DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and Syne2

DIOPT Version :9

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:NP_001005510.2 Gene:Syne2 / 319565 MGIID:2449316 Length:6874 Species:Mus musculus


Alignment Length:9011 Identity:1622/9011 - (18%)
Similarity:2952/9011 - (32%) Gaps:3218/9011 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 HIVRKVTTLSRAEENAQPAEDLLPPAKMIRSSELEYRRALPPAIESSSTQRREISDIVVGKEDNV 222
            ||.:...||| .:.| ||:.:::..|....:|.       ||..:.|..|.:        .....
Mouse   136 HIEKLAQTLS-CDYN-QPSPEVVSVAASSPTSS-------PPTKKCSKAQAQ--------ARWQW 183

  Fly   223 SAREALLRWARRSTARYPGVRVNDFTSSWRDGLAFSALVHRNRPDLLDWRKARNDRPRERLETAF 287
            ||::|||:||:...||...|.|.||.||||:|:||.|::|..||||:|....|:...::.|:.||
Mouse   184 SAKKALLQWAQEQCARSESVNVTDFKSSWRNGMAFLAVIHALRPDLIDMDSMRHRSNKDNLKEAF 248

  Fly   288 HIVEKEYGVTRLLDPEDVDTNEPDEKSLITYISSLYDVFPEPPSIHPLFDMESQRRVHEYRDLAQ 352
            .|.|.|..:.:||:|||||...|||||::||::.......:.|....    .:|.:|   ||.  
Mouse   249 RIAEHELKIPKLLEPEDVDVVNPDEKSIMTYVAQFLKYSKDAPGPGD----STQAKV---RDA-- 304

  Fly   353 QFIYWCREKTAYLQERSFPPTLIEMKRLLSDLQRFRSDEVSARKREKSKLIQIYKELERYFETVG 417
              :.|..     |||:.|       :::|.|         ||.:...:|    |..|..:.|::.
Mouse   305 --LVWLT-----LQEKRF-------QKMLKD---------SASETYCNK----YHSLLSFMESLN 342

  Fly   418 EVDVEAELRPDAIEKAWYRMNTALQDREVILQQEIERLERLQRLADKVQREIKHVDQKLTDLEGR 482
            |                        ::|..:.                          :..|:||
Mouse   343 E------------------------EKESFID--------------------------VLSLKGR 357

  Fly   483 IGEEGRRIERLHPVDAKSIVEALETEIRHLEEPIQDMNQDCHVLNEGRYPHVSELHKKVNKLHQR 547
            :||                                 :|:|                  .::|.|.
Mouse   358 MGE---------------------------------LNED------------------ESRLRQG 371

  Fly   548 WAQLRTNFHTNLVQKLSGLKYPVHETTVTRQTRMVVESRQIDTNPHFRDLQEHIEWCQNKLKQLL 612
            |..|.........|....|..|:.||....:....|....:.|:..:.:.:..|:...:..|.|:
Mouse   372 WTSLMHQVAAWRAQLDDALPSPLKETEAWLKDIEGVVQEGVPTSQSYSEARTLIQGKLSSFKSLM 436

  Fly   613 AA-DYGSDLPSVKEELDRQQHEHKIIDQFHTKILNDERQQTKFSGDELALYQQRLNQ-LQKVYAE 675
            .: ||.||                ::..|.:   |.|:........:|....:|:|. |.|.:..
Mouse   437 GSFDYHSD----------------VLMAFQS---NAEKSLPAVPPVKLEEMTRRINNVLGKNFIP 482

  Fly   676 LLSTSTKRLSDLDSLQHFLGQASAELQWLN----EKEQVEI-TRDWADKQLDLPSVHRYYENLMS 735
            ||.....:.|.|    ..|.:|.|:|...|    .||.||: ..||          |::      
Mouse   483 LLEFHDSKCSVL----ALLDEAKAKLDVWNGTYESKESVEVLLEDW----------HKF------ 527

  Fly   736 ELEKREMHFATILDRGEALLNQQHPASKCIEAHLTALQQQWAWLLQLTLCLEVHLKHATEYHQFF 800
               ..|..|...||..         ..||.|.:..:.::          |..:.    .||....
Mouse   528 ---TGEKKFLIQLDAS---------FQKCEEMYKNSARE----------CESIR----EEYMMLE 566

  Fly   801 GEIKDAEQWLAKRDEILNSKFSQSDFGLDQGETLLRGMQDLREELNAFGETVATLQRRAQTVVPL 865
            ..:....|:      |.|:|           .||.|.:....    .|.|.:|.|    :....|
Mouse   567 KNVHSCRQY------IHNTK-----------ATLQRALMSWA----TFEEDLALL----KASFDL 606

  Fly   866 NKRRQPVNRQGPVQAICAYKQQGQLQIEKGETVTLLDNSGRVKWRVRTAKGQEGPIPGACLLLPP 930
            .|:.|  .::.||:                   |||      :|..:.....|   .|:.|:...
Mouse   607 TKKEQ--IKEVPVE-------------------TLL------QWNTKHTSLNE---VGSFLIGVS 641

  Fly   931 PDQEAIDAAERLKRLFDRSVALWQKKHLRLRQNMIFATIRVVKGWDFDQFLAMGPEQRTAIRRAL 995
            ..:.|...::.|:||..|    |:|                        |:...|..:..:.:  
Mouse   642 SREVAASISKELRRLNKR----WRK------------------------FITKTPLLKLPLVK-- 676

  Fly   996 NDDADKLLSEGDPNDPQLRRLRREMDEVNRLFDEFEKRARAEEESKQASRIFTEECLAIKSKLED 1060
                   :.:..|.:.....|.:            |....||....:...:...|    |.::||
Mouse   677 -------IQDQPPGNSSGTSLSK------------ESAMAAEPGGSRGEDVKAAE----KQEVED 718

  Fly  1061 MARELDQIILAPLPRDLDSLEHVLEIHSDYE---RRLHLLEPELKHLQETFRTIALKTPVLKKSL 1122
                             :.....|:::.:.|   :::.:.|.:.|.:                 |
Mouse   719 -----------------EESAGQLKVNEEVEGLIKQVTIWESQTKSI-----------------L 749

  Fly  1123 DNLMELWKELNTQSGLHKDRLKLLEASLAGLEDNEHVI---SELENELARHQDL-------PSTA 1177
            |.|         |.|.|.|.        :..:..:|:|   |..|..|||.:|.       ||..
Mouse   750 DLL---------QHGDHADG--------SSADTLQHLIAKGSVYEELLARTEDTLQMDVQSPSNL 797

  Fly  1178 EGLQQVFKQLNHMQDIITQQQPQMDKMNDAADQLGRMGVPTKVLGDLKRLHSNVERLNTRWSAVC 1242
            |..|.|.                            |.|:..|:    :.....|:......|||.
Mouse   798 EPFQNVL----------------------------RAGLQAKI----QEAKQGVQITMVELSAVL 830

  Fly  1243 NQLGERMRSCETAIGLMKNLQSSVQVEESWVDGTTERLSAMPTATSAYELDKLLGAAIERKPKIE 1307
            ..|.:  ...|..:||        :|||:..:          ...|....::|||.  ..:|   
Mouse   831 KNLSD--EPLELDLGL--------KVEEAQKE----------LEVSILRAEQLLGQ--RERP--- 870

  Fly  1308 NVNVAGGRLIREAKIYD-------SKCLRFVDWLVEARPSFSPPRRDLRPADSDPGATQYYSQRL 1365
                 ||.|::..:..:       :|.||.|:.|....|.               ||.....::.
Mouse   871 -----GGFLLKYKEALEILNTNSLAKYLRAVEELKRTVPG---------------GAKLQLEEQS 915

