGERK-------------QHLLDSLQ--------------------------------VQQLFR 794

  Fly  6969 KAERLHLSNQRAKEVTGDIDELLEWFREMD----TTLREADLPAMEPKLVRAQLQEHRSINDDIS 7029
                             |:::...|.||.:    :|.|..||..     |:..:::|:::..:|:
  Fly   795 -----------------DLEDEAAWIREKEPIAASTNRGRDLIG-----VQNLIKKHQAVLAEIN 837

  Fly  7030 SQKGRVRDVTAASKKVLRESPQSENTATLREKLDDLKEIVDTVAQLCSERLGILEQALPLSEHFA 7094
            :.:.|:.:|.::.:.:|::.|.:.:  .:|::|:.|:|..:|:.:..|:|...|:.:|...::||
  Fly   838 NHEARLLNVISSGENMLKDQPFASD--DIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFA 900

  Fly  7095 DSHQGLTAWLDDMEQQISRLSMPALRPDQITLQQDKNERLLQSIAEHKPLLDKLNKTGEALGAL- 7158
            |:::. .:|:.:.|        |..........:|.:|.||:   :|:.|:..|...|..:.|| 
  Fly   901 DANEA-ESWMREKE--------PIATGSDYGKDEDSSEALLK---KHEALVSDLEAFGNTIQALQ 953

  Fly  7159 ------------VADDDGAK----------------------INEILDTDNARYAALRLELRERQ 7189
                        |.|..|.:                      :..:|:::|..:  .::|:.:||
  Fly   954 EQAKNCRQQETPVVDITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDW--WKVEVNDRQ 1016

  Fly  7190 QALESALQESSQFSDKLE-GMLRALANTVD---------QVN-QLDPLSALPQ----KIREQI-- 7237
            ..:.:|      :..|:: |:..:..|.||         |:| |.|.|.||.:    |:.|.:  
  Fly  1017 GFVPAA------YIKKIDAGLSASQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKA 1075

  Fly  7238 ----------------EDNDALMDD-----------LDKRQDAFSAVQRAANDVIAKAGNKADPA 7275
                            ::|.|.:.|           |.|:.|.|:. ...||:|  :..|..:.|
  Fly  1076 YVLVREAADLAQWIRDKENHAQIADVVGEDLEEVEVLQKKFDDFND-DLKANEV--RLANMNEIA 1137

  Fly  7276 VR-----------DIKAKLEKLNNLWNDVQNATKKRGSSLDDILSVAEPFWKQLNSVMKTLKDLE 7329
            |:           .|:.:::.||..||::|..|.::.|.|.           ..:.|.:..:|::
  Fly  1138 VQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKASQLG-----------SAHEVQRFHRDID 1191

  Fly  7330 ETLS--CQEPPAAQPQDIKKQQVALQEI--RHE-----IDQTKPEVEQVRRHGSNLMNMCGEPDK 7385
            ||..  .::..|....|:.|...::|.:  :||     :...:.::.|:....:.||.  ..||.
  Fly  1192 ETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLDETANRLMQ--SHPDT 1254

  Fly  7386 PE---VKKHIEDLDNAWDNITALYAKREENLIDAMEKAMEFHETLQNLLKFLTKAEDKFAHLGA- 7446
            .|   .|:  ::::..||.|......|:|.|:|:.:           |.:||:...|..|.:.: 
  Fly  1255 AEQTYAKQ--KEINEMWDQIITKSTARKEKLLDSYD-----------LQRFLSDYRDLLAWINSM 1306

  Fly  7447 --------VGSDIDAVKRQIEQLKSFKDEV-------------------------DPHMVEVEA- 7477
                    :.:|:...:..||:.::.:.|:                         :.|..|::| 
  Fly  1307 MSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEIDAR 1371

  Fly  7478 ---------LNRQAVELTERTSPEQAASIREPLSVVNRRWEALLRGMVERQKQLEHAL-LHLGQF 7532
                     ...:.::.....|||    |:|.:..:.:..|.|.:...||:.|||..| |.|...
  Fly  1372 AGTFGAFEQFGNELLQANHYASPE----IKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMR 1432

  Fly  7533 QHALNELLVWINKTDSTL--DQLKPIPGDPQLLEVELAKLKVLANDIQAHQNSVDTLNDAGRQLI 7595
            ...|.|  .|::..::.|  |......|:   :|..:.|.:.....|..|:..:..|.....|||
  Fly  1433 DCELAE--SWMSAREAFLNADDDANAGGN---VEALIKKHEDFDKAINGHEQKIAALQTVADQLI 1492

