DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and Y8A9A.2

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_001364778.1	Gene:	Y8A9A.2 / 173723	WormBaseID:	WBGene00021171	Length:	1358	Species:	Caenorhabditis elegans

Alignment Length:	720	Identity:	165/720 - (22%)
Similarity:	249/720 - (34%)	Gaps:	233/720 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  2899 LGVIAAPVLAGGAI-----VSGVKSLIKSVKSPTEDAKSTEKPKEPQTSFIEQERRKE------- 2951
            :|:|.|.:|:....     :|.::.  :|.:.|.::..:||.|...:|::....|.|.
Worm    14 IGIINADILSDPNYRIFRDISAIRQ--RSFERPVKNVSTTELPTYYETNYNISRRVKRQACASSC 76

  Fly  2952 --LQPQQVPSEVDNLLSETENF-ISSTT-------ANFIANEKQQDKPDTLPQESNL-------- 2998
              |:....|: .:.|:: |||| |:.:|       |:...........|.|.|..::
Worm    77 APLEKATTPA-YEGLIA-TENFYITYSTDGSGCPIADLTCVGGDMATLDYLDQNGDIITLGDGGD 139

  Fly  2999 ---PLEVE----------STST------------LT--TTTVTTITTSSTTTETGNLEPVVVEDV 3036
               .||.:          :|:|            ||  ..|.||.|||||||.|.         .
Worm   140 DYNILEAQLKCFAFGWGAATATEVIDGNSLNCNVLTDIPVTTTTSTTSSTTTTTA---------T 195

  Fly  3037 STTVKEDKVVVKPSTVPEDKTEVSKITETITTVTSNETD-TVPEKISQKSASEESAKKDPVVTKD 3100
            |||        :.::...|.|.....||:.|..||..|| |..|..::.:....|...|...|:.
Worm   196 STT--------ESTSTSTDSTTTESTTESTTESTSTSTDSTTTESTTESTTESTSTSTDSTTTES 252

  Fly  3101 TSSRPAETETSPKPVQKEPTPDPAQNTEFPESIKKDPTPEPDYKETATEAAQITPKEASPAPTNK 3165
            ||:....|.|                         :.|.|...:.|:|.....|.:..|   |:.
Worm   253 TSTSTDSTTT-------------------------ESTTESTTESTSTSTDSTTTESTS---TST 289

  Fly  3166 NEQSAEPTSKPEPMPRTAKKEEISEIEPPFTAPLAPFVDQLAETKITEIKTEFKEPVTSSQTITT 3230
            :..:.|.|:                             :...|:..|..::...|..|.|.|.:|
Worm   290 DSTTTESTT-----------------------------ESTTESTSTSTESTTTESTTESTTEST 325

  Fly  3231 ITTTVKTVDEHPIVEEVDEVSKSEKIVDVEEPTVHQQEPIKVNETSDDSTRTEPTNEIVHEERVV 3295
            .|:|..|..|.                               ..||.|||.||.|.|.. .|...
Worm   326 STSTDSTTTES-------------------------------TSTSTDSTTTESTTEST-TESTS 358

  Fly  3296 TVEEPTITETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPSSPAETKEIEQTTNDDQK 3360
            |..:.|.||:| :|:|.:|||.|::|.|  .|:|:|..::...|....|..|:    .:|:.|..
Worm   359 TSTDSTTTEST-STSTDSTTTESTTEST--TESTSTSTDSTTTESTTESTTES----TSTSTDST 416

  Fly  3361 KPEEIVDTEKKTTEQKPVETIPTEPISTSETTTVTLTTKTTIVDEGKLHPPSDIEQIIQPHSTSD 3425
            ..|   .|.:.|||.....|..|...||:|:||.:.:|.|   |.......::        ||::
Worm   417 TTE---STTESTTESTSTSTDSTTTESTTESTTESTSTST---DSTTTESTTE--------STTE 467

  Fly  3426 KHQSLVDFIEQEKGTQPAEGGSNILQNVKDAAKLGALAIVGAPVLAGKALVDALTTEKTLKPEHS 3490
            ...:..|....|..|:.                                     |||.|   ..|
Worm   468 STSTSTDSTTTESTTES-------------------------------------TTEST---STS 492

  Fly  3491 TSQVVTETVEELPTEIITTSTATLVTKVTTTTTTTTTSTSEGTPDDEALDVVKLPAELVESSVKR 3555
            |....||:..|..||..:|||.:..|:.|:|:|.:||:.|..|..|.....|...|    |....
Worm   493 TDSTTTESTTESTTESTSTSTDSTTTESTSTSTDSTTTESTSTSTDSTTTEVTTTA----SDSST 553

  Fly  3556 EVPRT 3560
            .||||
Worm   554 TVPRT 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068	73/336 (22%)
		DUF4775	3026..3357	CDD:330579	71/331 (21%)
		SMC_N	<4904..5566	CDD:330553
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:321951
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:332967
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
Y8A9A.2	NP_001364778.1	TSP1	1203..1252	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900