DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and SYNE1

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	XP_006715470.1	Gene:	SYNE1 / 23345	HGNCID:	17089	Length:	8846	Species:	Homo sapiens

Alignment Length:	10060	Identity:	1855/10060 - (18%)
Similarity:	3514/10060 - (34%)	Gaps:	2981/10060 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 LPPAKMIRSSELEYRRALPPAIESSST----QRREISDIVVGKEDNVSAREALLRWARRSTARYP 240
            ||..:.:.||     .:...:|.||.|    .:|:::..:.|     :|::|||:|.:.:..:..
Human   149 LPQLQSLSSS-----ASSVDSIVSSETPSPPSKRKVTTKIQG-----NAKKALLKWVQYTAGKQT 203

  Fly   241 GVRVNDFTSSWRDGLAFSALVHRNRPDLLDWRKARNDRPRERLETAFHIVEKEYGVTRLLDPEDV 305
            |:.|.||..|||.|:||.:::|..||:|:|....:....||.||.||.|.|.|.|:.||||||||
Human   204 GIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDV 268

  Fly   306 DTNEPDEKSLITYISSLY-----------------DVFPEPPS---------------------- 331
            |.::|||||::||::...                 ::.|..||
Human   269 DVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKEMKVW 333

  Fly   332 ------------------------------------------IHP-------------------- 334
                                                      |.|
Human   334 IEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDR 398

  Fly   335 ----LFDMESQ-----------------------------RRVHE-------------------- 346
                |||...|                             ::|||
Human   399 VTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNT 463

  Fly   347 ----------YR---------------DLAQQFIYWCREKTAYLQERSFPPTLIEMK-RLLS--- 382
                      ||               |:|::|.:.......:|.:..|    :|:| ||||
Human   464 DAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEF----LELKYRLLSLLV 524

  Fly   383 ---------------------DLQRFRS------------------------------------- 389
                                 .||.:.|
Human   525 LAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAEN 589

  Fly   390 -----DEVSARKRE--------KSKLIQIYKELERYFETVGEVDV---EAELRPDAIEKA----- 433
                 :|.:|:.|.        :|.|.::....:||..||..:..   :||...:..|.|
Human   590 VMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFF 654

  Fly   434 -----WYRMNTALQDREVILQQEIERLERLQRLADKVQREIKHVDQKLTDLEGRIGEEGRRIERL 493
                 |.:.:||:.|....|   ||..:.:      |.|::|   |:|..|.||..|....:::.
Human   655 RNLPHWIQQHTAMNDAGNFL---IETCDEM------VSRDLK---QQLLLLNGRWRELFMEVKQY 707

  Fly   494 HPVDA-----------------------KSIVEALETE-------IRHLEE-----PIQD----- 518
            ...|.                       |.:.|.||..       |:.||:     |:.|
Human   708 AQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKI 772

  Fly   519 MNQDCHVL------NEGRYPHVSELHKKVNKLHQRWAQLRTNFHTNLVQKLSGLKYPVHETTVTR 577
            :.:..|::      .||:     |:...::||.::..::: ..::.|:.:...|..|:.|  :.:
Human   773 ITKTAHLITKESPQEEGK-----EMFATMSKLKEQLTKVK-ECYSPLLYESQQLLIPLEE--LEK 829

  Fly   578 QTRMVVES------------RQIDTNPHFRDLQEHIEWCQNKLKQLLA-ADYGSD-------LPS 622
            |.....:|            |:..::..|:...:.:..||...|:.|. .:.||.       |.:
Human   830 QMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSN 894

  Fly   623 VKEELDRQQHEHKIID-----QFHTKILNDERQQTKFSGDELALYQQRLNQLQKVY--------- 673
            |.:..|:.:.:.:|.|     |...|...|.::..:.:...:..:::...:|:||.
Human   895 VLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEE 959

  Fly   674 ----AELLSTSTKRLSDLDS--LQHFLGQASAELQWLNEKEQV-------EITRDWADKQLDLPS 725
                .|||...|:..|.||.  |..||.........|.|:||.       ::.:.|.|.|.:.|
Human   960 KGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAP- 1023

  Fly   726 VHRYYENLMSELEKREMHF-------ATILDRGEALLNQQHPASKCIEAHLTALQQQWAW----- 778
                |..|..:::..:..|       .|.||| |..|..|..:.|.|:.|......:...
Human  1024 ----YHLLHLKIDVEKNRFLASVEECRTELDR-ETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEK 1083

  Fly   779 LLQL--TLCLEVHLK----------HAT----------EYHQFFGEIKDAEQWLAKRDEILNSKF 821
            .|||  .||:::.::          |.|          .|.:.   ::|.::|   :|  ..|:|
Human  1084 RLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKL---MEDPDKW---KD--YTSRF 1140

  Fly   822 SQSDFGLDQGETLLRG-----------------MQDLREELNAFGETVATLQRRAQTVVPLNKRR 869
            |:....:...||.|:|                 ::::|..:...|||::.|:.|.:.:..::...
Human  1141 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSEN 1205

  Fly   870 QPVNRQGP--VQAICAYKQQGQL--QIEKGETVTLLDNSGR-VKWRVRTAKGQEGPIPGACLLLP 929
            : ..:||.  .:...::|....|  ::||     :|.|.|. |:::.......|..|.|:
Human  1206 E-AQKQGDELAKLSSSFKALVTLLSEVEK-----MLSNFGDCVQYKEIVKNSLEELISGS----- 1259

  Fly   930 PPDQEAIDAAERL---KRLFDRSVAL--WQKKHLRLRQNMIFATIRVVKGWDFDQFLAMGPEQRT 989
               :|..:.||::   :.||:....|  .|:|..|:.          .|..|..|.:|...:...
Human  1260 ---KEVQEQAEKILDTENLFEAQQLLLHHQQKTKRIS----------AKKRDVQQQIAQAQQGEG 1311

  Fly   990 AIRRALNDDADKLLSEGD----PNDPQLRR----LRR-EMDEVNR------------------LF 1027
            .:....:::..||.|..|    ..:.|.||    ||: |..|.|:                  .|
Human  1312 GLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1376

  Fly  1028 DEFEKRARAEEESKQASRIFTEECLAIKSKLEDMARELDQIILAPLPRDLDSLEHVLEIHSDYER 1092
            ...|..:...|::|:.|:  ..|.:|:::  |::.:|..:|.|.|..:.|            .::
Human  1377 SSLESLSSELEQTKEFSK--RTESIAVQA--ENLVKEASEIPLGPQNKQL------------LQQ 1425

  Fly  1093 RLHLLEPELKHLQETFRTIALKTPVLKKSLDNL------MELW-----KELN---TQSGLHKDRL 1143
            :...::.::|.|::|.........::|...|:.      :.:|     ||||   |.|.....::
Human  1426 QAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQI 1490

  Fly  1144 KLLEASLAGLEDNEHVISELENELARHQDLPSTAEGLQQVFKQLNHMQDIITQQQPQMDKMNDAA 1208
            ..::.::..:|.....|..||.|........:|.|..:...|        :||.:...:::.:.|
Human  1491 SQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK--------LTQIRRYGEELREHA 1547

