DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and BC024139

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_001136440.1	Gene:	BC024139 / 271278	MGIID:	2442591	Length:	772	Species:	Mus musculus

Alignment Length:	858	Identity:	177/858 - (20%)
Similarity:	292/858 - (34%)	Gaps:	285/858 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  7865 AWSG--MMQYLQETEQVLDQIIEEATASKEPQK---------------IKKYI---GKLKETHRQ 7909
            ||.|  .:|..:.||.|:.:.:........|.|               ::.::   |:|:.:...
Mouse    52 AWWGSRAVQVTEVTETVVTETVVTEAVEMAPCKPRGQPVQAPLAALDTLRSWLDGMGELQASQGP 116

  Fly  7910 LGAKQSVYDGTMRTGKNLL----ERAPKGDRPVLDK--MLIELKEQWTRVWSKSIDRQRKLEEAL 7968
            |.|..::....:|..:.||    ||||..: |.|.:  ...||..||.|:..::..|.|.||:.:
Mouse   117 LAADATLAASQLREQELLLRLLRERAPHVE-PRLREAGSPSELCTQWHRLVQQAETRWRLLEQLV 180

  Fly  7969 LLSGQFSDALGELLDWLKKAKSRLNE--NGPVHGDLETVQGLCEHHKHIEQDLQKRAAQMQGVLK 8031
            ..:..|..|...||..|..::..|.|  .||               |.:|:.|.......:||:.
Mouse   181 PAAQSFETACKALLVRLSSSEQLLAELWLGP---------------KGLEESLPYLQEVCEGVVA 230

  Fly  8032 TGRDLERSGNNPEVGRQLDEMQSIWEEVKSAVAKRGERLQVALVDAEKLNARVQALFDWLDHAEH 8096
            :.|||||.   .:.|::|.|:.|            .::.::......:...||:........|..
Mouse   231 STRDLERV---LQTGQRLAELLS------------SDQARLVRQQLNQFQERVKLTESQATCARQ 280

  Fly  8097 KLRYAKNAPDDEKVSREMMDIHMDF---------MKDLR------VREREKTETF-EYAEDIINK 8145
            ||.:|:.....:.:....::..::.         :|||:      |:..|:.|.. ::||.....
Mouse   281 KLLFAQRTESSKPLPPAGLEAQLELEGSASTPPQLKDLKQLSVQLVQLAERLEQLAQWAETSSQV 345

  Fly  8146 AYP----------------DAIPIIKNWLSIIQQR------WEEVRQ--WAINRESKLEQHLQSL 8186
            |.|                |..|:..:||...:|.      ||...|  ..:..::.:|: |:..
Mouse   346 AAPAVTIWEQSLSSAMLQADTKPLEGHWLETREQDFGPKAIWEPAVQISCGLADQAAIEK-LKPE 409

  Fly  8187 KDLDDTIEELL--------AWLS-----------------------------------GLEGTLL 8208
            :|.:.:::|.|        :||.                                   .|||.||
Mouse   410 RDWNPSLQEFLWEQQTLAVSWLGRRGAADYGSTCHLGLLMDLQGCRAAMSSPSCERIHTLEGVLL 474

  Fly  8209 NLKH--EQL---PDEIPPVE----KLIEDHKEFMENTARRQNEVDRACKPRQLPPGARKPSRSGK 8264
            .:.|  |:|   |..:...|    |:::.|....|                 :||..
Mouse   475 LVGHLVEKLVLCPHRLSQAEPLGIKVVQAHSLLEE-----------------MPPAL-------- 514

  Fly  8265 TPVFKGSRDQGLNARKGSRITPTRDTPDRDRLPHYGPRFSPSTSGPELEFRSPRAKLLWTKWRDV 8329
            ||.:.....:.:.|.......|..|...|.:....|              :.|: :|.|..|...
Mouse   515 TPKYWTRAPREILALMSLDQEPPGDLASRAKACLLG--------------KIPK-ELSWRPWWSE 564

  Fly  8330 WMLSWERQRLLNDHLLYLKDVERARNFSWDDWRKRFLKYMNHKKSRLTDLFRKMDKDNNGMIPRD 8394
            .|.:|.           |:..|.::..  :|.|               |.:.::::.:....|.|
Mouse   565 VMENWS-----------LRKPEHSKRS--EDKR---------------DQWERLEQGHQVQDPAD 601

  Fly  8395 VFIDGILNTKFDTSGLEMKAVADLFDRNGEGLIDWQEFIAALRPDWQERKP-----------AND 8448
            .|    |:|:      |..:|       |:|   |..:      :|..|.|           .:.
Mouse   602 SF----LSTE------EQDSV-------GQG---WPSY------NWGRRGPLHKVSITFKPGLSS 640

  Fly  8449 SDKIHDEVKRLVMLCTCRQKFRVFQVGEGKYRFG--DSQKLRLVRILRSTVMVRVGGGWVALDEF 8511
            ..|..:.|.|.             :..||....|  ...|::.....|..:||||||||.|||||
Mouse   641 GQKQPNSVVRA-------------RNPEGSSASGARGRPKVQGALAARGAMMVRVGGGWAALDEF 692

  Fly  8512 LQKNDPCRAKGRTNIELREQFILADGVSQSMAAFTPRRSTPNAAATASSSPHAHNGGSSNLPPYM 8576
            |.||||.||||||:.::.|:|:.......:....|.|..|.|...|             |.|..:
Mouse   693 LVKNDPVRAKGRTSQKIHERFLCWTPSVPAPEVITLRLWTSNQMGT-------------NRPLSL 744

  Fly  8577 SGQGPIIKVRERS 8589
            ....||:|.|..|
Mouse   745 KTGLPIVKDRRDS 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068
		DUF4775	3026..3357	CDD:330579
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103	31/128 (24%)
		SPEC	7973..8181	CDD:238103	47/249 (19%)
		EF-hand_7	8373..8437	CDD:316058	11/63 (17%)
		GAS2	8450..8522	CDD:128539	28/73 (38%)
		Herpes_ICP4_C	8550..>8795	CDD:332854	10/40 (25%)
BC024139	NP_001136440.1	SPEC	<157..267	CDD:295325	32/139 (23%)
BC024139	NP_001136440.1	GAS2	<675..701	CDD:295345	19/25 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900