  Fly  1366 DNLNTKNDRLLEQLS---QRLKTAIEVNGSDGLQYAESLQKPLKTFRVDFSAGSVPTGDGYAARQ 1427
            ...:.|.:.|..::|   |:||.|||         .|.|:..:                   ||.
Mouse   916 RVASAKWEPLRHEISLYLQQLKIAIE---------EEKLRDNI-------------------ARL 952

  Fly  1428 EDLYTTTYSTTQISSTKTTKSSTKSVYSSDG-----------LDAASQEVSTAGLPQSQIQFNEI 1481
            |..........:...|:..:...::..|.:.           |....:|:::   |:.|      
Mouse   953 EKQINKEKKLIRRGRTRGLRKEHEACLSPESIKCQLEHHVGVLRVLCEELTS---PEDQ------ 1008

  Fly  1482 RTLKRSQQLGGHSVLDIAGIRD--PRTGRVLTIGEAIQLRILDVRTGEMLVGDRRITLEQAADQG 1544
            :.|||:             :||  .:..|:|.....|.                  |..|::..|
Mouse  1009 QELKRA-------------LRDYEQKIARLLKCASEIH------------------TTLQSSQGG 1042

  Fly  1545 LIDLQLAKQLLEPGAGRDASGRELSLLEVIQREISEAESGYETAEKRIKVNNTVTVEQTSGELGS 1609
            .::.:.|....|.|. |||.|.       :..||.:.:...|.|.:.||     ...||| || .
Mouse  1043 ALEERSALITTENGR-RDADGE-------VPLEIPDNQLSTEKAMEPIK-----NFSQTS-EL-K 1092

  Fly  1610 PENPRNIADAITAGSVDTKTGLYRVKSGQTIS-----LAEAY--ERGYLIRH-----ESVTI--- 1659
            |:...:|.:                |.|:..|     |.|.|  :||.|.:|     ..||.   
Mouse  1093 PQQEESIME----------------KEGKDCSASLSDLQERYDTQRGLLEQHLQDSKSRVTSDFA 1141

  Fly  1660 ---KSNALCLSDAIAHGLVDGAGWIADRNS-GDKFRLDSAIANQLIDASVREVVDAKRDTKITLQ 1720
               :.::.||...:|...|    .:||.:: .:||.:.|....:|:..:.:.|::.:||. :...
Mouse  1142 SEQERSSACLQSKLAELQV----LLADTDAHWEKFEITSLNLRRLMSDAEKPVLNQERDL-LKGN 1201

  Fly  1721 EALQSGVLNAKTGRYVNEVTKEKLTFAEARNRQLIVKPYTLKDICDLNLLDKQAQITSPMRREKL 1785
            |.:..|:||.:                                   :..|:...||..|:.:|  
Mouse  1202 EQVLHGLLNTR-----------------------------------MESLEMALQIVLPLEKE-- 1229

  Fly  1786 SIMQAIEAGVLDGNLLKCITKRKGELVTLQEAIADGIVLPAECKYRDFMTGELISIPEAVERGLI 1850
                             |......:|.....|:.|  :.|.|                       
Mouse  1230 -----------------CSLLCASDLPLCTVAVQD--LHPVE----------------------- 1252

  Fly  1851 SSVAQRSIFDIDG-FKDLRSNDYVSFNVALSRDLLRRKSTGFALETGRDSLVPLEVAVSEGLVRQ 1914
                      ||| :::|             ||:             |||:.. ::.|...|...
Mouse  1253 ----------IDGVYQNL-------------RDI-------------RDSIAK-QIRVCTSLEEP 1280

  Fly  1915 EVYEMFSRGIGVQNASGKELSVFDLVYHNLIDPKTGYLLDPKTGETVPLDTAIERKFITPEGALL 1979
                        .|:..:||...|                         ..||:           
Mouse  1281 ------------SNSVPRELHTLD-------------------------QCAIQ----------- 1297

  Fly  1980 LSSLLNITLTTETVTRTINRYVTIRAGSQEPVDSVLLTFTEAVRQGFIDEERQLFKDPKTGNIYS 2044
                 :|.|.......|:|:.|.:|   ::.:|::         :||:...|.            
Mouse  1298 -----DIVLKCRLQLETMNQKVEMR---EDALDAL---------EGFLASLRA------------ 1333

  Fly  2045 VQQALNYGLLVPDSNQTVPEPTNRKKTKSTITIVTKQIIPEAEPIKLNTQHTKYVEKSVEIPISQ 2109
                                                                  .:.|.|:|..:
Mouse  1334 ------------------------------------------------------AKLSAELPADR 1344

  Fly  2110 ELVKPHRVVSEFINL--EKSSYIEQNVTERQIMELPPGGWRLKDAIEQRLFNPDTGVFHVQGTDR 2172
            ...|...|:||.|.|  ||:..:::.:  |.:      |..:|||               :|.:.
Mouse  1345 PAPKAPEVLSEDILLMKEKAGPLDERL--RTL------GINIKDA---------------EGGEN 1386

  Fly  2173 LVNFEECINKQIINNLSLSVIDPNTGDKISVQSAFERDILDSYGNYTNSRKQVQGMRSAID-ESK 2236
            ..    |  ::::..||::::                                     |:| :||
Mouse  1387 TT----C--ERLVGALSVNLV-------------------------------------AMDGQSK 1408

  Fly  2237 IILETVPATRGANQKTILRITKVNNIPDVLEVSTPLKDAPPKFVEVLTCQRELASPEPLQIAPGA 2301
                                                ::.||:..::|    |..|.:.|::    
Mouse  1409 ------------------------------------EEGPPEDKKLL----EACSSKNLEL---- 1429

  Fly  2302 IYDPSTALVIFTQTGETENIFDAARQGLVDEQLIKI--VDPTTKQPISVTEAIARSIYDPKTATI 2364
                            .:||.|      :..|:.||  .|||                       
Mouse  1430 ----------------FKNIQD------LQNQISKIGLKDPT----------------------- 1449

  Fly  2365 LDSEGQPVDLITATKLGLLSVVGAPLVAAEGALRTVRFVTDPRTGEQIPVEVAYERGIVSRDQLH 2429
                                   ||.|.                                    |
Mouse  1450 -----------------------APAVK------------------------------------H 1455

  Fly  2430 RGRS---FDSEPATVEDKVVVLQRMRKVILKPKDALRKGIID--EETCEILENTSNFTNPKGEVV 2489
            |.:|   .|.:...:|::.|.:|::...:.:.||...|.:|.  |:|..:.|:|      |..|.
Mouse  1456 RKKSLLRLDKDLDGLEEEKVRIQKIAGSLPRFKDGSEKNVIQQCEDTAALWEST------KASVT 1514

  Fly  2490 NITEALNTGLIDGRRGQVIDPQNNRVLNLRQAVEQKIIDSEQTNHILMPLAKSLSVPRLADQGLI 2554
            ...|...:.|...|:.|.|  :||....:::  |:.|| |:|.::    :.|.....::|     
Mouse  1515 ESLEQCGSALELLRQYQNI--KNNLTALIQK--EEGII-SQQASY----MGKDNLKKKIA----- 1565

  Fly  2555 DPQTQTIVHPESGYPLSIHEAI--VCEVLDPHSKLHKPEKCTLEEAITKGIINADDSTFNYKNKT 2617
              :.:|:....|.: |.:.:.|  :|:.|..|                                 
Mouse  1566 --EIETVKEEFSDH-LEVVDKINQICKNLQYH--------------------------------- 1594

  Fly  2618 LNITEAIEAKLFDPSYDQQKSKVEIPPVGMIFPVAVEKSLVEPSKRVVLHPSTKKALPIKQAIEE 2682
            ||..:..|    ||.::::.:.:                             ..:.|.|.:..||
Mouse  1595 LNKMKTFE----DPPFEKEANAI-----------------------------VDRWLDINEKTEE 1626