  Fly  1209 DQLGRMGVPTKVLGDL---KRLHSNVERLNTRWSAVCNQLGERMRSCETAIGLMKNLQSSVQVEE 1270
            ..|     ...:||.|   ::...|:.::....|...::|...::.|.:|....|.||..:.:.:
Human  1548 QCL-----EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQ 1607

  Fly  1271 SWVDGTTERLSAMPTATSA-------------------YELDKLLGAAIERKPKIENVNVAGGRL 1316
            :     .|.||:..||.||                   .:.:.:|..|.||:..:||:.....||
Human  1608 A-----LESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRL 1667

  Fly  1317 IREAKIYDSKCLRFVDWLVEARPSFSPPRRDLRPAD--SDPGATQ--------------YYSQRL 1365
            .:|..       .|:.||.......|.|..|: .||  ...|..|              :||:.|
Human  1668 EKELS-------SFLTWLERGEAKASSPEMDI-SADRVKVEGELQLIQALQNEVVSQASFYSKLL 1724

  Fly  1366 D------NLNTKND----RL-LEQLSQR------------------------------------- 1382
            .      ::.:|:|    :| ||||.:|
Human  1725 QLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIK 1789

  Fly  1383 -----LKTAIEVNGSDGLQYAESLQKPLKTFRVDFSAGSVPTGDGYAA------RQEDLY----- 1431
                 |:|..|::..|. |.|.:..|. ....|:...|.:.:..|:.|      |.|||:
Human  1790 LFLSELQTTSEISIMDH-QVALTRHKD-HAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGK 1852

  Fly  1432 ----------------------------------------------TTTYSTTQISSTKTTKSST 1450
                                                          ..|.|..:..|....|...
Human  1853 AEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN 1917

  Fly  1451 KSVYSSDGLDAASQEVSTAGLPQSQIQF------NEIRTLKR--SQQLGG--HSVLDIAGIRDPR 1505
            .::.::..|::|:  ||..|: .|:.|:      :|.||..|  :.||.|  ..:.::.|.:...
Human  1918 DALQNAKALESAA--VSLDGI-LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1979

  Fly  1506 TGRVLTIGEAIQ---------LRILDVRTG-EMLVGDRRITLEQAADQGLIDLQLAKQLLE---- 1556
            ...:..:.:|.|         :..::.||. |.|....|..|:|.       |::..||.:
Human  1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR-------LRVFNQLEDELNS 2037

  Fly  1557 --------PGAGRDASGRELSLLEVIQREISEAESGYETAEKRIKVNNTVTVEQTSGELGSPENP 1613
                    ....:..:.::::....:.|||:..|..::..::.|..|.    .|..|.:......
Human  2038 HEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ----GQCCGLIDLMREY 2098

  Fly  1614 RNIADAIT-----AGSV-DTKTGL---------------------YRVKSGQTISLAEAYERGYL 1651
            :|:..|::     |.|| .|:|.:                     |:.|     .|.....:|..
Human  2099 QNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQK-----DLDNFTSKGKH 2158

  Fly  1652 IRHESVTIKSNALCLSDAIAHGLVDGAGWI-----ADRNSGDKFRLDSAIANQLIDASVREVVDA 1711
            :..|...|.|:...|........||  .|:     .:.|. |:.|:..:|.:.::  |.|:.::.
Human  2159 LLSELKKIHSSDFSLVKTDMESTVD--KWLDVSEKLEENM-DRLRVSLSIWDDVL--STRDEIEG 2218

  Fly  1712 KRDTKITLQEALQSGVLNAKTGRYVNEVTKEKLTF-AEARNRQLIVKPYTLKDICDLNLLDKQAQ 1775
            ..:..:   ..:...:.|........|:.||   | :|.:|:.|.::....| :.||..|.|..:
Human  2219 WSNNCV---PQMAENISNLDNHLRAEELLKE---FESEVKNKALRLEELHSK-VNDLKELTKNLE 2276

  Fly  1776 ITSPMRREKLSIMQAIEAGVLDGNLLKCITK-RKGELVTLQEAIADGIVLPAECKYRDFMTGELI 1839
            ....::..:..:||.:|..       |.||: .||   ||::..|....:.   |:.:.:|....
Human  2277 TPPDLQFIEADLMQKLEHA-------KEITEVAKG---TLKDFTAQSTQVE---KFINDITTWFT 2328

  Fly  1840 SIPEAVERGLISSVAQ-------RSIFDIDGFKDLRSNDYVSFNVALSRDLLR---RKSTGFALE 1894
            .:.|:     :.:.||       :.:.||.  |:|:|.   ..|::.:::.|.   ||.....||
Human  2329 KVEES-----LMNCAQNETCEALKKVKDIQ--KELQSQ---QSNISSTQENLNSLCRKYHSAELE 2383

  Fly  1895 T-GR--DSLVPLEVAVS-----------EGLVR------QEVYEMFSRGIGVQNASGKELS---- 1935
            : ||  ..|:....|||           |.|.:      ||..|.|   :|.: |:.||.|
Human  2384 SLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWF---LGAK-AAAKESSDRTG 2444

  Fly  1936 ---VFDLVYHNLIDPKTGYLLDPKTGETVPLDTAIERKFITPEGALLLSSLLNITLTTETVTRTI 1997
               |.:...|:|.:     :||..:.....||.      :|.||..|.:.|      ::.:..:|
Human  2445 DSKVLEAKLHDLQN-----ILDSVSDGQSKLDA------VTQEGQTLYAHL------SKQIVSSI 2492

  Fly  1998 NRYVTIRAGSQEPVDSVL---LTFTEAVRQ------GFIDEERQLFKDPKTGN--IYSVQQALNY 2051
            ...:|   .:.|...:.|   |...:|::.      .|.|:.|:|       |  |:.:::..|.
Human  2493 QEQIT---KANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL-------NLWIHEMEERFNT 2547

  Fly  2052 GLLVPDSNQTVPEPTNRKKTKSTITIVTKQIIPEAEPIKLNTQHTKYVEK-----SVEIPISQEL 2111
            ..| .:|.|.:||   :|.....:.:...:::...|.:...:|..:.:.:     ..|..:..:|
Human  2548 ENL-GESKQHIPE---KKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQL 2608

  Fly  2112 VKPH----RVVSEFINLEKSSYIEQNVTERQIMELPPGGW--------RL---------KDAIEQ 2155
            :..|    |:..|.:...:.:..|....|..:..:    |        ||         ||.:|:
Human  2609 LTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSM----WFWVKAIQDRLACAESTLGSKDTLEK 2669

  Fly  2156 RLFN-PDTGVFHVQGTDRLVNF-----EECI---NK--QIINNLSLSVIDPNTGD----KISVQS 2205
            ||.. .|..:...:|..:| |.     |:.:   ||  |.:....|..:.....|    .:..||
Human  2670 RLSQIQDILLMKGEGEVKL-NMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQS 2733

  Fly  2206 AFERDILDSYGNYTNSRKQVQGMRSAIDE----------------------SKIILETVPATRG- 2247
            ..| .::..:.:|...:.|::....::|:                      ..|:.|....||.
Human  2734 TLE-SVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL 2797

