DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and EVPL

DIOPT Version :10

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:NP_001307676.1 Gene:EVPL / 2125 HGNCID:3503 Length:2055 Species:Homo sapiens


Alignment Length:2331 Identity:480/2331 - (20%)
Similarity:841/2331 - (36%) Gaps:603/2331 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   450 QEIERL-ERLQRLADKVQREIKHVDQKLTDLEGRIGEEGRRIERLHPVDAKSIVEALET--EIRH 511
            ||:..| .|:|..||:|:|:|....::|..            :||:...::::....||  .::.
Human    37 QELALLISRMQANADQVERDILETQKRLQQ------------DRLNSEQSQALQHQQETGRSLKE 89

  Fly   512 LEEPIQDMNQDCHVLNEGRYPHVSELHKKVNKLHQRWAQLRTNFHTNLVQKLSGLKYPVHETTVT 576
            .|..::|:..|.......::|...|:.|.:.:||:|..|....:..            ::|    
Human    90 AEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRA------------LYE---- 138

  Fly   577 RQTRMVVESRQIDTNPHFRDLQEHIEWC---QNKLKQLLAADYGSDLPSVKEELDRQQHEHKIID 638
               :||:..          |:...::|.   :.|.||:.|..||..:    .||::|..||.|:.
Human   139 ---KMVLPP----------DVGPRVDWARVLEQKQKQVCAGQYGPGM----AELEQQIAEHNILQ 186

  Fly   639 QFHTKILNDERQQTKFSGDELALYQQRLNQL--------QKVYAELLSTSTKRLSDLDSLQHFLG 695
            :                  |:..|.|:|..|        :..|.:||..::.|...|.||...|.
Human   187 K------------------EIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQ 233

  Fly   696 QASAELQWLNEKEQVEITRDWADKQLDLPSVHRYYENL-MSELEKREMHFATILDRGEALLNQQH 759
            ..:.:|..|.|:::..:.:||:|...|...|.|.||:. ..||..:|.....:.|.||.::..:|
Human   234 GCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRH 298

  Fly   760 PASKCIEAHLTALQQQWAWLLQLTLCLEVHLKHATEYHQFFGEIKDAEQWLAKRDEILNSKFSQS 824
            ||...|:||..||:.:|...|.|.:|.|..|:|..:|.:|..|.....|.|||.:..|::|:|.:
Human   299 PAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363

  Fly   825 DFGLDQGET-LLRGMQDLREELNAFGETVATLQRRAQTVVPLNKRRQPVNRQGPVQAICAYKQQG 888
            ..|.....| ||:.::...:.|.........||||::.|.||.:||.|..:...|.:||.: ..|
Human   364 PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDW-DSG 427

  Fly   889 QLQIEKGETVTLLDNSGRVKWRVRTAKGQEGPIPGACLLLPPPDQEAIDAAERLKRLFDRSVALW 953
            ::|:.:||...|:||:....|.|:...|:....|.||..:|.||.   ||..|..||.....||.
Human   428 EVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDP---DAVARASRLASELQALK 489

  Fly   954 QK---KHLRLRQNMIFATIRVVKGWDFDQFLAMGPEQRTAIRRALNDDADKLLSEGDPNDPQLRR 1015
            ||   ...||:.:.: .::|     ...|....||.:.....|..........|..|..:||.::
Human   490 QKLATVQSRLKASAV-ESLR-----PSQQGTQGGPGRGGCGARRSRFRLPTAPSGSDLANPQAQK 548

  Fly  1016 LRREMDEVNRLFDEFEKRARAEEESKQASRIFTEECLAIKSKLEDMARELDQIILAPL--PRDLD 1078
            |..:|..::....:.|::..|                        .||       |||  |..|:
Human   549 LLTQMTRLDGDLGQIERQVLA------------------------WAR-------APLSRPTPLE 582

  Fly  1079 SLEHVLEIHSDYERRLHLLEPELKHLQ---ETFRT------IALKTPVLKKSLDNLMELWKELNT 1134
            .||..:..|....:||..|..|.:..|   |.|.:      .||:.||   :|:::...:.::..
Human   583 DLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPV---ALNSVKNKFSDVQV 644

  Fly  1135 QSGLHKDRLKLLEASLAGLEDNEHVISELENELARHQDLPSTAEGLQQVFKQLNHMQDIITQQQP 1199
            ...|:.::.|........::|.:.||...|..|.:...:|:....||:...:|...:..:.:||.
Human   645 LCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQT 709

  Fly  1200 QMDKMNDA--ADQLGRMGVPT---KVLGDLKRLHSNVERLNTRWSAVCNQLGERMRSCETAIGLM 1259
            .:.:::.|  |.:.....:..   :...||.|....|..|..|:.||.:||..|.:..:.|....
Human   710 CVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTY 774

  Fly  1260 KNLQSSVQVEESWV-----------DG--------------------------TTERLS-AMPTA 1286
            :..::......||:           ||                          |...|| |:..|
Human   775 QQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAA 839

