DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and Evpl

DIOPT Version :9

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:XP_036012216.1 Gene:Evpl / 14027 MGIID:107507 Length:2121 Species:Mus musculus


Alignment Length:2447 Identity:497/2447 - (20%)
Similarity:871/2447 - (35%) Gaps:696/2447 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   450 QEIERL-ERLQRLADKVQREIKHVDQKLTDLEGRIGEEGRRIERLHPVDAKSIVEALET--EIRH 511
            ||:..| .|:|..||:|:|:|....:||.. :.:.||:.:.::...           ||  .::.
Mouse    37 QELALLISRMQANADQVERDILETQKKLQQ-DRQNGEQNQALQHQQ-----------ETGRNLKE 89

  Fly   512 LEEPIQDMNQDCHVLNEGRYPHVSELHKKVNKLHQRWAQLRTNFHTNLVQKLSGLKYPVHETTVT 576
            .|..::|:..|.......::|...|:.|.:.:||:|..|..:.:..            ::|    
Mouse    90 AEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECSEYRA------------LYE---- 138

  Fly   577 RQTRMVVESRQIDTNPHFRDLQEHIEWCQNKLKQLLAADYGSDLPSVKEELDRQQHEHKIIDQFH 641
               :||:..   |..|.. |....:|..||.:::   ..||..:    .||::|..||.|:.:  
Mouse   139 ---KMVLPP---DVGPRV-DWARVLEQKQNLVRE---GHYGPGM----AELEQQVAEHNILQR-- 187

  Fly   642 TKILNDERQQTKFSGDELALYQQRL--------NQLQKVYAELLSTSTKRLSDLDSLQHFLGQAS 698
                            |:..|.|:|        |.::..|.|||..::.|...|.||...|...:
Mouse   188 ----------------EIEAYGQQLRTLVGPDANTIRNQYRELLKAASWRRQSLGSLYTHLQGCT 236

  Fly   699 AELQWLNEKEQVEITRDWADKQLDLPSVHRYYENLMSELE------------------KREMHFA 745
            .:|..|.:::...:.:||:|...|...|.|.||.....|.                  .|..||.
Mouse   237 KQLSALADQQGRILQQDWSDLMPDPAGVRREYEVCGDRLRPGQRGCLGPSSCSWPSRFNRPQHFK 301

  Fly   746 ------------TILDRGEALLNQQHPASKCIEAHLTALQQQWAWLLQLTLCLEVHLKHATEYHQ 798
                        .:.|..:.::...|||...|:.|..||:.:|...|.|.:|.|..|:...:|.:
Mouse   302 QHELLAQERSINQLEDDADRMVELGHPAIGPIQVHQEALKMEWQNFLNLCICQESQLQRVEDYRR 366

  Fly   799 FFGEIKDAEQWLAKRDEILNSKFSQSDFGLDQGET------LLRGMQDLREELNAFGETVATLQR 857
            |..|.....|.|||....|::|     :|...|::      ||..::...::|......|..||:
Mouse   367 FQEEADSVSQTLAKLSSNLDTK-----YGFGTGDSSGSPTELLLQLEAEEKQLAIAERAVGDLQQ 426

  Fly   858 RAQTVVPLNKRRQPVNRQGPVQAICAYKQQGQLQIEKGETVTLLDNSGRVKWRVRTAKGQEGPIP 922
            |:|.|.||.:||.|..:...|.:||.: ..|::|:.:||..||.||:....|.|:...|:....|
Mouse   427 RSQEVAPLPQRRNPSKQPLHVDSICDW-DSGEVQLLRGERYTLKDNADPYTWLVQGPGGETKSAP 490

  Fly   923 GACLLLPPPDQEAIDAAERLKRLFDRSVALWQKKHLRLRQNMIFATI--------RVVKGWD--- 976
            .|||.:|.||.||:..|.||......     .|:.|...:|.:.|..        :..:||.   
Mouse   491 AACLCIPAPDPEAVAKASRLATELQT-----LKQKLSTEKNRLKAAAVEHLQPGQQGTRGWSGRA 550

  Fly   977 ---------------FDQFLAMGP----------------EQRTAIRRALNDDADKLLSEGD--- 1007
                           |.|   .||                ..:|::         .|||...   
Mouse   551 NGWACWVGGTPSRLFFPQ---SGPAHPPGPAGTQGGPISGRHKTSL---------ALLSPAPAGS 603

