DRSC/TRiP Functional Genomics Resources

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Protein Alignment shot and Vwf

DIOPT Version :9

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:NP_446341.1 Gene:Vwf / 116669 RGDID:621759 Length:2812 Species:Rattus norvegicus


Alignment Length:2018 Identity:369/2018 - (18%)
Similarity:619/2018 - (30%) Gaps:724/2018 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  4332 LSDPRTGRQITLLESMRSFVVNP---HLPCYFDEQTEQMYTLSETCRN--------GIINRREGV 4385
            ||.|.:.|      |.||....|   .|.|..|....|....::||:|        |.::   |.
  Rat   753 LSSPLSHR------SKRSLSCRPPMVKLVCPADNPRAQGLECAKTCQNYDLECMSLGCVS---GC 808

  Fly  4386 FREPG----SNSFVPL--------GEALSLGLIVDIENAGFGLYELLSMGFYETSTRKVLHPVTN 4438
            ...||    .|..|.|        |||.|.|             :.:.:|......|       :
  Rat   809 LCPPGMVRHENRCVALERCPCFHQGEAYSPG-------------DTVKIGCNTCVCR-------D 853

  Fly  4439 RKLNLNEACVEDVVSLSSSL--VKHHETG---KYLRLANAIKEQLVDDSRGCYNLGNEQLDLQAA 4498
            |:.|    |...|...:.|.  :.|:.|.   ||| .....:..||.|                 
  Rat   854 RRWN----CTTHVCDATCSALGMAHYLTFDGLKYL-FPGECQYVLVQD----------------- 896

  Fly  4499 RARGLIVSNRRLLSLELVLRQQLYRPETGKFCDPTTGEYLDLIEAIHSGFIDPATTVFKNQLTGK 4563
                                          :|..::|.:..|:.  :.|...|:....|.     
  Rat   897 ------------------------------YCGGSSGTFRILVG--NEGCTYPSVKCKKR----- 924

  Fly  4564 ELPLTEAIENGDIDVSKGRVFDPKSKSAYNYDVALSRGILVTITRPLTDRN--DVVRRQDSVELL 4626
               :|..::.|:|::..|.                     |.:.|||.|.:  ::|.....|.||
  Rat   925 ---VTILVDGGEIELFNGE---------------------VNVKRPLKDESHFEMVESGQYVILL 965

  Fly  4627 NQTPVSVVISKPREMSLEEAIRYNIIDPKTALVRDFDSFK---FLPYSVAVERGLVDTTKRTLVD 4688
            ....:|||..  ..:|:...::|...:....|..:||..:   |...|:.||...:|......|.
  Rat   966 LGQGLSVVWD--HRLSISVVLKYTYQEHVCGLCGNFDGIQNNDFTSSSLQVEEDPIDFGNSWKVS 1028

  Fly  4689 PKALYFAFDPTLIVYVREPVTFDQAAESKCLDLQTGLLTYVPASVPGSATAAPASDDSANDSLTV 4753
            |                      |.|:::.|.|...|          :|........:..||...
  Rat  1029 P----------------------QCADTRKLSLDVSL----------AACHNNIMKQTMVDSSCR 1061

  Fly  4754 IETPKVYTLKEAASAGVVDPDSAL---VKDLAKAKLVRLPEAFRKGL-----MDANKANVLNTQT 4810
            |.|..::    .....:|||:..|   :.|....:.:.....|...:     :.|....|:..:.
  Rat  1062 ILTSDIF----QGCNRLVDPEPYLDICIYDTCSCESIGDCSCFCDTIAAYAHVCAQHGQVVAWRK 1122

  Fly  4811 SKLC--------TLQEAYESGL---ICTPKRSFGLLEAITFNLYNP---------TNGC------ 4849
            ..||        ..:.:||...   .|.|        |......:|         ..||      
  Rat  1123 PTLCPQSCEERNVRENSYECEWRYNSCAP--------ACPVTCQHPEPLACPVQCVEGCHAHCPP 1179