  Fly  2248 ----ANQKTILRITKVNNIPDVLEVSTPLKDAPPKFVEVLTCQRELASPEPLQIAPGAIYDPSTA 2308
                |..:.:...|:..:..|     |..::...:|.:::|     .:.|.::.....:.|   .
Human  2798 HRLIAKSRELYEKTEDESFKD-----TAQEELKTQFNDIMT-----VAKEKMRKVEEIVKD---H 2849

  Fly  2309 LVIFTQTGETENIFDAARQGL------------VDEQLIKIVDPTTKQPI-----SVTEAIARSI 2356
            |:......|..:...:|::.|            ..::|.||.:....:.|     |..|::|..:
Human  2850 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEV 2914

  Fly  2357 YDPKTAT---ILDSEGQPV--------DLITATKLGLLSVVGAPLVAAEGALRTVRFVTDPRTGE 2410
            ....||:   ::.:|.|.:        |.:..|:..|.::|      ::.||....|     :|:
Human  2915 KQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV------SQMALSEQEF-----SGQ 2968

  Fly  2411 QIPVEVAYE------RGIVSRDQLHRGRSFDSEPATVEDK-VVVLQRMRKVILKPKDALRKGIID 2468
            ...:|.|.|      :....:..|..|::.|.|......| ..:|..::|...:.:| |:..:
Human  2969 VAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED-LKSQL-- 3030

  Fly  2469 EETCEILENTSNFTNPKGEVVNITEALNTGLIDGRRGQVIDPQNNRVLNLRQAVEQKIIDSEQ-T 2532
            .|.|....:.|.::   |:|..:.:..|...:...:|    .||...: |:|...:...|.:| .
Human  3031 NELCRFSRDLSTYS---GKVSGLIKEYNCLCLQASKG----CQNKEQI-LQQRFRKAFRDFQQWL 3087

  Fly  2533 NHILMPLAKSLSVPRLADQGLIDPQT------QTIVHPESGYPLSIHEAIVCEVLDPHSKLHKPE 2591
            .:..:..||...:|    |.:.:..|      :.:...|:|.                   ||
Human  3088 VNAKITTAKCFDIP----QNISEVSTSLQKIQEFLSESENGQ-------------------HK-- 3127

  Fly  2592 KCTLEEAITKGIINADDSTFNYKNKTLNITEAIEA-----KLFDPSYDQQKSKVEIPPVGM-IFP 2650
               |...::||.:.   ||...|.|...|...:.|     |.|..:..|::|.:|...:.| .|.
Human  3128 ---LNMMLSKGELL---STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE 3186

  Fly  2651 VAVE--KSLVEPSKRVVLHPSTKKA--LPIKQAIEENFIMSIPYSPKPDAIEVVTAMEQDL--ID 2709
            |:.|  :..:..::::| |.|:.:.  ||.|:. |:..:.|:        :|.:...|..|  :.
Human  3187 VSAEPIQDWLSKTEKMV-HESSNRLYDLPAKRR-EQQKLQSV--------LEEIHCYEPQLNRLK 3241

  Fly  2710 VAAQTL---TVPSTGERIPLRQAMENGVLVVKNLS-------DFVITQKPIPKTEIMETVRAVHT 2764
            ..||.|   ...|...|..:.| :.:..|.:.||:       |.::.:    ..:....::.:..
Human  3242 EKAQQLWEGQAASKSFRHRVSQ-LSSQYLALSNLTKEKVSRLDRIVAE----HNQFSLGIKELQD 3301

  Fly  2765 VTTKTIELMQGYVLISNN----EVQNVNTGEVCSLEEAKELG----ILREESTTRETKAAAGESP 2821
            ..|..|.::..|...:::    :.:.:....:.|:::.||:.    :.|.||..:.|      ||
Human  3302 WMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNT------SP 3360

  Fly  2822 ESVGDVGTSGDQTVIVEERTQTV------VVSSDTR-KQEMQ-VVSTTQSTK----------DTS 2868
            |.:          ..::::.|:|      ::|:..| |.::: .:|...|.:          |:.
Human  3361 EGI----------PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSM 3415

  Fly  2869 VPSVSEIETKGSKEPSKTLQNVKDAAKLGALGVIAAPVLAGGAIVSGVKSLIKSVKSPTEDAKST 2933
            ..:::|.|.:.::...||       ..||...::...||:       ..||:::::  .:.|..|
Human  3416 EANLNESERQHAELRDKT-------TMLGKAKLLNEEVLS-------YSSLLETIE--VKGAGMT 3464

  Fly  2934 EKPKEPQTSFIEQERRKELQP--QQVPSEVDNLLSETENFISSTTANFIANEKQQD--------- 2987
            |       .::.|...::||.  :.:.......::::|..:.      :..|.|:|
Human  3465 E-------HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVR------LHQEYQRDLKAFEVWLG 3516

  Fly  2988 -KPDTLPQESNLPLEVESTSTLTTTTVTTITTSSTTTETGNLEPVVVEDVSTTVKEDKVVVKPST 3051
             :.:.|.|.|.|    |..:....||:..:.........|.   .::..|..| :||   |.||.
Human  3517 QEQEKLDQYSVL----EGDAHTHETTLRDLQELQVHCAEGQ---ALLNSVLHT-RED---VIPSG 3570

  Fly  3052 VP--EDKTEVS----------KITETITTVTS--NETDTVPEKISQ-----KSASEESAKKDPVV 3097
            :|  ||:...|          :::||.|...:  |:...:.:|..|     |:|.|:.:.:
Human  3571 IPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPR---- 3631

  Fly  3098 TKDTSSRPAETETSPKPVQKEPTPDPAQNTEFPESIK--KDPTPEPDYKETATEAAQITPKEASP 3160
            |:..|:|      :.|.:|..      |..::.|.:.  :|     :.:|....|.:|.  :.|.
Human  3632 TRRQSNR------ATKEIQLH------QMKKWHEEVTAYRD-----EVEEVGARAQEIL--DESH 3677

  Fly  3161 APTNKNEQSAEPTSKPEPMPRTA------KKEEISEIEPPFTAPLAPFVD---------QLAETK 3210
            ..:....|:.:.||:.:.:....      .:|||..:|.. .:.|:.:.|         :...||
Human  3678 VNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEES-ESSLSSYSDWYGSTHKNFKNVATK 3741

  Fly  3211 ITEIKTEF---------------------------------------------KEPVTSSQTITT 3230
            |.::.|..                                             ||.....:.:..
Human  3742 IDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKE 3806

  Fly  3231 ITTTVKTVDEHPIVEEVDEVSK--SEKIVDVEEPTVHQQEPIKVNETSDDSTRTEPTNEIVHEER 3293
            :|:||:  .||..:|:...::|  |:|...:.:.....||.:.|.|        ||..|: :|::
Human  3807 LTSTVR--KEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE--------EPKMEL-YEKK 3860

  Fly  3294 VVTVEEPTITETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPSSPAETKEIEQTTNDD 3358
            ....:..::.:|.::......:.....|..|......|:|:               :|:|..:|.
Human  3861 AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKD---------------KIDQLQSDY 3910

  Fly  3359 Q-----------KKPEEIVDTEKKTTEQKPVE---------TIPTEPISTSETTTVT-------- 3395
            |           ....::.|.|...:|.:.||         .:..:.:.||...|:|
Human  3911 QDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKA 3975