  Fly  2683 NFIMSIPYSPKPDAIEVVTAMEQDLIDVAAQTLTVPSTGERIPLRQAMENGVLVVKNLSDFVITQ 2747
                                                 .||.:....|:.:.:.::||..| ..|:
Mouse  1627 -------------------------------------YGENLGRALALWDKLFIIKNNID-EWTE 1653

  Fly  2748 KPIPKTEIMETVRAVHTVTTKTIELMQGYVLISNNEVQNVNTGEVCSLEEAKELGILREESTTRE 2812
            :.:.|.|                          ::|:...:.|.:     .:||.:|.|:|    
Mouse  1654 QILGKAE--------------------------SHELTEEDRGRL-----KEELKVLEEQS---- 1683

  Fly  2813 TKAAAGESPESVGDVGTSGDQTVIVEERTQTVVVSSDTRKQEMQVVSTTQSTK------------ 2865
                 .|....|.|:.:               ::.|:.:..|:||:.::..:|            
Mouse  1684 -----AEFSRRVADIQS---------------LLQSNEKPLELQVMESSVLSKMKDVKTHVAGGS 1728

  Fly  2866 DTSVPSVSEIETKGSKEPSKTLQNVKDAAKLGALGVIAAPVLAGGAIVSGVKSLIKSVKSPTEDA 2930
            ::..||.|..|.:...:.:||...:                         .:||:.:: ||::..
Mouse  1729 NSYAPSGSTAELREDLDQAKTQMGM-------------------------TESLLNAL-SPSDSL 1767

  Fly  2931 KSTEKPKEPQTSFIEQERRKELQPQQVP-------------SEVDNLLSETENFISSTTANFIAN 2982
            :...|.:|.|....:|:....:...|:.             :.|.||.:..:|.:....|.|: |
Mouse  1768 EIFTKLEEIQQQIFQQKHSMTVLENQIGCLTPELSELKRQYASVSNLFNTKKNALQDHFATFL-N 1831

  Fly  2983 EKQQDKPDTL------------PQESNLPLE--VESTSTLTTTTVTTITTSSTTTETGNLEPVVV 3033
            |:.::..|..            |.|:.|.||  ::..|..            .|...||.:   :
Mouse  1832 EQCKNFNDWFSNVKTNLQECFEPPETKLSLEQRLQKLSDF------------LTLGGGNSK---I 1881

  Fly  3034 EDVSTTVKEDKVVVKPSTVPE-------DKTEVSKITETITTVTSNETDTVPEKISQKSASEESA 3091
            :.|.|.::..|:::..:.|.|       .:.|:..:                |.|.|..|.|   
Mouse  1882 QQVETVLQHVKMLLPKAHVKELDSWLRSQELELENM----------------ESICQARAGE--- 1927

  Fly  3092 KKDPVVTKDTSSRPAETETSPKPVQKEPTPDPAQNTEFPESIKKDPTPEPDYKETATEAAQITPK 3156
                                             .|..|.:.::.    |.|.            :
Mouse  1928 ---------------------------------LNNSFQQLLRL----EDDC------------R 1943

  Fly  3157 EASPAPTNKNEQSAEPTSKPEPM-----PRTAKKEEISEIEPPFTAPLAPFVDQLAETKITEIKT 3216
            ..|...||:.|...:.....|.|     ..|.|:|:...:        |...|.|.|..:||.:.
Mouse  1944 SLSKWLTNQEENWGKMEVSGERMDLFSQALTRKREQFETV--------AQLSDSLKEHGLTEGEE 2000

  Fly  3217 EFKEPVTSSQTITTITTTVKTVDEHPIV-EEVDEVSKSEKIVDVEEPTVHQQEPIKVNETSDDST 3280
            ..||             :...:|.:..: .::.|:.:.:|:...|:.:        .|:.:||  
Mouse  2001 TIKE-------------STHLIDRYQALWRQLHEIEEEDKLPAAEDQS--------FNDLADD-- 2042

  Fly  3281 RTEPTNEIVHEERVVTVEEPTITETTVTTTTITTTTTSSSEETLP-QENTATVKETPLNEPVPSS 3344
                   ::|     .::|  |.|:.:        ..:|||..:| :|....:||.     :...
Mouse  2043 -------VIH-----WIKE--IKESLM--------ALNSSEGKMPLEERIQKIKEI-----IALK 2080

  Fly  3345 PAETKEIEQTTNDDQKKPEEIVDTEKKTTEQKPVETIPTEPISTSETTTVTLTTKTTIVDEGKLH 3409
            |....:|:......:.....:.        |:....:..:..||.......|:.:..:|.||   
Mouse  2081 PEGDAKIQMVMRQAEHCEAPLA--------QETFTDLSNQWDSTLHLANTYLSHQEKLVLEG--- 2134

  Fly  3410 PPSDIEQIIQPHSTSDKHQSLVDFIEQEKGTQPAEGGSNILQNVKDAAKLGALAIVGAPVLAGKA 3474
                 |:.:|  |..|....|.:..:|::                                ||.|
Mouse  2135 -----EKYLQ--SKEDLRLMLTELKKQQE--------------------------------AGFA 2160

  Fly  3475 LVDALTTE----KTLKPEHSTSQVVTETVEELPTEIITTSTATLVTKVTTTTTTTTTSTSEGTPD 3535
            |...|..:    |..|.....:|.:|..:|||      .|....:.:.|...:.:.....|....
Mouse  2161 LQPGLPEKQAQLKIYKKFLQKAQDLTSLLEEL------KSQGNYLLECTKNPSFSEEPWLEVKHL 2219

  Fly  3536 DEAL------DVVKLPAELVESSVKR----EVPRTLAIGDAISQKLISPDECQVIVDGEQQSQTV 3590
            .|:|      .|.||...:.|.|..:    ::..||   |.||::..|      :.||.:..   
Mouse  2220 HESLLQQLQDSVQKLEGHVQEHSSYQVCLTDLSSTL---DDISKEYFS------LCDGSKDQ--- 2272

  Fly  3591 STLLKEEQLSPLDEVQIIDDKLI----VLQQVSYLVDADTELTPQNLYELNIYDPENQYFIDPST 3651
              ::.:|::..|.|   ::.:|.    .|::.|.|..:..:.|                   .|.
Mouse  2273 --IMAKERMQKLQE---LESRLRFQGGALKKASALAKSIKQNT-------------------SSV 2313

  Fly  3652 GQKISFHTLVFDMNVFNPETILVKNFSTGKYETLTAALERPLLDRHTGHMVDPKTGKKIPFFECV 3716
            |||                 |:..:..:.||:      ::.|.:|                    
Mouse  2314 GQK-----------------IIKDDIRSLKYK------QKDLENR-------------------- 2335

  Fly  3717 DRQWIIRANPEEQKPSGIENVTIDTQTGQVVLDDGRVCSIVEAINSGKLDIQ-SISVRD-PVSGE 3779
                             ||:...:|:.|        :.||:::.:|.:..:: |:.|.: |.:.|
Mouse  2336 -----------------IESAKQETENG--------LNSILKSKSSTEKHVKFSLPVEEMPATSE 2375

  Fly  3780 V-IPLRMAIELGVVDMQAGTVIDIQTLKEIPMELAFQLGFLVPGARKPISLEAAVRKGLYDPETG 3843
            | .|.|.:..:|    ::|...:..|...:.|.|:.||.         ::::.:::....:.|..
Mouse  2376 VPKPTRESAAVG----ESGGARETNTNSAVEMILSKQLS---------LNVQESMQNAQDEREVN 2427

  Fly  3844 KLFDSESQNQVDVQKSIEIGLVDPKISLIVDTVTKKEVKLDCAIEDDLVLPATGQIKDNKNNTLV 3908
            :|     |||   ...::|.|.:.::..:.:..|..|.: ..|||   :|..:..:...:...||
Mouse  2428 EL-----QNQ---PLELDIMLRNEQLKGMEELSTHLEAR-RAAIE---LLEQSQHLNQTEEQALV 2480