  Fly  1008 -PNDPQLRRLRREMDEVNRLFDEFEKR--ARAEEESKQASRIFTEE-----CLAIKSKLEDMARE 1064
             |.|||.:.|..:|.:::....:.|::  :.|.....|:|.:...|     |.....:|:.:..|
Mouse   604 APADPQGQTLLSQMTQLDGDLGQIERQVLSWARSPLSQSSSLKDLEGRIHSCEGTAQRLQSLGAE 668

  Fly  1065 LD------QIILAPLPRDLDSLE------HVLEIHSDYERRLHL----------LEPELKHLQET 1107
            .:      :..|:..|....:|:      .|...::|.:...||          ||   |.:||.
Mouse   669 KEAAQQECEAFLSTKPTGSAALQLPVVLNSVKNRYNDVQSLCHLYGEKAKAALGLE---KQIQEA 730

  Fly  1108 FRTI-------ALKTPV------LKKSLDNLMELWKELNTQS----GLHKDRLKLLEASLAGLED 1155
            .|.|       ||:.||      |::.:..|....|||..|.    |||:.           |:.
Mouse   731 DRVIQGFEAALALEGPVPEGSGALQERVSELQRQRKELLQQQACVLGLHRQ-----------LKA 784

  Fly  1156 NEHVISELENELARH-QDLPSTAEGLQQVFKQLNHMQDIITQQQPQMDKMNDAADQLG-RMGVPT 1218
            .||..|.|:|..... ||||                     :||.|:..:.|....:| ::.:..
Mouse   785 TEHACSALQNNFQEFCQDLP---------------------RQQRQVRALTDRYHAVGDQLDLRE 828

  Fly  1219 KVLGD----LKRLHSNVERLNTRW---------------SAVCNQLGERMRSCETAIG------- 1257
            |::.|    .::|.::.:.|:: |               |.:..:|..:.|..:..:|       
Mouse   829 KIVQDASLTYQQLRNSRDNLSS-WLEQLPHHRVQPSDGPSQISYKLQAQKRLIQEILGREQDQAT 892

  Fly  1258 ---LMKNLQSSVQVEESWVDGTTERLSAMPT-ATSAYELDKLLGAAIERKPKIENVNVAGGRLIR 1318
               |.::||.::|..|...|  |.|.|..|. |.||.:  :|...:::...:.:..|:|  :...
Mouse   893 VSRLTRDLQEALQDYELQAD--TYRCSLEPALAVSAPK--RLRVISLQESIQAQEKNLA--KAYT 951

  Fly  1319 EAKIYDSKCLRFVDWLVEARPSFSPPRRDLRPADSDPGATQYYSQRLDNLNTKNDRLLEQLSQRL 1383
            |....:.:.||.:::          .::.||..:.|......:|.|..:.:..:.|..|  |:.|
Mouse   952 EVAAAEQQQLRQLEF----------AKKMLRKKELDEDIQAIHSARQGSGSPAHARTAE--SEVL 1004

  Fly  1384 KTAIEVNGSDGLQYAESLQKPLKTFRVDFSAGSVPTGDGYAARQEDLYTTTYSTTQISSTKTTKS 1448
            ||.:|   .:..:.|| :|:.|:..|....  .:.|....|..:|......|...|:.|   ..|
Mouse  1005 KTQLE---EERKRVAE-VQRDLEEQRQRLL--QLRTQQPVARLEEKEVVEFYRDPQLES---NLS 1060

  Fly  1449 STKSVYSSDG---------LDAASQEV----STAGLPQSQIQFNEIRTLKR-----SQQLGGHSV 1495
            ...|....:|         |:|.:|:|    ......|..:...|:..::|     ||....||.
Mouse  1061 QAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHLLTKEVTQIERDPGLDSQVTQLHSE 1125

  Fly  1496 LD-IAGIRDPRTGRVLTIGEAIQLRILDVRTGEMLVGDRRITLEQAADQGLIDLQLAKQLLEPGA 1559
            :. :.|.....|.|:    |.::..:|.:...||.|.::.:..|....:..:::..|.|.|....
Mouse  1126 MQRLRGENGVLTARL----EELKDELLALEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRLQI 1186

  Fly  1560 GRDASGRE--LSLLEVIQREISEAESGYETAEKRIKVNNTVTVEQTSG---------ELGSPENP 1613
            ..||:.|:  ...:..||..|.:.|....:.|.::.|.....|||..|         .|...|..
Mouse  1187 EEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKN 1251