  Fly  3396 --------------LTTK-TTIVDEGKLHPPSDIEQIIQPH--STSD------------------ 3425
                          |..| .|::.:...|..:.::|.:..|  .|.|
Human  3976 MMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEH 4040

  Fly  3426 ---KHQSLVDFIEQ------------EKGTQPAEGGSNILQNVKDAAKLGALAIVGAPVLA---- 3471
               ||.|..|.::|            |...||....:..::.||....|...|.....:|.
Human  4041 ELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCD 4105

  Fly  3472 -GKALV-----DALTTEKTLKPEHSTSQVVT---ETVEELPTEI--------------------- 3506
             ..|.|     |...||:|::.:...:|.:|   |.::.|.:|:
Human  4106 LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL 4170

  Fly  3507 -------ITTSTATLVTKVTTTTTTTTT--------STSEGTPD--------DEALDVVKLPAEL 3548
                   :.:.....|.|:.:...:..|        :..|.:|:        |:.||:.:....|
Human  4171 ELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNL 4235

  Fly  3549 VESSVKRE--VPRTLAIGDAISQKLISPDECQVIVDGEQQSQTVSTLLKEEQLSPLDEVQIIDDK 3611
               .::||  :.||....|.::...:..::.....|...:|...||.:..|.|..|
Human  4236 ---CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKL--------- 4288

  Fly  3612 LIVLQQVSYLVDADTELTPQNLYE-LNIYDPENQYFIDPSTGQKISFHTLVFDMNVFNPETILVK 3675
            .:.||:..|.:: |.:...|.:.| ||:.|.|           .:...|...:...|..|.::.:
Human  4289 ALALQERKYAIE-DLKDQKQKMIEHLNLDDKE-----------LVKEQTSHLEQRWFQLEDLIKR 4341

  Fly  3676 NF--STGKYETLTAALERPLLDRHTGHMVDPKTGKKIPFFECVDRQWIIRANPEEQKPS---GIE 3735
            ..  |....|.|.....|                    |.|.:  :|     .|||:|:   .::
Human  4342 KIQVSVTNLEELNVVQSR--------------------FQELM--EW-----AEEQQPNIAEALK 4379

  Fly  3736 NVTIDTQTGQVVLDDGRVCSIVEAINSGKLDIQSISVRDPVSGEVIPLRMAIELGVVDMQAGTVI 3800
            ..........:::|...:||.:||   .::.::|: ::|..       |:..:||:.:.|
Human  4380 QSPPPDMAQNLLMDHLAICSELEA---KQMLLKSL-IKDAD-------RVMADLGLNERQ----- 4428

  Fly  3801 DIQTLKEIPMELAFQLGFLVPGARKPISLEAAVRKGLYDPETGKLFDSESQNQVDVQKSIEIGLV 3865
                                           .::|.|.|.::
Human  4429 -------------------------------VIQKALSDAQS----------------------- 4439

  Fly  3866 DPKISLIVDTVTKKEVKLDCAIEDD-----LVLPATGQIKDNKNN-------TLVPFDVGVQ--- 3915
              .::.:.|.|.::...|:.|:.:.     .|..||.||:.::..       .|:|.||..|
Human  4440 --HVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKT 4502

  Fly  3916 ----QCLLKT--DNVT--WSLPELLQREYYTPSTGKVLNPVTGEEILLQQAIEM---GFVELETT 3969
                |..|||  :.||  |:....|.:|.......:||..:...:.:....::.   ...|||..
Human  4503 CKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4567

  Fly  3970 LVK----DVDHDKILPGKEAAKVGLLDTVRGTLSSPNISLDEAFVKGYLISTKKPLSLVDCLLRG 4030
            ||.    ..|.||.....:.|.:         ::.|.|:|..
Human  4568 LVSRKHFKEDFDKACHWLKQADI---------VTFPEINLMN----------------------- 4600

  Fly  4031 LYDPSTAKFTIDDKQLDLKAAIAQKLINPEELVLLDPKTESIISITEAIAKGYLDPIEGYVINPY 4095
                       :..:|..:.|..|.::..      .|:.|:::...:...:..| |....|.:.|
Human  4601 -----------ESSELHTQLAKYQNILEQ------SPEYENLLLTLQRTGQTIL-PSLNEVDHSY 4647

  Fly  4096 ASTKLSLHEALENRILIPPKRK-RSLPDAV-----YRGLYDPKTGQFSNT----VTREKLTTERA 4150
            .|.||:......|.|:...|.| ..:.:|:     |..|.:..|...|..    :...|:.|:.|
Human  4648 LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLA 4712

  Fly  4151 IRRGILDPDSTVVNVGSGQIIPFGVATETGIVDSKHGTVRDADDHPIDFKEAF-DRGILVEAKKP 4214
            :...:...|..                 ..|:|...| :.:|.|.....||.| ..|...:..|.
Human  4713 VEEALSLQDGC-----------------RAILDEVAG-LGEAVDELNQKKEGFRSTGQPWQPDKM 4759

  Fly  4215 LRLIEAVVKNVYDEVDGHFVDPKSGEKLNFAEALNTNLLDEHSVQIRDFKTGLYKQLNLTHAKDT 4279
            |.|:     .:|     |.:..::.::::..|. .|:...||....:.    |.:||.....:.:
Human  4760 LHLV-----TLY-----HRLKRQTEQRVSLLED-TTSAYQEHEKMCQQ----LERQLKSVKEEQS 4809

  Fly  4280 GI----IDAQNSKLLYNNQTMTLK-----------HAFDIGILMDVNAPISIQRAIHQGLFDDKT 4329
            .:    :.|:....:|::...:|:           |..|:...:|   |::.::|.||.......
Human  4810 KVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD---PLAYEKARHQIQSWQGE 4871

  Fly  4330 GKLSDPRTGRQITLLESMRSFVVNPHLPCYFDEQTEQMYTLSETCRNGIINRREGVFREPGSNSF 4394
            .||.....|..:|..||        .:....|.|||...:|....|         |..|.....:
Human  4872 LKLLTSAIGETVTECES--------RMVQSIDFQTEMSRSLDWLRR---------VKAELSGPVY 4919

  Fly  4395 VPLGEALSLGLIVDIENAGFGLYELLSMGFYETSTRKVLHPVTNRKLNLNEACVEDVVSLSSSLV 4459
            :.|.       :.||:.      |:                   ||:.:::..|:..:.:.::|
Human  4920 LDLN-------LQDIQE------EI-------------------RKIQIHQEEVQSSLRIMNAL- 4951

  Fly  4460 KHHETGKYLRLANAIKEQLVDDSRGCYNLGNEQLDLQAARARGLIVSNRRLLSLELVLRQQLYRP 4524
            .|.|..|:.:....|...|   ......|.....|:|.|      :..|:....|:..:.|
Human  4952 SHKEKEKFTKAKELISADL---EHSLAELSELDGDIQEA------LRTRQATLTEIYSQCQ---- 5003