  Fly  3909 PFDVGVQQCLLKTDNVTWSLPELLQREYYTPSTGK-----VLNPVTGEEILLQQAIEMGFVELET 3968
            ........|.|.:          ||:|.:|....|     :|:....:.::.:.::.....|:|:
Mouse  2481 LPAARPSVCHLGS----------LQQELHTLKKTKERQYGLLSGFQDQLVMAEASLNTSLAEVES 2535

  Fly  3969 TLVKDVDHDKILPGKEAAKVGLLDTVRGT----------LSSPNISLDEAFVKGYLISTKKPLSL 4023
            ..:..:|....| ||....:|.::..:|:          |||...:.|:..|:..:...:....|
Mouse  2536 LKIGSLDSATYL-GKIKKFLGSVENQQGSLSKLRTEWAHLSSLLAAADQKLVESQMKHLEHGWEL 2599

  Fly  4024 VDCLL-RGLYDPSTAKFTID---DKQLDLKAAIAQK-------LINP-EELVLLDPKTESIISIT 4076
            |:.|. |..:..:|....:.   :|..|||.::.|:       |.:| ::..::|          
Mouse  2600 VEQLAHRKCFQQATEHSELTCLLEKLQDLKVSLHQQQQRLTLSLNSPGQQAAIVD---------- 2654

  Fly  4077 EAIAKGYLDPIEGYVINPYASTK--------LSLHEALENRILIPPKRKRSLPDAVYRGLYDPKT 4133
                          ::.|.|..:        |.....|..:.|...|.|::|.||:         
Mouse  2655 --------------MVTPAAELQAIKCEFSGLKWQAELHMKRLWGEKDKKTLEDAI--------- 2696

  Fly  4134 GQFSNTVTREKLTTERAIRRGILDPDSTVVNVGSGQIIPFGVATETGIVDSKHGTVRDADDHPID 4198
                |.:.::                                                       
Mouse  2697 ----NNLNKQ------------------------------------------------------- 2702

  Fly  4199 FKEAFDRGILVEAKKPL-RLIEAVVKNVYDEVDGHFVDPKSGEKLNFAE------ALNTNLLDEH 4256
                      :||.:|| |.:|..:|..  |:.....:..|..|...||      .|..|:|.  
Mouse  2703 ----------MEALEPLNREVENRIKKC--ELQNRIKETLSWVKNTMAELVVPIALLPDNILS-- 2753

  Fly  4257 SVQIRDFKTGLYKQLNLTHAKDTGIIDAQNSKLLYNNQTMTLKHAFDIGILMDVNAPISIQRAIH 4321
              |||..|        |.|   .||:..|.:                :.:|::....|:...|..
Mouse  2754 --QIRKCK--------LIH---DGILGNQQA----------------VELLVEEVRGITPSLAPC 2789

  Fly  4322 QGLFDDKTGKLSDPRTGRQITLLESMRSFVVNPHLPCYFDEQTEQM-YTLSETCRNGIINRREGV 4385
            :|  |.....|.|.::..|..||:|              .|:::|: ..|.|..:...|..:..:
Mouse  2790 EG--DGLNALLEDLQSQHQALLLKS--------------TERSQQLELKLEEKSKLFAIIGKVQL 2838

  Fly  4386 FREPGSNSFVPLGEALSLGLIVDIENAGFGLYELLSMGFYETSTRKVLHPVTNRKLNLNEACVED 4450
            ..|.......|.|:                          ..||...|    .|:|.:.:|..:.
Mouse  2839 TLEESETLMSPTGD--------------------------RASTEAEL----ERRLAILKASQQQ 2873

  Fly  4451 VVSLSSSLVKHHE--TGKYLRLANAIKEQLVDDSRGCYNLGNEQLDLQAARARGLIVSNRRLLSL 4513
            :....|:|..|.:  |..| :.||..:...:||            .|:..:||    :||     
Mouse  2874 LQDTESALSAHLQELTNAY-KDANVFERLFLDD------------QLKNLKAR----TNR----- 2916

  Fly  4514 ELVLRQQLYRPETGKFCDPTTGEYLDLIEAIHSGFIDPATTVFKNQ---LTGKELPLTEAIENGD 4575
                        |.:|......|....:|: :..|.|.|..:.|..   |.|..|||.:.:|. |
Mouse  2917 ------------TQRFLQNNGSELKQKMES-YREFHDKAAVLQKEAECILHGGLLPLRQELEQ-D 2967

  Fly  4576 IDVSKGRVFDPKSKSAYNYDVALSRGILVTITRPLTDRN--DVVRRQDSVELLNQTPVSVVISKP 4638
            .....|.:.|         .:|..||   ::::.||...  |.:.......||.:....|:   .
Mouse  2968 AKEQLGNLRD---------KLAAIRG---SLSQVLTSEEVFDTIGLSWDGSLLARLQTQVL---E 3017

  Fly  4639 REMSLEEAIRYNIIDPKTALVRDFDSFKFLPYSVAVERGLVDTTKRTLVDPKALYFAFDPTLIVY 4703
            ||..:|            ..::..|:|     .:|.:|.....:|...||               
Mouse  3018 REREVE------------GKIKQLDTF-----LIARDRHQASISKIRAVD--------------- 3050

  Fly  4704 VREPVTFDQAAESKCLDLQTGLLTYVPASVPGSATAAPASDDSANDSLTVIETPKVYTLKEAASA 4768
                :...:.|||         |..||:..|.|                        ||..|   
Mouse  3051 ----LQIKKGAES---------LLKVPSMSPES------------------------TLLNA--- 3075

  Fly  4769 GVVDPDSALVKDLAKAKLVRLPEAFRKGLMDANKA-----NVLNTQTSKLCT-----LQEAYESG 4823
                  ..|::.:.|:|.:| .|..||  :..|:|     .....|..|||.     ||||.::.
Mouse  3076 ------QTLIQKIEKSKRLR-DEIIRK--LSKNEAFDDSFKESEMQRLKLCAEENSRLQEALQNM 3131

  Fly  4824 LICTPKRSFG-------------LLEAITFNLYNPTNGCLVDPFQMHPDIIRRRKFTLAEAIGS- 4874
            |:....|..|             :|:.|...|..|.  |:    .:....|:..|.|. ||.|. 
Mouse  3132 LLELQPREMGEKEFREKLENALHVLKQIQSRLQQPL--CV----NLGVQHIQHEKETW-EAFGEQ 3189

  Fly  4875 ------GL----VDPSSTVVRDPSTGVIVPLTAAIS------SGLIDATEGRLTDANEPKNNID- 4922
                  ||    :........|..||.:......|.      |..|......|.||.:..|..| 
Mouse  3190 VEAEMCGLRAVRITEEQREENDSGTGGMEAKLRDIEGLHMELSKSISLRADVLNDAYDSANRYDE 3254

  Fly  4923 -------LVKAAEKGLL---LPAEQRQAVFEKFNMCEENVNDLLKWVTTVEQKISSVGGPREKID 4977
                   ::.:.|..||   :.....|...|..::.:|.:...:..:.::.:.:.::..|..| :
Mouse  3255 LVAGALRIITSLEATLLSYRVDLHNPQKTLELAHLKQEELQSSVADLRSLTETLGAISSPEAK-E 3318

  Fly  4978 ELRNQINAL----KQIKDEIESQQRPVATCLE--------------QIRQIVLTGGDVLSAPEVT 5024
            :||..:..|    ..:|..:|:|:.....|||              ::|::.:..|.     .:.
Mouse  3319 QLRCTLEVLAAKNSALKAGLEAQEAEEERCLENYKCFRKMKEEICSRLRKMEMDLGQ-----SIF 3378