  Fly  1287 TSAYE---------LDKLLGAAIERKPKI----ENVNVAGGRLIREAKIYDS---------KCLR 1329
            ...||         |:..|..:..::|::    |::......|   ||.|..         :.|.
Human   840 LQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNL---AKAYTEVAAAQQQLLQQLE 901

  Fly  1330 FVDWLVEARPSFSPPRR--DLRPADSDPGATQYYSQRLD-NLNTKNDRLLEQLSQRLKTAIEVNG 1391
            |...::|.:......||  |.:.....|......|:.|. .|..:..|:     .|::..:|...
Human   902 FARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRV-----ARVQHELEAQR 961

  Fly  1392 SDGLQYAESLQKPLKTFR----VDF-----SAGSV--------PTGDGYAARQEDLYTTTYSTTQ 1439
            |..||.  ..|:||:...    |:|     ..||:        ..|...|..|.||........|
Human   962 SQLLQL--RTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQ 1024

  Fly  1440 ISSTKTTKSS---TKSVYSSD---GLDAASQEVSTAGLPQSQIQFNEIRTLKRSQQLGGHSVLDI 1498
            :.|.:.|...   ||.|...:   |||:.:        .|.:||.         |||.|...:..
Human  1025 LESKRKTMQPHLLTKEVTQVERDPGLDSQA--------AQLRIQI---------QQLRGEDAVIS 1072

  Fly  1499 AGIRDPRTGRVLTIGEAIQLRILDVRTGEMLVGDRRITLEQAADQGLIDLQLAKQLLEPGAGRDA 1563
            |.:            |.::..:|.:...|:.|.::.:..|....:..:::..|.|.|......||
Human  1073 ARL------------EGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDA 1125

  Fly  1564 SGRELS--LLEVIQREISEAESGYETAEKRIKVNNTVTVEQTSGELGSPENPRNIADAITAGSVD 1626
            :.|:.:  .:..:|..|.:.|....:.|.::.|.....|||..|.|......|::.:.       
Human  1126 ARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEE------- 1183

  Fly  1627 TKTGLYRVKSGQTISLAEAYERGYLIRHESVTIKSNALCLSDAIAHGLVDGAGWIADRNSGDKFR 1691
                 .|.|                                                        
Human  1184 -----ERTK-------------------------------------------------------- 1187

  Fly  1692 LDSAIANQLIDASVREVVDAKRDTKITLQEAL-QSGVLNAKTGRYVNEVTKEKLTFAEARNRQLI 1755
             ::.:|.:|.|...:..|..|:..|:.|||.: :...::.:|.:   |:|:.|....|...::..
Human  1188 -NATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQ---EITRLKAKLQEMAGKRSG 1248

  Fly  1756 VKPYTLKDICDLNLLDKQ------AQITSPMRREKLSIMQAIEAGVLDGNLLKCITKRKGELVTL 1814
            |:....|.:.||.:|..|      .::|..:.|.:.|           ..:|:.|.:.|.:|   
Human  1249 VEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERS-----------PEVLREIDRLKAQL--- 1299

  Fly  1815 QEAIADGIVLPAECKYRDFMTGELISIPEAVERGLISSVAQRSIFDIDGFKDLRSNDYVSFNV-A 1878
                                 .||::     ..|.    :|..:..:.|.:|....:...... .
Human  1300 ---------------------NELVN-----SHGR----SQEQLIRLQGERDEWRRERAKVETKT 1334

  Fly  1879 LSRDLLR-RKSTGFALETGRDSLVPLEVAVSEGLVRQEVYEMFSRGIGVQNASGKELSVFDLVYH 1942
            :|::::| .|......|..|......|.|.........|||:.|:.:.::....:|..|...|..
Human  1335 VSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1399

  Fly  1943 NLIDPK--------TGYLLDPKTG-------ETVPLDTAIERKFITPEGALLLSSLLNITLTTET 1992
            ...|||        :| .||.:.|       |...|...:|.:    ||.|......:..|..|.
Human  1400 TQKDPKLREEHSRLSG-SLDEEVGRRRQLELEVQQLRAGVEEQ----EGLLSFQEDRSKKLAVER 1459

  Fly  1993 VTRTINRYVTIRAGSQE---PVDSVLLTFTEAVRQGFIDEERQLFKDPKTGNIYSVQQALNYGLL 2054
            ..|.:    |:|....|   |      |..|.:   .::|..:|.|||   ::....:||.:.| 
Human  1460 ELRQL----TLRIQELEKRPP------TVQEKI---IMEEVVKLEKDP---DLEKSTEALRWDL- 1507

  Fly  2055 VPDSNQTVPEPTNR------------KKTKSTITIVTKQIIP-------EAEPIK----LNTQHT 2096
              |..:|.....||            :|.||....:.|::|.       |.|..:    ||.:.|
Human  1508 --DQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERT 1570

  Fly  2097 KYVEKSVEI------------------------------------PISQEL-VKPHRVVSEFINL 2124
            ....:..|.                                    .:.||| ....:...:.:.|
Human  1571 ARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQL 1635