  Fly  4525 ETGKFCDPTTGEYLDLIEAIHSGFIDPATTVFKNQLTGKELPLTEAIENGDIDVSKGRVFDPKSK 4589
                       .|..:.:|.:....|....:   ||.|..|.:..|.||..   |....|..:.:
Human  5004 -----------RYYQVFQAANDWLEDAQELL---QLAGNGLDVESAEENLK---SHMEFFSTEDQ 5051

  Fly  4590 SAYNYDVALSRGILVTITRPL---TDRNDVVRRQDSVELLNQTPVSVVISKPREMSLEEAIRYNI 4651
            ...|.:...|   ||....||   |.:.|:.::..|:||.:|           .||.:...:.::
Human  5052 FHSNLEELHS---LVATLDPLIKPTGKEDLEQKVASLELRSQ-----------RMSRDSGAQVDL 5102

  Fly  4652 IDPKTALVRDFDSFKFLPYSVAVERGLVDTTKRTLVDPKALYFAFDPTLIVYVREPVTFDQAAES 4716
            :...||...|:...:    ...:|  |::.|::.|.:     |:...|...:..|    ::.:|.
Human  5103 LQRCTAQWHDYQKAR----EEVIE--LMNDTEKKLSE-----FSLLKTSSSHEAE----EKLSEH 5152

  Fly  4717 KCLDLQTGLLTYVPASVPGSATAAPASDDSANDSLTVIET--PKVYTLKEAASAGVVDPDSALVK 4779
            |.|                               ::|:.:  .|:..|:|.|        |.|.|
Human  5153 KAL-------------------------------VSVVNSFHEKIVALEEKA--------SQLEK 5178

  Fly  4780 ---DLAKAKLVR--------------LPEAFRKGLMDA-NKANVLNTQTSKLCTLQEAYESGLIC 4826
               |.:||.|.|              :.:...|.|.|| ::....|.:..|...:.:..:..|..
Human  5179 TGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPG 5243

  Fly  4827 TPKRSFGLLEAITFNLYNPTNGCLVDPFQMHPDIIRRRKFTLAEAIGSGLVDPSSTVVRDPSTGV 4891
            :........|.:|...|:.|....::..|....::|::..::       |.|.::     |:.|.
Human  5244 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSM-------LQDGAA-----PTPGE 5296

  Fly  4892 IVPLTAAISSGLIDATEGRLTDANEP-KNNIDLVKAAEKGLLLPAEQRQAVFEKFNMCEENVNDL 4955
            ..||...|:     |.:.|..:..|. |.|..|||...|       .|:       |.|..:|.:
Human  5297 EPPLMQEIT-----AMQDRCLNMQEKVKTNGKLVKQELK-------DRE-------MVETQINSV 5342

  Fly  4956 LKWVTTVEQKISSVGGPREKIDELRNQINALKQIKDEIESQQRPVATCLEQIRQIVLTGGDVLSA 5020
            ..||...::.:   |.|..:||.   |:..|:.:..|..:.::.:....|:.::..|....:|.:
Human  5343 KCWVQETKEYL---GNPTIEIDA---QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPS 5401

  Fly  5021 PEVTTLENSGRELRSRVDRVNDRTVRLLRRLEAGRDELT----KLRSELDVFSDWLQVARRTLED 5081
            .....|.....:|:.| |::.|: ::.:.:.:|...||:    ||..:|...
Human  5402 ELSLQLAEVALDLKIR-DQIQDK-IKEVEQSKATSQELSRQIQKLAKDLTTI------------- 5451

  Fly  5082 KERSLSDLTRLPSQADSVREFVSD--VIGHQAD-----LRFITMAAQKFVDESKEFLAILNDFRT 5139
                   ||:|.::.|:|.:..:|  |:|.:.|     |..:..|.|||::::.:....|.....
Human  5452 -------LTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIG 5509

  Fly  5140 SLPERLPHVEPLSSAESPIRQEVSLVSAQYKDLLNRVNALQDRVSGLGGRQREYQDALDKANEWL 5204
            .|.|.  |.:.:..||                  ||::.|....|.|    .||.:.|:...:|:
Human  5510 KLTEL--HQQTIRQAE------------------NRLSKLNQAASHL----EEYNEMLELILKWI 5550

  Fly  5205 RSVHPRVSRIISE-PIAGDPKGVQDQMNEAKALHNELLSSGRLVDNAQQALDNLLRSLGGQLSPM 5268
            ..     :::::. .||.:.   ..|:.|...||..||...:.:|:..:|:...|:.|.......
Human  5551 EK-----AKVLAHGTIAWNS---ASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTE 5607

  Fly  5269 EINQLELPIADLKNNYQQL-------LDNLGEHCKTLDKTLVQSQGVQDALDSLVGWVNQAEDKF 5326
            :::|   .:|:|....::|       |.||.:..|.:.|...:.:.:|.||:       ||:
Human  5608 KMSQ---QVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE-------QAQ--- 5659

  Fly  5327 KMNLRPASLIKERLQEQIREHKVLLADLQSHQASIDSVQVSAKHLLASASNARIAKKVESNLNDV 5391
             ..|....:.:..|:||:...:.||::::|.:..:.:||:....|       ||.:.|.::| .:
Human  5660 -ATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSAL-------RIPEDVVASL-PL 5715

  Fly  5392 TVKFEKLYEKANKRGEFLDDVYNRLSRYLDEISTVEQRMASLQEALDSR----ETSLLSTEELAR 5452
            .....:|.|:|::.........|.:...:.:....||.|..||:.::..    |...::|..:..
Human  5716 CHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQE 5780

  Fly  5453 RMNELSRDKDQLAPQFEDCVRSGKDLISLRDVTDTGVLRDRIKALESQWRNINISIDERAKLSKQ 5517
            ...::||.::                           |..:||..:.|..::|    .:.|:...
Human  5781 LQAQISRHEE---------------------------LAQKIKGYQEQIASLN----SKCKMLTM 5814

  Fly  5518 KAEQQLAYEGLKDQVLSWLASTEARVNGLPPVAIDLD----------------RIKQQHDELKPI 5566
            ||:.            :.:..|...|.||.....|||                ...:.|..|.|:
Human  5815 KAKH------------ATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPV 5867

  Fly  5567 ------------------CKDYRDYAPTIDKINDIGAQYDAL-----------IRPESPARKRST 5602
                              |:.....|.|...:|...|.|.||           |.|.:.| .:..
Human  5868 TEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEF 5931

  Fly  5603 YSPIKRTSPLRRMSGDARSPSPTKGGILSPLSTGSSGFGSRRSSQDGFQ--LSELSPVQQQLSEI 5665
            |.|....|...::....||....|..|.....|.......::..||..|  .:::..::.:|||.
Human  5932 YEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES 5996

  Fly  5666 NNRYGLIGVRLNDRQHELDNLNEELRKQYENLKGLAQFLERIQRQLPKESVSNKDEAERCIKQAR 5730
            .........::.:.|..|..|.:|:..       |...:..:|..|.:|.||...||:..
Human  5997 PEPGRSPESQMAEHQSFLQALMDEILM-------LQDEINELQSSLAEELVSESCEADPA----- 6049

