DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shot and syne3

DIOPT Version :9

Sequence 1:	NP_725339.1	Gene:	shot / 36542	FlyBaseID:	FBgn0013733	Length:	8805	Species:	Drosophila melanogaster
Sequence 2:	NP_001076483.2	Gene:	syne3 / 100009645	ZFINID:	ZDB-GENE-070209-271	Length:	1100	Species:	Danio rerio

Alignment Length:	1526	Identity:	288/1526 - (18%)
Similarity:	515/1526 - (33%)	Gaps:	550/1526 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  5190 QREYQDALDKANEWLRSVHPRVSRIISEPIAGDPKGVQDQMNEAKALHNELLSSGRL-VDNAQQA 5253
            |.|::::|::|..|::::..|:.:  ::...|....::.::.|.:.:|: |...|:: :|....|
Zfish     6 QHEFRESLEEARSWMQAIQERLKQ--NDDTKGPRSALEVRLRETEKIHS-LEPDGQVKMDRVLVA 67

  Fly  5254 LDNLLRSLGGQLSPMEINQLELPIADLKNNYQQLLDNLGEHCKTLDKTLVQSQGVQDALDSLVGW 5318
            .:.|||:...:|.    ||....:.|||..|...|..: .||.:..:.:               |
Zfish    68 SEALLRNGDEELK----NQTHCKLKDLKAFYDDTLTYI-IHCHSRIEWV---------------W 112

  Fly  5319 VNQAE------------DKFKMNLRPASLIKERLQE---QIREHKVLLADLQSHQASIDSVQVSA 5368
            ::.:|            :|...:|.|...::..|||   |:...:||.:|:|..
Zfish   113 LHWSEYLKAHEEFGLWLEKMHRSLEPLLEMQLGLQEKLWQVDHLRVLHSDIQGQ----------- 166

  Fly  5369 KHLLASASNARIAKKVESNLNDVTVKFEKL----YEKANKRGEFLDDVYNRLSRYLDEISTVEQR 5429
                        |:.:|..|::....|.:.    .::..::|  |.:.||.:.....|..|:.|:
Zfish   167 ------------AQFLERLLDEAAALFNRTGDPSVDEQTQQG--LQEAYNHIRDRAQERLTLAQK 217

  Fly  5430 MA----SLQEALDSRETSLLSTEELARRMNELSRDKDQLAPQFEDCVRS-GKDLISLRDVTDTGV 5489
            :|    ..|..:...::.|:|..|...|.:::...........:|...| .|:.::|:.:..
Zfish   218 IAEEHQQYQSCVHKFQSWLVSKTEEVSRFSDVDDSTQNRLKALQDLGASIAKEELTLQHIEK--- 279

  Fly  5490 LRDRIKALESQWRNINISIDERAKLSKQKAEQQLAYEGLKDQVLSWLASTEARVNGLPPVAIDLD 5554
            |.:.:||        |.|.....|::::..|.:||::.|:..:|......:          |.||
Zfish   280 LSEAVKA--------NTSPAGAEKITQEIEELRLAWQRLRQTLLELKEELQ----------ISLD 326

  Fly  5555 RIKQQHDELKPICKD-YRDYAPTIDKINDIGAQYDALIRPESPARKRSTYSPIKRTSPLRRMSGD 5618
                ..:|....||: :.|.|                                |..:.::::|||
Zfish   327 ----SENEYSERCKELWADLA--------------------------------KLRTLVQKLSGD 355

  Fly  5619 ARSPSPTKGGILSPLSTGSSGFGSRRSSQDGFQLSELSPVQQQLSEINNRYGLIGVR--LNDRQH 5681
            .                         .|:||.:..|....|.::.        .|||  |..::.
Zfish   356 L-------------------------ESRDGERTEEHMVAQWKMH--------TGVRNKLIAQEP 387

  Fly  5682 ELDNLNEELRKQYENLKGLAQFLERIQRQLPKESVSNKDEAERCIKQARKILEDMYEKQSLLDTT 5746
            .::.|...|::.:               :.|::|.|..||....:|:.:.:....:...|..:|.
Zfish   388 SVEELKSRLKELF---------------RFPQDSKSLSDEVLAVVKEYQSVKGRSFRLSSESETA 437

  Fly  5747 KAQ---------------VKDILRRKSDVPGAEQLRQENDSIQEKWKNLNDICKNRIAFSEKLRD 5796
            ..|               |..:|...|||       .|...|....:|:..:.||.:...|:| .
Zfish   438 LRQILQDPLHGFSQWSQLVSQVLEASSDV-------TEFSHIALLVQNIEKLLKNSVQLQERL-S 494

  Fly  5797 FLDTHGNLKSWLDSKERMLTVLGPISSDPR---MVQSQVQQVQVLREEFRTQQPQLKHFQELGHD 5858
            .|....:|.|.:..:|:...:||.:|.|.|   ::.||:||
Zfish   495 LLQVKSDLLSAVFGQEKAEDLLGELSGDMRKRELLHSQLQQ------------------------ 535

  Fly  5859 VVDHLAGTPDAQAVEIKLKDILGKWDDLVGKLDDRANSLGGAADSSKEFDAAVNRLREALQNISD 5923
                                              |.|.|.|....:|:|..|.:.:...|.:|.|
Zfish   536 ----------------------------------RKNRLQGLISKTKDFSNAYDSIHTKLSSIKD 566

  Fly  5924 NLDTLPTDGDHQENLRKIENLERQLEGQRPLLADVEQSAA------TLCNILGDPASRADVNSRV 5982
            ..  :.|||...:.|.|    :.|.:..|.:..|:|:..|      ||  :..:|.:|.......
Zfish   567 QF--VSTDGLQPDILAK----KSQADQLRVIRKDLEECEAHIIALETL--VSSNPTNRTKFERLY 623

