DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and LOC100495047

DIOPT Version :9

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:XP_031760478.1 Gene:LOC100495047 / 100495047 -ID:- Length:1826 Species:Xenopus tropicalis


Alignment Length:1931 Identity:582/1931 - (30%)
Similarity:987/1931 - (51%) Gaps:203/1931 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly  6765 LAESRQGLRHLVLSYQDLVAWMESMEAELKRFKSVPVYAEKLLEQMDHLLELNENIAGHASNVES 6829
            :|.:....:.|:.::||.|:..|....||.|........||..|.:.   .|.:.:....:.:|.
 Frog    59 IAPAAHQFQQLLDTFQDWVSATEMRLTELWRATGSMGQIEKAHEDVQ---VLYQEVQSKPAELEG 120

  Fly  6830 TVESGAELMKHISNDEAIQLKDKLDSLQRRYGDLTNRGGDLLKSAQNALPLVQQFHEAHNRLVEW 6894
            .:|.|..|::.:|.:||...::|:|:|:.||..:.....|:.:..:..|       ||..||   
 Frog   121 VLEKGQMLLELVSGEEAQLTQEKMDTLRVRYVIIAQSAADIRQRLEQTL-------EATLRL--- 175

  Fly  6895 MQSAEAALAPSEPRQADVLRLEGELADMRPILDSINQVGPQLCQLSPGEGAATIESIVTRDNRRF 6959
                       :|.|.||....|.   |..::.||...|.:...||            |.|..:.
 Frog   176 -----------DPSQEDVSIWLGR---MEKLVASITSEGAERIPLS------------TSDVEKL 214

  Fly  6960 DSIVEQIQRKAERLHLSNQRAKEVTGDIDELLEWFREMDTTLREADLPAMEPKLVRAQLQEHRSI 7024
            :.::     .:|..||||...:  .|.:..|                 .:|.:.:.|||:||:.:
 Frog   215 EQVI-----LSELTHLSNIEGR--FGGLSCL-----------------TLEMEAIEAQLREHKLL 255

  Fly  7025 NDDISSQKGRVRDVTAASKKVLRESPQSENTATLREKLDDLKEIVDTVAQLCSERLGILEQALPL 7089
            ..:|...:|.:..:...|:.:|...| ......|:..|..|:|:...:..|.:.....||.:|.|
 Frog   256 AVEILQHRGILERLLCISETLLSLCP-DPTQERLKTHLMSLRELYPRIVALGATPPACLEHSLSL 319

  Fly  7090 SEHFADSHQGLTAWLDDMEQQISRLSMPALRPDQITLQQDKNERLLQSIAEHKPLLDKLNKTGEA 7154
            ...|:::.:.|..|:.:||:.:::|....|.......||::.:.|.:.|||||||:.||::....
 Frog   320 LTQFSEAEEELLPWMQEMEEAVAQLRNMELTDTDFRGQQEQLQSLREVIAEHKPLVTKLHRVSCK 384

  Fly  7155 LGALVADDDGAKINEI-LDTDNARYAALRLELRERQQALESALQESSQFSDKLEGMLRALANTVD 7218
            |..|  ..|||.:.:: .:....:|.:||..:|:....||..:...||.|::::.|...|....:
 Frog   385 LSEL--SPDGAHVFQLRFEAAEKQYCSLREAVRQAAAILEDTVPRYSQLSERMDLMRDNLERVRE 447

  Fly  7219 QVNQLDPLSALPQKIREQIEDNDALMDDLDKRQDAFSAVQRAANDVIAKAGNKADPAVRDIKAKL 7283
            ::.....:|..|.:||||:.:|..:..:|:|...|...:.:...::.:.|.:....| :.::.:.
 Frog   448 RLQNCSAVSGEPSRIREQLRENSLVQAELEKLGMALQNINKQGTELSSSAPSGGSQA-QVLQQQA 511