  Fly  5731 KILEDMYEKQSLLDTTKAQVKDILRRKSDVPGAEQLRQE--NDSIQEKWKNLNDICKNRIAFSEK 5793
                :....||.| |..|:....:|.|:.  |..||.:|  ||.::|:.:            .:.
Human  6050 ----EQLALQSTL-TVLAERMSTIRMKAS--GKRQLLEEKLNDQLEEQRQ------------EQA 6095

  Fly  5794 LRDFLDTHGNLKSW-LDSKERMLTVLGPISSDPRMVQSQVQQVQVLREEFRTQQPQLK----HFQ 5853
            |:.:......|.|| |.:|..:.|.|.| ..:|..:::|:...|.:..|...:...|.    |.:
Human  6096 LQRYRCEADELDSWLLSTKATLDTALSP-PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNE 6159

  Fly  5854 ELGHDVVDHLAGTPD-AQAVEIKLKDILGKWDDLVGKLDDR-ANSLGGAADSSKEFDAAVNRLRE 5916
            .|   :::..|.|.| |:.:..||:.:.|...:|...|.|: .|...|.|...:|.|..:...:.
Human  6160 NL---LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQQGTAQEKEESDVDLTATQS 6221

  Fly  5917 -ALQNISDNLDTLPTDGDHQENLRKIENLERQLEGQRPLLADV---------EQSAATLCNILGD 5971
             .:|.......|..|. ..|.:|::.:.||::|..|:.||..|         :.|||   ...||
Human  6222 PGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAA---ETSGD 6282

  Fly  5972 PASRADVNSRVAALEKQYLALQKKLDTKKAETEASLRDGRHFAENCSKTLGWLGGELSNLTDRLL 6036
            ...:.||.|:...:|                                       ||.|:..|::.
Human  6283 AGEKPDVLSQELGME---------------------------------------GEKSSAEDQMR 6308

  Fly  6037 VSAHKPTLQHQIDTHEPIYREVMAREHEVIMLINKGKDLT---------DRQQDRGVKRDLDRIQ 6092
            :...  :|..:..|.:.:.:.|:.:|.|.::.....:.|:         ..|....|...||.:.
Human  6309 MKWE--SLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLN 6371

  Fly  6093 QQWEKL-------RREAVDRHTRLQTCMEHCKKYSQTSETFLAWLRTAEDKLADLTPGVLSKAKL 6150
            |.:|::       :|:::....:|         |...|.| ..||...|::|...|  .|...:.
Human  6372 QAFEEVSSQSGGAKRQSIHLEQKL---------YDGVSAT-STWLDDVEERLFVAT--ALLPEET 6424

  Fly  6151 ETRLRDLQTFRSEVWKHSGEFENTKGL-GETFLSSCDIDKEPIKAELQDIRDRWERLNNDLIARA 6214
            ||.|.:.:....::.:.|.|.:..|.| .:.|..:.| :::.|:..|..:..|...|::.:..|.
Human  6425 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD-NRDVIEDTLGCLLGRLSLLDSVVNQRC 6488

  Fly  6215 HEIENCSRRLDDFNDELRNLDHSLG--------------------------RCEDRLAAHDALGG 6253
            |:::...:::.:|.::|:.|..||.                          :.||.|...||  |
Human  6489 HQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA--G 6551

  Fly  6254 -----------AAKDPKLLE-----------------RVKAIREELTNLSKPLQSLKALAKDISA 6290
                       ..:.|.:.|                 |...:.:.||..|:..::|:.||..:..
Human  6552 IIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLET 6616

  Fly  6291 EARAAGGDADHLTS---EVDGLADRMSELQGRLDDRC----------------------GELQSA 6330
            ......||...:.|   |:..|.|:..|....|:...                      .||.:.
Human  6617 GQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6681

  Fly  6331 ATAVSQFNEQMKSLGIDL-------NDLETEIEKLSPPGREIKIVQVQIDDVGKIQTKLDRLVGR 6388
            |:||.   ::....|::|       :.|:.:.::||   |::::|:..|..||.::...|||:.|
Human  6682 ASAVL---KRAHKRGVELEYILETWSHLDEDQQELS---RQLEVVESSIPSVGLVEENEDRLIDR 6740

  Fly  6389 ---------------------LEDAERAADVLVDAGFAADTTQTRE----QISTLRKTLGRLDNR 6428
                                 |:|.:|....:..:...:...|..|    ..:.:.|.|.||:..
Human  6741 ITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETI 6805

  Fly  6429 VR-------DHEDNLH--STLKALREFYDHQSQTLDDIQDVSDEFKRMKPVGSELDQIRRQQEDF 6484
            ::       :..|.:|  .:.|...||:..||.|                |..||:.:|.....|
Human  6806 LKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVT----------------VPQELEMVRDHLNAF 6854

  Fly  6485 RNFRERKVEPLAINVDKVNVAGRDLVRSAGSGVSTTAIEKDLEKLNDRWNDLKER---MNERDRR 6546
            ..| .::|:..:.....|...|..|:|.  ..|.|..:..:|.:::.:|.||...   :.|:..:
Human  6855 LEF-SKEVDAQSSLKSSVLSTGNQLLRL--KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6916

  Fly  6547 LDVALLQSGKFQEALAGLSKWLSDTEEMVANQK---PPSSDYKVVKAQLQEQKFL------KKML 6602
            |.:..|.|   :.|::.:..|:|..|.::...:   ..|..||.:...||:.|..      |::.
Human  6917 LQMDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT 6978

  Fly  6603 LDRQNSMGSLANLGKEVANHCEPGERASIEKQLNDLMKRFDALTDGAEQRELDLEEAMEVAKRFH 6667
            :|..|.  |:..:..:.. ..:..::....:||..:.|.:..|.....::...||..:|....:.
Human  6979 VDFVNQ--SVLQISSQDV-ESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYE 7040

  Fly  6668 DKISPLELWLDNTERSVKAMELIPTDEEKIQQRIREHDRLHD------------------EILGK 6714
            :.:..|:.|.:..|:.:|....| .|:..:|..:::...|.|                  .|..|
Human  7041 NNVQCLKTWFETQEKRLKQQHRI-GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNK 7104

  Fly  6715 KPDFS--------DLADVTAQLMHLVSDEEAVNLGEKVRGVTERYTGLVDASDNIGALLAESRQG 6771
            |.|.|        :|....|.|.|:|...:.:     ::.|.::::....|.|.|.:.|.|:|..
Human  7105 KEDVSSIVMSTLRELGQTWANLDHMVGQLKIL-----LKSVLDQWSSHKVAFDKINSYLMEARYS 7164

  Fly  6772 LRHLVL-------------SYQDLVAWMESMEAELKRFKSVPVYAEKLLEQMDHLLELNENIAGH 6823
            |....|             :.|:|...:|..|..|::|.|:   ..:||::.            |
Human  7165 LSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSI---TNQLLKEC------------H 7214

  Fly  6824 ASNVESTVESGAE-------LMKHISNDEAIQLKDKLDSLQRRYGDLT-----------NRGGDL 6870
            ....|:...:..|       |::.|:  |.:|....|..|.:||.|.:           :|..:|
Human  7215 PPVTETLTNTLKEVNMRWNNLLEEIA--EQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7277