  Fly  4850 --LVDPFQMHPDIIRRRKFTLAEAIGSGLV----------DP-------------SSTVVRDPST 4889
              ::|  ::....:..:...:.|..|..|.          ||             :....::|..
  Rat  1180 GKILD--ELLQTCVDAQDCPVCEVAGRRLASGKKITLSPNDPQHCQNCHCDGVNLTCEACQEPGG 1242

  Fly  4890 GVIVPLTAAISSGLIDATEGRLTDANEPK-NNIDLVKAAEKGLLLPAEQR--QAVFEKFNMCEEN 4951
            .|:.|..|.:||     |...:.|..||. :|....|..:...||....|  :|.||        
  Rat  1243 LVVPPTDAPVSS-----TTPYVEDTPEPPLHNFYCSKLLDLVFLLDGSYRLSEAEFE-------- 1294

  Fly  4952 VNDLLKWVTTVEQKISSVGGPREKIDELRNQIN-ALKQIKD------EIESQQRPVATCLEQIR- 5008
               :||         :.|.|..|::...:.:|. |:.:..|      |:.:::||     .::| 
  Rat  1295 ---VLK---------AFVVGTMERLHISQKRIRVAVVEYHDGSHAYLELRARKRP-----SELRR 1342

  Fly  5009 ---QIVLTGGDVLSAPEVTTLENSGRELRSRVDRVNDRTVRLLRRLEAGRDELTKLRSELDVFSD 5070
               ||...|..:.|..||  |:.:..::..::||.....|.||  |.|.::.....|    .|:.
  Rat  1343 IASQIKYVGSQLASTSEV--LKYTLFQIFGKIDRPEASRVILL--LTASQEPQRMAR----YFTR 1399

  Fly  5071 WLQVARRTLEDKERSLSDLTRLPSQADSVREFVSDVIGHQADLRFITMAAQKFVDESKEFL---- 5131
            :||..:     |::.:               .:...||..|:|:.|.: .:|...|:|.||    
  Rat  1400 YLQGFK-----KKKVI---------------LIPVGIGPHANLKQIRL-IEKQAPENKAFLLSGV 1443

  Fly  5132 --------AILNDFRTSLPERLPHVEPLSSAESPIRQEVSLVSAQYKDLLNRVNALQDRVSGLGG 5188
                    .|:|......||.....:|...|...:...:|.||:...   .|.:.:.|.|..|..
  Rat  1444 DELEQRRDEIINYLCDLAPEAPAPTKPPQVAHITVSPGISGVSSPGP---KRKSLVLDVVFVLEA 1505

  Fly  5189 RQREYQDALDKANEWLRSVHPRVSRIISEPIAGDPKGVQDQMNEAKALHNELLSSGRLVD----- 5248
            .....:...:|:.|:|..|..|:.  :|      |.|.          |..:|.....|:     
  Rat  1506 SDEVGEANFNKSKEFLEEVIQRMD--VS------PAGT----------HIAVLQYSYTVNVEYTF 1552

  Fly  5249 -NAQQALDNL-----LRSLGGQLSPMEINQLELPIADLKNNYQQLLDNLGEHCKTLDKTLVQSQG 5307
             .||...|.|     :|..||.                :.|..|.|..|.||      :...|||
  Rat  1553 KEAQSKEDVLRHVREIRYQGGN----------------RTNTGQALQYLSEH------SFSPSQG 1595

  Fly  5308 VQDALDSLVGWVNQAEDKFKMNLRPASLIKERLQEQIREHKVLLADLQSHQASIDSVQVSAKHLL 5372
            .::...:||         :.:...|||       ::||.   |..|:|.....:.|         
  Rat  1596 DREQAPNLV---------YMVTGNPAS-------DEIRR---LPGDIQVVPIGVGS--------- 1632

