DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and Ppl

DIOPT Version :9

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:NP_032935.2 Gene:Ppl / 19041 MGIID:1194898 Length:1754 Species:Mus musculus


Alignment Length:1995 Identity:460/1995 - (23%)
Similarity:773/1995 - (38%) Gaps:544/1995 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   436 RMNTALQDREVILQQEIERLERLQRLADKVQREIKHVDQKL-TDL----EGRIGEEGRRIERLHP 495
            :.:..:|.|.:..::..:.:|:||:.||:|:|.|...:.|: :||    ||::.|  .|...|..
Mouse    12 KYSPTVQTRSISNKELSDLIEQLQKNADQVERNIVDTEAKMQSDLARMQEGQLPE--HRDAALQN 74

  Fly   496 V-DAKSIVEALETE---IRHLEEPIQDM-NQDCHVLNEGRYPHVSELHKKVNKLHQRWAQLRTNF 555
            | |::.::..||.:   .:|::.|..|| .:|...|.| |..::...||::..|..:.|..|.|:
Mouse    75 VSDSEKLLYVLEADSAIAKHMKHPQGDMIAEDIRQLKE-RVTNLRGKHKQMYSLAVKEADPRVNW 138

  Fly   556 HTNLVQKLSGLKYPVHETTVTRQTRMVVESRQIDTNPHFRDLQEHIEWCQNKLKQLLAADYGSDL 620
            .| ||.:                                            ||.:|.:..:|:||
Mouse   139 DT-LVDE--------------------------------------------KLDKLSSQSFGTDL 158

  Fly   621 PSVKEELDRQQHEHKIIDQFHTKILNDERQQTKFSGDELALYQQRLNQLQKVYAELLSTSTKRLS 685
            |.|    |.|..:|.|   ||.::        |..|..||..:::.::||..|.:||:.|..|..
Mouse   159 PLV----DSQVEQHNI---FHNEV--------KAIGPHLAKDKEQNSELQAKYQKLLTASQARQQ 208

  Fly   686 DLDSLQHFLGQASAELQWLNEKEQVEITRDWADKQLDLPSVHRYYENLMS-ELEKREMHFATILD 749
            .|.|||.::.:.:.||.||:::.:..:..||:|:.||.||..|.|||.:: .||.:|.....:..
Mouse   209 HLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHT 273

  Fly   750 RGEALLNQQHPASKCIEAHLTALQQQWAWLLQLTLCLEVHLKHATEYHQFFGEIKDAEQWLAKRD 814
            .|:.||..:||....||||:.|:..:|...|.|.:|.|.|||:..:||||..::|||::.|.|.|
Mouse   274 EGDQLLTAEHPGRNSIEAHMEAVHAEWKEYLNLLICEESHLKYMEDYHQFHKDMKDAQELLRKVD 338

  Fly   815 EILNSKFSQSDFGLDQGETLLRGMQDLREELNAFGETVATLQRRAQTVVPLNKRRQPVNRQGPVQ 879
            ..||.|:|.......|.|.|||.:.|..:.|:.:.:.|..||||.|.||||..||:...:..||:
Mouse   339 SDLNQKYSPDFKDRYQIELLLRELDDQEKALDKYEDVVRGLQRRGQQVVPLKYRRETPLKPIPVE 403

  Fly   880 AICAYKQQGQLQIEKGETVTLLDNSGRVKWRVRTAKGQEGPIPGACLLLPPPDQEAIDAAERLKR 944
            |:|.::....| |.:|.:.||..|:|. .|.:..:.|::...|..|.::||.|.||:..|:.|..
Mouse   404 ALCDFESDQGL-ISRGYSYTLQKNNGE-SWELTDSTGKKLAAPAVCFIIPPTDPEALALADSLGS 466

  Fly   945 LFDRSVALWQKKHLRLRQNMIFATIRVVKGWDFDQFLAMGPEQRTAIRRALNDDADKLLSE--GD 1007
            .: |||.                                  ::.|..:.||....:.|.:|  ||
Mouse   467 QY-RSVR----------------------------------QKATGSKHALQQRHEVLRTENPGD 496

  Fly  1008 PNDPQLRRLRREMDEVNRLFDEFEK-----------RARAEEESKQAS---RIFTEECLAIKSKL 1058
            .:|.|.|:|...:|:|....|..||           :.||.|:|.:.:   :..|.|.|.|:.:.
Mouse   497 ASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAIEDSAERAKGLKNITNELLQIEPEK 561

  Fly  1059 EDMARELDQII-------LAPLPRDLDSLEHVLEIHSDYERRLHLLEPELKHLQETFRTIALKTP 1116
            .....|.:..:       .|||.:     ..|.:.:..|||.:.|||.    .||       |..
Mouse   562 TQCTAECEAFVQALPASGTAPLLK-----TRVEDTNQKYERLVWLLEA----AQE-------KVD 610

  Fly  1117 VLKKSLDNLMELWKELNTQSGLHKDRLKLLEASLAGLEDNE-----HVI----SELE---NELAR 1169
            |..: |:|.::..:||...   :::||         ::|:.     ||:    .|||   :||..
Mouse   611 VANR-LENSLQRGRELLAS---YENRL---------IQDDTMPESGHVLDSKRQELEAMASELQA 662