  Fly  5025 TLENSGRELRSRVDRVNDRTVRLLRRLEAGRDELTKLRSELDVFSDWLQVARRTLEDKERSLSDL 5089
            .|..|.:|..:|:::....|..||    :.:::|.|||..|....     .|.|..|...:|...
Mouse  3379 PLPRSYKEALARLEQSKALTSNLL----STKEDLVKLRQLLRHLR-----CRSTENDATCALGVA 3434

  Fly  5090 TRLPSQADSVREFVSDVIGHQADLRFITMAAQKFVDESKEFLAILNDFRTSLPERLPHVEPLSSA 5154
            :.|..:..|:.|...:......:|:    ...||:.|..|..||:.:   :|.|.||.:...::|
Mouse  3435 SALWEKWLSLLEAAREWQQWGGELK----REWKFISEEIEREAIILE---TLQEDLPEISKTNAA 3492

  Fly  5155 ----------------ESPIRQEVSLVSAQYKDLLNRVNALQDRVSG------------LGGRQR 5191
                            ||..:|::.|..     ||.||.::|:...|            :|..|.
Mouse  3493 PTEELWQLLDSLCQHQESVEKQQLLLAL-----LLQRVRSIQNIPEGTETGETIPALQEIGSMQE 3552

  Fly  5192 E--------------YQDALDKANEWLRSVHPRVSRIISEPIAGD-----PKGVQDQMNEAKALH 5237
            .              .|..:.....:|:.:.. |.|:. |.|:..     |:|..::..:.:.|.
Mouse  3553 RCDRLLHTTRKNKDLVQAEIQAQQSFLKEIKD-VKRVF-EQISTSFPNLAPEGHPERAEQFEELR 3615

  Fly  5238 NELLSSGRLVDNAQQALDNLLRSLGGQLS------PMEI-NQLE--------------------L 5275
            : :|..|:|      :.:|::..|..:.|      |.|| :|:|                    .
Mouse  3616 S-ILQKGKL------SFENIMEKLRIKYSEMYSIVPAEIGSQVEECRSALEDAEEKMSSEVSKSS 3673

  Fly  5276 PIADLKNNYQQLLDNLGEHCKTLDKTLVQ-SQGVQDA-------LDSLVGW---VNQAEDKFKMN 5329
            |.:.::...:::  |.|.||  ::|.|.| |:.:::|       .|.|..|   :|:.:.:.:  
Mouse  3674 PSSIMRRKIERI--NNGLHC--VEKMLQQKSRNIEEAHEIQKKIWDELDLWHSKLNELDSEVQ-- 3732

  Fly  5330 LRPASLIKE---RLQEQIREHKVLLADLQSHQASIDSVQVSAKHLLASASNARIAKKVESNLNDV 5391
                ..:::   :.||.:..   |:|..|.||      |||.:           |:...|.||..
Mouse  3733 ----DFVEQDPGQAQEWMDN---LMAPFQQHQ------QVSQR-----------AESRTSQLNKA 3773

  Fly  5392 TVKFEKLYEKANKRGEFLDDVYNRLSR--YLDEISTVEQRMASLQEALDSRET--SLL------- 5445
            |:|.|:..:.......:::.....|:.  ..|...|:..|.::||.||:..|.  |||       
Mouse  3774 TIKMEEYNDLLKSTEVWIEKTSCLLANPACYDSSRTLSHRASTLQMALEDSEQKHSLLHSIFTDL 3838

  Fly  5446 -------STEELARRMNELSRDKDQLAPQFEDCVRSGKDLISLRDVTDTGV-LRDRIKALESQWR 5502
                   .|::|.:.::|||   ||:|...:..:.:   |..::.|.|..| :...:||:|.:..
Mouse  3839 EDLSIIFETDDLIQTIHELS---DQVAALQQQIMEA---LPHVQQVADDVVAIESEVKAMEKKVA 3897

  Fly  5503 NINISIDERAKLSKQ----KAEQQLAY-----EGLKD------QVLSWLASTEARVNGLPPVAID 5552
            .|...:     |||:    ..|:.|.:     |.:..      :::::.........|..|:.:.
Mouse  3898 KIKAIL-----LSKEIFDFPPEEHLKHGEVILENIHPMKKTIAEIMTYQVELRLPQTGTKPLPVF 3957

  Fly  5553 ------------LDRIKQQHDE-LKPICKDYRDYAPTIDKINDIGAQYDALIRPESPARKRSTYS 5604
                        |:.:.|:.:| ||.:.|...:....||.:..:...|.|.|.||..::.     
Mouse  3958 QRTSQLLQDVKLLENVTQEQNELLKVVIKQTAECDEEIDSLKQMLTNYSAEISPEHVSQN----- 4017

  Fly  5605 PIKRTSPLRRMSGDARSPSPTKGGILSPLSTGSSGFGSRRSSQDGFQLSELSPVQQQLSEINNRY 5669
                                                          |:::|..:|.::..:..:.
Mouse  4018 ----------------------------------------------QVADLPSLQGEMERLEKQI 4036

  Fly  5670 GLIGVRLNDRQHEL--D------NLNEELRKQYENLKGLAQFLERIQRQLPKESVSNKDEAERCI 5726
                :.||.::.:|  |      ||:|.|:::.:.:.      ::......:.:|:.:|.:||.:
Mouse  4037 ----LNLNQKKEDLLVDLKTAVLNLHEHLKQEQQEVG------DKPSAGASECTVAERDASERKL 4091

  Fly  5727 KQARKILEDMYEKQSLLDTTKAQVKDIL------RRKSDVPGAEQLRQENDSIQEKW----KNLN 5781
            .:...:        |.|...|.:.::..      ||:::.|.|            .|    |:..
Mouse  4092 SRTNSM--------SFLPVVKEEAEESSVKSEDGRRRTEPPSA------------SWSFLGKHSK 4136

  Fly  5782 DICKNRIAFSEKLRDFLDTHGNLKSWLDSKERMLTVLGPISSDPRMVQSQVQQVQVLREEFRTQQ 5846
            |:..:..:.|.......|..|.: |..||.  |:.::.|.|..              .||.....
Mouse  4137 DLEGDGASSSSSATIVQDADGRI-STCDSS--MVHIIAPDSGS--------------TEEGPAPS 4184

  Fly  5847 PQLKHFQELGHDVVDHLAGTPDAQAVEIKLKDILGKWDDLVGKLDDRANSLGGAADSSKEFDAAV 5911
            |:|....|         ..||..:|..:......|.::..|.:...|      .||..:.....|
Mouse  4185 PRLSQTDE---------GATPPIEAALLDFPREQGAFESTVERSRPR------PADILRVCKTQV 4234

  Fly  5912 NRLREALQNISDNLDTLPTDGDHQENLRKIENLERQLEGQRPLLADVEQSAATL----------- 5965
            .:|...||..:...:....|.|.|      :.:|.:|.|.:.:|.::|...|:|           
Mouse  4235 AKLELWLQQANVAFEPETVDADMQ------QVVEEELAGCQAMLTEIEYKVASLLETCKDQGLGD 4293

  Fly  5966 -------------------CNI----------------------------LGDPASRADVNSRVA 5983
                               ||:                            :..||..::::|  .
Mouse  4294 CGTTQQEAEALSWKLKTVKCNLEKVQMVLQEKFSEDQHPSTLKKPSEPHDVDQPAGLSELDS--V 4356

  Fly  5984 ALEKQYLALQKK------LDTKKAETEASLRDGRHFAE-NCSKTLGWLGGELSNL-TDRLLVSAH 6040
            ..|:...:.||.      |:.|.:|.:..::    |.| |..||  ||.|...|. .:|...|:.
Mouse  4357 LTERPQFSRQKDAPQPQILELKPSEQKDLIK----FTELNAKKT--WLQGHQENEDANRQSASSS 4415

