DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and 9530053A07Rik

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_001158127.1	Gene:	9530053A07Rik / 319482	MGIID:	2442118	Length:	2581	Species:	Mus musculus

Alignment Length:	590	Identity:	112/590 - (18%)
Similarity:	201/590 - (34%)	Gaps:	178/590 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  3574 PDECQVIVDGEQQ-SQTVSTL--LKEEQLSPLDEV-------------------QIIDDKLIVLQ 3616
            || .:|.::.|:: ||:||.:  :|.|.|....||                   |.:..||:|.:
Mouse   485 PD-FKVFIENERRGSQSVSFVRSVKLEALGIKLEVRREYQGKVLVDGILHYLPFQALGGKLVVFR 548

  Fly  3617 QVSYLVDADTELTPQNLYELNIYDPENQYFIDPSTGQKISFHTLVFDMNVFNPETILVKNFSTGK 3681
            |..|.:       .:..:.|::     .|..|.....|:       ..|.||....|..||:...
Mouse   549 QGKYAI-------LRTNFSLSV-----SYNWDTHVTAKV-------PSNYFNSVCGLCGNFNGDP 594

  Fly  3682 YETLTAALERPLLDRHTGHMVDPKT-GKKIPFFECVDRQWIIRAN----PEEQ------KPSGIE 3735
            .:.|...:.        ...:||:. |||          |::.::    .:||      ....:.
Mouse   595 RDDLGKQIR--------AEAIDPRDFGKK----------WLVSSHLGCRTDEQHLCPDFNKGLVS 641

  Fly  3736 NVTIDTQTGQVVLDDGRVCSIVEAINSGKLDIQSISVRDPVSGEVIPLRMAIELGVVDMQAGTVI 3800
            |:|.:.:....:....:.|..|.|.||..::......|.|  |:..||...:.......|:..||
Mouse   642 NITQNCRIFTNISGHFKHCWRVPAYNSAYIECAYDCCRMP--GQTKPLCDTLATYTAICQSSGVI 704

  Fly  3801 ----DIQTL--KEIPMELAFQL------------------------------GFLVPG-ARKPIS 3828
                ..:||  ...|....::|                              |:::.| |..|::
Mouse   705 VYPWRTETLCPMTCPPHSHYELCQRGCPLTCGDQPVPGGCGSDCYESCVCDEGYVLSGEACVPLA 769

  Fly  3829 LEAAVRKGLY---------DPETGKLFDSESQNQVDVQKSIEIGLVDP-KISLIVDTVTKKEVKL 3883
            ....|.:|:|         .||...|...:....|..|.|    ...| ::..::|.:      |
Mouse   770 SCGCVYQGIYHAPGDEFYPGPECNSLCHCDKGGLVSCQPS----HCSPHEVCKVLDGI------L 824

  Fly  3884 DCAIEDDLVLPATGQIKDNKNNTLVP---FDVGVQQCLLKTDNVTWSLPEL----------LQRE 3935
            .|..|..    ||.|:....:.|...   ||. :..|:.......|:.|.|          :|..
Mouse   825 RCVGEGS----ATCQVSGASHYTTFDGRHFDF-MGTCVHVLAQTCWTRPGLKPFTILQENAVQGN 884

  Fly  3936 YYTPSTGKVLNPVTGEEILLQQ---AIEMGFVELETTLVKDVDHDKILPGKEAAKVG---LLDTV 3994
            .....|.|:...|....:.|:|   .:::..|:::..::  :|.|::    :|.:.|   :::|.
Mouse   885 KQVSVTKKITIEVANYTLQLEQNQWKVKVNGVDMKLPVL--LDEDRV----QAFRHGTDMVIETK 943

  Fly  3995 RGTLSSPNISLDEAFVKGYLISTKKPLSLVD--CLLRGLYDPSTAKFTIDDKQLDLKAAIAQKLI 4057
            .|.|.|.::.        |.:..|.|.:...  |.|.|.|:        ||.:.|.:.:...:..
Mouse   944 FGLLVSYDLK--------YSVRVKVPHNYYKHMCGLCGDYN--------DDPKNDFQKSDGSQAA 992

  Fly  4058 NPEEL 4062
            :..||
Mouse   993 SSNEL 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068
		DUF4775	3026..3357	CDD:330579
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
9530053A07Rik	NP_001158127.1	VWD	56..212	CDD:278521
		C8	257..326	CDD:214843
		TIL	329..383	CDD:280072
		VWD	448..598	CDD:278521	29/132 (22%)
		C8	644..714	CDD:285899	15/71 (21%)
		TIL	718..771	CDD:280072	6/52 (12%)
		VWC	773..827	CDD:302663	12/63 (19%)
		VWD	828..988	CDD:214566	36/186 (19%)
		C8	1033..1108	CDD:214843
		TIL	1111..1164	CDD:280072
		VWC	1166..1219	CDD:302663
		VWD	1252..1411	CDD:278521
		C8	1450..1525	CDD:214843
		TIL	1529..1583	CDD:280072
		VWD	1651..1802	CDD:278521
		C8	1839..1913	CDD:214843
		TIL	1916..1969	CDD:280072
		VWD	2039..2179	CDD:278521
		C8	2219..2294	CDD:214843
		TIL	2297..2350	CDD:280072
		VWC	2352..2404	CDD:302663
		VWD	2404..2558	CDD:295339
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900