  Fly  7284 EKLNNLWNDVQNATKKRGSSLDDILSVAEPFWKQLNSVMKTLKDLEET-LSCQEPPAAQPQDIKK 7347
            |:|...|..:.:..::|...|..:|::||.||..|:.:..||.|.::| |.|:| |...|..|:.
 Frog   512 EQLLGEWRSLCSQGEERDLWLSGLLTLAERFWHGLSDLALTLSDTQQTVLDCEE-PGNDPDSIRT 575

  Fly  7348 QQVALQEIRHEIDQTKPEVEQVRRHGSNLMNMCGEPDKPEVKKHIEDLDNAWDNITALYAKREEN 7412
            :..|:..:|.:||..:.:::.:...|..||::||:.:||.|.|.:::|.:.|:.:..|:.:|...
 Frog   576 RLDAMLALREDIDNQQTDLDTLGTIGVELMSLCGDMEKPHVTKSLDELYSLWNGLNKLWNERYNR 640

  Fly  7413 LIDAMEKAMEFHETLQNLLKFLTKAEDKFAHLGAVGSDIDAVKRQIEQLKSFKDEVDPHMVEVEA 7477
            |.:.::..:.:.:|.|.|..:|..||.:.:....||.|::.||||:..||.||.|:..|.:|:|.
 Frog   641 LEEQLKATLRYQDTTQRLRDWLLSAELRISEQFLVGGDLEVVKRQLCDLKEFKRELYQHRLELET 705

  Fly  7478 LNRQAVELTERTSPEQAASIREPLSVVNRRWEALLRGMVERQKQLEHALLHLGQFQHALNELLVW 7542
            |.    .:.....|:.:|| ..|:..:..||::|....|.||.|||.|||.|||||:.|.|||.|
 Frog   706 LG----HMNGGKVPKDSAS-ECPVGDLRERWDSLEEEAVNRQHQLEDALLGLGQFQNQLEELLNW 765

  Fly  7543 INKTDSTLDQLKPIPGDPQLLEVELAKLKVLANDIQAHQNSVDTLNDAGRQLIETEKGSVEASTT 7607
            ::.|...|...:....|.|..|:||||.|||.||:.:|..:|:::|:||..::.:..|. .|.|.
 Frog   766 LSHTTEQLQGPRAPCIDLQACEIELAKHKVLRNDVLSHARTVESVNEAGSGILLSSTGD-GAETL 829

  Fly  7608 QEKLRKLNNEWKQLLQKASDRQHELEEALREAHGYIAEVQDILGWLGDVDAVIGASKPVGGLPET 7672
            |.:||:||..|:.:..|...||.|||..|........|:.::|.||..|:..:..|:|:.|..::
 Frog   830 QARLRELNQRWEFVQGKTERRQLELENDLSRVQDVTLEITELLQWLEQVETHLSLSRPIWGHLDS 894

  Fly  7673 ATEQLERFMEVYNELDENRPKVETIQAQGQEYIKRQNQMKVSSSNLQHTLRTLKQRWDAVVSRAS 7737
            |.|.|...:::..:::..:|...:::.:.|..:......:.||:  :|.||.|:|:|::...|..
 Frog   895 AREALAEHLDLCKDMESKQPTYNSVRDRLQHLLASCTLPRGSSA--EHQLRILEQKWESAHCRVQ 957

  Fly  7738 DKKIKLEIALKEATEFHDTLQAFVEWLTQAEKLLSNAEPVSRVLETIQAQMEEHKVLQKDVSTHR 7802
            ::|.:|...|...|||::|:|....||.|||...:.|.|.|.||||:..|::|||.|.:::....
 Frog   958 ERKERLSDGLAMITEFYNTMQELSAWLAQAECRATTAPPPSVVLETVTNQIQEHKGLLQEIKLQD 1022

  Fly  7803 EAMLLLDKKGTHLKYFSQKQDVILIKNLLVSVQHRWERVVSKAAERTRALDHGYKEAREFNDAWS 7867
            |.:..|:...:.||..|:|.:..|.::|:.|.:.|..:|..:|.||.|:|:...|.|::|:::..
 Frog  1023 EKLSGLELVCSRLKDVSRKPEGDLTQSLVQSTRERLGKVQERAGERGRSLEEARKLAKQFSESAH 1087