  Fly  6041 K-------------PTLQHQIDTHEPIYREVMAREH-EVIMLINKGKDLTDRQQDR--------G 6083
            |             |......|..:.::.|:.:|.: .|..|:.....||......        .
Mouse  4416 KVPSPGNAASDSTLPLQAQSGDKWQYLHHELTSRPNPSVPQLVEPQVALTTSTLPSVSVYNFRCP 4480

  Fly  6084 VKRDLDRIQQQWEKLRREAVDRHTRLQTCMEHCKKYSQTSETFLAWLRTAEDKLADL-------- 6140
            ...:|.....|.|:||:||    ..:||      :.|.|.||::    :.:.:|.:|        
Mouse  4481 TADELQAYTTQLEELRQEA----NTIQT------QGSMTEETYI----SLDKRLFELFLSLSRCL 4531

  Fly  6141 --------TPGVLSK---------AKLETRLRDL---------QTFRSEVWKHSGEFENTKGLGE 6179
                    .||:|.:         .||...|:.|         ...::..|         .|...
Mouse  4532 GSVEGLLQRPGLLREDACAQQVFFQKLALELKKLYLALGDKKDDFLKAVTW---------PGKEA 4587

  Fly  6180 TFLSSCDIDKEPIKAELQDIRDRW-------------------ERLNNDLIAR-------AHEI- 6217
            |.|..| ||...:..|....|..|                   :||.:.||.:       .:|| 
Mouse  4588 TLLPEC-IDALTVSLESVQSRAAWRDASLKAGLEHSRSYQNEVKRLYSQLIKKKTALQQSLNEIS 4651

  Fly  6218 -ENCSRRL---DDFNDELRNLDHSLGRCED---RLA-AHDALGGAAKDPKLLERVKAIRE----E 6270
             ::.|::|   |....||:|.:..:.:..|   ||. .|..|....|...:|:.:..|..    |
Mouse  4652 GQSISKQLQKADVHTAELQNSEKQVAKLRDEGERLRFPHGLLQDVYKLEDVLDSMWGILRARYLE 4716

  Fly  6271 LTN--LSKPLQS-LKALAKDIS-AEARAAGGDADHLTSEV------------------------- 6306
            |::  |||.||: |:.:|:.:| .:.:.|.....|..|:.                         
Mouse  4717 LSSPFLSKSLQTLLQGMAELVSIGKGKLAADPLQHAKSKAALQAQLQDHKAFFQKLVADMLLIQT 4781

  Fly  6307 -------------DGL-ADRMSELQGRLDDRC---GELQSAATAVSQFNEQMKSLGIDLNDLETE 6354
                         :|. |::::|::...::.|   .:|||......:|::...||..||..|.:.
Mouse  4782 YSATMFPPSLQKGEGFGAEQVAEVRALEEEACLRGAQLQSMLQKWEEFDDNYASLEKDLEALISS 4846

  Fly  6355 IEKLSPPGREIKIVQVQIDDVGKIQTKLDRLVGRL-----EDAERAADVLVDAGFAADTTQTREQ 6414
            :..:|......:.:..:|....:|:..:|....||     |..:.||.|        ...:...|
Mouse  4847 LPSVSLVEETEERLLERISFYQQIKRNIDGKHARLCQTLNEGRQLAASV--------SCPEPEGQ 4903

  Fly  6415 ISTLRKTLGRLDNRVRDHEDNLHSTLKALREF---YDHQSQTLDDIQDVSDEFKRMK-PVGSELD 6475
            |:.|.:....|:.|:......|.:.||.|..:   .|..::.|:..|...:.:|... .|..:|:
Mouse  4904 IARLEEQWLSLNKRIDQELHRLQTLLKHLLSYSRDSDELTRWLETSQQTLNYWKEQSLNVSQDLN 4968

  Fly  6476 QIRRQQEDFRNFRERKVEPLAINVDKVNVAGRDLVRSAGSGV------STTAIEKDLEKLNDRWN 6534
            .||...:.|..|.:...|..::         :..|.|.|:.:      .|..:...|.:...:|.
Mouse  4969 TIRSNIDRFFKFSKEVDERSSL---------KSAVMSTGNQLLHLKEADTATLRASLAQFEQKWT 5024

  Fly  6535 -------DLKERMNERDRRLDVALLQSGKF--QEALAGLSKWLSDTEEMVANQ-----KPPSSDY 6585
                   |::|::::         ||..|.  :||::.:..|::..|...|.:     |..:|..
Mouse  5025 VLITQLPDIQEKLHQ---------LQMEKLPSREAISEMISWMNAVEPQAAGKDTELSKSSASQV 5080

  Fly  6586 KVVKAQLQEQKF---LKKMLLDRQN-SMGSLANLGKEVANHCEPGERASIEKQLNDLMKRFDALT 6646
            |.:..:|:|.:.   .|:.::|..| |:..|:....|...:    ||....:.|.::.:::..:.
Mouse  5081 KHLLQKLKEFRMEMDYKQWVVDFVNQSLLQLSTCDVESKRY----ERTEFAEHLGEMNRQWQRVH 5141

  Fly  6647 DGAEQRELDLEEAMEVAKRFHDKISPLELWLDNTERSVK---------AMELIPTDEEKIQQRIR 6702
            ....::...||:.:|......:|:..|..||:..|..:|         :||.:..|.:.|:.::.
Mouse  5142 GTLNRKIQHLEQLLESITENENKVQNLNSWLEAQEERLKMLQKPESAVSMEKLLLDCQDIENQLA 5206

  Fly  6703 EHDRLHDEIL--------GKKPDFSDLADVTAQLMHLVSD--EEAVNLGEKVRGVTERYTG---L 6754
            ...:..||:.        |..|...|:|....:|....::  .:...|...|:.|.:.:..   |
Mouse  5207 LKSKALDELRQSSLTMDGGDVPLLEDMASGIVELFQKKNNVTSQVHQLRASVQSVLQEWKACDKL 5271

  Fly  6755 VDASDNIGALLAESRQGLRHLVLSYQDLVAWMESMEAELKRFKSVPVYAEKLLEQMDHLLELNEN 6819
            .|.:......|..|.:..:..|||.|.|...::::||.....::.....|||.|.:..|.....:
Mouse  5272 YDEATMRTTQLTYSMEHSKPAVLSLQALACQVQNLEALQDEAENGERSWEKLQEVIGRLKASCPS 5336

  Fly  6820 IAGHASNVESTVESGAELMKHISNDEAIQLKDKLDSLQRRYGDLTNRGGDLLKSAQNALPLVQQF 6884
            :||                         .:::|......|:..:.....|.|:.|:..|.|.:..
Mouse  5337 MAG-------------------------IIEEKCQDAHSRWTQVNQDLADQLQEARGQLQLWKAP 5376

  Fly  6885 HEAHNRLVEWMQSAEAA-------------LAPSEPRQ-ADVLRLEGELADMRPILDSINQVGPQ 6935
            |.||.....|:|..||.             ||...||. .|:..|:.:|...:......:.:..|
Mouse  5377 HNAHAEAAAWLQQQEAKFQQLANTNLSGDNLADILPRALKDIKGLQSDLQKTKEAFLENSTLSDQ 5441

  Fly  6936 LCQ----LSPG---------EGAATIESIVTRDNRRFDSIVEQIQRKAERLHLSNQRAKEVTGDI 6987
            |.|    .:||         :.||.:|.::...:..|:.::.|.:...:||..|.........::
Mouse  5442 LPQPEERSTPGLHSGQRHSLQTAAYLEKMLLAKSNEFEIVLAQFKDFTDRLAYSKDLIVHKEENL 5506