  Fly  1614 RNIADAITAGSVDTKTGLYRV--KSGQTISLAEAYERGYLIRHES-VTIKSNALCLSDAIAHGLV 1675
            .|:|.|.....:..|   |||  |....:.|.|.....:.:..|: ..|:.....|.:.      
Mouse  1252 NNVALARELQELQEK---YRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQET------ 1307

  Fly  1676 DGAGWIADRNSGDKFRLDSAIANQLIDASVREVVDAKRDTKITLQEALQSGVLNAKTGRYVNEVT 1740
                  ..:.||.:..::..:....:..:.:.||:.|        |..|..|.:.|....:.|:.
Mouse  1308 ------GSKKSGVEQEVEKLLPELEVLRAQKPVVEYK--------EVTQEVVRHEKNPEVLREID 1358

  Fly  1741 KEKLTFAE----------------------ARNRQLIVKPYTLKDICDLN---LLDKQAQITSPM 1780
            :.|....|                      .|.|..:......|::....   :|:|:|:.....
Mouse  1359 RLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDPVLEKEAERLRQE 1423

  Fly  1781 RREKLSIMQAIEAGV--LDGNLLKCITKRKGELVTLQEAIADGIVLPAECKYRDFMTGELISIPE 1843
            .||.:...:|.|..|  |...||....:|..|.:.:||.    :|...:.|.|:..:        
Mouse  1424 VREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEV----VVTQKDPKLREEHS-------- 1476

  Fly  1844 AVERGLISSVAQRSIFDID---------------GFKDLRSNDYVSFNVALSRDL---------L 1884
            .:.|.|...|.:|...:::               .|::.||.     .:|..|:|         |
Mouse  1477 RLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSK-----KLAAERELRQLTLKIQEL 1536

  Fly  1885 RRKSTGFALETGRDSLVPLE----VAVSEGLVRQEVYEMFSRGIGV-QNASGKELSVFDLVYHNL 1944
            .::......:...:.:|.||    :..|...:|:|:.:..:|...: :...|.::.| ||:....
Mouse  1537 EKRPPALQEKIIMEEVVKLEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQV-DLLQKTK 1600

  Fly  1945 IDPKTGYLLDPKTGETVPLDTAIERKFITPEGALLLSSLLNITLTTETVTRTINRYVTIRAGSQE 2009
            ...||.|    |....|..|..:|.:                   ...|...:||....|.|.:|
Mouse  1601 SQEKTIY----KEVIRVEKDPVLEGE-------------------RARVWEILNRERAARKGREE 1642

  Fly  2010 PVDSV--LLTFTEAVRQGFIDEERQL--FKDPKTGNIYSVQQALNYGLLVPDSNQTVPEPTNRKK 2070
            .|.|:  .:...||:|:.:..||.:|  .:|..:.:...:|:.|.             |...:|:
Mouse  1643 DVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLR-------------ELEQQKQ 1694

  Fly  2071 TKSTITIVTKQIIPEAEPIKLNTQHTKYVEKSVEIPISQELVKPHRVVSEF---INLEKSSYIEQ 2132
            .|:      :|:..|...:...|:..:           |:..:..:.|::.   |..||....|:
Mouse  1695 QKA------RQLQEEGRLLSQKTESER-----------QKAAQRSQAVTQLEAAILQEKDKIYEK 1742

  Fly  2133 NVTERQIMELPPGGWRLKDAIEQRLFNPDTGVFHVQGTDRLVNFEECINKQIINNLS--LSVIDP 2195
               ||.:.:|                       |.:.:...:|.|....:   .|||  :.:::|
Mouse  1743 ---ERTLRDL-----------------------HTKVSREELNQETQTRE---TNLSTKICILEP 1778

  Fly  2196 NTGDKISVQSAFERDILDSYGNYTNSRKQVQGMR---------SAIDESKIILETVPATRGANQK 2251
            .||:.:|...|::|.::|. |.|.    |:|.:.         |...|..::|:    .:...|.
Mouse  1779 ETGNDMSPYEAYKRGVIDR-GQYL----QLQELECDWEEVTTSSPCGEESVLLD----RKSGKQY 1834

