DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and GAS2L2

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_644814.1	Gene:	GAS2L2 / 246176	HGNCID:	24846	Length:	880	Species:	Homo sapiens

Alignment Length:	343	Identity:	96/343 - (27%)
Similarity:	137/343 - (39%)	Gaps:	78/343 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  8456 VKRLVMLCTCRQKFRVFQVGEGKYRFGDSQKLRLVRILRSTVMVRVGGGWVALDEFLQKNDPCRA 8520
            |:.||..|||..:|.:.:|.|||||.|||..|..:||||:.|||||||||..|..:|.|:||||.
Human   210 VQSLVSHCTCPVQFSMVKVSEGKYRVGDSNTLIFIRILRNHVMVRVGGGWDTLGHYLDKHDPCRC 274

  Fly  8521 KGRTN--------------IELREQFILADGVSQSMAAFTPRRS--------------------- 8550
            ...::              .|:|.|    ||.||:....|..||
Human   275 TSLSHKPGSFLKPPAPPVQHEVRVQ----DGPSQTQPTMTISRSQSPPPPVDWKTYTSSDRRLRP 335

  Fly  8551 -TPNAAATASSSPHAHNGGSSNLPPYMSGQGPIIKVRERSVRSIPMSRPSRSSLSASTPDSLSDN 8614
             ||     :|..|....|..:.....|:   |.::.:|||:  ||..|...:..|..:|.|.|..
Human   336 PTP-----SSPRPRRERGAGTGASREMA---PFLRCQERSL--IPSWRQPTAGDSPPSPQSSSTQ 390

  Fly  8615 EG------SHGGPSGRYTPR----KVTYTSTRTGLTPGGSRAGS---------KPNSRPLSRQGS 8660
            :|      |.|....||.|.    ::..:.........|:.||:         :..::.:|.:|.
Human   391 KGRDPQCTSSGKREERYPPELPRGRIPTSWVHEETDSWGTDAGNPTPQRLRAIEATTKGISARGP 455

  Fly  8661 KP-PSRHGST----LSLDSTDDHTPSRIPQRKPS---TGSTASGTTPRPARLSVTTTTTPGSRLN 8717
            .| |...|..    |.|...|:...:....|:|.   :.:...|.|..|.||......|||....
Human   456 SPLPRSFGPAECLGLRLPLRDEAKGAFFQFREPESVRSPTPVQGLTKIPIRLPPARPPTPGRSFP 520

  Fly  8718 GTSTITRKTASGSASPAP 8735
            |.::.:.:|..| ..|.|
Human   521 GATSGSPRTELG-RDPIP 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068
		DUF4775	3026..3357	CDD:330579
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539	37/65 (57%)
		Herpes_ICP4_C	8550..>8795	CDD:332854	50/235 (21%)
GAS2L2	NP_644814.1	CH	34..159	CDD:237981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..200
		GAS2	207..274	CDD:280367	36/63 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..360		16/88 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..437		14/64 (22%)
		Interaction with ADORA2A. /evidence=ECO:0000250\|UniProtKB:Q5SSG4	438..880		23/101 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..533		11/44 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..880
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810