  Fly  6988 DELLEWFRE--MDTTLREA-DLPAMEPKLVRAQLQEHRSINDDISSQKGRVRDVTAASKKVLRES 7049
            ::|....:|  .|..|... .|.|..|.:.|...:..|....|::     ::.:.:.:::.:|. 
Mouse  5507 NKLYHEEKEEVPDLFLNHVLALTAQSPDIERLNEESLRLPLSDVT-----IKTLQSLNRQWIRA- 5565

  Fly  7050 PQSENTATLREKLDDLKEIVDTVAQLCSERLGILEQALPLSEHFADSHQGLTAWLDDMEQQISRL 7114
                 |||   .||...|:         :..|:.|:.|    |:.:      .|:..:|:....|
Mouse  5566 -----TAT---ALDHYSEL---------QGNGLNEKFL----HYCE------RWIQVLEKIQESL 5603

  Fly  7115 ------SMPALRPDQITLQQDKNERLLQSIAEHKPLLDKLNKTGEALGALVADDDGAKINEILDT 7173
                  |:|||      |:|.|...:|::..          .|.:|    |||....:..::|||
Mouse  5604 SVEVAHSLPAL------LEQQKTYEILEAEV----------STNQA----VADAYVTQSLQLLDT 5648

  Fly  7174 -----------------DNARYAALRLELRERQQALESALQESSQFSDKLEGMLRALANTVDQVN 7221
                             |..:.||  ..:|:|:..:...:.:...|:..:|.:||.||:|    :
Mouse  5649 AEIEKRPEFVSEFSKLSDQWQRAA--RGVRQRKCDISRLVTQWRFFTTSVEDLLRFLADT----S 5707

  Fly  7222 QLDPLSALPQKIREQIEDNDALMDDLDKRQDAFSAVQ--RAANDVIAK----------------A 7268
            ||  |||:                   |.||.:|..|  |..:::.:|                |
Mouse  5708 QL--LSAV-------------------KEQDCYSLCQTRRLVHELKSKEIHLQRWRTTYALALEA 5751

  Fly  7269 G----NKADPAVRD-IKAKLEKLNNLWNDVQNATKKRGSSLDDILSVAEPFWKQLNSVMKTLKDL 7328
            |    |...|..|: :..::.:|...|.|.:.:.   |..:..:.|.||. |.|....:|.||..
Mouse  5752 GEKLRNTPSPETREFVDGQISRLQESWKDTELSL---GEVISRLQSTAET-WDQCKKKIKKLKKR 5812

  Fly  7329 EETLSCQ-EPPAAQPQD-IKKQQVALQEIRHEIDQTKPEVEQVRRHGSNLMNMCGEPDKPEVKKH 7391
            .:.|..| |.|..:..: :.:::..::|:...:......:::::...::|.......|...:|:.
Mouse  5813 LQALKAQSEDPLPELHEALHEEKELIKEVEKSLANWTHSLKELQTMKADLSQHILAEDVTVLKEQ 5877

  Fly  7392 IEDLDNAWDNITALYAKREENLIDAMEKAMEFHETLQNLLKFLTKAEDKFAHLGAVGSDIDAVKR 7456
            |:.|...|:::....|.|::.:.|.:...:.|:|..:.|..:|.:.|:|......|     :::.
Mouse  5878 IQLLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADV-----SIEE 5937

  Fly  7457 QIEQL-KSFKDEVDPHMVEVEALNRQAVELTERTSPEQAASIREPLSVVNRRWEALLRGMVERQK 7520
            .||:| |...:|:.........|.:...:|.:.:|..:||.:.|.||.:|.||:.|...:..|.|
Mouse  5938 MIEKLQKDCMEEISLFTENKLQLKQMGDQLIKASSKAKAAELEEKLSKINDRWQHLFDVIGSRVK 6002

  Fly  7521 QLEHALLHLGQFQHALNELLVWINKTDSTLDQLKPI---PGDPQLLEVELAKLKVLANDIQAHQN 7582
            :|:.....:.|....::.|..|:.:.:|.|.  ||:   ..|.|.::..||:.:.|..||:.|..
Mouse  6003 KLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDNQEIQKRLAEQQDLQRDIEQHSA 6065

  Fly  7583 SVDT--------LNDAGRQLIETEKGSVEASTTQEKLRKLNNEWKQLLQKASDRQHELEEALREA 7639
            .|::        |:|:.....|||..|::.:|     |.|:..|:.:...:.:|:.::||..|..
Mouse  6066 GVESVFNICDVLLHDSDACANETECDSIQQTT-----RSLDRRWRNICAMSMERRMKIEETWRLW 6125

  Fly  7640 HGYIAEVQDILGWLGDVDAVIGASKPVGGLPETATEQLERFMEVYNELDENRPKVETIQAQGQEY 7704
            ..::.:......||...:...........|...|.|:|:||.....::.|...::|.|..|.:. 
Mouse  6126 QKFLDDYSRFEDWLKSAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRR- 6189

  Fly  7705 IKRQNQMKVSSSNLQHTLRTLKQRWDAVVSRASDKKIKLEIALKEATEFHDTLQAFVEWLTQAEK 7769
            :.|:|:.. ::|.|:..:....||||.:..|.:....:|.....:..||..|.::.:.|||:.:.
Mouse  6190 LARENRTD-TASKLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDL 6253

  Fly  7770 LLSNAEPVSRVLETIQAQMEEHKVLQKDVSTHREAMLLLDKKGTHLKYFSQKQDVILIKNLLVSV 7834
            .|:|.|..|.  ...:.:|.:....|::::.:...:..|...|..|...|:..|.:||::.|..:
Mouse  6254 QLTNVEHFSE--SDAEDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEEL 6316

  Fly  7835 QHRW--------ERVVSKAAERTRALDHGYKEAREFN-----------DAWSGMMQYLQETE-QV 7879
             ||:        .|...:....|..|| ..|||.|..           |:|....:..:.|. |.
Mouse  6317 -HRYCQEVFGRVSRFHRRLTSHTPGLD-DEKEASENETDIEDPREIQADSWRKRRESEEPTSPQS 6379

  Fly  7880 LDQII-----EEATASKEPQKIKKYIGKLKETHR-QLGAKQSVYDG------TMRTGKNLLERAP 7932
            |..::     .|.:..:.|..:...  .|:..|. .:|...|..|.      :..:||::.|..|
Mouse  6380 LCHLVPPALGHERSGCETPVSVDSI--PLEWDHTGDVGGSSSHEDDEEGPFYSALSGKSISEGHP 6442

  Fly  7933 -----------------KGDR---PV-----------LDKMLIE---------LKE--------- 7948
                             :|||   ||           ..|:|:.         |||         
Mouse  6443 WHVPDSPSHSKHHYKHMEGDRTEAPVPTDASTPFKSDYVKLLLRQGTDDSKEGLKEAQQEDEQLA 6507

  Fly  7949 -----------QWTRVWSKSIDRQRKLEEALLLSGQFSDALGELLDWLKKAKSRLNENGPVHGDL 8002
                       :|..:.::.:..:.:|::.:   .|....:|.:..||          |....:|
Mouse  6508 TLTGQQPGAFDRWELIQAQELHSKLRLKQTV---QQLKSDIGSIAAWL----------GKTEAEL 6559

  Fly  8003 ETVQGLCEHHKHIEQDLQKRAAQMQGVLK---TGRDLERSGN----------NP---EVGRQLDE 8051
            |.:: |.|....| |::..|..::|.:||   |.:.|..|.|          :|   |:..:|.:
Mouse  6560 EALK-LAEPPSDI-QEIALRVKRLQEILKAFDTYKALMVSVNVSHKEYLPSQSPEATELQNRLHQ 6622

  Fly  8052 MQSIWEEVKSAV-AKRGERLQVALVDAEKLNARVQALFDWLDHAEHKLRYAK-NAPD-DEKVSRE 8113
            :...|:.|:..: :.||: |:.:|:..:..:...|.|..||..||.:.:.|. .:|: |.:|..|
Mouse  6623 LSLSWDSVQGVLDSWRGD-LRQSLMQCQDFHQLSQDLLLWLATAESRRQKAHVTSPEADRQVLLE 6686