  Fly  2252 TI---LRITKVN----------NIP---DVLEVSTPLKDAPPKFVEVLTCQRELASPEPLQ---I 2297
            :|   ||..:::          .:|   ..|.|:...|.:....:..:..:..:.||.|..   .
Mouse  1835 SIEAALRCRRISKEEYHRYKDGRLPISEFALLVAGETKPSSSLSIGSIISKSPVCSPGPQSTGFF 1899

  Fly  2298 APGAIYDPSTALVIFTQTGETENIFDAARQGLVDEQLIKIVDPTTKQPISVTEAIARSIYDPKTA 2362
            :||..:            |.||:.|..|          .|.|.||....|:..|:|:::.||   
Mouse  1900 SPGLSF------------GLTEDSFPIA----------GIYDTTTDNKCSIKAAVAKNMLDP--- 1939

  Fly  2363 TILDSEGQPVDLITATKLGLLSVVGAPLVAAEGALRTVRFVTDPRTGEQIPVEVAYERGIVSRDQ 2427
                                  :.|..|:.|:.|   ...:.|..:.|:..|..|.|||::....
Mouse  1940 ----------------------ITGQKLLEAQAA---TGGIVDLLSRERYSVHKAVERGLIENTS 1979

  Fly  2428 LHRGRSFDSEPATVEDKVVVLQRMRKVILKPKDALRKGIIDEETCEILENTSNFTNPKGEVVNIT 2492
            ..|..:.......:||.|.   |.|   |...:|::||.:.:|:  :|.:.            :.
Mouse  1980 TQRLLNAQKAFTGIEDPVT---RKR---LSVGEAIQKGWMPQES--VLPHL------------LV 2024

  Fly  2493 EALNTGLIDGRRGQVIDPQNNRVLNLRQAVEQKIIDSEQTNHILMPLAKSLSVPRLADQGLIDPQ 2557
            :.|..||||.:|                           |..|        .||:....|:|...
Mouse  2025 QHLTGGLIDPKR---------------------------TGRI--------PVPQAVLCGMISED 2054

  Fly  2558 TQTIVHPESGYPLSIHEAIVCEVLDPHSKLHKPEKCTLEEAI 2599
            ...::..||||..        ::.||.:|    |:.:.:||:
Mouse  2055 LGQLLQDESGYEK--------DLTDPITK----ERLSYKEAM 2084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401
CH 223..327 CDD:306753
SPEC 471..689 CDD:238103 44/227 (19%)
SPEC 690..866 CDD:238103 51/211 (24%)
SH3 885..922 CDD:327375 11/36 (31%)
SPEC 1047..1250 CDD:238103 53/267 (20%)
SPEC 1153..1390 CDD:238103 55/268 (21%)
PLEC <1498..1526 CDD:197605 5/27 (19%)
Plectin 1949..1981 CDD:307019 6/31 (19%)
DNA_pol3_delta2 <2711..3178 CDD:331068
DUF4775 3026..3357 CDD:330579
SMC_N <4904..5566 CDD:330553
SPEC 5304..5513 CDD:238103
SPEC <5658..5787 CDD:321951
SPEC 5793..6007 CDD:238103
SPEC 6011..6220 CDD:238103
SPEC 6118..6330 CDD:238103
PRK09039 <6279..6441 CDD:332967
SPEC 6443..6660 CDD:238103
SPEC 6663..6878 CDD:238103
SPEC 6880..7087 CDD:238103
SPEC 6986..7196 CDD:238103
SPEC 7196..7417 CDD:238103
SPEC 7314..7526 CDD:238103
SPEC 7528..7747 CDD:238103
SPEC 7749..7968 CDD:238103
SPEC 7973..8181 CDD:238103
EF-hand_7 8373..8437 CDD:316058
GAS2 8450..8522 CDD:128539
Herpes_ICP4_C 8550..>8795 CDD:332854
EvplXP_036012216.1 SPEC <302..>387 CDD:413338 22/84 (26%)
SH3_10 433..497 CDD:407754 23/64 (36%)
RGS 666..>810 CDD:413378 40/178 (22%)
Smc <753..1096 CDD:224117 82/402 (20%)
SMC_prok_B 937..1732 CDD:274008 169/915 (18%)
Plectin <1775..1803 CDD:395552 9/32 (28%)
PLEC 1907..1942 CDD:197605 13/69 (19%)
Plectin 1944..1983 CDD:395552 10/41 (24%)
PLEC 1981..2018 CDD:197605 11/44 (25%)
Plectin 2022..2059 CDD:395552 12/83 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 46 1.000 Domainoid score I12038
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.900

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