  Fly  5983 AALEKQYLALQKKLDTKKAETEASLRDGRHFAENCSKTLGWL-------------GGELS----- 6029
            |.....|.||:.|::    |:|.::.:...|.||......||             .||.|
Zfish   624 ADWRLLYKALRMKVN----ESEENIGEHESFHENILNMEKWLMIMKQKLDSFRGSEGEWSIDNRQ 684

  Fly  6030 NLTDRLLVSAHKPTLQ-HQIDTHEPIYREVMAREHEVIMLINKGKDLTDRQQDRGVKRDLDRIQQ 6093
            :..:|.|....:..|| ||.:          |:.|.|:.       .|..:....:.:||.|:::
Zfish   685 HEAERALGEFPEKELQLHQTE----------AQGHTVLA-------KTSEEGKVHILQDLKRLRE 732

  Fly  6094 QWEKLRREAVDRHTRLQTCMEHCKKYSQTSETFLAWLRTAEDKLADLTPGVLSKAKLETRLRDLQ 6158
            .|..|...:::.:..|||                   ...:|:.||
Zfish   733 SWMSLHTLSLNLYRLLQT-------------------TEFQDRWAD------------------- 759

  Fly  6159 TFRSEVWKH----SGEFENTKGLGETFLSSCDIDKEPIKAELQDIRDRWERLNNDLIARAHEIEN 6219
                   .|    |.:||      |.|::.   ||.|                :.|:...||.|:
Zfish   760 -------GHQQGLSSDFE------EGFITG---DKRP----------------DPLLRFHHEAES 792

  Fly  6220 CSRRLDDFNDELRNLDHSLGRCEDRLAAHDALGG--AAKDPKLLERVKAIREELTNLSKPLQSLK 6282
            ..         |:.|:.|....:|.:.| ..||.  :.:|.::..|.:::.:         |||
Zfish   793 TG---------LQELERSTEADQDLIPA-IVLGSIPSPRDSEVWRRERSVLD---------QSL- 837

  Fly  6283 ALAKDISAEARAAGGDADHLTSEVDGLADR---MSELQGRLDDRCGELQSAATAVSQF-NEQMKS 6343
                         ..:.|.:||.|:...:|   ..|::|.     |:|..:|.....: .|.|.|
Zfish   838 -------------DDEVDAVTSGVNRTVNRKKMQMEMKGG-----GDLVGSAGWTGDWVTEHMTS 884

  Fly  6344 LGIDLNDL----ETEIEKLSPPGREIKIVQVQIDDVGKIQTKLDRLVGRLEDAERAADVLVD-AG 6403
            .|||..|:    |||.|...   :.:|..|::.||.         |.|. :...|.||.... :.
Zfish   885 SGIDELDMHGRYETEPEVAQ---KRMKPSQIRHDDT---------LTGS-QGPRRPADTEAQRSQ 936

  Fly  6404 FAADTTQTREQISTL---RKTLGRLDNRVRDHEDNLHSTLKALRE-FYDHQSQTLDDIQDVSDEF 6464
            |.|...:..::::.:   :::|...:.|:|      .:|||.||. ....|||           |
Zfish   937 FEAWLHKQNDKLTGILSNQRSLSAKELRIR------QNTLKDLRAGVVWGQSQ-----------F 984

  Fly  6465 KRMKPVGSELDQIRRQQEDFRNFRERKVEPLAINVDKVNVAGRDLVRSAGSGVSTTAIEKDLEKL 6529
            :::..     ||..|..||.                                        :||:|
Zfish   985 QKLLE-----DQQHRSVEDM----------------------------------------ELEEL 1004

  Fly  6530 NDRWNDLKERMNERDRRLDVALLQSGKFQEALAGLSKWLSDTEEMVANQKPPSSD---YKVVKAQ 6591
            ..||...|.::.|           :...:|::.|      ..:|.|.:.|..|..   |:|.:..
Zfish  1005 RYRWMLYKSKLKE-----------AADLKESVGG------QIQEHVRSGKASSGPGFLYRVCRVA 1052

  Fly  6592 LQEQKFLKKMLL--------DRQNSMGSLAN 6614
            |..|..|..:||        |...|. ||||
Zfish  1053 LPLQLLLLALLLLAFLLPMMDEGTSC-SLAN 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH	223..327	CDD:306753
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3	885..922	CDD:327375
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1981	CDD:307019
		DNA_pol3_delta2	<2711..3178	CDD:331068
		DUF4775	3026..3357	CDD:330579
		SMC_N	<4904..5566	CDD:330553	75/400 (19%)
		SPEC	5304..5513	CDD:238103	39/232 (17%)
		SPEC	<5658..5787	CDD:321951	25/145 (17%)
		SPEC	5793..6007	CDD:238103	45/222 (20%)
		SPEC	6011..6220	CDD:238103	42/231 (18%)
		SPEC	6118..6330	CDD:238103	37/220 (17%)
		PRK09039	<6279..6441	CDD:332967	39/173 (23%)
		SPEC	6443..6660	CDD:238103	37/184 (20%)
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		EF-hand_7	8373..8437	CDD:316058
		GAS2	8450..8522	CDD:128539
		Herpes_ICP4_C	8550..>8795	CDD:332854
syne3	NP_001076483.2	SPEC	114..322	CDD:295325	44/243 (18%)
syne3	NP_001076483.2	KASH	<1070..1100	CDD:287506	6/14 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900