  Fly  7596 ETEKGSVEASTTQEKLRKLNNEWKQLLQKASDRQHEL--EEALREAHGYIAEVQDILGWLGDVDA 7658
              .:....::...||.:::...|:.|.:...:::..|  |:.|::   :..:..:|..|:.:   
  Fly  1493 --AQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTLQQ---FSRDADEIENWIAE--- 1549

  Fly  7659 VIGASKPVGGLPETATEQLERFMEVYN-------------ELDENRPKVETIQAQGQEYIKRQNQ 7710
                      ..:.|||  |.:.:..|             ||..|..:::::.|.|...|.:: |
  Fly  1550 ----------KLQLATE--ESYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKK-Q 1601

  Fly  7711 MKVSSSNLQHTLRTLKQRWDAVVSRASDKKIKLEIALKEATEFHDTLQAFVEWLTQAEKLLSNAE 7775
            ...|...:|..|..:..:|:.:..:.::|.:||:.|.|:.| :...::....||.:.|.||: .|
  Fly  1602 CSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRT-YIAAVKDLDFWLGEVESLLT-TE 1664

  Fly  7776 PVSRVLETIQAQMEEHKVLQKDVSTHREAMLLLDKKGTHLKYFSQKQDVILIKNLLVSVQHRWER 7840
            ...:.|.::|..|::|::::.|:..|.:.:..::.:...| ..|.:.|...|:....|:..|:||
  Fly  1665 DSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQADSL-VESGQFDTAGIQEKRQSINERYER 1728

  Fly  7841 VVSKAAERTRALDHGYKEAREFND-----AWSGMMQYLQETEQVL--DQIIEEATASKEPQKIKK 7898
            :.:.||.|...|:......:.|.|     :|      ::|.:.::  |....:.|.   .|.:||
  Fly  1729 ICNLAAHRQARLNEALTLHQFFRDIADEESW------IKEKKLLVGSDDYGRDLTG---VQNLKK 1784

  Fly  7899 YIGKLKETHRQLGAKQSVYDGTMRTGKNLLERAPKGDRPVLDKMLIELKEQWTRVWSKSIDRQRK 7963
               |.|....:||:.:.........|:.|::.:..| .|.:::.|..|.:.|..:.:.:..|.:|
  Fly  1785 ---KHKRLEAELGSHEPAIQAVQEAGEKLMDVSNLG-VPEIEQRLKALNQAWAELKNLAATRGQK 1845

  Fly  7964 LEEALLLSGQFSDALGELLDWLKKAKSRLNENGPVHGD-LETVQGLCEHHKHIEQDLQKRAAQMQ 8027
            |:|:|... ||...:.|...|:.:.:..|:...  :|| :..||||.:.|...|.|......:..
  Fly  1846 LDESLTYQ-QFLAQVEEEEAWITEKQQLLSVED--YGDSMAAVQGLLKKHDAFETDFTAHKDRCS 1907

  Fly  8028 GVLKTGRDLERSGNNPEVGRQLDEMQSIWEEVKSAVAKRGERLQVALVDAEKLNARVQ-ALFD-- 8089
            .:...|.:|..:.|:.                ..::|:|.::|::.|.:...|.||.: ||.|  
  Fly  1908 LICDQGSELVEAKNHH----------------GESIAQRCQQLRLKLDNLSALAARRKGALLDNS 1956

  Fly  8090 --------------WLDHAEHKLRYAKNAPDDEKVSREMMDIHMDFMKDLRVRER--EKTETFE- 8137
                          |:|..|:.:|      .||            |.:||...:.  .|.|||: 
  Fly  1957 AYLQFMWKADVVESWIDDKENYVR------SDE------------FGRDLSTVQTLLTKQETFDA 2003

  Fly  8138 ---------------YAEDIINKAYPDAIPIIKNWLSIIQQRWEEVRQWAINRESKL----EQHL 8183
                           ..:.:||.::..:..|:|....:| .||:::|..:..|:.:|    ||..
  Fly  2004 GLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDVI-ARWQKLRDASNTRKDRLLAMQEQFR 2067

  Fly  8184 Q---------------------SLKDLDD-----TIEELLA------------------------ 8198
            |                     :.:||.|     :|||:.|                        
  Fly  2068 QIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASLSSAEADFKALAA 2132

