DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and VWCE

DIOPT Version :9

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:NP_689931.2 Gene:VWCE / 220001 HGNCID:26487 Length:955 Species:Homo sapiens


Alignment Length:294 Identity:68/294 - (23%)
Similarity:100/294 - (34%) Gaps:93/294 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  8500 RVGGGWVALDEFLQKNDPCRAKGRTNIELREQFILADGVSQSMAAFTPR-------RSTPNAAAT 8557
            :|..|.|    |...::||.   |...:|.|  :..:.|....|...|.       .|.|::.:.
Human   693 KVANGQV----FTLDDEPCT---RCTCQLGE--VSCEKVPCQRACADPALLPGDCCSSCPDSLSP 748

  Fly  8558 ASS----SPHAH------------------NGGSSNLPPYMSGQGPIIKVRERSVRSIPMSRPSR 8600
            ...    |||.:                  |..|...||..|...|::.:.:..:|:..|.    
Human   749 LEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGPPTASPSRPVLHLLQLLLRTNLMK---- 809

  Fly  8601 SSLSASTPDSLSDNEGSHGGPSGRYTPRKVTYTSTRTGLT---PGGSRAGSKPNSRP-LSRQGSK 8661
               :.:.|.|          |:|.:.|.     |...|||   ||      :|.:.| ||...|.
Human   810 ---TQTLPTS----------PAGAHGPH-----SLALGLTATFPG------EPGASPRLSPGPST 850

  Fly  8662 PPSRHGSTLSLDSTDDHTPSRIPQRKPSTGSTASGTTPRPARLSVTTTTTPGSRLNGTSTITRKT 8726
            ||.  ..||.|.|.....|   |...|....:|||     |::.......||:.|...|.::...
Human   851 PPG--APTLPLASPGAPQP---PPVTPERSFSASG-----AQIVSRWPPLPGTLLTEASALSMMD 905

  Fly  8727 ASGSASP---------APTSNGGMSRSSSIPALT 8751
            .|.|.:|         :||:    ||.|:..|.|
Human   906 PSPSKTPITLLGPRVLSPTT----SRLSTALAAT 935

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401
CH 223..327 CDD:306753
SPEC 471..689 CDD:238103
SPEC 690..866 CDD:238103
SH3 885..922 CDD:327375
SPEC 1047..1250 CDD:238103
SPEC 1153..1390 CDD:238103
PLEC <1498..1526 CDD:197605
Plectin 1949..1981 CDD:307019
DNA_pol3_delta2 <2711..3178 CDD:331068
DUF4775 3026..3357 CDD:330579
SMC_N <4904..5566 CDD:330553
SPEC 5304..5513 CDD:238103
SPEC <5658..5787 CDD:321951
SPEC 5793..6007 CDD:238103
SPEC 6011..6220 CDD:238103
SPEC 6118..6330 CDD:238103
PRK09039 <6279..6441 CDD:332967
SPEC 6443..6660 CDD:238103
SPEC 6663..6878 CDD:238103
SPEC 6880..7087 CDD:238103
SPEC 6986..7196 CDD:238103
SPEC 7196..7417 CDD:238103
SPEC 7314..7526 CDD:238103
SPEC 7528..7747 CDD:238103
SPEC 7749..7968 CDD:238103
SPEC 7973..8181 CDD:238103
EF-hand_7 8373..8437 CDD:316058
GAS2 8450..8522 CDD:128539 6/21 (29%)
Herpes_ICP4_C 8550..>8795 CDD:332854 56/237 (24%)
VWCENP_689931.2 EGF_CA 142..180 CDD:214542
cEGF 200..223 CDD:315355
EGF_CA 220..262 CDD:214542
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..329
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..380
VWC 386..440 CDD:327433
VWC 501..559 CDD:327433
VWC 572..625 CDD:214564
VWC 629..684 CDD:327433
VWC 687..742 CDD:327433 12/57 (21%)
Atrophin-1 <726..944 CDD:331285 58/252 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 812..889 29/107 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 903..955 10/37 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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