DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and Tecta

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_001365531.1	Gene:	Tecta / 21683	MGIID:	109575	Length:	2155	Species:	Mus musculus

Alignment Length:	657	Identity:	138/657 - (21%)
Similarity:	211/657 - (32%)	Gaps:	217/657 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1232 ERLNTRWSAVC-NQLGERMRSCETAIGLMKNLQSSVQVEESWVDGTTERLSAMPTATSAYELDKL 1295
            |||..:...:| |..|:......|..|  |.:.|||.:.:||   .|..:...|.|.|..||...
Mouse  1612 ERLQNKVCGLCGNFNGDMTDDYVTLRG--KPVVSSVVLAQSW---KTNGMQKRPLAPSCNELQFS 1671

  Fly  1296 LGAAIERKPKIENVNVAGGRLIREAKIYDSKCLRFVDWLVEARPSFSPPRRDLRPADSDPGATQY 1360
            ..||     ..:||::       :|...|..||:    |.:.:..|.|....|.|...      |
Mouse  1672 QYAA-----TCDNVHI-------QAMQGDGYCLK----LTDMKGFFQPCYGLLDPLPF------Y 1714

  Fly  1361 YSQRLDN-LNTKNDRLLEQLSQRLKTAIEVNGSDGLQYAESLQK----------------PLKTF 1408
            .|..||. .|.|.    .||...|....|...|.|:...|.::|                |.:|.
Mouse  1715 ESCYLDGCYNHKK----FQLCGSLAAYGEACRSFGILSTEWIEKENCSGVVEDPCVGADCPNRTC 1775

  Fly  1409 RVDFSAGSV------PTGDGYAARQEDLYTTTYSTTQISSTKTTKSSTKSVYSSDGLDAASQEVS 1467
            .:| :.|.:      |.   |.....|:         |.:..|.|             ||..|||
Mouse  1776 ELD-NGGELCGCIEPPP---YGNNSHDI---------IDAEVTCK-------------AAQMEVS 1814

  Fly  1468 TAGLPQSQIQFNEIRTLKRSQQLGGHSVLDIAGIRDPRT-----------GRVLTIGEAIQLRIL 1521
            .:.....|:.|.........:|..|....|....:...|           |..:.....|.:...
Mouse  1815 ISKCKLFQLGFEREGVRINDRQCSGIEGEDFISFQINNTKGNCGNIVQSNGTHIMYKNTIWIESA 1879

  Fly  1522 DVRTGEMLVGDRRITLEQAADQGLIDLQLAKQLLEPGAGRDASGRELSLLEVIQREISEAESGYE 1586
            : .||.::..||.|.:|.:....| |:                  ::||..|::..:|
Mouse  1880 N-NTGNIITRDRTINVEFSCAYEL-DI------------------KISLDSVVKPMLS------- 1917

  Fly  1587 TAEKRIKVNNTVTVEQTSGELGSPENPRNIADAITAGSVDTKTGLYRVKSGQTISLAEAYERGYL 1651
                  .:|.||..::                    ||..||..||:     ..|....|.:|.:
Mouse  1918 ------VINLTVPTQE--------------------GSFTTKMALYK-----NASYKHPYRQGEV 1951

  Fly  1652 IRHESVTIKSNALCLSDAIAHGL-VDGAG------------WIADRNSGDKFRLDSAIANQLIDA 1703
            :           |...|.:..|: |.||.            ....|:|.||.|.      .:|:.
Mouse  1952 V-----------LTTRDVLYVGVFVVGADSTHLILTLNKCYATPSRDSNDKLRY------FIIEG 1999

  Fly  1704 SVREVVDAKRDTKITLQEALQSGVLNAKTGRYVNEVTKEKLTFAEARNRQLI----VKPYTLKDI 1764
            ..:.:    :|..|.::|   :||  :.|.|:...|.|....:.|......:    .:.|:.|..
Mouse  2000 GCQNI----KDNTIGIEE---NGV--SLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKIN 2055

  Fly  1765 CDLN-------LLDKQAQITS--PMRREKLSI------MQAIEAGVLDGNLLKCITKRKGELVTL 1814
            |..|       ..:.:.||.|  |:||::|..      .:.|....:||.|..|:|.      :|
Mouse  2056 CPQNSRIATDYSKEHKEQIISVGPIRRKRLDWCEDNGGCEQICTSRVDGPLCSCVTG------SL 2114

  Fly  1815 QEAIADG 1821
            ||   ||
Mouse  2115 QE---DG 2118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103	6/18 (33%)
		SPEC	1153..1390	CDD:238103	43/159 (27%)
		PLEC	<1498..1526	CDD:197605	3/38 (8%)
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068
		DUF4775	3026..3357	CDD:330579
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
Tecta	NP_001365531.1	NIDO	98..254	CDD:214712
		VWD	322..478	CDD:395046
		C8	517..591	CDD:214843
		TIL	597..650	CDD:410995
		VWC	652..706	CDD:327433
		VWD	703..865	CDD:214566
		C8	905..981	CDD:214843
		TIL	984..1036	CDD:410995
		VWD	1100..1258	CDD:395046
		C8	1300..1368	CDD:400886
		TIL	1372..1425	CDD:410995
		VWD	1487..1639	CDD:395046	8/28 (29%)
		C8	1685..1757	CDD:214843	22/85 (26%)
		ZP	1805..2059	CDD:214579	64/350 (18%)
		FXa_inhibition	2089..2121	CDD:405372	11/39 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900