  Fly  8114 MMDIHMDFMKDLRVREREKTETFEYAEDIINKA----YPDA---IPIIKNWLSIIQQRWEEVRQ- 8170
            .....|...|:|..|:.:.:...|.:..::.|.    |.:|   :.:|:..|..:|   |:|.| 
Mouse  6687 CQKDLMRLEKELVARQPQVSSLREISSSLLVKGQGEDYIEAEEKVHVIEKKLKQLQ---EQVAQD 6748

  Fly  8171 -WAINRESKLEQHLQSLKDLDDTIEELLAWLSGLEGTLLNLKHEQLPDEIP----PVEKLIEDHK 8230
             .::.|....:..|.|..::|          ||          ||||....    |....:|:.:
Mouse  6749 LMSLQRSLDPDASLTSFDEVD----------SG----------EQLPAAFAKSPRPRWTFLEEEE 6793

  Fly  8231 EFMENTARRQNEVDRACKPRQLPPGARKPSRSGKTPVFKGS 8271
            | .|.|..|...:|        .||:.:|.||..:.|.:.:
Mouse  6794 E-EEETDSRMPHLD--------SPGSSQPRRSFLSRVIRAA 6825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401 69/215 (32%)
CH 223..327 CDD:306753 48/103 (47%)
SPEC 471..689 CDD:238103 37/219 (17%)
SPEC 690..866 CDD:238103 33/180 (18%)
SH3 885..922 CDD:327375 5/36 (14%)
SPEC 1047..1250 CDD:238103 36/215 (17%)
SPEC 1153..1390 CDD:238103 52/256 (20%)
PLEC <1498..1526 CDD:197605 5/29 (17%)
Plectin 1949..1981 CDD:307019 2/31 (6%)
DNA_pol3_delta2 <2711..3178 CDD:331068 76/512 (15%)
DUF4775 3026..3357 CDD:330579 54/344 (16%)
SMC_N <4904..5566 CDD:330553 160/825 (19%)
SPEC 5304..5513 CDD:238103 52/241 (22%)
SPEC <5658..5787 CDD:321951 23/146 (16%)
SPEC 5793..6007 CDD:238103 46/277 (17%)
SPEC 6011..6220 CDD:238103 58/294 (20%)
SPEC 6118..6330 CDD:238103 62/330 (19%)
PRK09039 <6279..6441 CDD:332967 36/210 (17%)
SPEC 6443..6660 CDD:238103 44/244 (18%)
SPEC 6663..6878 CDD:238103 43/236 (18%)
SPEC 6880..7087 CDD:238103 47/236 (20%)
SPEC 6986..7196 CDD:238103 45/235 (19%)
SPEC 7196..7417 CDD:238103 50/245 (20%)
SPEC 7314..7526 CDD:238103 46/214 (21%)
SPEC 7528..7747 CDD:238103 52/229 (23%)
SPEC 7749..7968 CDD:238103 58/310 (19%)
SPEC 7973..8181 CDD:238103 54/235 (23%)
EF-hand_7 8373..8437 CDD:316058
GAS2 8450..8522 CDD:128539
Herpes_ICP4_C 8550..>8795 CDD:332854
Syne2NP_001005510.2 Actin-binding 1..286 62/166 (37%)
CH 33..135 CDD:237981
CH 184..283 CDD:278723 48/98 (49%)
Spectrin 1 299..380 29/213 (14%)
Spectrin 2 381..474 19/111 (17%)
Spectrin 3 475..577 29/153 (19%)
Spectrin 4 578..680 30/187 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..723 9/89 (10%)
Spectrin 5 727..834 30/172 (17%)
Smc 806..1698 CDD:224117 255/1687 (15%)
Spectrin 6 835..928 24/137 (18%)
Spectrin 7 929..1030 25/150 (17%)
Spectrin 8 1120..1211 22/95 (23%)
Spectrin 9 1262..1322 18/129 (14%)
Spectrin 10 1323..1409 27/262 (10%)
Spectrin 11 1410..1514 34/221 (15%)
PRK03918 <1414..2000 CDD:235175 150/997 (15%)
Spectrin 12 1515..1626 28/193 (15%)
Spectrin 13 1627..1728 24/156 (15%)
Spectrin 14 1729..1820 18/116 (16%)
Spectrin 15 1821..1928 25/174 (14%)
Spectrin 16 1929..2026 23/133 (17%)
SPEC 1934..>2076 CDD:295325 36/210 (17%)
Spectrin 17 2027..2122 21/139 (15%)
Spectrin 18 2123..2233 28/157 (18%)
Smc 2167..3049 CDD:224117 220/1276 (17%)
Spectrin 19 2234..2350 32/219 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2338..2397 14/70 (20%)
Spectrin 20 2422..2503 21/102 (21%)
Spectrin 21 2504..2610 19/106 (18%)
Spectrin 22 2611..2707 22/197 (11%)
SMC_prok_B 2692..>3557 CDD:274008 220/1187 (19%)
Spectrin 23 2708..2821 35/161 (22%)
Spectrin 24 2822..2923 28/164 (17%)
Spectrin 25 2924..3027 27/131 (21%)
Spectrin 26 3028..3133 35/173 (20%)
Spectrin 27 3134..3239 21/111 (19%)
Spectrin 28 3240..3343 19/103 (18%)
Smc 3247..4049 CDD:224117 170/933 (18%)
Spectrin 29 3344..3456 24/125 (19%)
Spectrin 30 3457..3563 24/117 (21%)
Spectrin 31 3564..3669 20/113 (18%)
Spectrin 32 3670..3767 25/126 (20%)
Spectrin 33 3768..3870 26/104 (25%)
Spectrin 34 3871..3976 17/112 (15%)
Spectrin 35 3977..4074 22/157 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4062..4152 15/115 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4171..4193 7/44 (16%)
Spectrin 36 4218..4337 19/130 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4326..4348 0/21 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4401..4429 4/27 (15%)
Spectrin 37 4507..4626 23/132 (17%)
Spectrin 38 4627..4714 20/86 (23%)
Spectrin 39 4715..4823 20/107 (19%)
Spectrin 40 4824..4929 22/112 (20%)
SPEC 4868..5039 CDD:295325 36/187 (19%)
Spectrin 41 4930..5037 21/115 (18%)
Spectrin 42 5038..5150 22/124 (18%)
SPEC 5049..>5218 CDD:238103 34/172 (20%)
Spectrin 43 5151..5252 20/100 (20%)
Spectrin 44 5253..5377 28/148 (19%)
SPEC 5302..5446 CDD:295325 33/168 (20%)
Spectrin 45 5378..5473 21/94 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5435..5459 5/23 (22%)
Spectrin 46 5474..5576 21/115 (18%)
Spectrin 47 5577..5691 28/145 (19%)
Spectrin 48 5692..5786 27/121 (22%)
Spectrin 49 5787..5894 19/107 (18%)
Spectrin 50 5895..6004 28/113 (25%)
SPEC 5906..6120 CDD:238103 54/225 (24%)
Spectrin 51 6005..6122 29/123 (24%)
Spectrin 52 6123..6230 23/108 (21%)
SPEC 6124..6334 CDD:238103 45/214 (21%)
Spectrin 53 6231..6342 24/113 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6336..6473 28/139 (20%)
Spectrin 54 6450..6534 11/83 (13%)
Spectrin 55 6535..6650 28/130 (22%)
SPEC 6539..6756 CDD:238103 54/232 (23%)
Spectrin 56 6651..6767 28/118 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6790..6812 8/30 (27%)
KASH <6845..6874 CDD:287506
Sufficient for interaction with SUN2. /evidence=ECO:0000250|UniProtKB:Q8WXH0 6861..6874
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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