  Fly  1170 HQDLPSTAEGLQQVFKQLNHMQDIITQQQPQMDKMNDAADQLGRMGVPTKVLGDLKRLHSNVERL 1234
            |:.|....|...||.||.:  ..:.::.|....                    ||:|..:.|.:|
Mouse   663 HKSLLGEVEQNLQVAKQCS--SSLASRFQEHCP--------------------DLERQEAEVHKL 705

  Fly  1235 NTRWSAVCNQLGERMRSCETA--------IGLMKNLQSSVQVEESWVDGTTERLSAMPTATSAYE 1291
            |.|::.:..|:..|.:|.::|        .|..:.||...:. .|:....|:.|..|.|.....:
Mouse   706 NQRFNNLSQQVERRAQSLQSARAAYDEYCSGYNRVLQFLAKT-PSYEPQETDSLGQMETKLKNQK 769

  Fly  1292 LDKLLGAAIERKPKIENVNVAGGRLIREAKIYDSKCLRFVDWL---------VEARPSFSPPRRD 1347
              .||.....|:.:::.|.....:..:..|.|:.:..:....|         |..|.....|...
Mouse   770 --NLLDELASREQEVQKVYADSQQYQQAVKDYELEAEKLRSLLDLENGRNSHVNKRARLQSPAAK 832

  Fly  1348 LRPADSDPGA--TQYYS---QRLDNLNTKNDRLLEQLSQRLKTAIEVNG---SDGLQYAESLQKP 1404
            ::..::...|  |:..:   |||.||....: ||.|..:...|...:.|   |.|::....::|.
Mouse   833 VKEEEAALAAKFTEVNAINRQRLQNLEFALN-LLRQQPEAGVTHETLQGGKLSSGMEETWKIKKE 896

  Fly  1405 LKTFRVDFSAGSVPTGDGYAARQEDLYTTTYSTTQISSTKTTKSSTKSVYSSDGL----DAASQE 1465
            |               :....|::.|.....|..:...|...:...:|:...:.|    |.|.:|
Mouse   897 L---------------EEEIERRQQLENEVKSAQEEIQTLKDQGPQESLVRKEVLKKVPDPALEE 946

  Fly  1466 VSTAGLPQ--------SQIQFNEIRTLK-RSQQL------GG--HSVLDIAGIRDPRT--GRVLT 1511
             |...|.|        :|:...|:..|: |.|.|      ||  :.|.::..|...|.  ..||.
Mouse   947 -SFQQLQQTLAEEQHKNQLLQEELGALQLRLQALEQETRDGGQEYVVKEVLRIEPDRAQEDEVLQ 1010

  Fly  1512 IGEAIQL--RILDVRTGEMLVGDRRITL---------EQAADQGLIDLQ-----------LAKQL 1554
            :.|.::.  |....|..|:|:..:|:..         |:..::.::.||           |.::.
Mouse  1011 LREELEALRRQKGAREAEVLLLQQRVAALAAEKSRVQEKVTEREVVKLQNDPQLEAEYRRLQEEH 1075

  Fly  1555 LEPGAGRDASGRELSLLEVIQREISEAESGYETAEKRIKVNNTVTVEQTSGELGSPENPRNIADA 1619
            ...|..|:....|||.|   |.::...|.....||.:|.|...:.||:               ||
Mouse  1076 QREGTLREKQEEELSFL---QAKLRRLEKERAMAEGKITVKEVLKVEK---------------DA 1122

  Fly  1620 ITAGSVDTKTGLY-----RVKSGQTISLAEAYERGYLIRHESVTIKSNALCLSDAIAHGLVDGAG 1679
            .....|:..|..|     :.:|||.       |:..|:|..                        
Mouse  1123 AVEREVNDLTRQYEDEAAKARSGQR-------EKTELLRKI------------------------ 1156

  Fly  1680 WIADRNSGDKFRLDSAIANQLIDASVREVV--DAKRDTKIT---------------LQEALQS-- 1725
            |          .|:...|..::...|||:|  |.|.::::.               .:|.|:|  
Mouse  1157 W----------ALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKFRGAEEQLKSYQ 1211

  Fly  1726 GVLNAKTGR----YVNEVTKEKLTFAE--------ARNRQLIVKPYTLKDICDLNLLDKQAQI-- 1776
            ..|.|...|    .|.|||||.:.:..        .|.|:.|:....|.:.|||.:...:.:|  
Mouse  1212 SELEALRNRGPQVEVKEVTKEVIKYTTDPETEQELQRLREEIMDKTRLIERCDLEIYQLKQEIQA 1276

  Fly  1777 ---TSPMRREKLSIMQAIEAGVLDGNLLKCITKRKGELVTLQEAIADGIVLPAECKYRDFMTGEL 1838
               |.|..:.: .::|.|.....|..     ||::.|.:.:|        |..|.|.:..:.||.
Mouse  1277 LKDTKPQVQTR-EVVQEILQFQEDPQ-----TKKEVESLRIQ--------LSEEQKKQVDLEGER 1327