  Fly  8199 ----------------W--LSGLEGTLLNLKHEQLPDEIPPVEKLIEDHKEFMENTARRQNEVDR 8245
                            |  :..||.|..||            :|:||:....:...|:||.|.|:
  Fly  2133 LDQKIKSFNVGPNPYTWFTMEALEETWRNL------------QKIIEERDGELAKEAKRQEENDK 2185

  Fly  8246 ACK---------------PRQLPPGARKPSRSGKTPV-FKGSRDQGLNAR--KGSRITPTRDTPD 8292
            ..|               .|....|.   :|.|.:.: ..||.:|.|.|.  |.:.:...|  .|
  Fly  2186 LRKEFAKHANLFHQWLTETRYYMLGY---NRQGTSMMEGSGSLEQQLEALRVKATEVRARR--VD 2245

  Fly  8293 RDRLPHYGP----------RFSP-STSGPELEFRSPRAKLLWTKWRDVWMLSWERQRLLNDHLLY 8346
            ..::...|.          |::. ||.|            |..:|..:..||...|..|...:  
  Fly  2246 LKKIEELGALLEEHLILDNRYTEHSTVG------------LAQQWDQLDQLSMRMQHNLEQQI-- 2296

  Fly  8347 LKDVERARNFSW--DDWRKRFLKYMNHKKSRLTDLFRKMDKDNNGMIPRDVFIDGILNTKFDTSG 8409
                 :|||.|.  :|..|.|           :.:|:..|||.:|.:....|...:....:|...
  Fly  2297 -----QARNHSGVSEDSLKEF-----------SMMFKHFDKDKSGKLNHQEFKSCLRALGYDLPM 2345

  Fly  8410 L-------EMKAVADLFDRNGEGLIDWQEFIA 8434
            :       |.:|:.|:.|.|.:|.:..||:||
  Fly  2346 VEEGQPDPEFEAILDVVDPNRDGYVSLQEYIA 2377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401
CH 223..327 CDD:306753
SPEC 471..689 CDD:238103
SPEC 690..866 CDD:238103
SH3 885..922 CDD:327375
SPEC 1047..1250 CDD:238103
SPEC 1153..1390 CDD:238103
PLEC <1498..1526 CDD:197605
Plectin 1949..1981 CDD:307019
DNA_pol3_delta2 <2711..3178 CDD:331068
DUF4775 3026..3357 CDD:330579
SMC_N <4904..5566 CDD:330553
SPEC 5304..5513 CDD:238103
SPEC <5658..5787 CDD:321951
SPEC 5793..6007 CDD:238103 4/29 (14%)
SPEC 6011..6220 CDD:238103 47/229 (21%)
SPEC 6118..6330 CDD:238103 45/223 (20%)
PRK09039 <6279..6441 CDD:332967 29/168 (17%)
SPEC 6443..6660 CDD:238103 35/218 (16%)
SPEC 6663..6878 CDD:238103 45/230 (20%)
SPEC 6880..7087 CDD:238103 33/210 (16%)
SPEC 6986..7196 CDD:238103 48/248 (19%)
SPEC 7196..7417 CDD:238103 60/287 (21%)
SPEC 7314..7526 CDD:238103 48/267 (18%)
SPEC 7528..7747 CDD:238103 43/235 (18%)
SPEC 7749..7968 CDD:238103 49/225 (22%)
SPEC 7973..8181 CDD:238103 50/247 (20%)
EF-hand_7 8373..8437 CDD:316058 17/69 (25%)
GAS2 8450..8522 CDD:128539
Herpes_ICP4_C 8550..>8795 CDD:332854
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 6/59 (10%)
SPEC 1074..1287 CDD:238103 46/230 (20%)
SPEC 1182..1425 CDD:238103 48/261 (18%)
SPEC 1426..1638 CDD:238103 44/237 (19%)
SPEC 1533..1744 CDD:238103 49/232 (21%)
SPEC 1646..1850 CDD:238103 48/218 (22%)
SPEC 1852..2062 CDD:238103 50/247 (20%)
SPEC 1958..2176 CDD:238103 42/248 (17%)
SPEC 2072..2296 CDD:238103 45/252 (18%)
EFh 2311..2379 CDD:238008 18/78 (23%)
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 42/223 (19%)
SPEC 154..364 CDD:238103 48/247 (19%)
SPEC 261..470 CDD:238103 53/337 (16%)
SPEC 471..680 CDD:238103 43/224 (19%)
SPEC 682..893 CDD:238103 57/333 (17%)
Spectrin 893..>961 CDD:395348 17/79 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439923
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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