  Fly  7868 GMMQYLQETEQVLDQIIEEATASKEPQKIKKYIGKLKETHRQLGAKQSVYDGTMRTGKNLLE--R 7930
            .:::::||.:|.||....:.|.|:|  .||:.:...||..:.|.:|:.||:.|:|:|:.|.|  |
 Frog  1088 MLLEWMQEVDQSLDSSPIDTTMSQE--DIKQQLLLHKEFQKVLRSKRPVYEATLRSGRALREKGR 1150

  Fly  7931 APKGDRPVLDKMLIELKEQWTRVWSKSIDRQRKLEEALLLSGQFSDALGELLDWLKKAKSRLNEN 7995
            .|: |..:||::|.:|:|:|..:.::|.:||.||||:||.||:|.|||..|:|||.:|:.:|:|.
 Frog  1151 LPE-DGQMLDEVLGQLRERWEHICTRSTERQHKLEESLLFSGKFIDALQALMDWLYRAEPQLSEE 1214

  Fly  7996 GPVHGDLETVQGLCEHHKHIEQDLQKRAAQMQGVLKTGRDLERSGNNPE---VGRQLDEMQSIWE 8057
            .||.||.:.|..|.:.||..:::|.|||:.|:.:..:.|||.|.|.:.:   :.||::|:...|:
 Frog  1215 MPVGGDRDIVNDLLDKHKVFQKELGKRASCMKTLKHSVRDLSRGGISTDSHWLQRQMEELGHRWD 1279

  Fly  8058 EVKSAVAKRGERLQVALVDAEKLNARVQALFDWLDHAEHKLRYAKNAPDDEKVSREMMDIHMDFM 8122
            .|......:..||:.||..||:.::.|.:..:.|..:|..|:|.. .|::|:..::......:.|
 Frog  1280 LVCQLSVSKQARLEAALRQAEEFHSLVSSFLESLGESERTLKYGV-IPEEEQALQDCRRQQQELM 1343

  Fly  8123 KDLRVREREKTETFEYAEDIINKAYPDAIPIIKNWLSIIQQRWEEVRQWAINRESKLEQHLQSLK 8187
            ..|:.::..........::|:...:|:::..||:||:|.:.|::||..||..:..:::..:|||.
 Frog  1344 SALQCQQHALECIVSLGQEILVACHPNSVITIKSWLNITKTRYQEVMSWAHQQGERIKSQIQSLA 1408

  Fly  8188 DLDDTIEELLAWLSGLEGTLLNLKHEQLPDEIPPVEKLIEDHKEFMENTARRQNEVDRA---CK- 8248
            ...:.:..|:.|::..|..|.....:.||:::..:|:||..|..|||...:::.||:|.   || 
 Frog  1409 TEREEVTRLIDWITAAEEALSLRDQDPLPEDMAALEELISHHAVFMEELNKKEPEVERVTKNCKR 1473

  Fly  8249 --PRQLPPGARKPS----RSGKTPVFKGSRDQGLNARKGSRIT------PTRDTPDRDRLPHYGP 8301
              |...||.:||.|    .|.|:|            :.||.:|      ||         ||   
 Frog  1474 KVPETRPPTSRKNSAKRQNSLKSP------------QAGSSLTLLDLVPPT---------PH--- 1514

  Fly  8302 RFSPSTSGPELEFRSPRAKLLWTKWRDVWMLSWERQRLLNDHLLYLKDVERARNFSWDDWRKRFL 8366
                            .|:|| .:|:.:|.||.:||..|......|::::...:|.:..||||::
 Frog  1515 ----------------MAQLL-NRWQQLWFLSLDRQCRLQSAQQRLEELQEFAHFDFAVWRKRYM 1562

  Fly  8367 KYMNHKKSRLTDLFRKMDKDNNGMIPRDVFIDGILNTKFDTSGLEMKAVADLFDRNGEGLIDWQE 8431
            :::...|||:.|:||.:|:|.:|.|.:..|:|.:|:::|.|:.|||.|||::||.||:|.||:.|
 Frog  1563 QWIGQMKSRILDVFRGIDRDQDGRISQREFMDSVLSSRFPTNSLEMNAVANIFDINGDGFIDYYE 1627