  Fly  5373 ASASNARIAKKVESNLNDVTVKFEKLYEKANKRGEFLDDVYNRLSR-----YLDEISTVEQRMAS 5432
                        .:||.::                      .|:||     ::.:..|:.     
  Rat  1633 ------------RANLQEL----------------------ERISRPIAPIFIQDFETLP----- 1658

  Fly  5433 LQEALD-------SRETSLLSTEELARRMNELSRDKDQL----------APQFEDCVRSGKDLIS 5480
             :||.|       |:|...|.|   ...:.:.|:..|.:          |..|::.....|..||
  Rat  1659 -REAPDLVLRTCCSKEGLQLPT---LPPLPDCSQPLDVVLLLDGSSSLPASSFDEMKSFAKAFIS 1719

  Fly  5481 LRDV----TDTGVLRDRIKALESQWRNINISIDERAKLSKQKAEQQ-----LAYEGLKDQVLSWL 5536
            ..::    |...|:         |:.:|| :||....::::||..|     :..||...|:.:.|
  Rat  1720 KANIGPHLTQVSVI---------QYGSIN-TIDVPWNVAQEKAYLQSLVDLMQQEGGPSQIGNAL 1774

  Fly  5537 A----STEARVNGLPP------VAIDLDRIKQQHDELKPICKDYRDYAPTIDKINDIGAQYDALI 5591
            |    ...::::|..|      |.|.:|......|......:..|.....|    .:|.:||   
  Rat  1775 AFAVRYVTSQIHGARPGASKAVVMIIMDTSLDSVDTAVDAARSNRVAVFPI----GVGDRYD--- 1832

  Fly  5592 RPESPARKRSTYSPIKRTSPLRRMSGDARSPSPTK----GGILSPLSTGS-------SGFGSRRS 5645
                             .:.||.::|...|.:..|    ..:|:.::.|:       |||.....
  Rat  1833 -----------------EAQLRILAGPGASSNVVKLQQVEDLLTMVTPGNSFFHRLCSGFSGVCV 1880

  Fly  5646 SQDGFQLSELSPVQQQLSEINNRYGLIGVRLNDRQHELDNLNEELRKQYENLKGLAQFLERIQR- 5709
            .:||.:               .|.|.:.. |.|:.|.:..|..            .|.|.:..| 
  Rat  1881 DEDGNE---------------KRPGDVWT-LPDQCHTVTCLAN------------GQTLLQSHRV 1917

  Fly  5710 ---QLPKESVSNKDEAER------------CI---KQARKILEDMYEKQS----------LLDTT 5746
               ..|:.|.||.....|            |:   ...|.|:  .::.|:          :....
  Rat  1918 NCDHGPRPSCSNSQSPVRVEETCGCRWTCPCVCTGSSTRHIV--TFDGQNFKLTGNCSYVIFQNK 1980

  Fly  5747 KAQVKDILRRKSDVPGAEQLRQENDSIQEKWKNLNDICKNRIAFSEKLRDFLDTH--GNLKSWLD 5809
            :..::.:|...:..|||.|...:  :|:.|...|:...::.:..:...|..|..:  ||::    
  Rat  1981 EQDLEVVLHNGACSPGAVQTCMK--TIEVKHAGLSVELRSDMEMAVNGRPVLAPYVGGNMQ---- 2039

  Fly  5810 SKERMLTVLGPISSDPRMVQSQVQQVQVLREEFRTQQPQLKHFQELGHDVVDHLAGTPDAQAVEI 5874
                 :::.|.|..:.|                         |..|||.    |..||.....::
  Rat  2040 -----VSIYGAIMYEVR-------------------------FTHLGHT----LTFTPQNNEFQL 2070

  Fly  5875 KL--KDILGKWDDLVGKLDDRANSLGGAADSSKEFDAAVNRLREALQNISDNLDTLPTDGDHQEN 5937
            :|  |....|...|.|..|:     .||.|.:         ||:.         |:.||..    
  Rat  2071 QLSPKTFASKMYGLCGICDE-----NGANDFT---------LRDG---------TVTTDWK---- 2108