  Fly  2125 EKSSYIEQNVTERQIMELPPGGWRLKDAIEQRLFNPDTGVFHVQGTDR----LVNFEECINKQII 2185
            ::.|.:....||.:..:....|..| ..:|..:......::..:.|.|    .|:.||...:...
Human  1636 QEESKLLSQKTESERQKAAQRGQEL-SRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQT 1699

  Fly  2186 --NNLS--LSVIDPNTGDKISVQSAFERDILDSYGNYTNSRKQVQGMR---------SAIDESKI 2237
              .|||  :|:::|.||..:|...|::|.|:|. |.|.    |:|.:.         ....|..:
Human  1700 RETNLSTKISILEPETGKDMSPYEAYKRGIIDR-GQYL----QLQELECDWEEVTTSGPCGEESV 1759

  Fly  2238 ILETVPATRGANQKTI---LRITKVN----------NIP---DVLEVSTPLKDAPPKFVEVLTCQ 2286
            :|:    .:...|.:|   ||..:::          ::|   ..|.|:...|.:....:..:..:
Human  1760 LLD----RKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISK 1820

  Fly  2287 RELASPEPLQIAPGAIYDPSTALVIFTQTGETENIFDAARQGLVDEQ--LIKIVDPTTKQPISVT 2349
            ..||||.|...   :.:.||.:|                  ||.|:.  :..|.|.||....|:.
Human  1821 SPLASPAPQST---SFFSPSFSL------------------GLGDDSFPIAGIYDTTTDNKCSIK 1864

  Fly  2350 EAIARSIYDPKTA-TILDSE---GQPVDLITATKLGLLSVVGAPLVAAEGALRTVRF------VT 2404
            .|:|:::.||.|. .:|:::   |..|||::..:..:...:...|:......|.:..      :.
Human  1865 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIE 1929

  Fly  2405 DPRTGEQIPVEVAYERGIVSRDQL--HRGRSFDSEPATVEDKVVVLQRMRKVILKPK-------- 2459
            ||.|.:::.|..|.::|.:.|:.:  |                :.:|.:...::.||        
Human  1930 DPVTKKRLSVGEAVQKGWMPRESVLPH----------------LQVQHLTGGLIDPKRTGRIPIQ 1978

  Fly  2460 DALRKGIIDEETCEILENTSNF----TNP-KGEVVNITEALNTGLIDGRRGQVIDP 2510
            .||..|:|.||..::|::.|::    |:| ..|.::..||:.....|...|.::.|
Human  1979 QALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401
CH_PLEC-like_rpt2 223..327 CDD:409038
SPEC 471..689 CDD:238103 42/230 (18%)
SPEC 690..866 CDD:238103 55/177 (31%)
SH3_10 864..929 CDD:407754 21/64 (33%)
SPEC 1047..1250 CDD:238103 48/218 (22%)
SPEC 1153..1390 CDD:238103 57/304 (19%)
PLEC <1498..1526 CDD:197605 3/27 (11%)
Plectin 1949..1980 CDD:459901 10/37 (27%)
DUF5585 2860..>3198 CDD:465521
SMC_prok_B <4936..>5564 CDD:274008
SPEC 5304..5513 CDD:238103
SPEC <5658..5787 CDD:413338
SPEC 5793..6007 CDD:238103
SPEC 6011..6220 CDD:238103
SPEC 6118..6330 CDD:238103
PRK09039 <6279..6441 CDD:181619
SPEC 6443..6660 CDD:238103
SPEC 6663..6878 CDD:238103
SPEC 6880..7087 CDD:238103
SPEC 6986..7196 CDD:238103
SPEC 7196..7417 CDD:238103
SPEC 7314..7526 CDD:238103
SPEC 7528..7747 CDD:238103
SPEC 7749..7968 CDD:238103
SPEC 7973..8181 CDD:238103
FRQ1 <8375..8444 CDD:444056
GAS2 8450..8522 CDD:128539
PHA03307 8550..>8795 CDD:223039
EVPLNP_001307676.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 480/2331 (21%)
4 X 4 AA tandem repeats of K-G-S-P 12..28
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..85 4/31 (13%)
SPEC 228..415 CDD:238103 59/186 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..418 10/29 (34%)
SH3_10 404..468 CDD:407754 21/64 (33%)
Smc <651..>1154 CDD:440809 104/541 (19%)
Central fibrous rod domain 864..1695 182/1010 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 913..938 5/24 (21%)
Smc <930..>1473 CDD:440809 127/703 (18%)
Smc <1348..>1701 CDD:440809 71/377 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1658 3/21 (14%)
Globular 2 1696..2055 81/385 (21%)
Plectin <1710..1738 CDD:459901 10/32 (31%)
PLEC 1840..1877 CDD:197605 13/54 (24%)
Plectin 1880..1918 CDD:459901 6/37 (16%)
PLEC 1916..1953 CDD:197605 8/36 (22%)
Plectin 1957..1994 CDD:459901 9/36 (25%)
Blue background indicates that the domain is not in the aligned region.

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