Protein Alignment shot and GAS2L2

DIOPT Version :10

• Sequence 1: NP_725339.1
• Gene: shot / 36542
• FlyBaseID: FBgn0013733
• Length: 8805
• Species: Drosophila melanogaster
• Sequence 2: NP_644814.1
• Gene: GAS2L2 / 246176
• HGNCID: 24846
• Length: 880
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 96/343 - (27%)
• Similarity: 137/343 - (39%)
• Gaps: 78/343 - (22%)

  Fly  8456 VKRLVMLCTCRQKFRVFQVGEGKYRFGDSQKLRLVRILRSTVMVRVGGGWVALDEFLQKNDPCRA 8520
            |:.||..|||..:|.:.:|.|||||.|||..|..:||||:.|||||||||..|..:|.|:||||.
Human   210 VQSLVSHCTCPVQFSMVKVSEGKYRVGDSNTLIFIRILRNHVMVRVGGGWDTLGHYLDKHDPCRC 274

  Fly  8521 KGRTN--------------IELREQFILADGVSQSMAAFTPRRS--------------------- 8550
            ...::              .|:|.|    ||.||:....|..||
Human   275 TSLSHKPGSFLKPPAPPVQHEVRVQ----DGPSQTQPTMTISRSQSPPPPVDWKTYTSSDRRLRP 335

  Fly  8551 -TPNAAATASSSPHAHNGGSSNLPPYMSGQGPIIKVRERSVRSIPMSRPSRSSLSASTPDSLSDN 8614
             ||     :|..|....|..:.....|:   |.::.:|||:  ||..|...:..|..:|.|.|..
Human   336 PTP-----SSPRPRRERGAGTGASREMA---PFLRCQERSL--IPSWRQPTAGDSPPSPQSSSTQ 390

  Fly  8615 EG------SHGGPSGRYTPR----KVTYTSTRTGLTPGGSRAGS---------KPNSRPLSRQGS 8660
            :|      |.|....||.|.    ::..:.........|:.||:         :..::.:|.:|.
Human   391 KGRDPQCTSSGKREERYPPELPRGRIPTSWVHEETDSWGTDAGNPTPQRLRAIEATTKGISARGP 455

  Fly  8661 KP-PSRHGST----LSLDSTDDHTPSRIPQRKPS---TGSTASGTTPRPARLSVTTTTTPGSRLN 8717
            .| |...|..    |.|...|:...:....|:|.   :.:...|.|..|.||......|||....
Human   456 SPLPRSFGPAECLGLRLPLRDEAKGAFFQFREPESVRSPTPVQGLTKIPIRLPPARPPTPGRSFP 520

  Fly  8718 GTSTITRKTASGSASPAP 8735
            |.::.:.:|..| ..|.|
Human   521 GATSGSPRTELG-RDPIP 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH_PLEC-like_rpt2	223..327	CDD:409038
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3_10	864..929	CDD:407754
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1980	CDD:459901
		DUF5585	2860..>3198	CDD:465521
		SMC_prok_B	<4936..>5564	CDD:274008
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:413338
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:181619
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		FRQ1	<8375..8444	CDD:444056
		GAS2	8450..8522	CDD:128539	37/65 (57%)
		PHA03307	8550..>8795	CDD:223039	50/235 (21%)
GAS2L2	NP_644814.1	CH_GAS2L1_2	23..163	CDD:409117
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..200
		GAS2	206..274	CDD:460480	36/63 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..360		16/88 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..437		14/64 (22%)
		PHA03247	<419..875	CDD:223021	26/120 (22%)
		Interaction with ADORA2A. /evidence=ECO:0000250|UniProtKB:Q5SSG4	438..880		23/101 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	489..533		11/44 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..880