  Fly  5938 LRKIENLERQLEGQRPLLADVEQ---SAATLCNILGDPASRADVNSRVAALEKQYLALQKKLDTK 5999
             |.|:....|..|........||   |.::.|.:|.. ||.|:.:..:|......:..|.....:
  Rat  2109 -RLIQEWTVQQPGSTCQSVPEEQCPISDSSHCQVLLS-ASFAECHKVIAPATFHTICQQDSCHQE 2171

  Fly  6000 K-AETEASLRDGRHFAENCSKTLGWLGGELSNLTDRLLVSAHKPTLQHQIDTHEPIYRE------ 6057
            : .|..||.   .|........:.|      ..||...:|.....:.:..:...|.|.:      
  Rat  2172 RVCEVIASY---AHLCRTNGVCVDW------RTTDFCAMSCPPSLIYNHCERGCPRYCDGNTSFC 2227

  Fly  6058 -------VMAREHEVIMLINKG-----KDLTDRQQDRGVKRDLDRIQQQWEKLRREAVDRHTRLQ 6110
                   ....:|:|::   :|     :..|....|.||:.   :..:.|       |..|...|
  Rat  2228 GDHPSEGCFCPQHQVLL---EGSCVPEEACTQCVGDDGVRH---QFLETW-------VPDHQPCQ 2279

  Fly  6111 TCM 6113
            .||
  Rat  2280 ICM 2282

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401
CH 223..327 CDD:306753
SPEC 471..689 CDD:238103
SPEC 690..866 CDD:238103
SH3 885..922 CDD:327375
SPEC 1047..1250 CDD:238103
SPEC 1153..1390 CDD:238103
PLEC <1498..1526 CDD:197605
Plectin 1949..1981 CDD:307019
DNA_pol3_delta2 <2711..3178 CDD:331068
DUF4775 3026..3357 CDD:330579
SMC_N <4904..5566 CDD:330553 145/739 (20%)
SPEC 5304..5513 CDD:238103 41/234 (18%)
SPEC <5658..5787 CDD:321951 26/157 (17%)
SPEC 5793..6007 CDD:238103 44/221 (20%)
SPEC 6011..6220 CDD:238103 20/121 (17%)
SPEC 6118..6330 CDD:238103
PRK09039 <6279..6441 CDD:332967
SPEC 6443..6660 CDD:238103
SPEC 6663..6878 CDD:238103
SPEC 6880..7087 CDD:238103
SPEC 6986..7196 CDD:238103
SPEC 7196..7417 CDD:238103
SPEC 7314..7526 CDD:238103
SPEC 7528..7747 CDD:238103
SPEC 7749..7968 CDD:238103
SPEC 7973..8181 CDD:238103
EF-hand_7 8373..8437 CDD:316058
GAS2 8450..8522 CDD:128539
Herpes_ICP4_C 8550..>8795 CDD:332854
VwfNP_446341.1 VWD 35..179 CDD:278521
C8 218..292 CDD:214843
TIL 295..348 CDD:280072
VWD 377..540 CDD:214566
C8 580..648 CDD:285899
TIL 652..707 CDD:280072
VWD 856..1011 CDD:214566 40/239 (17%)
C8 1053..1127 CDD:214843 13/77 (17%)
TIL 1146..1196 CDD:280072 7/59 (12%)
VWA_N2 1198..1276 CDD:292782 17/82 (21%)
VWA 1277..1449 CDD:214621 47/225 (21%)
VWA 1498..1658 CDD:278519 47/261 (18%)
VWA 1691..1862 CDD:278519 38/204 (19%)
VWD 1950..2102 CDD:278521 36/216 (17%)
C8 2136..2199 CDD:285899 14/72 (19%)
TIL 2203..2254 CDD:280072 5/53 (9%)
VWC 2257..2321 CDD:214564 9/36 (25%)
VWC 2431..2494 CDD:214564
VWC 2581..2643 CDD:302663
CT 2726..2807 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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