  Fly  6871 LKSAQNALPLVQQFHEAHNRLVEWMQSAEAALAPSEPRQADVLRLEGELADMRPILDSINQVGPQ 6935
            ||:|.|.       ..|.:.:..|:|...           |:|:..|.:.|.   |..::::|.|
Human  7278 LKAATNK-------DIADDEVATWIQDCN-----------DLLKGLGTVKDS---LFFLHELGEQ 7321

  Fly  6936 LCQLSPGEGAATIESIVTRDNRRFDSIVEQIQRKAERLHLSNQRAKEVT----GDIDELLEWFRE 6996
            |.|......|:.|:|             :|:........|.....|:.|    |.:|  .|.|.:
Human  7322 LKQQVDASAASAIQS-------------DQLSLSQHLCALEQALCKQQTSLQAGVLD--YETFAK 7371

  Fly  6997 MDTTLREADLPAMEPKLVRAQ--LQ-EHRSINDDISSQKGRVRDVTAASKKVLRESPQSE--NTA 7056
                    .|.|:|..:|.|:  || :..|.:.|:|:.:.|:.::.....|....:|..:  |..
Human  7372 --------SLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7428

  Fly  7057 TLREKLDDLKEIV---------DTVAQLCSERLGILEQALPLSEHFADSHQGLTAWLDDMEQQIS 7112
            ..|..|:| |||.         ..::...:||...|:..|...:.|.:..:   .|::.:.|...
Human  7429 GYRLPLND-KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE---TWMEFLVQTEQ 7489

  Fly  7113 RLSMPALRPDQITLQQDKNERLLQSIAE--------HKPLLD--KLNKTGEALGALVADDDGAKI 7167
            :|::......|..|:|.:...|.|  ||        |..::|  :|.:.|:.       ||..:.
Human  7490 KLAVEISGNYQHLLEQQRAHELFQ--AEMFSRQQILHSIIIDGQRLLEQGQV-------DDRDEF 7545

  Fly  7168 NEILDTDNARYAALRLELRERQQALESALQESSQFSDKLEGMLRALANTVDQVNQLDPLSALPQK 7232
            |..|...:.::..:....::|:..::|.:::..::.:..|.:.:.|.    :|:.| |:|.| ..
Human  7546 NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV----EVSYL-PMSGL-GS 7604

  Fly  7233 IREQIEDNDALMDDLD-------KRQDAFSAVQRAANDVIAKAGNKADPAVRDIKAKLEKLNNLW 7290
            :...::....|.|::.       ::|.::.....|...::..|.:.|:.|   ::|:|.::...|
Human  7605 VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA---LQAELAEIQEKW 7666

  Fly  7291 NDVQNATKKRGSSLDDILSVAEPFWKQLNSVMKTLKDLEETLSCQEPPAAQPQDIKKQQVALQEI 7355
            .......:::...|..:|...|...|.:...::.|:..::.||...|.  ..:::..:|:..:|:
Human  7667 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD--HHEELHAEQMRCKEL 7729

  Fly  7356 RHEIDQTKPEVEQVRRHGSNLMNMCGEPDKPEVKKHIEDLDNAWDNITALYAKREENLIDAMEKA 7420
            .:.:.....::.|:......|.......|...:.:.:|.|...|:.:....:.|.:.:.:.:.:.
Human  7730 ENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEW 7794

  Fly  7421 MEFHETLQNLLKFLTKAEDKFAHLGAVGSDIDAVKRQIEQL-KSFKDEVDPHMVEVEALNRQAVE 7484
            ..|.|..:.|.::||:.|.|.:..|.:     .::..||:| |.:::|:.........|.:....
Human  7795 AVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQENKIQLQQMGER 7854

  Fly  7485 LTERTSPEQAASIREPLSVVNRRWEALLRGMVERQKQLEHALLHLGQFQHALNELLVWINKTDST 7549
            |.:.:...:|:.|...|..||.||:.||..:..|.|:|:..|:.:.|....::.|..|:...:|.
Human  7855 LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESE 7919

  Fly  7550 LDQLKPIPGD---PQLLEVELAKLKVLANDIQAHQNSVDT--------LNDAGRQLIETEKGSVE 7603
            |  .|||..|   .:.::.:|.:.:.|..||:.|...|.:        |:|......:.|..|::
Human  7920 L--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7982

  Fly  7604 ASTTQEKLRKLNNEWKQLLQKASDRQHELEEALREAHGYIAEVQDILGWLGDVDAVIGASKPVGG 7668
            .:|     |.|:..|:.:...:.:|:.::||..|....::.:......||...:.........|.
Human  7983 QAT-----RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 8042

  Fly  7669 LPETATEQLERFMEVYNELDENRPKVETIQAQGQEYIKRQNQMKVSSSNLQHTLRTLKQRWDAVV 7733
            :...|.|:|::|.....::.|...::|.|..|.:. :.|:|:.. |:.:|:..:....||||.:.
Human  8043 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRR-LARENRTD-SACSLKQMVHEGNQRWDNLQ 8105

  Fly  7734 SRASDKKIKLEIALKEATEFHDTLQAFVEWLTQAEKLLSNAEPVSRVLETIQAQMEEHKVLQKDV 7798
            .|.:....:|:..:.:..||.....:.:.|||:.:..|:|.|..|..  .:||::::.|..|:::
Human  8106 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC--DVQAKIKQLKAFQQEI 8168

  Fly  7799 STHREAMLLLDKKGTHLKYFSQKQDVILIKNLLVSVQHRWERVVSKAAERTRAL--------DHG 7855
            |.:...:..:..:|..|...|:..|..:|:..|..::...:.|..:.....:.|        :|.
Human  8169 SLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8233

  Fly  7856 YKEAREFNDAWSGMMQYLQETEQVLDQIIEEATASKEPQKIKKYIGKLKETHRQLGAKQSVYDGT 7920
            ..: ||.....|..:..|...::..|.::       .||........|.:..|           :
Human  8234 LSD-RELELEDSAALSDLHWHDRSADSLL-------SPQPSSNLSLSLAQPLR-----------S 8279

  Fly  7921 MRTGKNLLERAPKGDRPV-LDKMLIELKEQWTRVWSKSIDRQRKLEEALLLSGQFSDALGE---- 7980
            .|:|:         |.|. :|.:.:|        |....|..|.||.|:..:....|..|:
Human  8280 ERSGR---------DTPASVDSIPLE--------WDHDYDLSRDLESAMSRALPSEDEEGQDDKD 8327

  Fly  7981 ------------LLDWLKKAKSRLNENGPVHGDLETVQGLCEHHKHIEQDLQKRAAQMQGVLKTG 8033
                        ::....:|..:|.||        .::.....|..:|..::
Human  8328 FYLRGAVGLSDVMIPESPEAYVKLTEN--------AIKNTSGDHSALESQIR------------- 8371

  Fly  8034 RDLERSGNNPEVGRQLDEMQSIWEEVKSAVAKR---GERLQVALVDAEKLNARVQALFDWLDHAE 8095
                      ::|:.||:.:...::.::.:..:   |..|..:.....||.....:..|.:...|
Human  8372 ----------QLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE 8426