  Fly  8432 FIAALRPDWQERKPANDSDKIHDEVKRLVMLCTCRQKFRVFQVGEGKYRFGDSQKLRLVRILRST 8496
            |::||.|.....:...|:|:|.|||.|.|..|.|.::|:|.|:...:||||:||:||:||||||:
 Frog  1628 FVSALHPSRDPLRKCADADQIQDEVNRQVAQCNCPKRFQVEQISANRYRFGESQQLRMVRILRSS 1692

  Fly  8497 VMVRVGGGWVALDEFLQKNDPCRAKGRTNIELREQFILADGVSQSMAAFTPRRSTPNAAATASSS 8561
            :||||||||:||||||.||||||.|||||:::.|:::..|.|.......|               
 Frog  1693 LMVRVGGGWIALDEFLVKNDPCRVKGRTNLKINEKYLSPDSVPAGQLKCT--------------- 1742

  Fly  8562 PHAHNGGSSNLPPYMSGQGPIIKVRERSVRSIPMSRPSRSSL----SASTPDSLSDNEGSHGGPS 8622
                 |...||.|                :.|..|| |.|||    |||.|.|          |.
 Frog  1743 -----GNQGNLLP----------------KGISPSR-SNSSLSLYSSASAPSS----------PQ 1775

  Fly  8623 GRYTPRKVTYTSTRTGLTPGGSRAGSKPNSRPL---SRQGSK-PPS 8664
            |    ||:....||:|.....|:|...|:...|   :..||. |||
 Frog  1776 G----RKIVLRRTRSGDRTPRSQASLIPDGAELHFSAANGSAGPPS 1817

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401
CH 223..327 CDD:306753
SPEC 471..689 CDD:238103
SPEC 690..866 CDD:238103
SH3 885..922 CDD:327375
SPEC 1047..1250 CDD:238103
SPEC 1153..1390 CDD:238103
PLEC <1498..1526 CDD:197605
Plectin 1949..1981 CDD:307019
DNA_pol3_delta2 <2711..3178 CDD:331068
DUF4775 3026..3357 CDD:330579
SMC_N <4904..5566 CDD:330553
SPEC 5304..5513 CDD:238103
SPEC <5658..5787 CDD:321951
SPEC 5793..6007 CDD:238103
SPEC 6011..6220 CDD:238103
SPEC 6118..6330 CDD:238103
PRK09039 <6279..6441 CDD:332967
SPEC 6443..6660 CDD:238103
SPEC 6663..6878 CDD:238103 26/112 (23%)
SPEC 6880..7087 CDD:238103 42/206 (20%)
SPEC 6986..7196 CDD:238103 51/210 (24%)
SPEC 7196..7417 CDD:238103 56/221 (25%)
SPEC 7314..7526 CDD:238103 66/212 (31%)
SPEC 7528..7747 CDD:238103 69/218 (32%)
SPEC 7749..7968 CDD:238103 78/220 (35%)
SPEC 7973..8181 CDD:238103 61/210 (29%)
EF-hand_7 8373..8437 CDD:316058 31/63 (49%)
GAS2 8450..8522 CDD:128539 46/71 (65%)
Herpes_ICP4_C 8550..>8795 CDD:332854 32/123 (26%)
LOC100495047XP_031760478.1 SPEC 1298..1495 CDD:238103 51/197 (26%)
EF-hand_7 1569..1632 CDD:404394 30/62 (48%)
GAS2 1648..1716 CDD:396660 44/67 (66%)
SPEC <35..169 CDD:238103 26/112 (23%)
SPEC 319..532 CDD:238103 52/215 (24%)
SPEC 538..749 CDD:238103 68/216 (31%)
SPEC 752..965 CDD:238103 69/215 (32%)
SPEC 867..1076 CDD:238103 63/210 (30%)
SPEC 1078..1296 CDD:238103 79/220 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17559at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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