  Fly  1839 ISIPEAVER-------GLISSVAQRSIFDIDGFKDLRSNDYVSFNVALSRDL---------LRRK 1887
            .|..|.::|       |. ..|.::.:...:...|||: :..:|..::..:|         ||| 
Mouse  1328 ASQEEKIKRKEEELAQGK-ERVVRQEVVQYEDEPDLRA-EVTAFTNSIDAELRQIDKLHVELRR- 1389

  Fly  1888 STGFALETGRDSLV-PLEVAVSEGLVRQ----EVYEMFSRGIGVQNASGKELSVFDLVYHNLIDP 1947
                 |:..|..|. .||....|...|:    ||..:..|...::..                  
Mouse  1390 -----LQHRRAELERQLEELERERQARRAAELEVQRLQQRLAALEQE------------------ 1431

  Fly  1948 KTGYLLDPKTGETVPLDTAIERKFI------TPEGALLLSSLLNITLTTETVTRTINRYVTIRAG 2006
                  :.||||.|   |..::..:      |.|.|||.:.     |..|...|      .:..|
Mouse  1432 ------EAKTGEKV---THTQKVVLQQDPQQTREHALLRAQ-----LEEERHRR------QLLEG 1476

  Fly  2007 SQEPVDSVL-----------LTFTEAVR--QGFIDEERQLFKDPKTGNIYSVQQALNYGLLVPDS 2058
            ..||:...|           :.|:|:|:  :|..::|.|..|.       |:::           
Mouse  1477 ELEPLRRKLAALEKAEIKEKVVFSESVQVEKGDTEQEIQRLKK-------SLEE----------- 1523

  Fly  2059 NQTVPEPTNRKKTKSTITIVTKQIIPEAEPIKLNTQHTKYVEKSVEIPISQELVKPHRVVSEFIN 2123
                 |..::::..|.:|.:      ||:..:|...::|   .|.|:...:|  :.|::..|..|
Mouse  1524 -----ESQSKRELDSEVTRL------EAKLSELEFYNSK---SSKELDFLRE--ENHKLQLERQN 1572

  Fly  2124 LE-----KSSYIEQNVTE----RQIMELPPGG------WRLK---DAIEQRLFNPDTGVFHVQGT 2170
            |:     ..|.||...||    :.|..:..|.      |.|:   |.:::...:.|..:..:|  
Mouse  1573 LQLETRRLQSEIEMAATETRDLKNITTIDSGTHLNSRLWSLEKELDDLKKMSKDKDLEIDELQ-- 1635

  Fly  2171 DRLVNFEECINKQIINNL--SLSVIDPNTGDKISVQSAFERDILD 2213
             |.:.......:|..|:|  |:.||||:||.::|.:.|....::|
Mouse  1636 -RRLGSVAVKREQRENHLRRSIVVIDPDTGRELSPEEAHRAGLID 1679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401
CH 223..327 CDD:306753
SPEC 471..689 CDD:238103 55/227 (24%)
SPEC 690..866 CDD:238103 68/176 (39%)
SH3 885..922 CDD:327375 9/36 (25%)
SPEC 1047..1250 CDD:238103 50/221 (23%)
SPEC 1153..1390 CDD:238103 56/270 (21%)
PLEC <1498..1526 CDD:197605 7/31 (23%)
Plectin 1949..1981 CDD:307019 11/37 (30%)
DNA_pol3_delta2 <2711..3178 CDD:331068
DUF4775 3026..3357 CDD:330579
SMC_N <4904..5566 CDD:330553
SPEC 5304..5513 CDD:238103
SPEC <5658..5787 CDD:321951
SPEC 5793..6007 CDD:238103
SPEC 6011..6220 CDD:238103
SPEC 6118..6330 CDD:238103
PRK09039 <6279..6441 CDD:332967
SPEC 6443..6660 CDD:238103
SPEC 6663..6878 CDD:238103
SPEC 6880..7087 CDD:238103
SPEC 6986..7196 CDD:238103
SPEC 7196..7417 CDD:238103
SPEC 7314..7526 CDD:238103
SPEC 7528..7747 CDD:238103
SPEC 7749..7968 CDD:238103
SPEC 7973..8181 CDD:238103
EF-hand_7 8373..8437 CDD:316058
GAS2 8450..8522 CDD:128539
Herpes_ICP4_C 8550..>8795 CDD:332854
PplNP_032935.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 1/7 (14%)
SPEC 213..387 CDD:238103 65/173 (38%)
Spectrin 1 214..315 35/100 (35%)
Spectrin 2 321..483 59/198 (30%)
SMC_prok_B <467..1134 CDD:274008 162/790 (21%)
Spectrin 3 503..610 29/122 (24%)
DUF342 <903..993 CDD:302792 20/90 (22%)
SMC_prok_B <943..1638 CDD:274008 172/851 (20%)
FlaC <1509..1602 CDD:225888 24/126 (19%)
Interacts with BFSP2 and VIM. /evidence=ECO:0000269|PubMed:19029034 1555..1754 32/130 (25%)
PLEC <1655..1683 CDD:197605 10/25 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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