  Fly  8096 HKLRYAKNAPDDEKVSREMMDIHMDFMKDLRVREREKTETFEYAEDIINKAYPDAIPIIKNWLSI 8160
            |||:      ::|:.....:::|             .|||  ....:|:
Human  8427 HKLK------EEEESLPGFVNLH-------------STET--QTAGVID---------------- 8454

  Fly  8161 IQQRWEEVRQWAINRESKLEQHLQSLKDLDDTIEELLAWLSGLEGTLLNLKHEQLPDEIPPVEKL 8225
               |||.::..|:::|.:::|:||..:..:..:..:.|||...|..|..|:..:|..:|..:|..
Human  8455 ---RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 8516

  Fly  8226 IEDHKEFMENTARRQNEV--DRACKPRQLPPGARKPSRSGKTPVFKGSRDQGLNARKGSRITPTR 8288
            |:..||..:....|:..:  ...|.|......:            |.|||.
Human  8517 IKKLKELQKAVDHRKAIILSINLCSPEFTQADS------------KESRDL-------------- 8555

  Fly  8289 DTPDRDRLPHYGPRFSPSTSGPELEFRSPRAKLLWTKWRDVWMLSWERQRLLNDHLLYLKDVERA 8353
                :|||.....|:.             |...|..:||.          ||.|.|:      :.
Human  8556 ----QDRLSQMNGRWD-------------RVCSLLEEWRG----------LLQDALM------QC 8587

  Fly  8354 RNFSWDDWRKRFLKYMN-HKKSR-LTDLFRKMDKDNNGMIPRDVFIDG---------ILNTKFDT 8407
            :.|:....|. ||.... |:.|. |..:...:|:..|.::|.|..:|.         ::..|.:.
Human  8588 QIFTGQVGRP-FLNIKGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 8651

  Fly  8408 SGLEMKAVADLFDRNGEGLIDWQEFIAALRPDWQERKPANDSDKIHDEVKRLVMLCTCRQKFRVF 8472
            ...::: ||.|.|.:.:.|::      |...|..|.|     :|:|....||.:|
Human  8652 LESQLR-VASLQDMSCQLLVN------AEGTDCLEAK-----EKVHVIGNRLKLL---------- 8694

  Fly  8473 QVGEGKYRFGDSQKLRLVRILRSTVMVRVGGGWVALDEFLQKNDPCRAKGRTNIELREQFILADG 8537
             :.|......:.:||..|...:..:     ..|.:.||...........||:
Human  8695 -LKEVSRHIKELEKLLDVSSSQQDL-----SSWSSADELDTSGSVSPTSGRS------------- 8740

  Fly  8538 VSQSMAAFTP-RRSTPNAAATAS------SSPHAHN--GGS----SNLPPYMSGQGPIIKVRERS 8589
                    || |:.||....:.|      ||||:.:  |||    |...|..||:|.:.:|...:
Human  8741 --------TPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAA 8797

  Fly  8590 VR-------------SIPMSRPSRSSLSASTPDSLSDNEGSHGGPSGRYT 8626
            :.             .:|||....|.       :||:|......|..|||
Human  8798 LPLQLLLLLLIGLACLVPMSEEDYSC-------ALSNNFARSFHPMLRYT 8840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401	87/473 (18%)
		CH	223..327	CDD:306753	46/120 (38%)
		SPEC	471..689	CDD:238103	53/301 (18%)
		SPEC	690..866	CDD:238103	48/233 (21%)
		SH3	885..922	CDD:327375	9/39 (23%)
		SPEC	1047..1250	CDD:238103	38/219 (17%)
		SPEC	1153..1390	CDD:238103	63/327 (19%)
		PLEC	<1498..1526	CDD:197605	4/36 (11%)
		Plectin	1949..1981	CDD:307019	8/31 (26%)
		DNA_pol3_delta2	<2711..3178	CDD:331068	94/535 (18%)
		DUF4775	3026..3357	CDD:330579	72/413 (17%)
		SMC_N	<4904..5566	CDD:330553	135/701 (19%)
		SPEC	5304..5513	CDD:238103	37/212 (17%)
		SPEC	<5658..5787	CDD:321951	29/130 (22%)
		SPEC	5793..6007	CDD:238103	52/230 (23%)
		SPEC	6011..6220	CDD:238103	42/225 (19%)
		SPEC	6118..6330	CDD:238103	54/291 (19%)
		PRK09039	<6279..6441	CDD:332967	41/227 (18%)
		SPEC	6443..6660	CDD:238103	46/228 (20%)
		SPEC	6663..6878	CDD:238103	55/271 (20%)
		SPEC	6880..7087	CDD:238103	46/224 (21%)
		SPEC	6986..7196	CDD:238103	48/233 (21%)
		SPEC	7196..7417	CDD:238103	34/227 (15%)
		SPEC	7314..7526	CDD:238103	41/212 (19%)
		SPEC	7528..7747	CDD:238103	48/229 (21%)
		SPEC	7749..7968	CDD:238103	43/227 (19%)
		SPEC	7973..8181	CDD:238103	31/226 (14%)
		EF-hand_7	8373..8437	CDD:316058	14/73 (19%)
		GAS2	8450..8522	CDD:128539	12/71 (17%)
		Herpes_ICP4_C	8550..>8795	CDD:332854	27/102 (26%)
SYNE1	XP_006715470.1	CH	28..141	CDD:237981
		CH	187..285	CDD:278723	46/97 (47%)
		SPEC	1454..1661	CDD:295325	44/224 (20%)
		SPEC	1663..1874	CDD:238103	39/220 (18%)
		SPEC	2417..2622	CDD:238103	46/239 (19%)
		SPEC	2523..2739	CDD:238103	43/232 (19%)
		SPEC	2741..2944	CDD:295325	31/215 (14%)
		SPEC	3072..3283	CDD:238103	51/252 (20%)
		SPEC	3184..3395	CDD:238103	42/241 (17%)
		SPEC	3397..3602	CDD:295325	44/244 (18%)
		SPEC	3824..4042	CDD:238103	37/241 (15%)
		SPEC	4148..4344	CDD:295325	35/219 (16%)
		SPEC	4273..4459	CDD:295325	47/305 (15%)
		SPEC	4493..4677	CDD:295325	43/233 (18%)
		SPEC	4895..5088	CDD:295325	50/267 (19%)
		SPEC	5003..5216	CDD:238103	55/301 (18%)
		SPEC	5535..>5697	CDD:295325	38/187 (20%)
		SPEC	5643..5842	CDD:295325	48/260 (18%)
		SMC_prok_B	5944..6730	CDD:274008	174/886 (20%)
		SPEC	5971..6196	CDD:295325	57/259 (22%)
		SPEC	6808..7030	CDD:295325	47/246 (19%)
		SPEC	6926..7137	CDD:238103	40/219 (18%)
		SPEC	7046..7244	CDD:238103	43/220 (20%)
		SPEC	7173..7361	CDD:295325	46/238 (19%)
		SPEC	7365..7567	CDD:238103	46/224 (21%)
		SPEC	7469..7680	CDD:238103	38/231 (16%)
		SPEC	7793..8008	CDD:238103	52/226 (23%)
		SPEC	8012..8222	CDD:238103	42/213 (20%)
		SPEC	8476..8709	CDD:238103	60/315 (19%)
		KASH	<8814..8845	CDD:287506	11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810